Mutagenetix > Incidental Mutation

Incidental Mutation 'R6180:Nav2'

487999

Institutional Source

Beutler Lab

Gene Symbol

Nav2

Ensembl Gene

ENSMUSG00000052512

Gene Name

neuron navigator 2

Synonyms

Rainb1, HELAD1, Unc53H2, RAINB2, 5330421F07Rik, POMFIL2

MMRRC Submission

044322-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.483) question?

Stock #

R6180 (G1)

Quality Score

187.009

Status

Not validated

Chromosome

Chromosomal Location

48908716-49610090 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 49458167 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 647 (H647R)

Ref Sequence

ENSEMBL: ENSMUSP00000139309 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064395] [ENSMUST00000183659] [ENSMUST00000184124] [ENSMUST00000184945]

AlphaFold

E9Q842

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000064383

SMART Domains

Protein: ENSMUSP00000066835
Gene: ENSMUSG00000052512

Domain	Start	End	E-Value	Type
Blast:CH	18	79	2e-35	BLAST
PDB:2YRN\|A	18	80	3e-33	PDB
SCOP:d1dxxa1	29	81	4e-15	SMART
low complexity region	94	102	N/A	INTRINSIC
low complexity region	189	202	N/A	INTRINSIC
low complexity region	229	240	N/A	INTRINSIC
low complexity region	304	316	N/A	INTRINSIC
coiled coil region	378	408	N/A	INTRINSIC
low complexity region	472	483	N/A	INTRINSIC
low complexity region	505	517	N/A	INTRINSIC
low complexity region	532	554	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000064395
AA Change: H708R

PolyPhen 2 Score 0.122 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000067448
Gene: ENSMUSG00000052512
AA Change: H708R

Domain	Start	End	E-Value	Type
CH	84	187	1.58e-13	SMART
low complexity region	202	210	N/A	INTRINSIC
low complexity region	297	310	N/A	INTRINSIC
low complexity region	337	348	N/A	INTRINSIC
low complexity region	412	424	N/A	INTRINSIC
coiled coil region	486	516	N/A	INTRINSIC
low complexity region	580	591	N/A	INTRINSIC
low complexity region	613	625	N/A	INTRINSIC
low complexity region	640	662	N/A	INTRINSIC
low complexity region	846	857	N/A	INTRINSIC
low complexity region	920	944	N/A	INTRINSIC
low complexity region	947	967	N/A	INTRINSIC
low complexity region	990	1004	N/A	INTRINSIC
low complexity region	1062	1074	N/A	INTRINSIC
low complexity region	1343	1360	N/A	INTRINSIC
low complexity region	1368	1385	N/A	INTRINSIC
low complexity region	1417	1432	N/A	INTRINSIC
low complexity region	1454	1466	N/A	INTRINSIC
low complexity region	1526	1540	N/A	INTRINSIC
low complexity region	1614	1628	N/A	INTRINSIC
coiled coil region	1630	1717	N/A	INTRINSIC
low complexity region	1789	1800	N/A	INTRINSIC
coiled coil region	1841	1909	N/A	INTRINSIC
AAA	2093	2247	1.69e-5	SMART
low complexity region	2404	2430	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000183659
AA Change: H647R

PolyPhen 2 Score 0.387 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000139309
Gene: ENSMUSG00000052512
AA Change: H647R

