Incidental Mutation 'R6178:Trim30d'
ID 487875
Institutional Source Beutler Lab
Gene Symbol Trim30d
Ensembl Gene ENSMUSG00000057596
Gene Name tripartite motif-containing 30D
Synonyms TRIM30-3, Trim79
MMRRC Submission 044320-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R6178 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 104119221-104157056 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) T to G at 104137202 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 1 (M1L)
Ref Sequence ENSEMBL: ENSMUSP00000033211 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033211] [ENSMUST00000071069]
AlphaFold E9PWL0
Predicted Effect probably damaging
Transcript: ENSMUST00000033211
AA Change: M1L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000033211
Gene: ENSMUSG00000057596
AA Change: M1L

DomainStartEndE-ValueType
RING 15 58 1.72e-8 SMART
BBOX 91 132 5.25e-13 SMART
low complexity region 196 228 N/A INTRINSIC
Pfam:SPRY 350 491 1.9e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000071069
SMART Domains Protein: ENSMUSP00000065020
Gene: ENSMUSG00000057596

DomainStartEndE-ValueType
coiled coil region 23 84 N/A INTRINSIC
Pfam:SPRY 198 346 1.1e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000141063
SMART Domains Protein: ENSMUSP00000115684
Gene: ENSMUSG00000057596

