Incidental Mutation 'R6145:Camk2d'
| ID |
488798 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Camk2d
|
| Ensembl Gene |
ENSMUSG00000053819 |
| Gene Name |
calcium/calmodulin-dependent protein kinase II, delta |
| Synonyms |
CaMK II, 2810011D23Rik, 8030469K03Rik |
| MMRRC Submission |
044292-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.208)
|
| Stock # |
R6145 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
126596302-126846326 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 126805858 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 329
(I329T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129999
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000066452]
[ENSMUST00000066466]
[ENSMUST00000106399]
[ENSMUST00000106400]
[ENSMUST00000106401]
[ENSMUST00000106402]
[ENSMUST00000134466]
[ENSMUST00000145454]
[ENSMUST00000200171]
[ENSMUST00000171289]
[ENSMUST00000163226]
[ENSMUST00000199300]
|
| AlphaFold |
Q6PHZ2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000066452
|
| SMART Domains |
Protein: ENSMUSP00000066996
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
356 |
483 |
9.4e-67 |
PFAM |
|
Pfam:DUF4440
|
360 |
474 |
5.4e-13 |
PFAM |
|
Pfam:SnoaL_3
|
360 |
486 |
3.5e-12 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000066466
|
| SMART Domains |
Protein: ENSMUSP00000063359
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
346 |
473 |
7.4e-67 |
PFAM |
|
Pfam:DUF4440
|
350 |
464 |
4.7e-13 |
PFAM |
|
Pfam:SnoaL_3
|
350 |
476 |
3e-12 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000106399
AA Change: I329T
|
| SMART Domains |
Protein: ENSMUSP00000102007
Gene: ENSMUSG00000053819
AA Change: I329T
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
357 |
484 |
3.5e-67 |
PFAM |
|
Pfam:DUF4440
|
361 |
475 |
5.4e-13 |
PFAM |
|
Pfam:SnoaL_3
|
361 |
487 |
3e-12 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106400
|
| SMART Domains |
Protein: ENSMUSP00000102008
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
346 |
473 |
4.7e-67 |
PFAM |
|
Pfam:DUF4440
|
350 |
464 |
3.2e-13 |
PFAM |
|
Pfam:SnoaL_3
|
350 |
476 |
2.1e-12 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106401
|
| SMART Domains |
Protein: ENSMUSP00000102009
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
1.33e-110 |
SMART |
|
Pfam:CaMKII_AD
|
380 |
507 |
3.8e-67 |
PFAM |
|
Pfam:DUF4440
|
384 |
498 |
5.8e-13 |
PFAM |
|
Pfam:SnoaL_3
|
384 |
510 |
3.2e-12 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106402
AA Change: I329T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000102010
Gene: ENSMUSG00000053819
AA Change: I329T
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
380 |
507 |
1.1e-66 |
PFAM |
|
Pfam:DUF4440
|
384 |
498 |
8.1e-13 |
PFAM |
|
Pfam:SnoaL_3
|
384 |
510 |
5.3e-12 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129293
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131869
|
| SMART Domains |
Protein: ENSMUSP00000126412
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
1 |
109 |
5.1e-26 |
PFAM |
|
Pfam:Pkinase_Tyr
|
3 |
111 |
4.5e-12 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000134466
|
| SMART Domains |
Protein: ENSMUSP00000114801
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