Domain	Start	End	E-Value	Type
low complexity region	2	11	N/A	INTRINSIC
CH	23	126	6.19e-16	SMART
low complexity region	141	149	N/A	INTRINSIC
low complexity region	236	249	N/A	INTRINSIC
low complexity region	276	287	N/A	INTRINSIC
low complexity region	351	363	N/A	INTRINSIC
coiled coil region	425	455	N/A	INTRINSIC
low complexity region	519	530	N/A	INTRINSIC
low complexity region	552	564	N/A	INTRINSIC
low complexity region	579	601	N/A	INTRINSIC
low complexity region	785	796	N/A	INTRINSIC
low complexity region	859	883	N/A	INTRINSIC
low complexity region	886	906	N/A	INTRINSIC
low complexity region	929	943	N/A	INTRINSIC
low complexity region	1001	1013	N/A	INTRINSIC
low complexity region	1282	1299	N/A	INTRINSIC
low complexity region	1307	1324	N/A	INTRINSIC
low complexity region	1356	1371	N/A	INTRINSIC
low complexity region	1393	1405	N/A	INTRINSIC
low complexity region	1465	1479	N/A	INTRINSIC
low complexity region	1553	1567	N/A	INTRINSIC
coiled coil region	1569	1656	N/A	INTRINSIC
low complexity region	1728	1739	N/A	INTRINSIC
coiled coil region	1780	1848	N/A	INTRINSIC
AAA	2032	2186	1.69e-5	SMART
low complexity region	2343	2369	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000184124

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184155

Predicted Effect

probably benign
Transcript: ENSMUST00000184945
AA Change: H708R

PolyPhen 2 Score 0.207 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000139045
Gene: ENSMUSG00000052512
AA Change: H708R

Domain	Start	End	E-Value	Type
CH	84	187	1.58e-13	SMART
low complexity region	202	210	N/A	INTRINSIC
low complexity region	297	310	N/A	INTRINSIC
low complexity region	337	348	N/A	INTRINSIC
low complexity region	412	424	N/A	INTRINSIC
coiled coil region	486	516	N/A	INTRINSIC
low complexity region	580	591	N/A	INTRINSIC
low complexity region	613	625	N/A	INTRINSIC
low complexity region	640	662	N/A	INTRINSIC
low complexity region	846	857	N/A	INTRINSIC
low complexity region	920	944	N/A	INTRINSIC
low complexity region	947	967	N/A	INTRINSIC
low complexity region	990	1004	N/A	INTRINSIC
low complexity region	1062	1074	N/A	INTRINSIC
low complexity region	1343	1360	N/A	INTRINSIC
low complexity region	1368	1385	N/A	INTRINSIC
low complexity region	1417	1432	N/A	INTRINSIC
low complexity region	1454	1466	N/A	INTRINSIC
low complexity region	1526	1540	N/A	INTRINSIC
low complexity region	1614	1628	N/A	INTRINSIC
coiled coil region	1630	1717	N/A	INTRINSIC
low complexity region	1789	1800	N/A	INTRINSIC
coiled coil region	1841	1909	N/A	INTRINSIC
AAA	2093	2247	1.69e-5	SMART
low complexity region	2404	2430	N/A	INTRINSIC

