Mutagenetix > Incidental Mutation

Incidental Mutation 'R6137:Vmn2r9'

488394

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r9

Ensembl Gene

ENSMUSG00000091624

Gene Name

vomeronasal 2, receptor 9

Synonyms

EG435864

MMRRC Submission

044284-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

R6137 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

108842947-108852510 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 108849016 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 129 (I129T)

Ref Sequence

ENSEMBL: ENSMUSP00000129520 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170419]

AlphaFold

K7N6Z8

Predicted Effect

probably benign
Transcript: ENSMUST00000170419
AA Change: I129T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: I129T

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	77	412	8.1e-29	PFAM
Pfam:NCD3G	507	561	2.3e-16	PFAM
Pfam:7tm_3	592	829	3.4e-54	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176157

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.8%
20x: 93.3%

Validation Efficiency

98% (58/59)

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700092M07Rik	A	T	19: 8,740,784	D6V	probably damaging	Het
2310057M21Rik	G	T	7: 131,357,613	H165Q	probably damaging	Het
Akap13	T	A	7: 75,677,416	F721Y	probably damaging	Het
Akap6	A	T	12: 53,140,354	D1517V	probably damaging	Het
Amigo3	T	A	9: 108,053,728	S117T	probably damaging	Het
Atf7ip2	T	A	16: 10,201,411	N34K	probably damaging	Het
Cacnb1	A	C	11: 98,005,782	V351G	probably damaging	Het
Casp9	T	A	4: 141,805,349		probably null	Het
Ccdc51	C	T	9: 109,089,415	T24I	probably benign	Het
Cdh23	T	A	10: 60,434,512	Y618F	probably damaging	Het
Chd1	T	A	17: 15,758,688	W1271R	probably damaging	Het
Dars	T	C	1: 128,368,439	T386A	probably benign	Het
Dchs1	T	A	7: 105,765,106	D834V	probably damaging	Het
Dgkd	T	A	1: 87,936,381	V933E	possibly damaging	Het
Dnah17	A	G	11: 118,025,654	F4203S	probably damaging	Het
Fancm	T	C	12: 65,130,382	L2000P	probably damaging	Het
Fbxo11	A	T	17: 88,008,669	H444Q	probably benign	Het
Fbxw14	T	A	9: 109,276,222	T292S	probably damaging	Het
Fer1l6	T	C	15: 58,559,206	S237P	probably damaging	Het
Frem3	T	C	8: 80,615,047	I1323T	probably benign	Het
Grin2a	A	G	16: 9,653,449	F652L	probably benign	Het
Grin2b	T	A	6: 135,923,458	M142L	possibly damaging	Het
Helz	A	G	11: 107,619,060	Q503R	possibly damaging	Het
Ighv5-17	A	G	12: 113,859,295	Y69H	probably benign	Het
Il17ra	A	G	6: 120,475,582	N242S	probably benign	Het
Immp1l	G	C	2: 105,964,208	G117A	probably damaging	Het
Itm2c	T	C	1: 85,894,692	V10A	probably benign	Het
Kif1b	T	C	4: 149,238,426	K679E	possibly damaging	Het
Kng1	T	C	16: 23,074,645	V256A	possibly damaging	Het
Lamc2	T	G	1: 153,166,153	R78S	possibly damaging	Het
Loxl4	A	G	19: 42,598,793	F621S	probably damaging	Het
Lpl	T	A	8: 68,892,747	D134E	probably damaging	Het
Lypd3	T	C	7: 24,640,494	Y329H	probably benign	Het
Mettl13	T	C	1: 162,535,886	D225G	probably benign	Het
Myo7b	A	G	18: 31,999,974	F441L	probably damaging	Het
Nnt	T	A	13: 119,336,328	M699L	possibly damaging	Het
Nr1h3	A	T	2: 91,191,851	M144K	probably damaging	Het
Olfr1040	A	G	2: 86,145,969	V255A	probably benign	Het
Olfr1347	T	C	7: 6,488,845	T3A	probably benign	Het
Olfr325	A	T	11: 58,581,068	M75L	probably benign	Het
Pappa2	A	T	1: 158,871,543	Y667N	probably damaging	Het
Prps1l3	A	G	12: 57,238,888	I155V	probably benign	Het
Ptgs2	T	A	1: 150,100,993	N24K	probably benign	Het
Ralgds	A	T	2: 28,547,588	M514L	probably damaging	Het
Rbm47	G	C	5: 66,026,283	R326G	probably damaging	Het
Sacm1l	T	A	9: 123,569,005	V254D	probably damaging	Het
Selenot	A	T	3: 58,585,284	Q64L	probably damaging	Het
Sgsm2	G	A	11: 74,850,851	R1037W	probably damaging	Het
Slc22a12	A	G	19: 6,542,724	V10A	probably benign	Het
Spem2	G	T	11: 69,816,696	S481*	probably null	Het
Styk1	C	T	6: 131,311,016	G128D	probably damaging	Het
Tmc6	A	T	11: 117,776,328	L148Q	probably damaging	Het
Tmem138	A	C	19: 10,574,835		probably null	Het
Tnpo3	A	G	6: 29,555,268	V772A	probably benign	Het
Topaz1	T	C	9: 122,797,756	F1483S	possibly damaging	Het
Tuba4a	C	A	1: 75,216,055	C305F	probably damaging	Het
Ubap1	T	G	4: 41,379,262	F159V	possibly damaging	Het
Wwc2	A	T	8: 47,856,263	M828K	unknown	Het
Zfp236	A	T	18: 82,671,794	S187T	possibly damaging	Het