14 |
140 |
1e-33 |
PFAM |
|
Pfam:Pkinase_Tyr
|
14 |
141 |
4.8e-16 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145454
|
| SMART Domains |
Protein: ENSMUSP00000130769
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
14 |
140 |
1.4e-33 |
PFAM |
|
Pfam:Pkinase_Tyr
|
14 |
142 |
4.7e-16 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147043
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000200171
AA Change: I329T
|
| SMART Domains |
Protein: ENSMUSP00000143677
Gene: ENSMUSG00000053819
AA Change: I329T
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
380 |
507 |
9.8e-63 |
PFAM |
|
Pfam:DUF4440
|
384 |
498 |
2.5e-11 |
PFAM |
|
Pfam:SnoaL_3
|
384 |
509 |
5.7e-11 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171289
AA Change: I329T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000129999
Gene: ENSMUSG00000053819
AA Change: I329T
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
1.33e-110 |
SMART |
|
Pfam:CaMKII_AD
|
380 |
507 |
3.3e-63 |
PFAM |
|
Pfam:DUF4440
|
384 |
498 |
3.2e-12 |
PFAM |
|
Pfam:SnoaL_3
|
384 |
509 |
8.7e-12 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167417
|
| SMART Domains |
Protein: ENSMUSP00000131124
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:CaMKII_AD
|
53 |
180 |
4.8e-68 |
PFAM |
|
Pfam:DUF4440
|
57 |
171 |
8.2e-14 |
PFAM |
|
Pfam:SnoaL_3
|
57 |
183 |
4.2e-13 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000169051
|
| SMART Domains |
Protein: ENSMUSP00000132554
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
346 |
473 |
6.9e-67 |
PFAM |
|
Pfam:DUF4440
|
350 |
464 |
4.3e-13 |
PFAM |
|
Pfam:SnoaL_3
|
350 |
476 |
2.8e-12 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167985
|
| SMART Domains |
Protein: ENSMUSP00000126207
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:CaMKII_AD
|
59 |
130 |
2.2e-33 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000198487
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000198637
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000200010
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000171950
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197660
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163226
|
| SMART Domains |
Protein: ENSMUSP00000133019
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199300
|
| SMART Domains |
Protein: ENSMUSP00000143504
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
346 |
473 |
1.3e-62 |
PFAM |
|
Pfam:DUF4440
|
350 |
464 |
1.7e-11 |
PFAM |
|
Pfam:SnoaL_3
|
350 |
475 |
4.6e-11 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170149
|
| SMART Domains |
Protein: ENSMUSP00000130305
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:CaMKII_AD
|
37 |
164 |
3.1e-64 |
PFAM |
|
Pfam:DUF4440
|
41 |
155 |
8.8e-13 |
PFAM |
|
Pfam:SnoaL_3
|
41 |
167 |
1.8e-12 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 98.0%
- 20x: 95.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced response to heart induced stress. Mice homozygous for an allele that produces an oxidant-resistant product exhibit reduced response to myocardial infarction in a diabetic model. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810459M11Rik |
T |
A |
1: 86,052,942 (GRCm38) |
|
probably null |
