Mutagenetix > Incidental Mutation

Incidental Mutation 'R6173:Ptprc'

489115

Institutional Source

Beutler Lab

Gene Symbol

Ptprc

Ensembl Gene

ENSMUSG00000026395

Gene Name

protein tyrosine phosphatase receptor type C

Synonyms

Ly-5, T200, CD45, B220, Lyt-4

MMRRC Submission

044316-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6173 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

137990599-138103446 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 137995628 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Glycine at position 1157 (C1157G)

Ref Sequence

ENSEMBL: ENSMUSP00000138350 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000182283] [ENSMUST00000182755] [ENSMUST00000183301]

AlphaFold

P06800

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000112036

SMART Domains

Protein: ENSMUSP00000107667
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	5	30	5.8e-13	PFAM
low complexity region	31	64	N/A	INTRINSIC
Pfam:CD45	70	129	1.8e-24	PFAM
FN3	233	317	2.28e0	SMART
FN3	333	411	3.48e-1	SMART
transmembrane domain	426	447	N/A	INTRINSIC
PTPc	500	762	7.57e-127	SMART
PTPc	791	1077	1.39e-102	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000182283
AA Change: C1018G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000138800
Gene: ENSMUSG00000026395
AA Change: C1018G

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	32	4.2e-13	PFAM
low complexity region	33	66	N/A	INTRINSIC
Pfam:CD45	72	131	2.3e-24	PFAM
FN3	235	319	2.28e0	SMART
FN3	335	413	3.48e-1	SMART
transmembrane domain	428	449	N/A	INTRINSIC
PTPc	502	764	7.57e-127	SMART
PTPc	793	1079	1.39e-102	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000182755
AA Change: C994G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000138275
Gene: ENSMUSG00000026395
AA Change: C994G

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	34	5.5e-13	PFAM
Pfam:CD45	48	107	2.3e-24	PFAM
FN3	211	295	2.28e0	SMART
FN3	311	389	3.48e-1	SMART
transmembrane domain	404	425	N/A	INTRINSIC
PTPc	478	740	7.57e-127	SMART
PTPc	769	1055	1.39e-102	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000183301
AA Change: C1157G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000138350
Gene: ENSMUSG00000026395
AA Change: C1157G

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	33	2.7e-13	PFAM
low complexity region	111	128	N/A	INTRINSIC
low complexity region	170	205	N/A	INTRINSIC
Pfam:CD45	211	270	2.1e-24	PFAM
FN3	374	458	2.28e0	SMART
FN3	474	552	3.48e-1	SMART
transmembrane domain	567	588	N/A	INTRINSIC
PTPc	641	903	7.57e-127	SMART
PTPc	932	1218	1.39e-102	SMART

