Incidental Mutation 'R6136:Ralgds'
ID 488330
Institutional Source Beutler Lab
Gene Symbol Ralgds
Ensembl Gene ENSMUSG00000026821
Gene Name ral guanine nucleotide dissociation stimulator
Synonyms RalGDS, Rgds, Gnds
MMRRC Submission 044283-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.148) question?
Stock # R6136 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 28403137-28443093 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 28440577 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000118966 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028170] [ENSMUST00000100241] [ENSMUST00000113893] [ENSMUST00000140704]
AlphaFold Q03385
Predicted Effect probably null
Transcript: ENSMUST00000028170
SMART Domains Protein: ENSMUSP00000028170
Gene: ENSMUSG00000026821

DomainStartEndE-ValueType
RasGEFN 56 194 4.02e-37 SMART
low complexity region 239 285 N/A INTRINSIC
RasGEF 320 587 5.28e-118 SMART
low complexity region 613 626 N/A INTRINSIC
low complexity region 646 655 N/A INTRINSIC
low complexity region 683 712 N/A INTRINSIC
low complexity region 716 726 N/A INTRINSIC
RA 736 823 6.51e-22 SMART
Predicted Effect probably null
Transcript: ENSMUST00000100241
SMART Domains Protein: ENSMUSP00000097812
Gene: ENSMUSG00000026821

DomainStartEndE-ValueType
RasGEFN 111 249 4.02e-37 SMART
low complexity region 294 340 N/A INTRINSIC
RasGEF 375 642 5.28e-118 SMART
low complexity region 668 681 N/A INTRINSIC
low complexity region 701 710 N/A INTRINSIC
low complexity region 738 767 N/A INTRINSIC
low complexity region 771 781 N/A INTRINSIC
RA 791 878 6.51e-22 SMART
Predicted Effect probably null
Transcript: ENSMUST00000113893
SMART Domains Protein: ENSMUSP00000109526
Gene: ENSMUSG00000026821

DomainStartEndE-ValueType
RasGEFN 111 237 1.25e-42 SMART
low complexity region 282 328 N/A INTRINSIC
RasGEF 363 630 5.28e-118 SMART
low complexity region 656 669 N/A INTRINSIC
low complexity region 689 698 N/A INTRINSIC
low complexity region 726 755 N/A INTRINSIC
low complexity region 759 769 N/A INTRINSIC
RA 779 866 6.51e-22 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128680
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130281
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137513
Predicted Effect probably null
Transcript: ENSMUST00000140704
SMART Domains Protein: ENSMUSP00000118966
Gene: ENSMUSG00000026821

DomainStartEndE-ValueType
low complexity region 4 13 N/A INTRINSIC
RA 36 123 6.51e-22 SMART
Meta Mutation Damage Score 0.9589 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.0%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
PHENOTYPE: Homozygous mutant mice exhibit reduced tumor incidence, size and progression to malignancy in multistage skin carcinogenesis. [provided by MGI curators]
Allele List at MGI

All alleles(16) : Targeted(5) Gene trapped(11)

Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3100002H09Rik C A 4: 124,504,181 (GRCm39) G124C unknown Het
3425401B19Rik A T 14: 32,384,239 (GRCm39) D575E possibly damaging Het
Abca15 A T 7: 119,939,272 (GRCm39) H222L possibly damaging Het
Arhgef18 T C 8: 3,504,507 (GRCm39) V1013A probably benign Het
Arsj T C 3: 126,158,424 (GRCm39) M1T probably null Het
Atp10a A C 7: 58,478,088 (GRCm39) Q1377P probably benign Het
Atrip T A 9: 108,900,804 (GRCm39) E178D probably damaging Het
Cblif G A 19: 11,727,649 (GRCm39) A158T probably damaging Het
Chadl T C 15: 81,577,755 (GRCm39) N625D probably benign Het
Chrng G A 1: 87,137,523 (GRCm39) V320I probably benign Het
Cox11 T C 11: 90,535,221 (GRCm39) L84P probably damaging Het
Dchs1 T G 7: 105,410,132 (GRCm39) T1747P probably benign Het
Dnah12 A G 14: 26,597,227 (GRCm39) K3529E probably damaging Het
Ecd T C 14: 20,370,859 (GRCm39) N620S probably damaging Het
Fbn1 T A 2: 125,245,052 (GRCm39) K278N possibly damaging Het
Fcho2 T C 13: 98,926,275 (GRCm39) K103E probably damaging Het
Fzd7 T G 1: 59,522,419 (GRCm39) F101V probably damaging Het
Galnt13 G T 2: 54,406,491 (GRCm39) probably benign Het
Gm32647 C T 7: 94,124,939 (GRCm39) Het
Gm5624 A T 14: 44,797,333 (GRCm39) D152E probably benign Het
Heatr6 T A 11: 83,663,329 (GRCm39) V664E possibly damaging Het
Hpgd A G 8: 56,747,987 (GRCm39) D36G probably damaging Het
Ifnlr1 A G 4: 135,431,108 (GRCm39) T199A possibly damaging Het
Kalrn T G 16: 34,177,481 (GRCm39) D228A probably damaging Het
Miox T C 15: 89,219,524 (GRCm39) M47T probably damaging Het
Nampt A T 12: 32,880,301 (GRCm39) I65F probably benign Het
Ncf1 T C 5: 134,255,487 (GRCm39) K135E probably damaging Het
Nop53 G A 7: 15,672,314 (GRCm39) Q452* probably null Het
Or8u10 A G 2: 85,915,245 (GRCm39) L292S probably damaging Het
Pik3cg A G 12: 32,254,358 (GRCm39) V543A probably benign Het
Rap1a A G 3: 105,657,598 (GRCm39) V7A probably damaging Het
Rasal1 T C 5: 120,813,543 (GRCm39) V639A possibly damaging Het
Rassf8 A G 6: 145,761,382 (GRCm39) N236S probably benign Het
Rbm47 G C 5: 66,183,626 (GRCm39) R326G probably damaging Het
Sbno1 T C 5: 124,516,554 (GRCm39) D1272G probably benign Het
Setx A G 2: 29,038,039 (GRCm39) D1508G probably benign Het
Slc1a1 T A 19: 28,882,810 (GRCm39) L358Q probably damaging Het
Slc7a12 C A 3: 14,564,186 (GRCm39) L20I probably benign Het
Spata31g1 T C 4: 42,972,853 (GRCm39) S729P probably damaging Het
Spats2l C T 1: 57,941,302 (GRCm39) T187M probably damaging Het
Specc1l A G 10: 75,082,494 (GRCm39) D647G probably benign Het
Steap4 G A 5: 8,028,562 (GRCm39) R380Q probably damaging Het
Syne2 A G 12: 75,952,099 (GRCm39) S456G probably benign Het
Tfcp2 G T 15: 100,410,194 (GRCm39) T391N probably damaging Het
Tns2 T A 15: 102,015,465 (GRCm39) D122E probably damaging Het
Tshr A G 12: 91,505,008 (GRCm39) M649V probably benign Het
Ubr3 A G 2: 69,824,107 (GRCm39) T1440A probably benign Het
Urb2 A G 8: 124,756,831 (GRCm39) D846G probably benign Het
Vmn1r202 T C 13: 22,685,632 (GRCm39) T262A possibly damaging Het
Vmn2r61 G T 7: 41,916,455 (GRCm39) W356L probably damaging Het
Wdr11 T A 7: 129,220,427 (GRCm39) M605K possibly damaging Het