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.1%
20x: 94.5%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous null mice display impaired olfaction and hearing, increased latency in a hot plate test, degeneration of the optic nerve, decreased exploration in new environments, and weight loss. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 88 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610507B11Rik	A	G	11: 78,273,258 (GRCm38)	M1142V	possibly damaging	Het
Adam39	A	G	8: 40,826,573 (GRCm38)	N667S	probably benign	Het
Ap4e1	T	A	2: 127,066,588 (GRCm38)	C1085*	probably null	Het
BC035044	A	T	6: 128,885,034 (GRCm38)		probably benign	Het
Capn11	T	C	17: 45,630,766 (GRCm38)	D693G	probably damaging	Het
Cavin4	A	T	4: 48,663,917 (GRCm38)	H99L	possibly damaging	Het
Ccdc86	T	C	19: 10,948,581 (GRCm38)	K218R	possibly damaging	Het
Ccno	T	C	13: 112,989,845 (GRCm38)	S283P	probably damaging	Het
Ccser2	A	T	14: 36,940,319 (GRCm38)	S303T	probably benign	Het
Cd53	T	A	3: 106,767,364 (GRCm38)	N129I	probably damaging	Het
Cd63	G	A	10: 128,912,064 (GRCm38)		probably null	Het
Cyp2j6	G	C	4: 96,536,086 (GRCm38)	L145V	probably damaging	Het
Daam2	A	G	17: 49,469,666 (GRCm38)	M797T	probably damaging	Het
Dmgdh	G	A	13: 93,752,286 (GRCm38)	V811I	possibly damaging	Het
Dpysl4	A	T	7: 139,090,334 (GRCm38)	T123S	probably damaging	Het
Erap1	A	G	13: 74,666,226 (GRCm38)	E428G	possibly damaging	Het
Fam124b	T	A	1: 80,200,185 (GRCm38)	T366S	possibly damaging	Het
Fbxw22	T	C	9: 109,386,679 (GRCm38)	D167G	probably damaging	Het
Flrt2	C	T	12: 95,779,238 (GRCm38)	Q117*	probably null	Het
Ftsj3	A	T	11: 106,253,340 (GRCm38)		probably null	Het
Ggn	A	G	7: 29,173,049 (GRCm38)	Y618C	probably damaging	Het
Glis1	T	A	4: 107,627,513 (GRCm38)	S402T	probably benign	Het
Gm13762	T	G	2: 88,973,882 (GRCm38)	N3T	probably damaging	Het
Gm4781	T	A	10: 100,396,487 (GRCm38)		noncoding transcript	Het
Gm7168	T	A	17: 13,948,596 (GRCm38)	I75K	probably damaging	Het
Gm7298	C	T	6: 121,760,823 (GRCm38)	H348Y	probably benign	Het
Gria1	G	T	11: 57,242,792 (GRCm38)	R499L	probably damaging	Het
Gtf2ird2	C	T	5: 134,216,547 (GRCm38)	T549M	probably damaging	Het
H2-M10.6	T	A	17: 36,814,286 (GRCm38)	V323E	probably damaging	Het
Hoxb3	G	A	11: 96,346,103 (GRCm38)	V336I	probably benign	Het
Il12b	G	A	11: 44,412,626 (GRCm38)	A327T	probably benign	Het
Inpp4a	C	A	1: 37,380,102 (GRCm38)	P588T	probably benign	Het
Kctd12	C	A	14: 102,981,591 (GRCm38)	D284Y	probably damaging	Het
Kif28	C	A	1: 179,697,772 (GRCm38)		probably null	Het
Krt2	T	C	15: 101,815,044 (GRCm38)	N332S	probably benign	Het
Lama2	G	A	10: 26,981,499 (GRCm38)	T3118I	probably benign	Het
Lgi1	T	C	19: 38,264,956 (GRCm38)	L25P	probably damaging	Het
Lhx3	T	A	2: 26,201,491 (GRCm38)	M269L	probably benign	Het
Lmtk2	A	T	5: 144,175,342 (GRCm38)	E960V	probably damaging	Het
Loxl4	A	T	19: 42,608,352 (GRCm38)	D60E	probably damaging	Het
Lrp2	T	A	2: 69,503,524 (GRCm38)	N1458Y	possibly damaging	Het