Meta Mutation Damage Score

0.5394

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.3%
20x: 95.2%

Validation Efficiency

96% (52/54)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
PHENOTYPE: Homozygous null mutants have defective T cell, B cell, and NK cell morphology and physiology. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ank2	T	C	3: 126,846,395 (GRCm39)	D219G	probably damaging	Het
Arap2	A	T	5: 62,906,965 (GRCm39)	I18N	probably damaging	Het
Baz1b	T	C	5: 135,271,361 (GRCm39)	S1315P	probably benign	Het
Bbs7	A	T	3: 36,646,523 (GRCm39)	C432*	probably null	Het
Bend3	A	G	10: 43,385,864 (GRCm39)	T86A	probably benign	Het
Cadm2	C	T	16: 66,679,729 (GRCm39)	V35I	probably benign	Het
Ch25h	A	G	19: 34,451,896 (GRCm39)	S211P	probably damaging	Het
Chd5	A	T	4: 152,463,848 (GRCm39)	H1476L	probably damaging	Het
Chia1	T	C	3: 106,036,338 (GRCm39)		probably null	Het
Clpx	C	A	9: 65,209,161 (GRCm39)	S92*	probably null	Het
Dazl	A	T	17: 50,594,599 (GRCm39)	M152K	probably benign	Het
Dnah17	A	G	11: 117,930,772 (GRCm39)	S3748P	probably damaging	Het
Dock2	T	C	11: 34,212,388 (GRCm39)	K1251R	probably null	Het
Esr1	T	C	10: 4,696,760 (GRCm39)	V203A	probably damaging	Het
F830045P16Rik	A	G	2: 129,305,588 (GRCm39)	I262T	probably damaging	Het
Foxp1	G	A	6: 98,992,471 (GRCm39)	Q41*	probably null	Het
Foxp1	C	A	6: 98,992,475 (GRCm39)		probably null	Het
Fshb	T	C	2: 106,887,638 (GRCm39)	E127G	possibly damaging	Het
Galk2	A	G	2: 125,701,137 (GRCm39)		probably benign	Het
Gid4	A	G	11: 60,323,241 (GRCm39)	D111G	probably damaging	Het
Gm14412	G	A	2: 177,006,330 (GRCm39)	P522S	probably damaging	Het
Iqank1	A	G	15: 75,917,237 (GRCm39)	E290G	probably damaging	Het
Mfap4	A	G	11: 61,376,245 (GRCm39)		probably null	Het
Mfsd2a	A	G	4: 122,845,039 (GRCm39)	V224A	probably benign	Het
Mocos	A	T	18: 24,809,639 (GRCm39)	Y414F	probably benign	Het
Mrto4	T	C	4: 139,077,755 (GRCm39)	I27V	probably benign	Het
Muc4	A	G	16: 32,554,958 (GRCm39)		probably benign	Het
Mug1	T	A	6: 121,840,752 (GRCm39)	I534N	probably damaging	Het
Mup20	A	T	4: 61,972,267 (GRCm39)	L7Q	unknown	Het
Nlrp2	T	C	7: 5,340,808 (GRCm39)	E2G	probably damaging	Het
Or11g1	A	G	14: 50,651,654 (GRCm39)	I218V	possibly damaging	Het
Or12k7	A	G	2: 36,959,091 (GRCm39)	Y258C	possibly damaging	Het
Or2y16	T	C	11: 49,335,299 (GRCm39)	V207A	probably benign	Het
Or6z5	C	T	7: 6,477,835 (GRCm39)	A242V	probably damaging	Het
Parn	T	C	16: 13,469,675 (GRCm39)	T209A	possibly damaging	Het
Psip1	T	A	4: 83,391,286 (GRCm39)		probably null	Het
Rad17	A	C	13: 100,759,389 (GRCm39)	V546G	probably benign	Het
Rc3h2	GCC	GCCC	2: 37,304,745 (GRCm39)		probably null	Het
Safb	A	G	17: 56,904,798 (GRCm39)	E124G	probably damaging	Het
Sart3	C	T	5: 113,881,267 (GRCm39)	A938T	probably benign	Het
Skint5	T	C	4: 113,392,907 (GRCm39)	T1242A	unknown	Het
Slc13a5	C	T	11: 72,144,023 (GRCm39)	E352K	probably benign	Het
Sohlh2	G	T	3: 55,104,419 (GRCm39)	V263F	probably benign	Het
Strn	A	G	17: 79,008,298 (GRCm39)	Y107H	probably damaging	Het
Tbx15	G	T	3: 99,161,203 (GRCm39)	E3*	probably null	Het
Tespa1	A	G	10: 130,183,172 (GRCm39)	D39G	probably benign	Het
Trp73	A	T	4: 154,188,798 (GRCm39)	D54E	probably damaging	Het
Ttll5	A	T	12: 85,980,151 (GRCm39)	S912C	probably damaging	Het
Utp14b	A	T	1: 78,643,554 (GRCm39)	D484V	probably benign	Het
Utp14b	A	C	1: 78,643,557 (GRCm39)	N485T	probably benign	Het
Vmn2r29	T	C	7: 7,234,369 (GRCm39)	E839G	probably benign	Het
Vmn2r6	G	C	3: 64,467,176 (GRCm39)	P108A	probably damaging	Het
Vps8	T	G	16: 21,314,682 (GRCm39)		probably null	Het
Zfp36l1	A	T	12: 80,156,320 (GRCm39)		probably null	Het
Zfp998	T	A	13: 66,579,608 (GRCm39)	T292S	probably benign	Het
Zp3r	A	T	1: 130,519,305 (GRCm39)		probably null	Het

