Incidental Mutation 'R6179:Fpr3'
ID487957
Institutional Source Beutler Lab
Gene Symbol Fpr3
Ensembl Gene ENSMUSG00000079700
Gene Nameformyl peptide receptor 3
SynonymsLXA4-R, Fpr-rs1, Lxa4r, Fprl1
MMRRC Submission 044321-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R6179 (G1)
Quality Score225.009
Status Not validated
Chromosome17
Chromosomal Location17887852-17971677 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 17970657 bp
ZygosityHeterozygous
Amino Acid Change Tryptophan to Stop codon at position 63 (W63*)
Ref Sequence ENSEMBL: ENSMUSP00000111227 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054871] [ENSMUST00000115565]
Predicted Effect probably null
Transcript: ENSMUST00000054871
AA Change: W63*
SMART Domains Protein: ENSMUSP00000093316
Gene: ENSMUSG00000079700
AA Change: W63*

DomainStartEndE-ValueType
Pfam:7tm_1 43 302 2.2e-43 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000115565
AA Change: W63*
SMART Domains Protein: ENSMUSP00000111227
Gene: ENSMUSG00000079700
AA Change: W63*

DomainStartEndE-ValueType
Pfam:7tm_1 43 302 1.5e-36 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 93.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930426L09Rik T C 2: 18,998,842 probably benign Het
4930590J08Rik T C 6: 91,942,330 S657P probably damaging Het
Abca9 T C 11: 110,134,254 I988V probably benign Het
Aox4 T A 1: 58,231,503 D280E probably benign Het
Apob T A 12: 8,005,060 L1353* probably null Het
Atp2b1 C T 10: 99,022,829 R222C probably damaging Het
AW209491 T G 13: 14,637,083 S174A possibly damaging Het
B930094E09Rik G C 18: 31,609,858 probably benign Het
Cbln3 G T 14: 55,884,060 P43Q possibly damaging Het
Ccdc181 A T 1: 164,279,918 T57S probably benign Het
Ccr2 A C 9: 124,105,971 N96T probably damaging Het
Cep131 T C 11: 120,066,011 I868V probably benign Het
Chd2 A G 7: 73,444,323 I1535T probably damaging Het
Chl1 A T 6: 103,683,243 T377S probably benign Het
Cpeb3 A G 19: 37,088,453 F439L probably damaging Het
Crb2 T C 2: 37,790,257 V399A probably damaging Het
Cry2 C T 2: 92,413,842 G329R probably damaging Het
Dock4 A G 12: 40,731,869 E691G probably benign Het
Edil3 A T 13: 88,821,989 H3L probably benign Het
Endod1 T C 9: 14,357,461 I243V probably benign Het
Gm498 A G 7: 143,871,787 T58A probably benign Het
Gtse1 T G 15: 85,868,957 N424K possibly damaging Het
Kcnt1 G A 2: 25,893,180 V252M probably damaging Het
Kif1bp G A 10: 62,563,250 Q130* probably null Het
Lmbrd2 T G 15: 9,149,175 I48M probably damaging Het
Lrrc7 T G 3: 158,353,432 I13L probably damaging Het
Mbd4 A G 6: 115,845,425 S408P probably benign Het
Mphosph10 A G 7: 64,378,781 V542A possibly damaging Het
Msto1 C A 3: 88,910,947 R331L probably damaging Het
Myh10 G A 11: 68,802,153 E1425K probably damaging Het
Nup43 T C 10: 7,678,673 I340T probably benign Het
Olfr350 T C 2: 36,850,834 S263P possibly damaging Het
Pcm1 T A 8: 41,283,632 M884K probably damaging Het
Phf20 T A 2: 156,298,653 L749H probably damaging Het
Pigp T C 16: 94,370,367 R22G probably null Het
Polr2b T C 5: 77,320,977 M200T probably damaging Het
Ppig T A 2: 69,750,127 D668E unknown Het
Prss3 G A 6: 41,375,126 R68C probably benign Het
Retreg3 G A 11: 101,103,895 probably benign Het
Shank1 T C 7: 44,357,206 F2116L possibly damaging Het
Spg21 T C 9: 65,468,808 S33P possibly damaging Het
Spns3 A G 11: 72,499,523 S432P probably damaging Het
Stra6 A G 9: 58,135,169 E27G probably damaging Het
Tanc1 A G 2: 59,842,976 Q1468R probably benign Het
Tbce T G 13: 14,019,777 E99A probably benign Het
Tmem106b T C 6: 13,084,253 V252A probably damaging Het
Trim10 A G 17: 36,877,031 T380A probably damaging Het
Trim31 T A 17: 36,909,609 D472E probably damaging Het
Vmn2r28 G A 7: 5,488,004 Q415* probably null Het
Vwf G A 6: 125,649,289 C7Y unknown Het
Yeats2 C T 16: 20,214,475 P1088L probably benign Het
Zfp40 C A 17: 23,178,380 V48L possibly damaging Het
Other mutations in Fpr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01067:Fpr3 APN 17 17970566 missense probably benign 0.17
IGL01520:Fpr3 APN 17 17971063 missense possibly damaging 0.69
IGL02166:Fpr3 APN 17 17970464 utr 5 prime probably benign
IGL02380:Fpr3 APN 17 17970992 missense probably benign 0.00
IGL02587:Fpr3 APN 17 17970691 missense probably benign 0.12
R1521:Fpr3 UTSW 17 17971015 missense probably damaging 1.00
R1533:Fpr3 UTSW 17 17970660 nonsense probably null
R1913:Fpr3 UTSW 17 17971408 missense probably damaging 0.96
R2099:Fpr3 UTSW 17 17971181 missense probably damaging 1.00
R2140:Fpr3 UTSW 17 17970617 missense probably damaging 1.00
R2206:Fpr3 UTSW 17 17970646 missense probably damaging 1.00
R2219:Fpr3 UTSW 17 17971382 missense possibly damaging 0.93
R2224:Fpr3 UTSW 17 17971193 missense probably damaging 1.00
R2244:Fpr3 UTSW 17 17971187 missense probably benign 0.03
R2994:Fpr3 UTSW 17 17970868 nonsense probably null
R5364:Fpr3 UTSW 17 17970544 missense probably benign 0.00
R6781:Fpr3 UTSW 17 17970716 missense probably benign 0.09
R6909:Fpr3 UTSW 17 17971167 missense probably benign 0.00
R7565:Fpr3 UTSW 17 17970965 missense probably damaging 1.00
R8008:Fpr3 UTSW 17 17971453 missense probably benign 0.03
X0021:Fpr3 UTSW 17 17971238 missense probably benign 0.06
Z1176:Fpr3 UTSW 17 17970993 missense possibly damaging 0.55
Predicted Primers PCR Primer
(F):5'- TTTCAGGTGCAGTCAAAATGGAAAC -3'
(R):5'- TGCAGGACACAAATACAGCG -3'

Sequencing Primer
(F):5'- GGAAACCAACTACTCTATCCCTTTG -3'
(R):5'- TACAGCGGTCCAAGGCAATG -3'
Posted On2017-10-10