Incidental Mutation 'R6183:Or4e5'
ID 487638
Institutional Source Beutler Lab
Gene Symbol Or4e5
Ensembl Gene ENSMUSG00000059887
Gene Name olfactory receptor family 4 subfamily E member 5
Synonyms MOR28, MOR244-1, GA_x6K02T2RJGY-491851-492792, Olfr1507
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R6183 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 52727392-52733152 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 52728188 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 78 (T78S)
Ref Sequence ENSEMBL: ENSMUSP00000146152 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073571] [ENSMUST00000205963] [ENSMUST00000206062] [ENSMUST00000206069] [ENSMUST00000206931]
AlphaFold Q0VEP0
Predicted Effect probably benign
Transcript: ENSMUST00000073571
AA Change: T78S

PolyPhen 2 Score 0.050 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000073260
Gene: ENSMUSG00000059887
AA Change: T78S

DomainStartEndE-ValueType
Pfam:7tm_4 34 308 1.1e-47 PFAM
Pfam:7TM_GPCR_Srsx 38 305 3.6e-9 PFAM
Pfam:7tm_1 44 290 9.1e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205963
AA Change: T51S

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000206062
AA Change: T78S

PolyPhen 2 Score 0.050 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect probably benign
Transcript: ENSMUST00000206069
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206087
AA Change: T78S
Predicted Effect probably benign
Transcript: ENSMUST00000206931
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 94.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 T A 5: 8,968,718 (GRCm39) D352E probably benign Het
Adgrb3 T A 1: 25,133,451 (GRCm39) I972L probably damaging Het
Alg3 T C 16: 20,429,391 (GRCm39) Y33C probably benign Het
Atp1a3 C T 7: 24,681,177 (GRCm39) G816D probably damaging Het
Ccdc121 T C 5: 31,645,320 (GRCm39) Y358H probably damaging Het
Ces1g C T 8: 94,057,867 (GRCm39) V145M possibly damaging Het
Clip1 A G 5: 123,780,667 (GRCm39) S339P probably damaging Het
Col2a1 G T 15: 97,886,671 (GRCm39) T378N unknown Het
Dennd4b ACAGCAGCAGCAGCAGCAGCAGCAGCAGCAG ACAGCAGCAGCAGCAGCAGCAGCAGCAG 3: 90,182,875 (GRCm39) probably benign Het
Dnah12 T A 14: 26,583,726 (GRCm39) L3207Q probably damaging Het
Efcab5 T C 11: 77,028,084 (GRCm39) T416A probably benign Het
Ephb1 A T 9: 102,072,524 (GRCm39) I85N probably damaging Het
Etnppl T C 3: 130,413,966 (GRCm39) C22R probably damaging Het
F830016B08Rik A G 18: 60,432,949 (GRCm39) T11A probably benign Het
Gm5458 C A 14: 19,649,712 (GRCm39) V171L probably damaging Het
Helb G T 10: 119,948,903 (GRCm39) probably null Het
Hnrnpll A G 17: 80,357,305 (GRCm39) V237A possibly damaging Het
Hps3 T C 3: 20,063,032 (GRCm39) T712A probably benign Het
Ibsp A G 5: 104,453,896 (GRCm39) E78G possibly damaging Het
Ighv1-62-2 G A 12: 115,410,056 (GRCm39) A111V probably damaging Het
Igkv4-63 G T 6: 69,355,108 (GRCm39) Q58K probably damaging Het
Iqcg T C 16: 32,851,293 (GRCm39) Y226C probably damaging Het
Khdc1a A T 1: 21,420,332 (GRCm39) D30V possibly damaging Het
Krtap5-5 C A 7: 141,783,524 (GRCm39) C42F unknown Het
Lmod3 T C 6: 97,229,514 (GRCm39) N7D probably damaging Het
Lvrn A G 18: 46,983,752 (GRCm39) N165S probably benign Het
Ms4a4c A G 19: 11,403,593 (GRCm39) T192A possibly damaging Het
