Incidental Mutation 'R6147:Vmn2r11'
ID 488937
Institutional Source Beutler Lab
Gene Symbol Vmn2r11
Ensembl Gene ENSMUSG00000091450
Gene Name vomeronasal 2, receptor 11
Synonyms EG384219
MMRRC Submission 044294-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R6147 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 109194739-109207318 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 109202700 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 126 (V126M)
Ref Sequence ENSEMBL: ENSMUSP00000133218 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164875]
AlphaFold E9Q4X4
Predicted Effect probably benign
Transcript: ENSMUST00000164875
AA Change: V126M

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: V126M

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 167 475 1.6e-29 PFAM
Pfam:NCD3G 520 574 9.1e-19 PFAM
Pfam:7tm_3 607 842 4.6e-55 PFAM
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.3%
  • 10x: 97.1%
  • 20x: 92.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acmsd C T 1: 127,657,157 (GRCm39) probably benign Het
Acsf3 T A 8: 123,508,213 (GRCm39) D236E probably damaging Het
Aqp1 G T 6: 55,313,595 (GRCm39) E40D probably benign Het
Arfgef2 A G 2: 166,713,415 (GRCm39) D1272G probably damaging Het
Arfip1 A G 3: 84,436,485 (GRCm39) V97A probably benign Het
Atp6v1b2 T A 8: 69,555,134 (GRCm39) Y165* probably null Het
Bclaf1 T A 10: 20,199,171 (GRCm39) D189E possibly damaging Het
Camsap2 G A 1: 136,273,138 (GRCm39) T13M probably damaging Het
Cblif G A 19: 11,724,936 (GRCm39) probably benign Het
Cntn5 T A 9: 10,012,894 (GRCm39) Y297F probably damaging Het
Cntnap5b G A 1: 99,978,506 (GRCm39) C174Y probably damaging Het
Cntrl A C 2: 35,055,745 (GRCm39) D1213A possibly damaging Het
Comtd1 C A 14: 21,898,883 (GRCm39) A20S probably damaging Het
Cspg4 A T 9: 56,796,056 (GRCm39) R1264W probably damaging Het
Cybb C G X: 9,316,989 (GRCm39) D246H probably benign Het
Dlgap2 T A 8: 14,777,294 (GRCm39) C180S probably benign Het
Ednra C T 8: 78,393,951 (GRCm39) probably benign Het
Efcab3 T C 11: 104,858,566 (GRCm39) V3875A unknown Het
Ephb6 A T 6: 41,593,715 (GRCm39) S533C probably damaging Het
Fndc1 A T 17: 7,972,594 (GRCm39) probably null Het
Gm12185 A G 11: 48,806,717 (GRCm39) I158T probably benign Het
Gm14325 A T 2: 177,474,600 (GRCm39) C161S probably damaging Het
Ighv9-1 T A 12: 114,057,840 (GRCm39) Q20L probably damaging Het
Khnyn G C 14: 56,125,060 (GRCm39) S438T probably damaging Het
Krt9 T C 11: 100,079,665 (GRCm39) S576G unknown Het
Lrriq4 A T 3: 30,713,228 (GRCm39) N443I probably damaging Het
Luzp1 A G 4: 136,268,374 (GRCm39) Y199C probably damaging Het
Map2k3 T A 11: 60,840,776 (GRCm39) Y268* probably null Het
Men1 T A 19: 6,387,272 (GRCm39) D248E probably damaging Het
Mfsd4b2 A T 10: 39,797,573 (GRCm39) C261S probably benign Het
Mpeg1 T G 19: 12,440,258 (GRCm39) I572S probably damaging Het
Mrgprb2 A G 7: 48,202,113 (GRCm39) V204A possibly damaging Het
Mycbp2 A T 14: 103,392,945 (GRCm39) C805* probably null Het
Nphs2 A T 1: 156,146,296 (GRCm39) K91* probably null Het
Obox3 A G 7: 15,359,926 (GRCm39) S248P probably damaging Het
Or12d17 T C 17: 37,777,430 (GRCm39) I111T probably benign Het
Or5w19 C T 2: 87,699,061 (GRCm39) T242I probably benign Het
Or8k22 A T 2: 86,162,844 (GRCm39) N285K probably damaging Het
Otogl G A 10: 107,612,978 (GRCm39) silent Het
Pan3 T C 5: 147,485,093 (GRCm39) probably benign Het
