Incidental Mutation 'R6150:Tekt3'
ID 489204
Institutional Source Beutler Lab
Gene Symbol Tekt3
Ensembl Gene ENSMUSG00000042189
Gene Name tektin 3
Synonyms 4933407G07Rik
MMRRC Submission 044297-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6150 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 62952485-62985786 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 62985483 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 430 (T430S)
Ref Sequence ENSEMBL: ENSMUSP00000042063 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035732]
AlphaFold Q6X6Z7
Predicted Effect possibly damaging
Transcript: ENSMUST00000035732
AA Change: T430S

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000042063
Gene: ENSMUSG00000042189
AA Change: T430S

DomainStartEndE-ValueType
Pfam:Tektin 99 481 5.6e-149 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.9%
Validation Efficiency 97% (56/58)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit defective sperm motility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh3a1 A G 11: 61,104,334 (GRCm39) T74A probably benign Het
Arhgef1 T C 7: 24,618,782 (GRCm39) probably null Het
Art1 C G 7: 101,756,294 (GRCm39) R162G probably benign Het
Boll T A 1: 55,309,812 (GRCm39) I280F possibly damaging Het
Cep44 T C 8: 56,992,840 (GRCm39) E258G probably benign Het
Cutc T A 19: 43,748,328 (GRCm39) V75E probably damaging Het
Dtx1 T C 5: 120,819,428 (GRCm39) K590R probably damaging Het
Eps8 A T 6: 137,494,172 (GRCm39) D295E probably damaging Het
Erc2 C A 14: 27,863,248 (GRCm39) S491Y probably damaging Het
F2rl3 G T 8: 73,489,366 (GRCm39) A198S probably benign Het
Fam83b G A 9: 76,399,639 (GRCm39) T488M probably damaging Het
Fitm2 A G 2: 163,311,994 (GRCm39) L73P probably damaging Het
Fxyd1 T C 7: 30,754,228 (GRCm39) probably null Het
Gm17186 T C 14: 51,918,183 (GRCm39) noncoding transcript Het
Hivep3 C A 4: 119,591,274 (GRCm39) S94* probably null Het
Ifna1 T A 4: 88,768,349 (GRCm39) M9K probably null Het
Igsf11 G A 16: 38,843,711 (GRCm39) E275K probably damaging Het
Itga1 G A 13: 115,104,769 (GRCm39) L1086F probably benign Het
Itgav T C 2: 83,606,780 (GRCm39) S374P probably benign Het
Jmy A T 13: 93,577,641 (GRCm39) N842K probably benign Het
Kcnh6 G A 11: 105,911,557 (GRCm39) V595M possibly damaging Het
Kif13b T A 14: 64,989,088 (GRCm39) I823N probably damaging Het
Kif26b T C 1: 178,743,111 (GRCm39) L1069P probably damaging Het
Kl T A 5: 150,912,318 (GRCm39) M689K possibly damaging Het
Kmt2b G T 7: 30,287,902 (GRCm39) probably benign Het
Map10 G A 8: 126,398,328 (GRCm39) D574N probably damaging Het
Mau2 A T 8: 70,472,487 (GRCm39) H565Q probably benign Het
Myb A G 10: 21,017,668 (GRCm39) I641T probably damaging Het
Naaladl2 C A 3: 24,606,214 (GRCm39) G15V probably null Het
Or10k2 G A 8: 84,267,782 (GRCm39) C3Y probably benign Het
Or3a4 A C 11: 73,945,145 (GRCm39) S147A probably benign Het
Or6c210 A G 10: 129,495,803 (GRCm39) I43V probably benign Het
Or7d11 A T 9: 19,966,170 (GRCm39) N78K probably benign Het
Otog A G 7: 45,913,483 (GRCm39) E772G possibly damaging Het
Pla2g4d T C 2: 120,100,045 (GRCm39) D674G probably damaging Het
Pmpcb A G 5: 21,942,137 (GRCm39) probably null Het
Pomk A G 8: 26,473,284 (GRCm39) V223A possibly damaging Het
Prpf40a T C 2: 53,047,927 (GRCm39) M197V probably benign Het
Serpina1e A G 12: 103,917,066 (GRCm39) V201A probably benign Het
Six5 C T 7: 18,831,446 (GRCm39) P646S probably benign Het
