|Institutional Source||Beutler Lab|
|Gene Name||chitinase, acidic 1|
|Synonyms||2200003E03Rik, YNL, AMCase, Chia|
|Is this an essential gene?||Possibly non essential (E-score: 0.374)|
|Stock #||R6173 (G1)|
|Chromosomal Location||106113229-106132120 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to C at 106129022 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000078134 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000079132] [ENSMUST00000139086]|
|Predicted Effect||probably null
|Predicted Effect||probably benign
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.8580|
|Coding Region Coverage||
|Validation Efficiency||96% (52/54)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Chia1||
(F):5'- TGGAAGAACAATGGAGCCCC -3'
(R):5'- GTTCAATGCCCCAGTGTAGG -3'
(F):5'- CCCAGCTGAGAAGCTCATTGTTG -3'
(R):5'- CCAGTGTAGGGGAACGCCAG -3'