Pate10 A G 9: 35,653,528 (GRCm39) T111A possibly damaging Het
Pate10 A T 9: 35,653,406 (GRCm39) Y70F possibly damaging Het
Pcdhb5 T A 18: 37,453,779 (GRCm39) L53Q probably damaging Het
Pcdhb9 G T 18: 37,535,494 (GRCm39) R496L possibly damaging Het
Peg10 C T 6: 4,754,499 (GRCm39) probably benign Het
Plce1 A G 19: 38,690,481 (GRCm39) K722E probably damaging Het
Plch1 A G 3: 63,630,302 (GRCm39) S489P probably damaging Het
Plekhg3 T C 12: 76,611,985 (GRCm39) V362A probably damaging Het
Prorp A G 12: 55,426,093 (GRCm39) Y168C probably damaging Het
Radil G A 5: 142,483,695 (GRCm39) H264Y probably benign Het
Ranbp2 C A 10: 58,315,250 (GRCm39) T1990K probably damaging Het
Rnf207 T C 4: 152,400,112 (GRCm39) D192G probably damaging Het
Ryr1 A T 7: 28,785,339 (GRCm39) F1784Y possibly damaging Het
Set T A 2: 29,956,836 (GRCm39) S2T probably benign Het
Slc26a2 T A 18: 61,334,757 (GRCm39) Y232F probably damaging Het
Sntb1 T A 15: 55,511,406 (GRCm39) M393L probably benign Het
Stx16 A G 2: 173,932,480 (GRCm39) T18A probably damaging Het
Stxbp5 A T 10: 9,684,216 (GRCm39) S585T possibly damaging Het
Sult2a7 T C 7: 14,199,088 (GRCm39) E313G probably damaging Het
Tbck A G 3: 132,400,207 (GRCm39) K86R probably benign Het
Tom1 A T 8: 75,781,320 (GRCm39) Q255L possibly damaging Het
Trbv4 A G 6: 41,036,637 (GRCm39) Y54C probably damaging Het
Trim34a A T 7: 103,910,398 (GRCm39) Q400L probably damaging Het
Trim42 G T 9: 97,245,382 (GRCm39) H473N probably benign Het
Tsbp1 T C 17: 34,637,897 (GRCm39) S31P possibly damaging Het
Tshr T A 12: 91,505,009 (GRCm39) M649K possibly damaging Het
Vps13b T A 15: 35,930,177 (GRCm39) H3971Q probably benign Het
Wdr75 T A 1: 45,858,698 (GRCm39) N622K probably benign Het
Wdr93 A T 7: 79,408,245 (GRCm39) Q242L probably benign Het
Other mutations in Vmn2r11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00925:Vmn2r11 APN 5 109,194,885 (GRCm39) missense probably benign 0.00
IGL01677:Vmn2r11 APN 5 109,201,823 (GRCm39) missense possibly damaging 0.50
IGL02048:Vmn2r11 APN 5 109,202,658 (GRCm39) missense probably benign 0.00
IGL02559:Vmn2r11 APN 5 109,200,046 (GRCm39) missense probably damaging 0.98
IGL02879:Vmn2r11 APN 5 109,201,704 (GRCm39) missense possibly damaging 0.95
IGL03084:Vmn2r11 APN 5 109,207,209 (GRCm39) missense probably benign 0.00
IGL03163:Vmn2r11 APN 5 109,201,692 (GRCm39) missense probably benign 0.41
IGL03289:Vmn2r11 APN 5 109,196,788 (GRCm39) splice site probably benign
IGL03294:Vmn2r11 APN 5 109,201,935 (GRCm39) missense probably benign 0.22
R0233:Vmn2r11 UTSW 5 109,201,968 (GRCm39) missense probably benign 0.16
R0233:Vmn2r11 UTSW 5 109,201,968 (GRCm39) missense probably benign 0.16
R0421:Vmn2r11 UTSW 5 109,207,294 (GRCm39) missense probably benign 0.00
R0549:Vmn2r11 UTSW 5 109,199,963 (GRCm39) missense possibly damaging 0.80
R0628:Vmn2r11 UTSW 5 109,195,597 (GRCm39) missense possibly damaging 0.88
R1523:Vmn2r11 UTSW 5 109,201,707 (GRCm39) missense probably benign 0.25
R1660:Vmn2r11 UTSW 5 109,201,724 (GRCm39) missense possibly damaging 0.79
R1827:Vmn2r11 UTSW 5 109,199,938 (GRCm39) missense probably benign 0.01
R1913:Vmn2r11 UTSW 5 109,202,654 (GRCm39) missense probably benign
R2260:Vmn2r11 UTSW 5 109,201,657 (GRCm39) nonsense probably null
R2400:Vmn2r11 UTSW 5 109,199,928 (GRCm39) missense probably benign 0.03
R3933:Vmn2r11 UTSW 5 109,201,260 (GRCm39) missense probably damaging 0.97
R4091:Vmn2r11 UTSW 5 109,202,616 (GRCm39) critical splice donor site probably null
