Incidental Mutation 'R6183:Iqcg'
ID 487643
Institutional Source Beutler Lab
Gene Symbol Iqcg
Ensembl Gene ENSMUSG00000035578
Gene Name IQ motif containing G
Synonyms 2400003L07Rik, esgd12d, repro1, stubby12d, G1-374-12
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6183 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 32834640-32876617 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 32851293 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 226 (Y226C)
Ref Sequence ENSEMBL: ENSMUSP00000110752 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115100]
AlphaFold Q80W32
Predicted Effect noncoding transcript
Transcript: ENSMUST00000105610
Predicted Effect probably damaging
Transcript: ENSMUST00000115100
AA Change: Y226C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000110752
Gene: ENSMUSG00000035578
AA Change: Y226C

DomainStartEndE-ValueType
low complexity region 3 50 N/A INTRINSIC
low complexity region 101 116 N/A INTRINSIC
coiled coil region 248 329 N/A INTRINSIC
IQ 371 393 1.54e-2 SMART
low complexity region 399 419 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231235
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 94.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous male mice are infertile and have very low epididymal sperm concentration with low motility, predominantly appearing as sperm heads without tails or with short tails. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 T A 5: 8,968,718 (GRCm39) D352E probably benign Het
Adgrb3 T A 1: 25,133,451 (GRCm39) I972L probably damaging Het
Alg3 T C 16: 20,429,391 (GRCm39) Y33C probably benign Het
Atp1a3 C T 7: 24,681,177 (GRCm39) G816D probably damaging Het
Ccdc121 T C 5: 31,645,320 (GRCm39) Y358H probably damaging Het
Ces1g C T 8: 94,057,867 (GRCm39) V145M possibly damaging Het
Clip1 A G 5: 123,780,667 (GRCm39) S339P probably damaging Het
Col2a1 G T 15: 97,886,671 (GRCm39) T378N unknown Het
Dennd4b ACAGCAGCAGCAGCAGCAGCAGCAGCAGCAG ACAGCAGCAGCAGCAGCAGCAGCAGCAG 3: 90,182,875 (GRCm39) probably benign Het
Dnah12 T A 14: 26,583,726 (GRCm39) L3207Q probably damaging Het
Efcab5 T C 11: 77,028,084 (GRCm39) T416A probably benign Het
Ephb1 A T 9: 102,072,524 (GRCm39) I85N probably damaging Het
Etnppl T C 3: 130,413,966 (GRCm39) C22R probably damaging Het
F830016B08Rik A G 18: 60,432,949 (GRCm39) T11A probably benign Het
Gm5458 C A 14: 19,649,712 (GRCm39) V171L probably damaging Het
Helb G T 10: 119,948,903 (GRCm39) probably null Het
Hnrnpll A G 17: 80,357,305 (GRCm39) V237A possibly damaging Het
Hps3 T C 3: 20,063,032 (GRCm39) T712A probably benign Het
Ibsp A G 5: 104,453,896 (GRCm39) E78G possibly damaging Het
Ighv1-62-2 G A 12: 115,410,056 (GRCm39) A111V probably damaging Het
Igkv4-63 G T 6: 69,355,108 (GRCm39) Q58K probably damaging Het
Khdc1a A T 1: 21,420,332 (GRCm39) D30V possibly damaging Het
Krtap5-5 C A 7: 141,783,524 (GRCm39) C42F unknown Het
Lmod3 T C 6: 97,229,514 (GRCm39) N7D probably damaging Het
Lvrn A G 18: 46,983,752 (GRCm39) N165S probably benign Het
Ms4a4c A G 19: 11,403,593 (GRCm39) T192A possibly damaging Het
Ncald A T 15: 37,397,476 (GRCm39) V68D probably damaging Het
Or4e5 T A 14: 52,728,188 (GRCm39) T78S probably benign Het
Pcdhgb7 A T 18: 37,885,315 (GRCm39) I162F probably damaging Het
Prokr1 T C 6: 87,565,834 (GRCm39) T4A possibly damaging Het
Qrich2 T A 11: 116,348,955 (GRCm39) probably benign Het
Rgl1 C T 1: 152,462,321 (GRCm39) E60K possibly damaging Het
Rtn1 A T 12: 72,455,265 (GRCm39) W21R probably benign Het