DomainStartEndE-ValueType
PDB:4B3N|B 58 197 3e-19 PDB
Blast:SPRY 122 209 4e-13 BLAST
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 94.0%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 T C 7: 45,678,468 (GRCm39) I61V probably benign Het
Afg3l2 G A 18: 67,542,598 (GRCm39) T616I possibly damaging Het
Aktip T C 8: 91,852,671 (GRCm39) N195S probably damaging Het
Ankfy1 G A 11: 72,645,285 (GRCm39) C788Y probably benign Het
Atg7 T A 6: 114,701,856 (GRCm39) I621N probably damaging Het
Becn1 T A 11: 101,182,336 (GRCm39) I283F probably damaging Het
Btnl12 T C 16: 37,676,422 (GRCm39) Y115C probably damaging Het
C4b T C 17: 34,952,380 (GRCm39) T1220A probably benign Het
Celsr1 C A 15: 85,785,222 (GRCm39) R3004M probably benign Het
Clspn A T 4: 126,471,529 (GRCm39) probably null Het
Csmd3 T C 15: 48,536,854 (GRCm39) Y116C probably damaging Het
Dcp1a T G 14: 30,245,261 (GRCm39) *603G probably null Het
Dmrtc1b C T X: 101,757,169 (GRCm39) P205S possibly damaging Het
Fev G T 1: 74,923,698 (GRCm39) probably benign Het
Fry T A 5: 150,377,987 (GRCm39) V393E probably damaging Het
Gm30646 A G 7: 30,132,081 (GRCm39) probably null Het
Gm3676 C T 14: 41,363,452 (GRCm39) E175K probably benign Het
Gm4847 T C 1: 166,469,905 (GRCm39) Y56C probably damaging Het
Gm5422 T C 10: 31,125,688 (GRCm39) noncoding transcript Het
Gstm6 A G 3: 107,848,397 (GRCm39) V174A probably benign Het
Isoc1 G T 18: 58,804,664 (GRCm39) V191F possibly damaging Het
Kalrn T A 16: 33,874,009 (GRCm39) D132V possibly damaging Het
Kcp T C 6: 29,482,887 (GRCm39) D1394G possibly damaging Het
Marchf10 T G 11: 105,280,440 (GRCm39) D615A probably damaging Het
Mau2 A G 8: 70,495,187 (GRCm39) I50T probably damaging Het
Mgp A G 6: 136,849,722 (GRCm39) C79R probably damaging Het
Mpdz T A 4: 81,226,602 (GRCm39) K1344N probably damaging Het
Mrgpre T A 7: 143,334,708 (GRCm39) Y265F possibly damaging Het
Mro G A 18: 74,006,295 (GRCm39) V80M possibly damaging Het
Mrpl44 G T 1: 79,755,895 (GRCm39) C167F possibly damaging Het
Muc5b A G 7: 141,410,079 (GRCm39) M1218V probably null Het
Naa16 T C 14: 79,620,780 (GRCm39) I100V possibly damaging Het
Nup205 A T 6: 35,220,778 (GRCm39) Y1860F possibly damaging Het
Or10aa3 A T 1: 173,878,533 (GRCm39) Y198F probably benign Het
Or14c40 A G 7: 86,313,819 (GRCm39) I316M probably benign Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or4c103 T C 2: 88,513,977 (GRCm39) Y33C probably damaging Het
Plcb3 A G 19: 6,932,071 (GRCm39) probably null Het
Pnpla3 G A 15: 84,065,132 (GRCm39) A309T probably benign Het
Ranbp10 A G 8: 106,498,296 (GRCm39) S624P possibly damaging Het
Ripor2 T C 13: 24,894,113 (GRCm39) S714P possibly damaging Het
Robo4 C T 9: 37,316,926 (GRCm39) Q414* probably null Het
Shc2 A G 10: 79,465,954 (GRCm39) I161T probably damaging Het
Slc35b2 C T 17: 45,877,302 (GRCm39) T143I probably benign Het
Slc39a13 T C 2: 90,898,880 (GRCm39) D77G probably damaging Het
Snx6 A C 12: 54,807,249 (GRCm39) D243E probably damaging Het
Taar8b A G 10: 23,967,711 (GRCm39) V161A probably benign Het
Tbr1 T A 2: 61,635,159 (GRCm39) D36E possibly damaging Het
Tdpoz2 T C 3: 93,559,618 (GRCm39) N118S probably benign Het
Tgfb1i1 T C 7: 127,852,517 (GRCm39) F478L probably damaging Het
Tmprss11f T C 5: 86,704,837 (GRCm39) D27G probably benign Het
Trpm7 A G 2: 126,679,301 (GRCm39) V420A probably damaging Het
Ubap2 G T 4: 41,206,981 (GRCm39) P199H probably benign Het
Ubash3b T C 9: 40,926,212 (GRCm39) T512A probably damaging Het
Zfp65 G A 13: 67,858,437 (GRCm39) P76S probably benign Het
Zic5 A T 14: 122,696,748 (GRCm39) H622Q unknown Het
Zpld1 A T 16: 55,053,993 (GRCm39) N266K probably damaging Het
Zswim1 A G 2: 164,667,972 (GRCm39) probably null Het
Other mutations in Trim30d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01620:Trim30d APN 7 104,121,333 (GRCm39) missense possibly damaging 0.81
IGL01818:Trim30d APN 7 104,121,267 (GRCm39) missense probably damaging 1.00
IGL02552:Trim30d APN 7 104,121,623 (GRCm39) missense probably damaging 0.98
IGL03000:Trim30d APN 7 104,122,476 (GRCm39) missense probably benign 0.26
R0608:Trim30d UTSW 7 104,121,692 (GRCm39) missense probably damaging 0.99
R0629:Trim30d UTSW 7 104,136,862 (GRCm39) missense probably damaging 1.00
R1390:Trim30d UTSW 7 104,132,610 (GRCm39) missense probably benign 0.41
R1460:Trim30d UTSW 7 104,121,311 (GRCm39) missense probably benign 0.00
R1474:Trim30d UTSW 7 104,121,701 (GRCm39) missense probably damaging 1.00
R1701:Trim30d UTSW 7 104,133,389 (GRCm39) nonsense probably null
R1799:Trim30d UTSW 7 104,132,682 (GRCm39) missense probably damaging 0.98
R2295:Trim30d UTSW 7 104,137,149 (GRCm39) missense probably damaging 1.00
R3898:Trim30d UTSW 7 104,132,736 (GRCm39) missense probably benign 0.01
R3953:Trim30d UTSW 7 104,121,728 (GRCm39) missense probably damaging 1.00
R3954:Trim30d UTSW 7 104,121,728 (GRCm39) missense probably damaging 1.00
R3955:Trim30d UTSW 7 104,121,728 (GRCm39) missense probably damaging 1.00
R3957:Trim30d UTSW 7 104,121,728 (GRCm39) missense probably damaging 1.00
R4086:Trim30d UTSW 7 104,137,007 (GRCm39) missense probably damaging 1.00
R4087:Trim30d UTSW 7 104,137,007 (GRCm39) missense probably damaging 1.00
R4089:Trim30d UTSW 7 104,137,007 (GRCm39) missense probably damaging 1.00
R4580:Trim30d UTSW 7 104,121,765 (GRCm39) missense possibly damaging 0.68
R4596:Trim30d UTSW 7 104,121,733 (GRCm39) missense probably benign 0.02
R4926:Trim30d UTSW 7 104,132,564 (GRCm39) missense probably benign 0.09
R5071:Trim30d UTSW 7 104,137,165 (GRCm39) missense probably damaging 1.00
R5074:Trim30d UTSW 7 104,137,165 (GRCm39) missense probably damaging 1.00
R5294:Trim30d UTSW 7 104,121,695 (GRCm39) missense probably damaging 1.00
R5477:Trim30d UTSW 7 104,121,347 (GRCm39) missense probably damaging 1.00
R5629:Trim30d UTSW 7 104,137,136 (GRCm39) missense possibly damaging 0.87
R5743:Trim30d UTSW 7 104,121,535 (GRCm39) nonsense probably null
R6244:Trim30d UTSW 7 104,136,817 (GRCm39) missense probably damaging 1.00
R6937:Trim30d UTSW 7 104,132,634 (GRCm39) missense probably damaging 1.00
R7014:Trim30d UTSW 7 104,132,543 (GRCm39) missense probably benign 0.01
R7323:Trim30d UTSW 7 104,132,555 (GRCm39) missense probably benign 0.41
R7659:Trim30d UTSW 7 104,121,554 (GRCm39) missense probably benign 0.01
R7982:Trim30d UTSW 7 104,121,817 (GRCm39) missense possibly damaging 0.95
R8353:Trim30d UTSW 7 104,136,947 (GRCm39) missense probably damaging 0.99
R8453:Trim30d UTSW 7 104,136,947 (GRCm39) missense probably damaging 0.99
X0026:Trim30d UTSW 7 104,137,172 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2017-10-10