Ltn1	A	T	16: 87,427,789 (GRCm38)	S16T	probably damaging	Het
Mllt6	G	A	11: 97,678,536 (GRCm38)	A875T	possibly damaging	Het
Mpp5	C	T	12: 78,817,310 (GRCm38)	H216Y	probably benign	Het
Mrgprb4	A	T	7: 48,198,826 (GRCm38)	I118N	probably damaging	Het
Mrps7	A	G	11: 115,604,881 (GRCm38)	T82A	possibly damaging	Het
Mug2	A	G	6: 122,079,606 (GRCm38)	E1170G	probably benign	Het
Nbeal2	T	C	9: 110,625,147 (GRCm38)	Y2710C	probably damaging	Het
Ndc1	A	T	4: 107,411,198 (GRCm38)	I644L	possibly damaging	Het
Olfr952	A	T	9: 39,426,712 (GRCm38)	Y120N	probably damaging	Het
Padi4	A	G	4: 140,756,473 (GRCm38)	M352T	possibly damaging	Het
Pcdhgc3	C	A	18: 37,806,937 (GRCm38)	D130E	probably damaging	Het
Pde6a	A	T	18: 61,284,092 (GRCm38)		probably null	Het
Pdpn	C	T	4: 143,299,222 (GRCm38)	G12R	probably damaging	Het
Pot1a	A	T	6: 25,771,621 (GRCm38)	D200E	probably benign	Het
Ppa1	A	T	10: 61,667,652 (GRCm38)	D236V	probably benign	Het
Ptprn2	T	A	12: 116,859,119 (GRCm38)	S273T	probably benign	Het
Rasgrf2	T	C	13: 92,029,101 (GRCm38)	E297G	probably damaging	Het
Rgl1	T	C	1: 152,519,172 (GRCm38)	N750S	probably damaging	Het
Rinl	A	G	7: 28,796,940 (GRCm38)	N449D	probably benign	Het
Samd8	T	A	14: 21,775,025 (GRCm38)	H79Q	probably benign	Het
Scn11a	T	C	9: 119,754,867 (GRCm38)	I1561V	probably benign	Het
Slc39a12	T	C	2: 14,396,127 (GRCm38)	L105P	probably benign	Het
Slc7a12	A	T	3: 14,481,140 (GRCm38)		probably null	Het
Slco1a4	A	G	6: 141,817,820 (GRCm38)	I390T	possibly damaging	Het
Snta1	T	C	2: 154,377,182 (GRCm38)	N411S	probably benign	Het
Srgap2	T	C	1: 131,349,541 (GRCm38)	T323A	probably benign	Het
Ssh2	G	T	11: 77,453,465 (GRCm38)	V759L	probably benign	Het
St5	A	C	7: 109,556,888 (GRCm38)	D218E	probably benign	Het
Swap70	G	T	7: 110,269,981 (GRCm38)	R327L	probably damaging	Het
Tbc1d4	C	A	14: 101,458,770 (GRCm38)	C914F	probably benign	Het
Tbx3	A	G	5: 119,674,067 (GRCm38)	D144G	probably damaging	Het
Tgfbr2	T	C	9: 116,110,144 (GRCm38)	K205R	possibly damaging	Het
Tmem94	A	T	11: 115,791,031 (GRCm38)		probably null	Het
Usf3	T	A	16: 44,221,105 (GRCm38)	F1983I	probably damaging	Het
Ush2a	T	A	1: 188,399,871 (GRCm38)	C763*	probably null	Het
Vmn1r115	A	C	7: 20,844,715 (GRCm38)	L91V	probably damaging	Het
Vmn1r201	A	T	13: 22,475,329 (GRCm38)	I238F	possibly damaging	Het
Vmn1r28	T	A	6: 58,265,491 (GRCm38)	S106R	probably damaging	Het
Vmn1r82	T	C	7: 12,305,085 (GRCm38)	V95A	probably damaging	Het
Vrk3	A	T	7: 44,769,611 (GRCm38)	N371I	possibly damaging	Het
Wnt8b	C	A	19: 44,511,643 (GRCm38)	A223E	probably benign	Het
Xirp2	T	C	2: 67,505,577 (GRCm38)		probably null	Het
Xpo7	T	C	14: 70,682,803 (GRCm38)	N642S	probably benign	Het
Ythdc1	G	A	5: 86,828,094 (GRCm38)	R520H	possibly damaging	Het
Zfp367	T	C	13: 64,135,390 (GRCm38)	E316G	probably damaging	Het
Zfp488	T	A	14: 33,970,794 (GRCm38)	R137S	possibly damaging	Het
Zfp532	G	T	18: 65,656,471 (GRCm38)	V994L	probably benign	Het

