Incidental Mutation 'R0526:Or4g17'
ID 48895
Institutional Source Beutler Lab
Gene Symbol Or4g17
Ensembl Gene ENSMUSG00000108931
Gene Name olfactory receptor family 4 subfamily G member 17
Synonyms GA_x6K02T2Q125-72430580-72431515, MOR245-13, Olfr1284
MMRRC Submission 038719-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.186) question?
Stock # R0526 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 111209347-111210282 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 111209837 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 164 (V164E)
Ref Sequence ENSEMBL: ENSMUSP00000147014 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062407] [ENSMUST00000209096]
AlphaFold Q8VF29
Predicted Effect possibly damaging
Transcript: ENSMUST00000062407
AA Change: V164E

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000052153
Gene: ENSMUSG00000108931
AA Change: V164E

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 7.2e-45 PFAM
Pfam:7TM_GPCR_Srsx 34 302 2.4e-5 PFAM
Pfam:7tm_1 41 287 2e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000209096
AA Change: V164E

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 92.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik A T 4: 137,182,535 (GRCm39) N230I possibly damaging Het
4933427D14Rik G T 11: 72,060,609 (GRCm39) Q687K probably damaging Het
Actrt2 A G 4: 154,751,869 (GRCm39) L89P probably damaging Het
Adamts1 A C 16: 85,599,260 (GRCm39) S113R probably benign Het
Agxt2 G T 15: 10,373,948 (GRCm39) C118F probably damaging Het
Akap8 G A 17: 32,536,266 (GRCm39) T49I probably benign Het
Alk A T 17: 72,176,748 (GRCm39) W1519R probably damaging Het
Atf7ip T A 6: 136,536,803 (GRCm39) F12Y probably damaging Het
Atp13a5 A G 16: 29,167,558 (GRCm39) C131R probably damaging Het
Atp8b4 A G 2: 126,269,283 (GRCm39) L168P probably damaging Het
Blm G T 7: 80,155,641 (GRCm39) S346* probably null Het
Ccnt2 T G 1: 127,727,182 (GRCm39) C199G probably damaging Het
Cd151 A T 7: 141,050,504 (GRCm39) H219L probably damaging Het
Cd200r2 A T 16: 44,735,410 (GRCm39) R248S probably damaging Het
Cdh3 A G 8: 107,282,078 (GRCm39) D822G possibly damaging Het
Clec4b1 T C 6: 123,046,729 (GRCm39) probably null Het
Cluh C A 11: 74,556,812 (GRCm39) L951I probably benign Het
Cog7 A T 7: 121,562,494 (GRCm39) probably null Het
Col25a1 C A 3: 130,270,043 (GRCm39) P197Q probably damaging Het
Csde1 T A 3: 102,963,742 (GRCm39) S636R possibly damaging Het
Ect2l C A 10: 18,075,688 (GRCm39) C66F possibly damaging Het
Elac2 T C 11: 64,890,262 (GRCm39) M671T probably benign Het
Evi5 T C 5: 107,969,614 (GRCm39) N143S probably benign Het
Ext2 A G 2: 93,636,430 (GRCm39) V228A probably damaging Het
Fbxo38 A G 18: 62,639,051 (GRCm39) Y1084H probably damaging Het
Fcgr4 T A 1: 170,856,760 (GRCm39) L209Q probably damaging Het
Fgd3 C T 13: 49,450,000 (GRCm39) S83N probably benign Het
Gigyf2 T A 1: 87,349,215 (GRCm39) M664K probably benign Het
Il27ra A T 8: 84,766,128 (GRCm39) S219T probably benign Het
Itprid2 A G 2: 79,487,690 (GRCm39) D591G probably benign Het
Kif15 T C 9: 122,826,862 (GRCm39) V800A probably damaging Het
Lmo7 T A 14: 102,137,996 (GRCm39) D666E probably damaging Het
Lrp5 T C 19: 3,678,295 (GRCm39) D520G probably damaging Het
Lrriq3 T A 3: 154,893,934 (GRCm39) M545K probably benign Het
Lsm5 T A 6: 56,680,310 (GRCm39) D44V probably damaging Het
Man1c1 G T 4: 134,296,379 (GRCm39) Y430* probably null Het
Map4 T A 9: 109,866,346 (GRCm39) probably null Het
Megf6 A G 4: 154,343,398 (GRCm39) K561R probably benign Het
Myo1e T C 9: 70,229,680 (GRCm39) Y173H probably damaging Het
Myo6 T A 9: 80,190,823 (GRCm39) S791R possibly damaging Het