Het |
| 4930402H24Rik |
T |
C |
2: 130,778,473 (GRCm38) |
I247V |
probably benign |
Het |
| Abca8b |
A |
G |
11: 109,973,808 (GRCm38) |
V316A |
probably benign |
Het |
| Acad10 |
A |
T |
5: 121,622,033 (GRCm38) |
V999D |
probably damaging |
Het |
| Acot8 |
A |
G |
2: 164,803,065 (GRCm38) |
V66A |
probably benign |
Het |
| Ankrd11 |
T |
C |
8: 122,892,661 (GRCm38) |
H1484R |
probably damaging |
Het |
| Anxa6 |
A |
G |
11: 54,994,904 (GRCm38) |
F405S |
probably damaging |
Het |
| Asmt |
G |
A |
X: 170,674,663 (GRCm38) |
V101I |
probably damaging |
Het |
| Atp1a2 |
C |
T |
1: 172,287,238 (GRCm38) |
V327I |
probably damaging |
Het |
| Brdt |
A |
G |
5: 107,377,999 (GRCm38) |
E906G |
possibly damaging |
Het |
| Cacna1g |
A |
T |
11: 94,462,261 (GRCm38) |
C313S |
probably damaging |
Het |
| Cavin4 |
A |
T |
4: 48,663,794 (GRCm38) |
H58L |
probably damaging |
Het |
| Ccdc78 |
C |
A |
17: 25,789,065 (GRCm38) |
P317T |
probably benign |
Het |
| Cdc16 |
T |
G |
8: 13,767,573 (GRCm38) |
Y295D |
possibly damaging |
Het |
| Cdyl2 |
T |
A |
8: 116,594,978 (GRCm38) |
N270I |
probably damaging |
Het |
| Cfap221 |
T |
A |
1: 119,984,816 (GRCm38) |
I114F |
possibly damaging |
Het |
| Dmxl1 |
A |
G |
18: 49,912,766 (GRCm38) |
E2414G |
possibly damaging |
Het |
| Dnah1 |
C |
A |
14: 31,300,970 (GRCm38) |
R1070L |
probably benign |
Het |
| Dnah14 |
T |
C |
1: 181,666,417 (GRCm38) |
S1713P |
probably benign |
Het |
| Dock10 |
C |
A |
1: 80,575,904 (GRCm38) |
G602* |
probably null |
Het |
| Ep400 |
A |
T |
5: 110,756,703 (GRCm38) |
V10D |
possibly damaging |
Het |
| Epas1 |
T |
C |
17: 86,829,429 (GRCm38) |
C807R |
probably benign |
Het |
| Esrrb |
C |
T |
12: 86,505,899 (GRCm38) |
P200L |
probably benign |
Het |
| Fbxw26 |
T |
C |
9: 109,732,623 (GRCm38) |
I168V |
probably benign |
Het |
| Fsip2 |
A |
T |
2: 82,993,768 (GRCm38) |
H6615L |
possibly damaging |
Het |
| Galk2 |
A |
T |
2: 125,946,842 (GRCm38) |
Q272L |
possibly damaging |
Het |
| Gas7 |
A |
C |
11: 67,629,612 (GRCm38) |
T43P |
probably damaging |
Het |
| Gm5134 |
A |
T |
10: 75,995,839 (GRCm38) |
I371F |
probably damaging |
Het |
| Gpr31b |
C |
T |
17: 13,051,379 (GRCm38) |
R301Q |
possibly damaging |
Het |
| Grk1 |
T |
A |
8: 13,405,765 (GRCm38) |
Y216* |
probably null |
Het |
| Grm5 |
T |
A |
7: 88,026,601 (GRCm38) |
M441K |
probably damaging |
Het |
| Heatr6 |
A |
G |
11: 83,766,136 (GRCm38) |
E408G |
probably damaging |
Het |
| Hoxc9 |
G |
T |
15: 102,983,959 (GRCm38) |
K201N |
probably damaging |
Het |
| Igsf10 |
T |
A |
3: 59,331,656 (GRCm38) |
Y368F |
possibly damaging |
Het |
| Il2ra |
A |
T |
2: 11,680,246 (GRCm38) |
D131V |
probably damaging |
Het |
| Imp4 |
A |
G |
1: 34,440,096 (GRCm38) |
E19G |
probably benign |
Het |
| Kcnk18 |
T |
C |
19: 59,235,607 (GRCm38) |
*395Q |
probably null |
Het |
| Kdm6b |
A |
T |
11: 69,405,026 (GRCm38) |
L805Q |
unknown |
Het |
| Lgr4 |
T |
A |
2: 110,007,243 (GRCm38) |
L427* |
probably null |
Het |
| Myt1l |
G |
A |
12: 29,832,381 (GRCm38) |
S525N |
unknown |
Het |
| Nasp |
G |
A |
4: 116,611,077 (GRCm38) |
T237I |
probably benign |
Het |
| Nell2 |
G |
T |
15: 95,473,561 (GRCm38) |
Q98K |
probably damaging |
Het |
| Nfasc |
C |
T |
1: 132,634,717 (GRCm38) |
G107R |
probably damaging |
Het |