Other mutations in Nav2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01097:Nav2	APN	7	49,571,194 (GRCm38)	missense	probably damaging	1.00
IGL01150:Nav2	APN	7	49,452,521 (GRCm38)	missense	probably benign	0.17
IGL01649:Nav2	APN	7	49,575,729 (GRCm38)	missense	probably damaging	1.00
IGL01662:Nav2	APN	7	49,571,209 (GRCm38)	missense	probably damaging	1.00
IGL02297:Nav2	APN	7	49,594,229 (GRCm38)	missense	probably damaging	0.98
IGL02313:Nav2	APN	7	49,558,773 (GRCm38)	missense	probably damaging	0.99
IGL02441:Nav2	APN	7	49,452,512 (GRCm38)	missense	probably damaging	1.00
IGL02472:Nav2	APN	7	49,546,041 (GRCm38)	missense	probably damaging	1.00
IGL02477:Nav2	APN	7	49,582,875 (GRCm38)	missense	probably damaging	0.99
IGL02725:Nav2	APN	7	49,565,095 (GRCm38)	missense	probably damaging	1.00
IGL02944:Nav2	APN	7	49,420,256 (GRCm38)	missense	probably damaging	0.99
IGL02953:Nav2	APN	7	49,548,423 (GRCm38)	missense	probably damaging	1.00
IGL03105:Nav2	APN	7	49,464,879 (GRCm38)	missense	probably damaging	1.00
IGL03234:Nav2	APN	7	49,462,008 (GRCm38)	missense	possibly damaging	0.94
IGL03274:Nav2	APN	7	49,362,099 (GRCm38)	missense	probably damaging	1.00
IGL03294:Nav2	APN	7	49,491,457 (GRCm38)	nonsense	probably null
R0006:Nav2	UTSW	7	49,453,230 (GRCm38)	missense	possibly damaging	0.50
R0070:Nav2	UTSW	7	49,570,714 (GRCm38)	missense	probably damaging	1.00
R0113:Nav2	UTSW	7	49,535,953 (GRCm38)	missense	probably damaging	1.00
R0306:Nav2	UTSW	7	49,545,903 (GRCm38)	missense	probably benign	0.01
R0346:Nav2	UTSW	7	49,604,585 (GRCm38)	missense	probably benign	0.11
R0539:Nav2	UTSW	7	49,461,938 (GRCm38)	missense	probably damaging	1.00
R0669:Nav2	UTSW	7	49,408,683 (GRCm38)	missense	probably damaging	1.00
R0785:Nav2	UTSW	7	49,420,333 (GRCm38)	missense	probably benign	0.06
R0970:Nav2	UTSW	7	49,584,153 (GRCm38)	missense	probably damaging	1.00
R1162:Nav2	UTSW	7	49,536,040 (GRCm38)	splice site	probably benign
R1274:Nav2	UTSW	7	49,604,430 (GRCm38)	nonsense	probably null
R1463:Nav2	UTSW	7	49,535,962 (GRCm38)	missense	probably damaging	1.00
R1464:Nav2	UTSW	7	49,362,204 (GRCm38)	missense	probably damaging	1.00
R1464:Nav2	UTSW	7	49,362,204 (GRCm38)	missense	probably damaging	1.00
R1536:Nav2	UTSW	7	49,545,934 (GRCm38)	missense	probably damaging	1.00
R1612:Nav2	UTSW	7	49,571,211 (GRCm38)	missense	probably damaging	1.00
R1638:Nav2	UTSW	7	49,452,465 (GRCm38)	missense	probably benign
R1731:Nav2	UTSW	7	49,548,174 (GRCm38)	missense	probably damaging	1.00
R1734:Nav2	UTSW	7	49,575,720 (GRCm38)	missense	probably damaging	1.00
R1865:Nav2	UTSW	7	49,548,195 (GRCm38)	missense	possibly damaging	0.95
R1945:Nav2	UTSW	7	49,464,872 (GRCm38)	missense	probably damaging	1.00
R1997:Nav2	UTSW	7	49,548,471 (GRCm38)	missense	probably benign	0.16
R2061:Nav2	UTSW	7	49,598,897 (GRCm38)	splice site	probably benign