Nol11 C A 11: 107,075,597 (GRCm39) E144* probably null Het
Ntng2 C T 2: 29,087,074 (GRCm39) R416Q probably damaging Het
Nxpe3 T A 16: 55,686,880 (GRCm39) I43F possibly damaging Het
Or5t5 A T 2: 86,616,691 (GRCm39) T206S possibly damaging Het
Pkd1l2 T C 8: 117,808,999 (GRCm39) I64V probably damaging Het
Prf1 G A 10: 61,136,033 (GRCm39) R103H probably benign Het
Rest A G 5: 77,428,874 (GRCm39) D431G probably damaging Het
Serpina10 A T 12: 103,583,127 (GRCm39) L439Q probably damaging Het
Sgk3 T G 1: 9,951,804 (GRCm39) V176G probably damaging Het
Slc19a3 A G 1: 83,000,454 (GRCm39) S188P probably damaging Het
Sorbs1 A G 19: 40,338,392 (GRCm39) I336T probably damaging Het
Strip1 C T 3: 107,527,355 (GRCm39) probably null Het
Syt4 T C 18: 31,576,799 (GRCm39) E185G possibly damaging Het
Tcaf3 T A 6: 42,566,738 (GRCm39) I784F probably damaging Het
Tgfbr3l G T 8: 4,299,439 (GRCm39) R74L possibly damaging Het
Thoc7 A G 14: 13,949,282 (GRCm38) M194T probably benign Het
Thsd7b T C 1: 129,879,129 (GRCm39) Y989H probably damaging Het
Tmem156 C T 5: 65,233,161 (GRCm39) V134I probably benign Het
Tnks A T 8: 35,320,457 (GRCm39) V738E probably benign Het
Trpm6 A T 19: 18,770,240 (GRCm39) I342F probably damaging Het
Vmn2r69 A T 7: 85,060,711 (GRCm39) V291D probably damaging Het
Wdr59 GGGTGGTG GGGTG 8: 112,207,172 (GRCm39) probably benign Het
Wnk1 T C 6: 119,928,953 (GRCm39) T1292A probably damaging Het
Yes1 T A 5: 32,812,584 (GRCm39) C285S probably benign Het
Zbed6 T C 1: 133,586,472 (GRCm39) I288M probably damaging Het
Zbtb49 T C 5: 38,371,263 (GRCm39) N206S probably benign Het
Other mutations in Or4g17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03024:Or4g17 APN 2 111,209,935 (GRCm39) missense possibly damaging 0.94
R0731:Or4g17 UTSW 2 111,209,638 (GRCm39) missense probably damaging 0.99
R1762:Or4g17 UTSW 2 111,209,918 (GRCm39) missense probably damaging 0.99
R1765:Or4g17 UTSW 2 111,209,491 (GRCm39) missense probably benign 0.39
R3106:Or4g17 UTSW 2 111,209,840 (GRCm39) missense probably benign 0.23
R3803:Or4g17 UTSW 2 111,209,638 (GRCm39) missense possibly damaging 0.95
R3894:Or4g17 UTSW 2 111,209,982 (GRCm39) missense probably benign 0.09
R4005:Or4g17 UTSW 2 111,210,088 (GRCm39) missense probably benign 0.05
R4227:Or4g17 UTSW 2 111,209,410 (GRCm39) missense probably benign
R4637:Or4g17 UTSW 2 111,209,927 (GRCm39) missense probably benign 0.03
R4707:Or4g17 UTSW 2 111,209,990 (GRCm39) missense probably damaging 1.00
R4762:Or4g17 UTSW 2 111,210,082 (GRCm39) missense probably damaging 1.00
R5150:Or4g17 UTSW 2 111,209,598 (GRCm39) missense probably damaging 1.00
R5309:Or4g17 UTSW 2 111,210,179 (GRCm39) missense possibly damaging 0.52
R5312:Or4g17 UTSW 2 111,210,179 (GRCm39) missense possibly damaging 0.52
R6554:Or4g17 UTSW 2 111,209,504 (GRCm39) missense possibly damaging 0.95
R6913:Or4g17 UTSW 2 111,209,347 (GRCm39) start codon destroyed probably null 0.03
R6980:Or4g17 UTSW 2 111,209,620 (GRCm39) missense possibly damaging 0.77
R6995:Or4g17 UTSW 2 111,209,708 (GRCm39) missense probably damaging 1.00
R7168:Or4g17 UTSW 2 111,210,224 (GRCm39) missense probably damaging 1.00
R7332:Or4g17 UTSW 2 111,209,738 (GRCm39) missense not run
R7464:Or4g17 UTSW 2 111,209,543 (GRCm39) missense probably damaging 1.00
R8125:Or4g17 UTSW 2 111,210,086 (GRCm39) missense probably damaging 0.99
R8963:Or4g17 UTSW 2 111,209,645 (GRCm39) missense probably damaging 1.00
R9660:Or4g17 UTSW 2 111,210,239 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TCCTCTACCACAGTGCCCAAGATG -3'
(R):5'- ACAAGTCCCCTGAAGACCTTTGCC -3'

Sequencing Primer
(F):5'- CTCCATCCACATTATGGGAGG -3'
(R):5'- AAGACCTTTGCCAGACTGTG -3'
Posted On 2013-06-12