| Nsun4 |
A |
G |
4: 116,040,206 (GRCm38) |
S203P |
probably damaging |
Het |
| Olfr24 |
T |
G |
9: 18,755,569 (GRCm38) |
D22A |
probably benign |
Het |
| Olfr855 |
T |
C |
9: 19,584,888 (GRCm38) |
V117A |
probably benign |
Het |
| Otogl |
G |
A |
10: 107,777,117 (GRCm38) |
|
silent |
Het |
| Pde10a |
T |
C |
17: 8,929,117 (GRCm38) |
V366A |
probably damaging |
Het |
| Pdxk |
T |
A |
10: 78,443,791 (GRCm38) |
D250V |
probably benign |
Het |
| Pih1d1 |
T |
A |
7: 45,159,044 (GRCm38) |
I179N |
probably damaging |
Het |
| Plaa |
T |
A |
4: 94,583,992 (GRCm38) |
I294F |
probably damaging |
Het |
| Pmel |
C |
A |
10: 128,715,935 (GRCm38) |
P213T |
probably damaging |
Het |
| Pom121l2 |
A |
T |
13: 21,982,302 (GRCm38) |
R248* |
probably null |
Het |
| Pou2f1 |
T |
C |
1: 165,875,433 (GRCm38) |
|
probably benign |
Het |
| Ppm1j |
G |
A |
3: 104,781,379 (GRCm38) |
R98H |
probably damaging |
Het |
| Prkdc |
C |
T |
16: 15,772,073 (GRCm38) |
P2600L |
probably damaging |
Het |
| Prom1 |
T |
C |
5: 44,029,649 (GRCm38) |
N422S |
probably benign |
Het |
| Pspn |
C |
T |
17: 56,999,467 (GRCm38) |
C154Y |
probably damaging |
Het |
| Ptdss1 |
T |
C |
13: 66,972,637 (GRCm38) |
|
probably null |
Het |
| Rapgef1 |
A |
G |
2: 29,736,666 (GRCm38) |
Y993C |
probably damaging |
Het |
| Scrn2 |
A |
C |
11: 97,032,853 (GRCm38) |
T219P |
probably benign |
Het |
| Sec23ip |
T |
G |
7: 128,778,484 (GRCm38) |
S874R |
probably damaging |
Het |
| Sept4 |
G |
A |
11: 87,585,246 (GRCm38) |
|
probably null |
Het |
| Slc15a3 |
C |
T |
19: 10,857,251 (GRCm38) |
L499F |
probably damaging |
Het |
| Spaca9 |
G |
A |
2: 28,693,781 (GRCm38) |
R64W |
probably damaging |
Het |
| Sra1 |
A |
G |
18: 36,667,575 (GRCm38) |
M193T |
probably damaging |
Het |
| Srsf4 |
G |
T |
4: 131,900,294 (GRCm38) |
|
probably benign |
Het |
| Syne1 |
T |
C |
10: 5,052,750 (GRCm38) |
D8055G |
probably damaging |
Het |
| Syne4 |
T |
A |
7: 30,316,563 (GRCm38) |
|
probably null |
Het |
| Tbc1d24 |
C |
A |
17: 24,208,229 (GRCm38) |
G253V |
probably damaging |
Het |
| Tbck |
T |
A |
3: 132,732,215 (GRCm38) |
I467N |
probably damaging |
Het |
| Tln1 |
T |
A |
4: 43,538,030 (GRCm38) |
M1857L |
possibly damaging |
Het |
| Ttll2 |
T |
C |
17: 7,351,632 (GRCm38) |
R299G |
probably benign |
Het |
| Ugt2b36 |
T |
G |
5: 87,066,213 (GRCm38) |
E524A |
probably benign |
Het |
| Vmn2r124 |
C |
T |
17: 18,062,851 (GRCm38) |
T269I |
probably benign |
Het |
| Vmn2r4 |
A |
G |
3: 64,406,943 (GRCm38) |
F206L |
probably benign |
Het |
| Zfp346 |
A |
G |
13: 55,115,574 (GRCm38) |
K156R |
probably damaging |
Het |
|
| Other mutations in Camk2d |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00160:Camk2d
|
APN |
3 |
126,838,272 (GRCm38) |
nonsense |
probably null |
|
|
IGL01113:Camk2d
|
APN |
3 |
126,780,412 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01125:Camk2d
|
APN |
3 |
126,798,285 (GRCm38) |
splice site |
probably benign |
|
|
IGL01912:Camk2d
|
APN |
3 |
126,810,632 (GRCm38) |
splice site |
probably null |
|
|
IGL01934:Camk2d
|
APN |
3 |
126,834,655 (GRCm38) |
splice site |
probably null |
|
|
IGL02184:Camk2d
|
APN |
3 |
126,797,773 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02218:Camk2d
|
APN |
3 |
