|Institutional Source||Beutler Lab|
|Gene Name||WD repeat containing, antisense to Trp73|
|Synonyms||DD57, Wdr8, 5330425N03Rik, 2610044M17Rik|
|Essential gene?||Probably essential (E-score: 0.793)|
|Stock #||R0524 (G1)|
|Chromosomal Location||154142372-154167420 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 154145307 bp (GRCm38)|
|Amino Acid Change||Tyrosine to Cysteine at position 45 (Y45C)|
|Ref Sequence||ENSEMBL: ENSMUSP00000030895 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000030895]|
AA Change: Y45C
PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
AA Change: Y45C
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification. [provided by RefSeq, Mar 2009]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Wrap73||
(F):5'- GGTCCACATGAAGCTAAGTGTGTCG -3'
(R):5'- AACAGCGCCAGACCAGTTAGTTAC -3'
(F):5'- CATGAAGCTAAGTGTGTCGAACAG -3'
(R):5'- CCAGACCAGTTAGTTACACATGAG -3'