|Institutional Source||Beutler Lab|
|Gene Name||six transmembrane epithelial antigen of the prostate 1|
|Is this an essential gene?||Possibly non essential (E-score: 0.256)|
|Stock #||R0525 (G1)|
|Chromosomal Location||5736317-5749326 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 5742903 bp|
|Amino Acid Change||Isoleucine to Phenylalanine at position 3 (I3F)|
|Ref Sequence||ENSEMBL: ENSMUSP00000015796 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000015796]|
|Predicted Effect||possibly damaging
AA Change: I3F
PolyPhen 2 Score 0.652 (Sensitivity: 0.87; Specificity: 0.91)
AA Change: I3F
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.1795|
|Coding Region Coverage||
|Validation Efficiency||100% (72/72)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Steap1||
(F):5'- CCATACAGCTTCAGTTCCAGGCATC -3'
(R):5'- AATGGTAGGTCATCCATTGGGCAAG -3'
(F):5'- CTCAGAGCAGCAGATTAGAATGC -3'
(R):5'- ggaaaggcagaggcagg -3'