Other mutations in Ptprc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
lochy	APN	1	138,011,528 (GRCm39)	splice site	probably benign
IGL00486:Ptprc	APN	1	138,043,359 (GRCm39)	missense	probably damaging	0.97
IGL00771:Ptprc	APN	1	138,041,415 (GRCm39)	missense	probably benign	0.00
IGL00833:Ptprc	APN	1	138,006,230 (GRCm39)	missense	possibly damaging	0.55
IGL00919:Ptprc	APN	1	138,041,380 (GRCm39)	missense	probably damaging	1.00
IGL01020:Ptprc	APN	1	138,047,911 (GRCm39)	critical splice acceptor site	probably null	0.00
IGL01024:Ptprc	APN	1	138,008,650 (GRCm39)	missense	probably damaging	1.00
IGL01302:Ptprc	APN	1	138,027,369 (GRCm39)	missense	possibly damaging	0.82
IGL01548:Ptprc	APN	1	138,027,219 (GRCm39)	critical splice donor site	probably null	0.00
IGL01620:Ptprc	APN	1	137,996,148 (GRCm39)	missense	possibly damaging	0.88
IGL01775:Ptprc	APN	1	137,992,497 (GRCm39)	missense	probably damaging	1.00
IGL01820:Ptprc	APN	1	137,993,936 (GRCm39)	missense	probably damaging	1.00
IGL02340:Ptprc	APN	1	137,998,957 (GRCm39)	missense	probably damaging	1.00
IGL02943:Ptprc	APN	1	138,027,251 (GRCm39)	missense	probably damaging	0.99
IGL03169:Ptprc	APN	1	138,041,357 (GRCm39)	missense	probably benign	0.15
IGL03308:Ptprc	APN	1	138,054,058 (GRCm39)	missense	possibly damaging	0.70
IGL03404:Ptprc	APN	1	138,020,739 (GRCm39)	missense	probably damaging	1.00
belittle	UTSW	1	138,137,493 (GRCm38)	intron	probably benign
Benighted	UTSW	1	138,054,039 (GRCm39)	critical splice donor site	probably null
bletchley	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
Blush	UTSW	1	138,045,458 (GRCm39)	intron	probably benign
bruise	UTSW	1	137,992,509 (GRCm39)	missense	probably damaging	1.00
chor_muang	UTSW	1	138,041,300 (GRCm39)	critical splice donor site	probably null
crystal	UTSW	1	137,999,993 (GRCm39)	critical splice donor site	probably null
Dumpling	UTSW	1	137,995,628 (GRCm39)	missense	probably damaging	1.00
fluorescent	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
fuchsia	UTSW	1	138,028,779 (GRCm39)	critical splice donor site	probably null
Gentian	UTSW	1	137,995,623 (GRCm39)	critical splice donor site	probably null
guotie	UTSW	1	137,996,139 (GRCm39)	nonsense	probably null
guotie2	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
Guotie3	UTSW	1	138,006,189 (GRCm39)	missense	possibly damaging	0.92
Gyoza	UTSW	1	138,011,305 (GRCm39)	missense	probably damaging	1.00
Half_measure	UTSW	1	137,998,987 (GRCm39)	missense	probably damaging	0.98
jirisan	UTSW	1	138,041,416 (GRCm39)	nonsense	probably null
mauve	UTSW	1	138,027,423 (GRCm39)	missense	probably benign
Perverse	UTSW	1	138,028,782 (GRCm39)	missense	probably benign	0.02
petechiae	UTSW	1	138,041,446 (GRCm39)	nonsense	probably null
ultra	UTSW	1	138,006,183 (GRCm39)	critical splice donor site	probably null
violaceous	UTSW	1	138,011,377 (GRCm39)	missense	possibly damaging	0.77
R0013:Ptprc	UTSW	1	138,041,297 (GRCm39)	splice site	probably null
R0189:Ptprc	UTSW	1	138,010,453 (GRCm39)	missense	probably benign	0.10
R0390:Ptprc	UTSW	1	138,050,313 (GRCm39)	missense	possibly damaging	0.71
R0504:Ptprc	UTSW	1	138,016,435 (GRCm39)	missense	probably damaging	1.00
R0602:Ptprc	UTSW	1	138,017,223 (GRCm39)	splice site	probably benign
R0627:Ptprc	UTSW	1	137,996,058 (GRCm39)	missense	probably damaging	0.99
R0632:Ptprc	UTSW	1	138,001,348 (GRCm39)	missense	probably benign	0.01
R0751:Ptprc	UTSW	1	138,020,668 (GRCm39)	missense	probably damaging	1.00
R0839:Ptprc	UTSW	1	138,028,870 (GRCm39)	missense	possibly damaging	0.47
R0942:Ptprc	UTSW	1	137,996,139 (GRCm39)	nonsense	probably null
R0943:Ptprc	UTSW	1	138,038,902 (GRCm39)	missense	probably damaging	0.96
R1159:Ptprc	UTSW	1	138,000,057 (GRCm39)	missense	probably damaging	1.00