Other mutations in Vmn2r9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00920:Vmn2r9	APN	5	108848024	missense	possibly damaging	0.79
IGL00972:Vmn2r9	APN	5	108849037	missense	probably benign	0.02
IGL01102:Vmn2r9	APN	5	108842945	splice site	probably null
IGL01892:Vmn2r9	APN	5	108847834	missense	probably damaging	1.00
IGL02086:Vmn2r9	APN	5	108847567	missense	probably damaging	1.00
IGL02118:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02119:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02120:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02121:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02123:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02131:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02132:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02171:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02185:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02186:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02346:Vmn2r9	APN	5	108842984	missense	probably benign	0.07
IGL02508:Vmn2r9	APN	5	108848201	missense	possibly damaging	0.70
IGL02815:Vmn2r9	APN	5	108842990	missense	possibly damaging	0.69
IGL03077:Vmn2r9	APN	5	108848307	splice site	probably benign
IGL03269:Vmn2r9	APN	5	108847954	missense	probably damaging	1.00
IGL03293:Vmn2r9	APN	5	108848131	missense	probably damaging	1.00
R0112:Vmn2r9	UTSW	5	108843125	missense	probably damaging	1.00
R0328:Vmn2r9	UTSW	5	108847539	missense	probably benign	0.11
R0382:Vmn2r9	UTSW	5	108847597	missense	probably damaging	1.00
R0521:Vmn2r9	UTSW	5	108848288	nonsense	probably null
R0975:Vmn2r9	UTSW	5	108843303	missense	probably damaging	1.00
R1216:Vmn2r9	UTSW	5	108847574	missense	probably damaging	1.00
R1458:Vmn2r9	UTSW	5	108848984	missense	probably benign	0.44
R1469:Vmn2r9	UTSW	5	108843828	missense	probably benign
R1469:Vmn2r9	UTSW	5	108843828	missense	probably benign
R1704:Vmn2r9	UTSW	5	108846400	missense	probably damaging	1.00
R1967:Vmn2r9	UTSW	5	108847522	missense	probably benign	0.03
R1991:Vmn2r9	UTSW	5	108846439	missense	probably damaging	0.99
R2410:Vmn2r9	UTSW	5	108848257	missense	probably damaging	1.00
R3419:Vmn2r9	UTSW	5	108846433	missense	probably damaging	0.96
R3852:Vmn2r9	UTSW	5	108848131	missense	probably damaging	1.00
R3873:Vmn2r9	UTSW	5	108847835	missense	probably benign	0.14
R3905:Vmn2r9	UTSW	5	108847919	missense	probably benign	0.37
R3908:Vmn2r9	UTSW	5	108847919	missense	probably benign	0.37
R3921:Vmn2r9	UTSW	5	108849055	missense	probably benign
R4156:Vmn2r9	UTSW	5	108847877	missense	possibly damaging	0.64
R4477:Vmn2r9	UTSW	5	108846277	missense	probably benign
R4478:Vmn2r9	UTSW	5	108846277	missense	probably benign
R4544:Vmn2r9	UTSW	5	108847685	missense	probably benign	0.00
R4546:Vmn2r9	UTSW	5	108847685	missense	probably benign	0.00
R4627:Vmn2r9	UTSW	5	108847597	missense	probably damaging	1.00
R5215:Vmn2r9	UTSW	5	108846485	missense	probably benign	0.03
R5361:Vmn2r9	UTSW	5	108848063	missense	probably damaging	1.00
R5587:Vmn2r9	UTSW	5	108847561	missense	probably damaging	1.00
R6054:Vmn2r9	UTSW	5	108848260	missense	probably damaging	0.99
R6106:Vmn2r9	UTSW	5	108845036	missense	probably benign
R6125:Vmn2r9	UTSW	5	108842970	missense	probably benign	0.01
R6920:Vmn2r9	UTSW	5	108849046	missense	possibly damaging	0.72
R7579:Vmn2r9	UTSW	5	108845082	missense	probably damaging	1.00
R8683:Vmn2r9	UTSW	5	108849007	missense	probably benign
R8964:Vmn2r9	UTSW	5	108848165	missense	probably benign	0.05
R9022:Vmn2r9	UTSW	5	108845057	missense	possibly damaging	0.90
R9118:Vmn2r9	UTSW	5	108843071	missense	probably damaging	0.99
R9125:Vmn2r9	UTSW	5	108848181	missense
R9240:Vmn2r9	UTSW	5	108848233	missense	possibly damaging	0.78
R9327:Vmn2r9	UTSW	5	108848975	missense	probably damaging	0.96
R9412:Vmn2r9	UTSW	5	108843618	missense	probably damaging	1.00
R9499:Vmn2r9	UTSW	5	108847718	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CTTGCAGGCACATGTAAATGG -3'
(R):5'- CTGCAAGAAGATATGAGTTCTTTCTGG -3'

Sequencing Primer
(F):5'- GAGGTCCTAAGTTCAATTCCCAGG -3'
(R):5'- GGTCAGTGTGGAGATGAAT -3'

Posted On

2017-10-10