R2117:Nav2	UTSW	7	49,464,580 (GRCm38)	missense	probably benign	0.00
R2174:Nav2	UTSW	7	49,452,663 (GRCm38)	missense	probably damaging	0.99
R2182:Nav2	UTSW	7	49,597,254 (GRCm38)	missense	probably benign	0.38
R2251:Nav2	UTSW	7	49,453,277 (GRCm38)	missense	probably damaging	1.00
R2283:Nav2	UTSW	7	49,491,404 (GRCm38)	missense	probably damaging	1.00
R2343:Nav2	UTSW	7	49,598,817 (GRCm38)	missense	possibly damaging	0.82
R2472:Nav2	UTSW	7	49,408,884 (GRCm38)	missense	probably benign
R2568:Nav2	UTSW	7	49,597,564 (GRCm38)	missense	probably damaging	1.00
R2656:Nav2	UTSW	7	49,545,942 (GRCm38)	missense	probably damaging	1.00
R2964:Nav2	UTSW	7	49,557,032 (GRCm38)	missense	probably damaging	1.00
R2966:Nav2	UTSW	7	49,557,032 (GRCm38)	missense	probably damaging	1.00
R3817:Nav2	UTSW	7	49,464,562 (GRCm38)	missense	probably benign	0.00
R3834:Nav2	UTSW	7	49,545,858 (GRCm38)	missense	possibly damaging	0.91
R4207:Nav2	UTSW	7	49,597,231 (GRCm38)	missense	probably damaging	1.00
R4207:Nav2	UTSW	7	49,572,298 (GRCm38)	splice site	probably null
R4411:Nav2	UTSW	7	49,398,109 (GRCm38)	missense	probably benign	0.37
R4413:Nav2	UTSW	7	49,398,109 (GRCm38)	missense	probably benign	0.37
R4440:Nav2	UTSW	7	49,575,263 (GRCm38)	splice site	probably benign
R4440:Nav2	UTSW	7	49,552,037 (GRCm38)	missense	possibly damaging	0.86
R4454:Nav2	UTSW	7	49,548,544 (GRCm38)	splice site	probably null
R4729:Nav2	UTSW	7	49,452,819 (GRCm38)	missense	probably benign	0.17
R4801:Nav2	UTSW	7	49,545,852 (GRCm38)	missense	possibly damaging	0.94
R4802:Nav2	UTSW	7	49,545,852 (GRCm38)	missense	possibly damaging	0.94
R4824:Nav2	UTSW	7	49,409,001 (GRCm38)	intron	probably benign
R4887:Nav2	UTSW	7	49,548,434 (GRCm38)	nonsense	probably null
R4908:Nav2	UTSW	7	49,604,510 (GRCm38)	missense	probably damaging	1.00
R4952:Nav2	UTSW	7	49,304,540 (GRCm38)	intron	probably benign
R4965:Nav2	UTSW	7	49,552,877 (GRCm38)	nonsense	probably null
R5169:Nav2	UTSW	7	49,548,483 (GRCm38)	nonsense	probably null
R5224:Nav2	UTSW	7	49,551,725 (GRCm38)	missense	probably benign	0.00
R5249:Nav2	UTSW	7	49,535,913 (GRCm38)	missense	probably damaging	1.00
R5285:Nav2	UTSW	7	49,548,234 (GRCm38)	missense	probably damaging	1.00
R5314:Nav2	UTSW	7	49,408,692 (GRCm38)	small deletion	probably benign
R5320:Nav2	UTSW	7	49,491,373 (GRCm38)	missense	probably benign	0.00
R5377:Nav2	UTSW	7	49,589,160 (GRCm38)	missense	probably benign	0.02
R5471:Nav2	UTSW	7	49,548,169 (GRCm38)	missense	probably damaging	1.00
R5754:Nav2	UTSW	7	49,557,046 (GRCm38)	missense	probably damaging	1.00
R5832:Nav2	UTSW	7	49,548,069 (GRCm38)	splice site	probably null
R5884:Nav2	UTSW	7	49,597,169 (GRCm38)	nonsense	probably null
R5921:Nav2	UTSW	7	49,304,576 (GRCm38)	intron	probably benign
R6208:Nav2	UTSW	7	49,564,103 (GRCm38)	missense	probably damaging	0.99
R6373:Nav2	UTSW	7	49,453,175 (GRCm38)	missense	probably damaging	1.00