Scart2 A G 7: 139,875,947 (GRCm39) T404A possibly damaging Het
Spast A G 17: 74,680,353 (GRCm39) I438M probably damaging Het
Sptbn5 C T 2: 119,889,898 (GRCm39) probably benign Het
Sry C G Y: 2,662,975 (GRCm39) Q228H unknown Het
Tas1r1 A G 4: 152,116,998 (GRCm39) I212T probably damaging Het
Tbc1d1 A G 5: 64,432,768 (GRCm39) N439D probably damaging Het
Tjp2 C T 19: 24,078,155 (GRCm39) A913T probably damaging Het
Tnfrsf26 A G 7: 143,165,494 (GRCm39) L47P probably damaging Het
Unc13a A T 8: 72,097,310 (GRCm39) S1195T probably damaging Het
Usp54 T C 14: 20,602,313 (GRCm39) R1346G probably damaging Het
Vmn1r54 T A 6: 90,246,272 (GRCm39) M62K possibly damaging Het
Vmn2r125 A T 4: 156,702,364 (GRCm39) D50V probably damaging Het
Vmn2r66 T C 7: 84,644,766 (GRCm39) D548G possibly damaging Het
Vmn2r95 T A 17: 18,664,192 (GRCm39) N470K probably damaging Het
Zc3h7a A T 16: 10,965,234 (GRCm39) I633N possibly damaging Het
Other mutations in Iqcg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01106:Iqcg APN 16 32,855,970 (GRCm39) missense possibly damaging 0.90
IGL01155:Iqcg APN 16 32,861,245 (GRCm39) missense probably damaging 0.99
IGL01602:Iqcg APN 16 32,837,348 (GRCm39) unclassified probably benign
IGL01605:Iqcg APN 16 32,837,348 (GRCm39) unclassified probably benign
IGL02243:Iqcg APN 16 32,865,962 (GRCm39) missense probably damaging 1.00
IGL02328:Iqcg APN 16 32,839,876 (GRCm39) missense probably benign 0.00
IGL02490:Iqcg APN 16 32,855,937 (GRCm39) nonsense probably null
IGL03297:Iqcg APN 16 32,856,002 (GRCm39) splice site probably benign
R0038:Iqcg UTSW 16 32,866,012 (GRCm39) missense probably benign 0.03
R0453:Iqcg UTSW 16 32,870,213 (GRCm39) splice site probably benign
R0719:Iqcg UTSW 16 32,861,215 (GRCm39) missense probably benign 0.26
R1191:Iqcg UTSW 16 32,870,313 (GRCm39) missense probably benign 0.43
R1544:Iqcg UTSW 16 32,865,895 (GRCm39) missense probably benign 0.01
R2292:Iqcg UTSW 16 32,870,253 (GRCm39) missense probably benign 0.25
R3725:Iqcg UTSW 16 32,840,909 (GRCm39) splice site probably null
R3726:Iqcg UTSW 16 32,849,411 (GRCm39) missense probably damaging 1.00
R3732:Iqcg UTSW 16 32,873,996 (GRCm39) unclassified probably benign
R3732:Iqcg UTSW 16 32,873,996 (GRCm39) unclassified probably benign
R3733:Iqcg UTSW 16 32,873,996 (GRCm39) unclassified probably benign
R3734:Iqcg UTSW 16 32,873,996 (GRCm39) unclassified probably benign
R3770:Iqcg UTSW 16 32,870,378 (GRCm39) synonymous silent
R4296:Iqcg UTSW 16 32,837,345 (GRCm39) unclassified probably benign
R4409:Iqcg UTSW 16 32,865,888 (GRCm39) critical splice donor site probably null
R4410:Iqcg UTSW 16 32,851,186 (GRCm39) missense possibly damaging 0.95
R4429:Iqcg UTSW 16 32,839,860 (GRCm39) missense probably benign 0.02
R4603:Iqcg UTSW 16 32,861,133 (GRCm39) critical splice donor site probably null
R4603:Iqcg UTSW 16 32,861,134 (GRCm39) missense probably null 0.68
R4979:Iqcg UTSW 16 32,839,884 (GRCm39) missense probably damaging 1.00
R5672:Iqcg UTSW 16 32,839,878 (GRCm39) missense probably damaging 0.99
R6965:Iqcg UTSW 16 32,851,174 (GRCm39) missense probably benign 0.06
R8135:Iqcg UTSW 16 32,849,394 (GRCm39) missense probably benign 0.20
R9260:Iqcg UTSW 16 32,855,973 (GRCm39) nonsense probably null
R9505:Iqcg UTSW 16 32,861,247 (GRCm39) missense probably benign 0.42
Z1177:Iqcg UTSW 16 32,849,390 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACAGCCTAATGTAGCACAAGT -3'
(R):5'- TTTATTATCCTGCGTGGGAGAA -3'

Sequencing Primer
(F):5'- GCCTAATGTAGCACAAGTTACCTC -3'
(R):5'- CTGGAACTCACTTTGTAGACCAGG -3'
Posted On 2017-10-10