126,840,153 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02804:Camk2d
|
APN |
3 |
126,797,738 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
IGL03347:Camk2d
|
APN |
3 |
126,796,901 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03354:Camk2d
|
APN |
3 |
126,796,966 (GRCm38) |
splice site |
probably null |
|
|
baryon
|
UTSW |
3 |
126,597,482 (GRCm38) |
nonsense |
probably null |
|
|
Neutron
|
UTSW |
3 |
126,780,420 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0024:Camk2d
|
UTSW |
3 |
126,797,723 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0024:Camk2d
|
UTSW |
3 |
126,797,723 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0628:Camk2d
|
UTSW |
3 |
126,810,624 (GRCm38) |
splice site |
probably benign |
|
|
R1114:Camk2d
|
UTSW |
3 |
126,840,292 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1433:Camk2d
|
UTSW |
3 |
126,808,224 (GRCm38) |
missense |
probably benign |
0.25 |
|
R2021:Camk2d
|
UTSW |
3 |
126,780,456 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2096:Camk2d
|
UTSW |
3 |
126,780,442 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2098:Camk2d
|
UTSW |
3 |
126,780,442 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2421:Camk2d
|
UTSW |
3 |
126,780,415 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2437:Camk2d
|
UTSW |
3 |
126,834,628 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2930:Camk2d
|
UTSW |
3 |
126,808,231 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R3738:Camk2d
|
UTSW |
3 |
126,771,839 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3969:Camk2d
|
UTSW |
3 |
126,796,959 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R4455:Camk2d
|
UTSW |
3 |
126,780,403 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4829:Camk2d
|
UTSW |
3 |
126,779,997 (GRCm38) |
intron |
probably benign |
|
|
R4916:Camk2d
|
UTSW |
3 |
126,783,975 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5277:Camk2d
|
UTSW |
3 |
126,684,741 (GRCm38) |
intron |
probably benign |
|
|
R5329:Camk2d
|
UTSW |
3 |
126,597,482 (GRCm38) |
nonsense |
probably null |
|
|
R5364:Camk2d
|
UTSW |
3 |
126,780,420 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5473:Camk2d
|
UTSW |
3 |
126,597,399 (GRCm38) |
utr 5 prime |
probably benign |
|
|
R5509:Camk2d
|
UTSW |
3 |
126,840,316 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5958:Camk2d
|
UTSW |
3 |
126,779,865 (GRCm38) |
intron |
probably benign |
|
|
R6010:Camk2d
|
UTSW |
3 |
126,797,714 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R7267:Camk2d
|
UTSW |
3 |
126,797,730 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
R7708:Camk2d
|
UTSW |
3 |
126,597,440 (GRCm38) |
start codon destroyed |
probably benign |
0.00 |
|
R8249:Camk2d
|
UTSW |
3 |
126,797,729 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8554:Camk2d
|
UTSW |
3 |
126,770,799 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R9489:Camk2d
|
UTSW |
3 |
126,767,560 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9698:Camk2d
|
UTSW |
3 |
126,840,184 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGGGTCCTAGTCTGTGTG -3'
(R):5'- TGTTAGAAACACACTGCTGGAC -3'
Sequencing Primer
(F):5'- TGTGACCTTCAGGAACTAGACATGC -3'
(R):5'- ACTGCTGGACAACTATCTCAAG -3'
|
| Posted On |
2017-10-10 |
Incidental Mutation