Incidental Mutation 'R6137:Styk1'
ID 488397
Institutional Source Beutler Lab
Gene Symbol Styk1
Ensembl Gene ENSMUSG00000032899
Gene Name serine/threonine/tyrosine kinase 1
Synonyms
MMRRC Submission 044284-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.341) question?
Stock # R6137 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 131299142-131353597 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 131311016 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 128 (G128D)
Ref Sequence ENSEMBL: ENSMUSP00000044098 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049150] [ENSMUST00000121078]
AlphaFold Q6J9G1
Predicted Effect probably damaging
Transcript: ENSMUST00000049150
AA Change: G128D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000044098
Gene: ENSMUSG00000032899
AA Change: G128D

DomainStartEndE-ValueType
transmembrane domain 31 53 N/A INTRINSIC
Pfam:Pkinase 119 387 3.2e-31 PFAM
Pfam:Pkinase_Tyr 119 387 1.8e-59 PFAM
low complexity region 399 410 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000121078
SMART Domains Protein: ENSMUSP00000112900
Gene: ENSMUSG00000032899

DomainStartEndE-ValueType
transmembrane domain 31 53 N/A INTRINSIC
Pfam:Pkinase_Tyr 67 298 2.5e-53 PFAM
Pfam:Pkinase 68 298 5.7e-29 PFAM
low complexity region 310 321 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135859
Meta Mutation Damage Score 0.9349 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.8%
  • 20x: 93.3%
Validation Efficiency 98% (58/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700092M07Rik A T 19: 8,740,784 (GRCm38) D6V probably damaging Het
2310057M21Rik G T 7: 131,357,613 (GRCm38) H165Q probably damaging Het
Akap13 T A 7: 75,677,416 (GRCm38) F721Y probably damaging Het
Akap6 A T 12: 53,140,354 (GRCm38) D1517V probably damaging Het
Amigo3 T A 9: 108,053,728 (GRCm38) S117T probably damaging Het
Atf7ip2 T A 16: 10,201,411 (GRCm38) N34K probably damaging Het
Cacnb1 A C 11: 98,005,782 (GRCm38) V351G probably damaging Het
Casp9 T A 4: 141,805,349 (GRCm38) probably null Het
Ccdc51 C T 9: 109,089,415 (GRCm38) T24I probably benign Het
Cdh23 T A 10: 60,434,512 (GRCm38) Y618F probably damaging Het
Chd1 T A 17: 15,758,688 (GRCm38) W1271R probably damaging Het
Dars T C 1: 128,368,439 (GRCm38) T386A probably benign Het
Dchs1 T A 7: 105,765,106 (GRCm38) D834V probably damaging Het
Dgkd T A 1: 87,936,381 (GRCm38) V933E possibly damaging Het
Dnah17 A G 11: 118,025,654 (GRCm38) F4203S probably damaging Het
Fancm T C 12: 65,130,382 (GRCm38) L2000P probably damaging Het
Fbxo11 A T 17: 88,008,669 (GRCm38) H444Q probably benign Het
Fbxw14 T A 9: 109,276,222 (GRCm38) T292S probably damaging Het
Fer1l6 T C 15: 58,559,206 (GRCm38) S237P probably damaging Het
Frem3 T C 8: 80,615,047 (GRCm38) I1323T probably benign Het
Grin2a A G 16: 9,653,449 (GRCm38) F652L probably benign Het
Grin2b T A 6: 135,923,458 (GRCm38) M142L possibly damaging Het
Helz A G 11: 107,619,060 (GRCm38) Q503R possibly damaging Het
Ighv5-17 A G 12: 113,859,295 (GRCm38) Y69H probably benign Het
Il17ra A G 6: 120,475,582 (GRCm38) N242S probably benign Het
Immp1l G C 2: 105,964,208 (GRCm38) G117A probably damaging Het
Itm2c T C 1: 85,894,692 (GRCm38) V10A probably benign Het
Kif1b T C 4: 149,238,426 (GRCm38) K679E possibly damaging Het
Kng1 T C 16: 23,074,645 (GRCm38) V256A possibly damaging Het
Lamc2 T G 1: 153,166,153 (GRCm38) R78S possibly damaging Het
Loxl4 A G 19: 42,598,793 (GRCm38) F621S probably damaging Het
Lpl T A 8: 68,892,747 (GRCm38) D134E probably damaging Het
Lypd3 T C 7: 24,640,494 (GRCm38) Y329H probably benign Het
Mettl13 T C 1: 162,535,886 (GRCm38) D225G probably benign Het
Myo7b A G 18: 31,999,974 (GRCm38) F441L probably damaging Het
Nnt T A 13: 119,336,328 (GRCm38) M699L possibly damaging Het
Nr1h3 A T 2: 91,191,851 (GRCm38) M144K probably damaging Het
Olfr1040 A G 2: 86,145,969 (GRCm38) V255A probably benign Het
Olfr1347 T C 7: 6,488,845 (GRCm38) T3A probably benign Het
Olfr325 A T 11: 58,581,068 (GRCm38) M75L probably benign Het
Pappa2 A T 1: 158,871,543 (GRCm38) Y667N probably damaging Het