Slc17a9 A G 2: 180,379,421 (GRCm39) I298V probably benign Het
Slc37a2 G T 9: 37,149,643 (GRCm39) T188K probably damaging Het
Slc6a11 T A 6: 114,222,579 (GRCm39) F525I probably benign Het
Slit2 A T 5: 48,461,516 (GRCm39) D1504V probably damaging Het
Srcap T A 7: 127,134,000 (GRCm39) M907K probably damaging Het
Sspo T C 6: 48,463,313 (GRCm39) L3746P probably benign Het
Supv3l1 A T 10: 62,271,501 (GRCm39) N376K possibly damaging Het
Tex2 A T 11: 106,457,906 (GRCm39) V508D probably benign Het
Tmem184c G T 8: 78,323,069 (GRCm39) Q598K probably benign Het
Ube2v1 G A 2: 167,459,874 (GRCm39) R42* probably null Het
Usp45 A C 4: 21,810,797 (GRCm39) D331A probably damaging Het
Vangl1 T C 3: 102,091,835 (GRCm39) T84A probably damaging Het
Vgll3 T A 16: 65,625,064 (GRCm39) probably null Het
Vmn1r61 T A 7: 5,613,678 (GRCm39) H212L probably benign Het
Vmn2r114 A G 17: 23,510,269 (GRCm39) V737A probably benign Het
Vmn2r35 A T 7: 7,789,555 (GRCm39) D727E probably damaging Het
Vps18 T A 2: 119,128,073 (GRCm39) Y965* probably null Het
Zfp521 A T 18: 13,977,135 (GRCm39) C1093S probably damaging Het
Zfp971 A C 2: 177,675,247 (GRCm39) H282P probably benign Het
Other mutations in Tekt3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00505:Tekt3 APN 11 62,961,064 (GRCm39) missense probably benign 0.19
IGL00851:Tekt3 APN 11 62,961,226 (GRCm39) missense probably benign 0.01
IGL01469:Tekt3 APN 11 62,964,294 (GRCm39) missense probably damaging 1.00
IGL02123:Tekt3 APN 11 62,974,766 (GRCm39) missense probably benign 0.05
R1517:Tekt3 UTSW 11 62,961,316 (GRCm39) missense probably damaging 1.00
R1616:Tekt3 UTSW 11 62,978,024 (GRCm39) splice site probably null
R1750:Tekt3 UTSW 11 62,960,867 (GRCm39) missense probably damaging 0.96
R2087:Tekt3 UTSW 11 62,985,523 (GRCm39) missense possibly damaging 0.95
R2174:Tekt3 UTSW 11 62,985,514 (GRCm39) missense possibly damaging 0.90
R2249:Tekt3 UTSW 11 62,974,778 (GRCm39) missense probably benign
R4835:Tekt3 UTSW 11 62,972,085 (GRCm39) missense probably benign 0.19
R5198:Tekt3 UTSW 11 62,961,134 (GRCm39) missense probably damaging 1.00
R5452:Tekt3 UTSW 11 62,985,619 (GRCm39) missense probably damaging 0.99
R5518:Tekt3 UTSW 11 62,974,768 (GRCm39) missense probably benign 0.00
R5946:Tekt3 UTSW 11 62,985,573 (GRCm39) missense probably damaging 0.98
R6191:Tekt3 UTSW 11 62,968,999 (GRCm39) missense probably damaging 0.98
R6547:Tekt3 UTSW 11 62,961,304 (GRCm39) missense possibly damaging 0.50
R6597:Tekt3 UTSW 11 62,972,085 (GRCm39) missense probably benign 0.19
R7259:Tekt3 UTSW 11 62,974,592 (GRCm39) missense possibly damaging 0.79
R7578:Tekt3 UTSW 11 62,985,486 (GRCm39) missense probably damaging 0.99
R7878:Tekt3 UTSW 11 62,961,277 (GRCm39) nonsense probably null
R8056:Tekt3 UTSW 11 62,974,785 (GRCm39) critical splice donor site probably null
R8082:Tekt3 UTSW 11 62,961,056 (GRCm39) missense probably benign 0.00
R8104:Tekt3 UTSW 11 62,968,945 (GRCm39) missense probably benign 0.33
R8865:Tekt3 UTSW 11 62,961,058 (GRCm39) missense probably benign
R8917:Tekt3 UTSW 11 62,978,052 (GRCm39) missense probably damaging 0.98
R9013:Tekt3 UTSW 11 62,974,684 (GRCm39) missense probably damaging 1.00
R9039:Tekt3 UTSW 11 62,972,169 (GRCm39) missense possibly damaging 0.59
Predicted Primers PCR Primer
(F):5'- TGAGGTTGACAATAGGGGATGATTC -3'
(R):5'- TTGAAAACTACTCTTCCCAGGG -3'

Sequencing Primer
(F):5'- CTGGTAATTCTGGAAGCATGCATAG -3'
(R):5'- TTCCCAGGGTCCCTAGCAGTAG -3'
Posted On 2017-10-10