R4624:Vmn2r11 UTSW 5 109,200,101 (GRCm39) missense probably damaging 0.99
R4762:Vmn2r11 UTSW 5 109,195,436 (GRCm39) missense probably damaging 1.00
R5256:Vmn2r11 UTSW 5 109,202,658 (GRCm39) missense probably benign 0.26
R5370:Vmn2r11 UTSW 5 109,195,421 (GRCm39) missense probably damaging 1.00
R5419:Vmn2r11 UTSW 5 109,207,224 (GRCm39) missense possibly damaging 0.55
R5516:Vmn2r11 UTSW 5 109,195,032 (GRCm39) missense probably damaging 0.98
R5643:Vmn2r11 UTSW 5 109,194,869 (GRCm39) missense probably damaging 1.00
R5671:Vmn2r11 UTSW 5 109,202,772 (GRCm39) missense probably benign 0.03
R5679:Vmn2r11 UTSW 5 109,202,708 (GRCm39) missense probably benign 0.00
R5739:Vmn2r11 UTSW 5 109,207,114 (GRCm39) critical splice donor site probably null
R5746:Vmn2r11 UTSW 5 109,201,560 (GRCm39) missense probably benign 0.41
R5995:Vmn2r11 UTSW 5 109,194,921 (GRCm39) missense probably damaging 1.00
R6220:Vmn2r11 UTSW 5 109,201,434 (GRCm39) missense probably benign 0.09
R6374:Vmn2r11 UTSW 5 109,201,679 (GRCm39) missense possibly damaging 0.65
R6491:Vmn2r11 UTSW 5 109,196,800 (GRCm39) missense possibly damaging 0.95
R6804:Vmn2r11 UTSW 5 109,201,350 (GRCm39) missense probably damaging 1.00
R6814:Vmn2r11 UTSW 5 109,194,976 (GRCm39) missense possibly damaging 0.81
R6872:Vmn2r11 UTSW 5 109,194,976 (GRCm39) missense possibly damaging 0.81
R7014:Vmn2r11 UTSW 5 109,201,289 (GRCm39) missense probably damaging 1.00
R7041:Vmn2r11 UTSW 5 109,202,816 (GRCm39) missense probably damaging 1.00
R7043:Vmn2r11 UTSW 5 109,200,098 (GRCm39) missense probably benign 0.00
R7050:Vmn2r11 UTSW 5 109,202,657 (GRCm39) missense probably benign 0.05
R7184:Vmn2r11 UTSW 5 109,201,281 (GRCm39) missense probably damaging 1.00
R7388:Vmn2r11 UTSW 5 109,202,742 (GRCm39) missense probably benign 0.05
R7477:Vmn2r11 UTSW 5 109,207,214 (GRCm39) missense possibly damaging 0.67
R7524:Vmn2r11 UTSW 5 109,201,848 (GRCm39) missense probably benign 0.01
R7682:Vmn2r11 UTSW 5 109,195,481 (GRCm39) missense probably benign 0.02
R7715:Vmn2r11 UTSW 5 109,195,307 (GRCm39) missense probably damaging 0.99
R7869:Vmn2r11 UTSW 5 109,199,986 (GRCm39) missense probably damaging 1.00
R8094:Vmn2r11 UTSW 5 109,201,626 (GRCm39) missense probably damaging 1.00
R8277:Vmn2r11 UTSW 5 109,202,833 (GRCm39) missense probably benign 0.00
R8506:Vmn2r11 UTSW 5 109,207,270 (GRCm39) missense probably benign 0.00
R8676:Vmn2r11 UTSW 5 109,201,626 (GRCm39) missense probably damaging 1.00
R8701:Vmn2r11 UTSW 5 109,195,556 (GRCm39) missense probably damaging 1.00
R8749:Vmn2r11 UTSW 5 109,195,319 (GRCm39) missense probably damaging 0.97
R9046:Vmn2r11 UTSW 5 109,202,850 (GRCm39) missense probably benign 0.00
R9138:Vmn2r11 UTSW 5 109,201,904 (GRCm39) missense probably damaging 1.00
R9267:Vmn2r11 UTSW 5 109,199,929 (GRCm39) missense possibly damaging 0.93
R9306:Vmn2r11 UTSW 5 109,196,831 (GRCm39) missense probably damaging 1.00
R9384:Vmn2r11 UTSW 5 109,201,266 (GRCm39) missense probably damaging 1.00
R9443:Vmn2r11 UTSW 5 109,195,159 (GRCm39) nonsense probably null
R9520:Vmn2r11 UTSW 5 109,201,455 (GRCm39) missense probably benign 0.35
R9596:Vmn2r11 UTSW 5 109,201,563 (GRCm39) missense possibly damaging 0.67
R9677:Vmn2r11 UTSW 5 109,201,332 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- ACTTGCAGGCACATGTAAATGG -3'
(R):5'- TGCCTTGTTTTAGAATACCTACAAG -3'

Sequencing Primer
(F):5'- GAGGTCCTAAGTTCAATTCCCAGG -3'
(R):5'- CCTGATCTTTTACCCAACA -3'
Posted On 2017-10-10