Prps1l3 A G 12: 57,238,888 (GRCm38) I155V probably benign Het
Ptgs2 T A 1: 150,100,993 (GRCm38) N24K probably benign Het
Ralgds A T 2: 28,547,588 (GRCm38) M514L probably damaging Het
Rbm47 G C 5: 66,026,283 (GRCm38) R326G probably damaging Het
Sacm1l T A 9: 123,569,005 (GRCm38) V254D probably damaging Het
Selenot A T 3: 58,585,284 (GRCm38) Q64L probably damaging Het
Sgsm2 G A 11: 74,850,851 (GRCm38) R1037W probably damaging Het
Slc22a12 A G 19: 6,542,724 (GRCm38) V10A probably benign Het
Spem2 G T 11: 69,816,696 (GRCm38) S481* probably null Het
Tmc6 A T 11: 117,776,328 (GRCm38) L148Q probably damaging Het
Tmem138 A C 19: 10,574,835 (GRCm38) probably null Het
Tnpo3 A G 6: 29,555,268 (GRCm38) V772A probably benign Het
Topaz1 T C 9: 122,797,756 (GRCm38) F1483S possibly damaging Het
Tuba4a C A 1: 75,216,055 (GRCm38) C305F probably damaging Het
Ubap1 T G 4: 41,379,262 (GRCm38) F159V possibly damaging Het
Vmn2r9 A G 5: 108,849,016 (GRCm38) I129T probably benign Het
Wwc2 A T 8: 47,856,263 (GRCm38) M828K unknown Het
Zfp236 A T 18: 82,671,794 (GRCm38) S187T possibly damaging Het
Other mutations in Styk1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00822:Styk1 APN 6 131,301,662 (GRCm38) missense possibly damaging 0.75
IGL01370:Styk1 APN 6 131,301,652 (GRCm38) missense probably damaging 1.00
IGL01833:Styk1 APN 6 131,302,366 (GRCm38) splice site probably benign
IGL02705:Styk1 APN 6 131,312,583 (GRCm38) missense probably benign 0.02
IGL03029:Styk1 APN 6 131,300,560 (GRCm38) missense probably benign 0.27
conviction UTSW 6 131,312,576 (GRCm38) missense probably benign 0.01
will UTSW 6 131,312,917 (GRCm38) critical splice donor site probably null
R0201:Styk1 UTSW 6 131,301,730 (GRCm38) splice site probably benign
R2267:Styk1 UTSW 6 131,312,576 (GRCm38) missense probably benign 0.01
R2268:Styk1 UTSW 6 131,312,576 (GRCm38) missense probably benign 0.01
R2269:Styk1 UTSW 6 131,312,576 (GRCm38) missense probably benign 0.01
R2919:Styk1 UTSW 6 131,313,004 (GRCm38) start gained probably benign
R3153:Styk1 UTSW 6 131,310,012 (GRCm38) nonsense probably null
R3154:Styk1 UTSW 6 131,310,012 (GRCm38) nonsense probably null
R4041:Styk1 UTSW 6 131,312,917 (GRCm38) critical splice donor site probably null
R4650:Styk1 UTSW 6 131,300,569 (GRCm38) missense probably damaging 1.00
R4739:Styk1 UTSW 6 131,300,466 (GRCm38) missense probably damaging 1.00
R5079:Styk1 UTSW 6 131,301,713 (GRCm38) missense probably damaging 1.00
R5497:Styk1 UTSW 6 131,304,707 (GRCm38) missense probably damaging 0.97
R5637:Styk1 UTSW 6 131,300,418 (GRCm38) missense possibly damaging 0.82
R6429:Styk1 UTSW 6 131,310,064 (GRCm38) missense possibly damaging 0.93
R7522:Styk1 UTSW 6 131,312,840 (GRCm38) splice site probably null
R8188:Styk1 UTSW 6 131,304,885 (GRCm38) missense probably benign 0.43
R9255:Styk1 UTSW 6 131,309,983 (GRCm38) missense probably damaging 1.00
R9704:Styk1 UTSW 6 131,301,649 (GRCm38) small deletion probably benign
R9705:Styk1 UTSW 6 131,301,649 (GRCm38) small deletion probably benign
R9712:Styk1 UTSW 6 131,301,649 (GRCm38) small deletion probably benign
R9714:Styk1 UTSW 6 131,301,649 (GRCm38) small deletion probably benign
R9715:Styk1 UTSW 6 131,301,649 (GRCm38) small deletion probably benign
R9725:Styk1 UTSW 6 131,301,649 (GRCm38) small deletion probably benign
R9725:Styk1 UTSW 6 131,301,647 (GRCm38) small deletion probably benign
R9750:Styk1 UTSW 6 131,301,649 (GRCm38) small deletion probably benign
R9751:Styk1 UTSW 6 131,301,649 (GRCm38) small deletion probably benign
R9752:Styk1 UTSW 6 131,301,649 (GRCm38) small deletion probably benign
R9753:Styk1 UTSW 6 131,301,649 (GRCm38) small deletion probably benign
R9771:Styk1 UTSW 6 131,301,649 (GRCm38) small deletion probably benign
R9778:Styk1 UTSW 6 131,311,029 (GRCm38) nonsense probably null
X0021:Styk1 UTSW 6 131,307,069 (GRCm38) critical splice donor site probably null
X0026:Styk1 UTSW 6 131,310,939 (GRCm38) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AACTCTGCATCAAGCTTCCC -3'
(R):5'- TGCCTCTGTACCTGCATCTAGG -3'

Sequencing Primer
(F):5'- CATGTGTGCTAATAGGCTTCTTAATG -3'
(R):5'- TGTACCTGCATCTAGGGGCAG -3'
Posted On 2017-10-10