R1442:Ptprc	UTSW	1	138,000,050 (GRCm39)	missense	probably damaging	1.00
R1489:Ptprc	UTSW	1	138,047,824 (GRCm39)	missense	possibly damaging	0.91
R1728:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1728:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1728:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1728:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1728:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1729:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1729:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1729:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1729:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1729:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1730:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1730:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1730:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1730:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1730:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1739:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1739:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1739:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1739:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1739:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1762:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1762:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1762:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1762:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1762:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1783:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1783:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1783:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1783:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1783:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1784:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1784:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1784:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1784:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1784:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1785:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1785:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1785:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1785:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1785:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1862:Ptprc	UTSW	1	138,039,965 (GRCm39)	missense	probably benign	0.13
R2145:Ptprc	UTSW	1	138,001,419 (GRCm39)	missense	probably damaging	1.00
R2290:Ptprc	UTSW	1	138,038,926 (GRCm39)	missense	probably benign	0.00
R2403:Ptprc	UTSW	1	138,016,270 (GRCm39)	missense	probably damaging	1.00
R2439:Ptprc	UTSW	1	137,993,890 (GRCm39)	missense	possibly damaging	0.67
R2887:Ptprc	UTSW	1	138,007,916 (GRCm39)	missense	probably damaging	1.00
R2906:Ptprc	UTSW	1	137,992,272 (GRCm39)	missense	possibly damaging	0.93
R3774:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3775:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3776:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3834:Ptprc	UTSW	1	138,011,305 (GRCm39)	missense	probably damaging	1.00
R4019:Ptprc	UTSW	1	138,006,254 (GRCm39)	missense	probably damaging	1.00
R4377:Ptprc	UTSW	1	137,995,663 (GRCm39)	missense	probably benign	0.04
R4580:Ptprc	UTSW	1	137,998,989 (GRCm39)	missense	probably benign	0.09
R4923:Ptprc	UTSW	1	138,006,236 (GRCm39)	missense	possibly damaging	0.93
R4925:Ptprc	UTSW	1	138,027,235 (GRCm39)	missense	probably benign	0.04
R4937:Ptprc	UTSW	1	138,017,238 (GRCm39)	missense	probably damaging	1.00
R4970:Ptprc	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
