Incidental Mutation 'R0524:Olfr1471'
ID48814
Institutional Source Beutler Lab
Gene Symbol Olfr1471
Ensembl Gene ENSMUSG00000096320
Gene Nameolfactory receptor 1471
SynonymsMOR202-47_p, MOR202-38, GA_x6K02T2RE5P-3777626-3778570
MMRRC Submission 038717-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.080) question?
Stock #R0524 (G1)
Quality Score225
Status Not validated
Chromosome19
Chromosomal Location13443409-13451527 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 13445864 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 284 (N284S)
Ref Sequence ENSEMBL: ENSMUSP00000149948 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096203] [ENSMUST00000217249] [ENSMUST00000217482]
Predicted Effect probably damaging
Transcript: ENSMUST00000096203
AA Change: N284S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000093917
Gene: ENSMUSG00000096320
AA Change: N284S

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.1e-53 PFAM
Pfam:7TM_GPCR_Srsx 33 303 1.1e-8 PFAM
Pfam:7tm_1 39 288 4e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213460
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213561
Predicted Effect probably damaging
Transcript: ENSMUST00000217249
AA Change: N284S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217482
AA Change: N284S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.7%
  • 10x: 96.4%
  • 20x: 92.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acbd3 CGAGGAGGAGGAGGAGGA CGAGGAGGAGGAGGA 1: 180,747,059 probably benign Het
Adamts16 T C 13: 70,800,894 E216G probably benign Het
Aoc3 C A 11: 101,337,511 P715T probably damaging Het
Bnipl T C 3: 95,249,829 D33G probably benign Het
Celsr2 T C 3: 108,401,587 H1701R probably damaging Het
Clca3b T A 3: 144,825,321 H756L probably benign Het
Clca4a A G 3: 144,969,393 W159R probably damaging Het
Ddx49 A T 8: 70,296,924 I252N probably damaging Het
Duox2 T C 2: 122,281,836 T1290A possibly damaging Het
Fam111a T A 19: 12,588,048 I431K probably damaging Het
Fam135b A T 15: 71,462,284 D1020E probably benign Het
Flii A G 11: 60,720,061 V514A probably damaging Het
Frmpd1 G A 4: 45,256,902 V157M probably damaging Het
Frmpd1 A G 4: 45,283,774 D865G probably benign Het
Gm6970 T A 19: 47,170,494 K214M unknown Het
Gsr G A 8: 33,669,180 probably null Het
Hps3 A T 3: 20,012,776 V542E probably damaging Het
Kcnj5 A G 9: 32,322,974 I15T probably benign Het
Kif2b T C 11: 91,575,724 R578G probably benign Het
Lamb2 A G 9: 108,484,372 R676G possibly damaging Het
Mrpl40 A G 16: 18,873,552 F94S possibly damaging Het
Myo7b C T 18: 32,013,424 V103M possibly damaging Het
Nmt2 T A 2: 3,305,437 W69R probably benign Het
Nsd3 C A 8: 25,700,577 Q1130K possibly damaging Het
Olfml1 T C 7: 107,590,177 S150P probably damaging Het
Olfr123 A T 17: 37,795,605 K54* probably null Het
Pask A T 1: 93,310,834 W1310R probably damaging Het
Pcdh18 T C 3: 49,755,642 Q408R probably damaging Het
Pfkm A G 15: 98,131,607 I700V probably benign Het
Pias1 A G 9: 62,952,178 V16A probably damaging Het
Pnpla8 C T 12: 44,283,618 Q318* probably null Het
Ppp1cc C T 5: 122,172,770 R142* probably null Het
Pygl T A 12: 70,207,724 N149I probably damaging Het
Rapgef6 T A 11: 54,690,284 S1285T probably benign Het
Rdh13 A C 7: 4,444,297 C10W probably damaging Het
Rgr A T 14: 37,038,295 C273S probably benign Het
Ripk4 G T 16: 97,755,287 Y22* probably null Het
Slc34a2 G A 5: 53,064,873 W302* probably null Het
Smarce1 G A 11: 99,214,062 T263M probably damaging Het
Sypl C T 12: 32,967,565 P94L possibly damaging Het
Tet3 A G 6: 83,379,942 I878T probably damaging Het
Tmem232 A G 17: 65,485,942 S87P probably damaging Het
Tmem260 A G 14: 48,472,478 T163A probably benign Het
Ttn T C 2: 76,725,452 Y30403C probably damaging Het
Ubash3b A T 9: 41,016,608 M468K probably benign Het
Ulk4 A G 9: 121,252,651 probably null Het
Vmn1r72 A G 7: 11,669,792 F243S probably benign Het
Wrap73 A G 4: 154,145,307 Y45C probably damaging Het
Zfp704 T C 3: 9,609,364 D119G unknown Het
Zfp719 A G 7: 43,589,253 probably null Het
Other mutations in Olfr1471
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Olfr1471 APN 19 13445624 missense probably benign 0.00
IGL01790:Olfr1471 APN 19 13445162 missense probably damaging 1.00
IGL02515:Olfr1471 APN 19 13445108 missense probably damaging 1.00
IGL02838:Olfr1471 APN 19 13445935 missense probably benign
IGL03182:Olfr1471 APN 19 13445443 missense possibly damaging 0.93
R0267:Olfr1471 UTSW 19 13445428 missense probably damaging 0.99
R1584:Olfr1471 UTSW 19 13445659 missense probably damaging 1.00
R2253:Olfr1471 UTSW 19 13445185 missense probably damaging 1.00
R5267:Olfr1471 UTSW 19 13445111 missense probably damaging 1.00
R6419:Olfr1471 UTSW 19 13445767 missense probably benign 0.00
R6495:Olfr1471 UTSW 19 13445625 missense probably benign 0.43
R7714:Olfr1471 UTSW 19 13445888 missense probably damaging 1.00
R7830:Olfr1471 UTSW 19 13445621 missense probably benign 0.33
R7882:Olfr1471 UTSW 19 13445587 missense probably benign 0.02
R7892:Olfr1471 UTSW 19 13445298 nonsense probably null
R7965:Olfr1471 UTSW 19 13445587 missense probably benign 0.02
R7975:Olfr1471 UTSW 19 13445298 nonsense probably null
Z1088:Olfr1471 UTSW 19 13445849 missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- GCTGAAGCACAGAGGAAGGCATT -3'
(R):5'- CAAGATTCAAGATTCCTGTATGACCAAGACC -3'

Sequencing Primer
(F):5'- CAGAGGAAGGCATTCTCTACCTG -3'
(R):5'- tgaagggaagaaacagaaaggg -3'
Posted On2013-06-12