Incidental Mutation 'R6142:Il5'
ID 488633
Institutional Source Beutler Lab
Gene Symbol Il5
Ensembl Gene ENSMUSG00000036117
Gene Name interleukin 5
Synonyms Il-5
MMRRC Submission 044289-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.162) question?
Stock # R6142 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 53611621-53615930 bp(+) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) G to A at 53611805 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000043369 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048605]
AlphaFold P04401
PDB Structure Crystal structure of murine interleukin-5 [X-RAY DIFFRACTION]
Predicted Effect probably null
Transcript: ENSMUST00000048605
SMART Domains Protein: ENSMUSP00000043369
Gene: ENSMUSG00000036117

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:IL5 21 132 5.3e-64 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151643
Meta Mutation Damage Score 0.9479 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 94.2%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit loss of normal airway hyperreactivity resulting from aeroallergen challenge, reduced numbers of CD5+ B cells in the peritoneal cavity at 2 weeks, and some altered responses to schistosomiasis infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy6 T C 15: 98,496,303 (GRCm39) M579V probably benign Het
Agtr1b T C 3: 20,370,558 (GRCm39) D16G probably benign Het
Akap12 C A 10: 4,263,740 (GRCm39) probably null Het
Alpk2 T C 18: 65,438,456 (GRCm39) E979G possibly damaging Het
Arfgap3 T C 15: 83,234,328 (GRCm39) D8G probably damaging Het
AW551984 G T 9: 39,508,410 (GRCm39) L369I probably benign Het
Bmp8b A T 4: 123,009,043 (GRCm39) H207L probably benign Het
Cc2d2a G T 5: 43,860,540 (GRCm39) V490F probably damaging Het
Cnot6l C T 5: 96,230,837 (GRCm39) V377I probably benign Het
Col25a1 T A 3: 130,376,978 (GRCm39) probably benign Het
Crocc2 C G 1: 93,118,201 (GRCm39) Q375E possibly damaging Het
Ganc T C 2: 120,261,218 (GRCm39) probably null Het
Gm28168 C A 1: 117,875,678 (GRCm39) D102E probably benign Het
Gm8212 T C 14: 44,438,684 (GRCm39) probably null Het
Gria2 T C 3: 80,709,024 (GRCm39) T53A probably benign Het
Hipk4 G A 7: 27,228,590 (GRCm39) V347M probably damaging Het
Hmgxb3 T C 18: 61,269,309 (GRCm39) E991G probably benign Het
Hyal1 G A 9: 107,456,573 (GRCm39) R420H probably benign Het
Kcnh7 T C 2: 62,569,704 (GRCm39) I731V possibly damaging Het
Lamb2 A T 9: 108,362,817 (GRCm39) K759* probably null Het
Lnpep A G 17: 17,786,943 (GRCm39) probably null Het
Lrch1 T C 14: 75,184,940 (GRCm39) E54G probably damaging Het
Msl3l2 A G 10: 55,991,461 (GRCm39) D62G possibly damaging Het
Mslnl T C 17: 25,963,531 (GRCm39) L339P probably damaging Het
Nfe2l2 T C 2: 75,509,761 (GRCm39) I20V probably damaging Het
Pgm5 A C 19: 24,801,772 (GRCm39) I152S probably damaging Het
Plcg2 C A 8: 118,312,010 (GRCm39) T434K probably benign Het
Prrc2c T C 1: 162,537,956 (GRCm39) E558G unknown Het
Ranbp3 T C 17: 56,993,018 (GRCm39) V12A probably benign Het
Rgsl1 A G 1: 153,687,984 (GRCm39) V635A probably benign Het
Rpap2 T C 5: 107,746,164 (GRCm39) V14A probably benign Het
Rxrg G T 1: 167,460,191 (GRCm39) A341S possibly damaging Het
Sbf2 A G 7: 109,948,182 (GRCm39) S1177P probably damaging Het
Sema6a T C 18: 47,414,266 (GRCm39) T498A probably benign Het
Slc13a4 G A 6: 35,278,718 (GRCm39) A57V probably damaging Het
Slc6a3 A T 13: 73,692,902 (GRCm39) D174V probably benign Het
Spart T G 3: 55,024,669 (GRCm39) V88G probably damaging Het
Tanc1 A T 2: 59,663,566 (GRCm39) R1108* probably null Het
Tas2r140 C T 6: 133,032,698 (GRCm39) G20E probably damaging Het
Tdrd6 A G 17: 43,940,373 (GRCm39) V225A probably benign Het
Tmem168 C A 6: 13,591,368 (GRCm39) A99S probably benign Het
Tnk2 T A 16: 32,488,917 (GRCm39) D252E probably damaging Het
Tpsg1 A T 17: 25,591,460 (GRCm39) H20L probably benign Het
Tram1l1 T C 3: 124,115,092 (GRCm39) F84S probably damaging Het
Vmn2r12 T A 5: 109,240,763 (GRCm39) I117L probably benign Het
Zfp148 T C 16: 33,315,829 (GRCm39) L219S possibly damaging Het
Zfp40 C A 17: 23,395,311 (GRCm39) E425D probably benign Het
Zfp773 T C 7: 7,135,481 (GRCm39) T372A probably benign Het
Other mutations in Il5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0437:Il5 UTSW 11 53,614,733 (GRCm39) splice site probably benign
R0893:Il5 UTSW 11 53,611,763 (GRCm39) missense probably benign
R1761:Il5 UTSW 11 53,614,557 (GRCm39) missense probably damaging 0.98
R5089:Il5 UTSW 11 53,612,655 (GRCm39) missense possibly damaging 0.68
R5454:Il5 UTSW 11 53,614,626 (GRCm39) missense probably damaging 0.97
R5861:Il5 UTSW 11 53,614,743 (GRCm39) missense probably benign 0.02
R8163:Il5 UTSW 11 53,614,813 (GRCm39) missense possibly damaging 0.93
R8442:Il5 UTSW 11 53,612,651 (GRCm39) missense probably damaging 1.00
R9469:Il5 UTSW 11 53,614,824 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AAATTGCTTGGGGATTCGGC -3'
(R):5'- GCAGCTATTTATGCATTCTGAAGAACC -3'

Sequencing Primer
(F):5'- GATTCGGCCCTGCTCTG -3'
(R):5'- TGCATTCTGAAGAACCATAGCGTC -3'
Posted On 2017-10-10