R5112:Ptprc	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
R5145:Ptprc	UTSW	1	138,017,304 (GRCm39)	missense	probably benign	0.07
R5158:Ptprc	UTSW	1	138,102,822 (GRCm39)	missense	possibly damaging	0.75
R5223:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R5593:Ptprc	UTSW	1	138,045,458 (GRCm39)	intron	probably benign
R5689:Ptprc	UTSW	1	138,045,515 (GRCm39)	missense	probably benign	0.01
R5885:Ptprc	UTSW	1	138,016,246 (GRCm39)	missense	probably damaging	1.00
R6010:Ptprc	UTSW	1	138,028,794 (GRCm39)	missense	probably benign	0.09
R6026:Ptprc	UTSW	1	137,998,987 (GRCm39)	missense	probably damaging	0.98
R6047:Ptprc	UTSW	1	138,028,779 (GRCm39)	critical splice donor site	probably null
R6328:Ptprc	UTSW	1	138,041,416 (GRCm39)	nonsense	probably null
R6383:Ptprc	UTSW	1	138,006,189 (GRCm39)	missense	possibly damaging	0.92
R6436:Ptprc	UTSW	1	138,011,377 (GRCm39)	missense	possibly damaging	0.77
R6492:Ptprc	UTSW	1	138,041,300 (GRCm39)	critical splice donor site	probably null
R6520:Ptprc	UTSW	1	138,007,881 (GRCm39)	nonsense	probably null
R6805:Ptprc	UTSW	1	137,995,623 (GRCm39)	critical splice donor site	probably null
R6830:Ptprc	UTSW	1	137,999,993 (GRCm39)	critical splice donor site	probably null
R6847:Ptprc	UTSW	1	138,016,283 (GRCm39)	missense	probably damaging	0.99
R6960:Ptprc	UTSW	1	138,006,183 (GRCm39)	critical splice donor site	probably null
R6995:Ptprc	UTSW	1	138,016,482 (GRCm39)	missense	probably damaging	1.00
R7009:Ptprc	UTSW	1	137,992,291 (GRCm39)	missense	probably damaging	0.97
R7041:Ptprc	UTSW	1	138,054,047 (GRCm39)	missense	probably benign	0.04
R7055:Ptprc	UTSW	1	138,017,309 (GRCm39)	missense	probably damaging	1.00
R7098:Ptprc	UTSW	1	138,027,423 (GRCm39)	missense	probably benign
R7164:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R7188:Ptprc	UTSW	1	137,998,918 (GRCm39)	missense	probably damaging	1.00
R7191:Ptprc	UTSW	1	138,028,782 (GRCm39)	missense	probably benign	0.02
R7204:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R7316:Ptprc	UTSW	1	137,992,509 (GRCm39)	missense	probably damaging	1.00
R7644:Ptprc	UTSW	1	137,995,645 (GRCm39)	missense	probably benign	0.01
R7948:Ptprc	UTSW	1	137,992,314 (GRCm39)	missense	probably benign	0.45
R8029:Ptprc	UTSW	1	138,006,197 (GRCm39)	missense	probably damaging	1.00
R8677:Ptprc	UTSW	1	138,011,335 (GRCm39)	missense	probably damaging	1.00
R8704:Ptprc	UTSW	1	138,043,362 (GRCm39)	missense	probably benign	0.34
R8824:Ptprc	UTSW	1	138,041,446 (GRCm39)	nonsense	probably null
R8921:Ptprc	UTSW	1	138,054,039 (GRCm39)	critical splice donor site	probably null
R8998:Ptprc	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
R8999:Ptprc	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
R9154:Ptprc	UTSW	1	138,016,302 (GRCm39)	missense	probably damaging	1.00
R9388:Ptprc	UTSW	1	138,011,380 (GRCm39)	missense	possibly damaging	0.87
R9428:Ptprc	UTSW	1	138,041,485 (GRCm39)	missense	probably benign	0.01
R9467:Ptprc	UTSW	1	137,993,960 (GRCm39)	missense	probably damaging	1.00
R9468:Ptprc	UTSW	1	138,044,754 (GRCm39)	missense	probably benign	0.01
R9479:Ptprc	UTSW	1	138,001,388 (GRCm39)	missense	probably benign	0.38
R9526:Ptprc	UTSW	1	137,996,111 (GRCm39)	missense	probably benign	0.02
R9632:Ptprc	UTSW	1	138,008,627 (GRCm39)	missense	probably damaging	1.00
R9710:Ptprc	UTSW	1	138,008,627 (GRCm39)	missense	probably damaging	1.00
R9714:Ptprc	UTSW	1	138,008,687 (GRCm39)	missense	probably damaging	1.00
R9777:Ptprc	UTSW	1	138,047,901 (GRCm39)	missense
Z1177:Ptprc	UTSW	1	137,995,645 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- TCAAATGATAGGCAGCAGCTACC -3'
(R):5'- CACTTCACCTCGGATTGCAG -3'

Sequencing Primer
(F):5'- GCTACCAGCCTAAAAGCCTGG -3'
(R):5'- TTGCAGAGGAAGGAGCCC -3'

Posted On

2017-10-10