Zfp647 G A 15: 76,796,285 (GRCm39) P125L probably damaging Het
Other mutations in Ralgds
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00426:Ralgds APN 2 28,442,230 (GRCm39) missense probably damaging 1.00
IGL01774:Ralgds APN 2 28,440,554 (GRCm39) nonsense probably null
IGL02747:Ralgds APN 2 28,438,122 (GRCm39) unclassified probably benign
IGL03135:Ralgds APN 2 28,439,100 (GRCm39) missense probably damaging 0.99
PIT4458001:Ralgds UTSW 2 28,432,486 (GRCm39) missense probably damaging 1.00
PIT4531001:Ralgds UTSW 2 28,435,226 (GRCm39) nonsense probably null
R0049:Ralgds UTSW 2 28,432,391 (GRCm39) synonymous silent
R0052:Ralgds UTSW 2 28,434,400 (GRCm39) critical splice donor site probably null
R0052:Ralgds UTSW 2 28,434,400 (GRCm39) critical splice donor site probably null
R0285:Ralgds UTSW 2 28,440,581 (GRCm39) splice site probably null
R0665:Ralgds UTSW 2 28,435,218 (GRCm39) missense probably damaging 0.98
R0718:Ralgds UTSW 2 28,439,128 (GRCm39) missense probably benign 0.37
R1755:Ralgds UTSW 2 28,440,558 (GRCm39) missense probably damaging 0.99
R1966:Ralgds UTSW 2 28,435,887 (GRCm39) missense probably damaging 0.96
R2873:Ralgds UTSW 2 28,438,781 (GRCm39) splice site probably null
R2874:Ralgds UTSW 2 28,438,781 (GRCm39) splice site probably null
R4082:Ralgds UTSW 2 28,442,283 (GRCm39) utr 3 prime probably benign
R4342:Ralgds UTSW 2 28,442,107 (GRCm39) missense probably damaging 1.00
R4344:Ralgds UTSW 2 28,442,107 (GRCm39) missense probably damaging 1.00
R4647:Ralgds UTSW 2 28,435,532 (GRCm39) critical splice donor site probably null
R4738:Ralgds UTSW 2 28,435,428 (GRCm39) missense probably damaging 1.00
R4762:Ralgds UTSW 2 28,442,164 (GRCm39) missense probably damaging 0.97
R5027:Ralgds UTSW 2 28,442,102 (GRCm39) critical splice acceptor site probably null
R5320:Ralgds UTSW 2 28,435,224 (GRCm39) missense probably damaging 1.00
R5738:Ralgds UTSW 2 28,432,538 (GRCm39) intron probably benign
R5969:Ralgds UTSW 2 28,432,426 (GRCm39) missense probably damaging 1.00
R6014:Ralgds UTSW 2 28,433,673 (GRCm39) missense probably damaging 0.97
R6137:Ralgds UTSW 2 28,437,600 (GRCm39) missense probably damaging 0.99
R6583:Ralgds UTSW 2 28,423,656 (GRCm39) missense probably damaging 0.99
R6618:Ralgds UTSW 2 28,440,523 (GRCm39) missense probably benign 0.09
R6801:Ralgds UTSW 2 28,438,448 (GRCm39) missense probably damaging 1.00
R7046:Ralgds UTSW 2 28,430,741 (GRCm39) missense probably damaging 1.00
R7095:Ralgds UTSW 2 28,439,320 (GRCm39) missense possibly damaging 0.83
R7276:Ralgds UTSW 2 28,435,884 (GRCm39) missense probably damaging 1.00
R7399:Ralgds UTSW 2 28,433,667 (GRCm39) missense possibly damaging 0.95
R7446:Ralgds UTSW 2 28,435,901 (GRCm39) missense probably damaging 0.99
R7560:Ralgds UTSW 2 28,437,607 (GRCm39) missense probably damaging 1.00
R8384:Ralgds UTSW 2 28,437,182 (GRCm39) missense probably damaging 1.00
R9422:Ralgds UTSW 2 28,435,184 (GRCm39) missense probably benign
X0028:Ralgds UTSW 2 28,438,711 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGCTTCAGGGGCACATAG -3'
(R):5'- GAGCATTCTTCCTGAAGTACCTGC -3'

Sequencing Primer
(F):5'- TCCCCAAGACCATGTGGAAGTTG -3'
(R):5'- GCTTTCTTATTTTAACCAGGCAATG -3'
Posted On 2017-10-10