R6450:Nav2	UTSW	7	49,594,366 (GRCm38)	missense	probably damaging	1.00
R6522:Nav2	UTSW	7	49,597,533 (GRCm38)	missense	probably damaging	1.00
R6626:Nav2	UTSW	7	49,594,352 (GRCm38)	missense	probably damaging	1.00
R6695:Nav2	UTSW	7	49,464,904 (GRCm38)	missense	probably benign	0.04
R6705:Nav2	UTSW	7	49,551,916 (GRCm38)	missense	probably damaging	1.00
R6842:Nav2	UTSW	7	49,458,169 (GRCm38)	missense	possibly damaging	0.91
R6847:Nav2	UTSW	7	49,491,456 (GRCm38)	missense	probably benign	0.14
R7287:Nav2	UTSW	7	49,420,328 (GRCm38)	missense	probably benign	0.01
R7312:Nav2	UTSW	7	49,461,924 (GRCm38)	missense	possibly damaging	0.55
R7315:Nav2	UTSW	7	49,548,289 (GRCm38)	missense	possibly damaging	0.61
R7337:Nav2	UTSW	7	49,551,773 (GRCm38)	missense	possibly damaging	0.56
R7366:Nav2	UTSW	7	49,554,203 (GRCm38)	splice site	probably null
R7451:Nav2	UTSW	7	49,552,829 (GRCm38)	splice site	probably null
R7545:Nav2	UTSW	7	49,582,857 (GRCm38)	missense	probably damaging	1.00
R7706:Nav2	UTSW	7	49,594,319 (GRCm38)	missense	probably benign	0.35
R7730:Nav2	UTSW	7	49,572,397 (GRCm38)	missense	probably damaging	1.00
R7812:Nav2	UTSW	7	49,597,173 (GRCm38)	missense	probably benign	0.13
R8097:Nav2	UTSW	7	49,587,777 (GRCm38)	missense	probably damaging	1.00
R8110:Nav2	UTSW	7	49,551,950 (GRCm38)	nonsense	probably null
R8119:Nav2	UTSW	7	49,453,484 (GRCm38)	missense	probably damaging	0.99
R8298:Nav2	UTSW	7	49,554,261 (GRCm38)	critical splice donor site	probably null
R8306:Nav2	UTSW	7	49,546,017 (GRCm38)	missense	probably benign	0.33
R8331:Nav2	UTSW	7	49,452,623 (GRCm38)	missense	probably benign
R8402:Nav2	UTSW	7	49,453,437 (GRCm38)	missense	probably benign	0.43
R8421:Nav2	UTSW	7	49,452,521 (GRCm38)	missense	probably benign
R8478:Nav2	UTSW	7	49,461,985 (GRCm38)	missense	probably damaging	0.99
R8724:Nav2	UTSW	7	49,491,436 (GRCm38)	missense	possibly damaging	0.82
R8753:Nav2	UTSW	7	49,452,572 (GRCm38)	missense	probably benign
R8835:Nav2	UTSW	7	49,598,803 (GRCm38)	missense	possibly damaging	0.83
R8933:Nav2	UTSW	7	49,461,957 (GRCm38)	missense	probably damaging	1.00
R8957:Nav2	UTSW	7	49,571,216 (GRCm38)	missense	probably damaging	1.00
R9069:Nav2	UTSW	7	49,558,813 (GRCm38)	missense	probably damaging	0.99
R9095:Nav2	UTSW	7	49,604,545 (GRCm38)	missense	probably damaging	1.00
R9223:Nav2	UTSW	7	49,552,851 (GRCm38)	missense	probably damaging	1.00
R9261:Nav2	UTSW	7	49,597,156 (GRCm38)	missense	probably damaging	1.00
X0023:Nav2	UTSW	7	49,547,899 (GRCm38)	missense	possibly damaging	0.47
Z1177:Nav2	UTSW	7	49,594,223 (GRCm38)	missense	probably benign	0.01
Z1177:Nav2	UTSW	7	49,452,761 (GRCm38)	missense	possibly damaging	0.47

Predicted Primers

PCR Primer
(F):5'- ATCTTTCTGGGCTCAGTCAC -3'
(R):5'- CAGGAGCTACAGTTTTGGGG -3'

Sequencing Primer
(F):5'- AGTCACCCTCTCCACGTGTG -3'
(R):5'- GCTACAGTTTTGGGGAGGAAC -3'

Posted On

2017-10-10