Ncald A T 15: 37,397,476 (GRCm39) V68D probably damaging Het
Pcdhgb7 A T 18: 37,885,315 (GRCm39) I162F probably damaging Het
Prokr1 T C 6: 87,565,834 (GRCm39) T4A possibly damaging Het
Qrich2 T A 11: 116,348,955 (GRCm39) probably benign Het
Rgl1 C T 1: 152,462,321 (GRCm39) E60K possibly damaging Het
Rtn1 A T 12: 72,455,265 (GRCm39) W21R probably benign Het
Scart2 A G 7: 139,875,947 (GRCm39) T404A possibly damaging Het
Spast A G 17: 74,680,353 (GRCm39) I438M probably damaging Het
Sptbn5 C T 2: 119,889,898 (GRCm39) probably benign Het
Sry C G Y: 2,662,975 (GRCm39) Q228H unknown Het
Tas1r1 A G 4: 152,116,998 (GRCm39) I212T probably damaging Het
Tbc1d1 A G 5: 64,432,768 (GRCm39) N439D probably damaging Het
Tjp2 C T 19: 24,078,155 (GRCm39) A913T probably damaging Het
Tnfrsf26 A G 7: 143,165,494 (GRCm39) L47P probably damaging Het
Unc13a A T 8: 72,097,310 (GRCm39) S1195T probably damaging Het
Usp54 T C 14: 20,602,313 (GRCm39) R1346G probably damaging Het
Vmn1r54 T A 6: 90,246,272 (GRCm39) M62K possibly damaging Het
Vmn2r125 A T 4: 156,702,364 (GRCm39) D50V probably damaging Het
Vmn2r66 T C 7: 84,644,766 (GRCm39) D548G possibly damaging Het
Vmn2r95 T A 17: 18,664,192 (GRCm39) N470K probably damaging Het
Zc3h7a A T 16: 10,965,234 (GRCm39) I633N possibly damaging Het
Other mutations in Or4e5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01336:Or4e5 APN 14 52,728,205 (GRCm39) missense probably damaging 1.00
IGL01367:Or4e5 APN 14 52,727,624 (GRCm39) missense probably benign 0.42
IGL01664:Or4e5 APN 14 52,728,002 (GRCm39) missense probably benign 0.01
IGL02890:Or4e5 APN 14 52,728,368 (GRCm39) missense probably benign
IGL03108:Or4e5 APN 14 52,727,533 (GRCm39) missense probably damaging 0.97
IGL03184:Or4e5 APN 14 52,728,380 (GRCm39) missense probably benign 0.20
R0563:Or4e5 UTSW 14 52,727,714 (GRCm39) nonsense probably null
R1080:Or4e5 UTSW 14 52,728,042 (GRCm39) nonsense probably null
R1558:Or4e5 UTSW 14 52,727,603 (GRCm39) missense probably benign 0.26
R1653:Or4e5 UTSW 14 52,728,229 (GRCm39) missense probably damaging 1.00
R1714:Or4e5 UTSW 14 52,727,871 (GRCm39) splice site probably null
R1720:Or4e5 UTSW 14 52,728,051 (GRCm39) nonsense probably null
R3430:Or4e5 UTSW 14 52,727,882 (GRCm39) missense possibly damaging 0.92
R4995:Or4e5 UTSW 14 52,727,988 (GRCm39) nonsense probably null
R5954:Or4e5 UTSW 14 52,727,624 (GRCm39) missense probably benign 0.42
R6518:Or4e5 UTSW 14 52,728,077 (GRCm39) missense probably damaging 1.00
R6651:Or4e5 UTSW 14 52,728,250 (GRCm39) missense probably benign 0.07
R6652:Or4e5 UTSW 14 52,728,250 (GRCm39) missense probably benign 0.07
R6653:Or4e5 UTSW 14 52,728,250 (GRCm39) missense probably benign 0.07
R7385:Or4e5 UTSW 14 52,727,638 (GRCm39) missense probably damaging 1.00
R7524:Or4e5 UTSW 14 52,727,750 (GRCm39) missense probably damaging 1.00
R8902:Or4e5 UTSW 14 52,728,010 (GRCm39) missense probably benign 0.02
R9165:Or4e5 UTSW 14 52,727,830 (GRCm39) missense possibly damaging 0.71
R9763:Or4e5 UTSW 14 52,728,307 (GRCm39) missense probably damaging 1.00
X0025:Or4e5 UTSW 14 52,727,923 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CCTCAAAGGTTTACAAATGGCC -3'
(R):5'- TGGAAAAGGCTGTCCTCATC -3'

Sequencing Primer
(F):5'- GGTTTACAAATGGCCACATAGCGATC -3'
(R):5'- GGCTCACAGGTTTATCTACAAATCCG -3'
Posted On 2017-10-10