Incidental Mutation 'R0526:Nol11'
ID 48943
Institutional Source Beutler Lab
Gene Symbol Nol11
Ensembl Gene ENSMUSG00000018433
Gene Name nucleolar protein 11
Synonyms 1500002M01Rik
MMRRC Submission 038719-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.933) question?
Stock # R0526 (G1)
Quality Score 172
Status Not validated
Chromosome 11
Chromosomal Location 107057489-107080207 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 107075597 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 144 (E144*)
Ref Sequence ENSEMBL: ENSMUSP00000102368 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018577] [ENSMUST00000106757]
AlphaFold Q8BJW5
Predicted Effect probably null
Transcript: ENSMUST00000018577
AA Change: E144*
SMART Domains Protein: ENSMUSP00000018577
Gene: ENSMUSG00000018433
AA Change: E144*

DomainStartEndE-ValueType
SCOP:d1jmxb_ 32 176 3e-3 SMART
Pfam:NUC205 200 243 3.7e-26 PFAM
low complexity region 619 629 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106757
AA Change: E144*
SMART Domains Protein: ENSMUSP00000102368
Gene: ENSMUSG00000018433
AA Change: E144*

DomainStartEndE-ValueType
SCOP:d1jmxb_ 32 176 3e-3 SMART
Pfam:NUC205 200 243 7.3e-29 PFAM
low complexity region 599 609 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136917
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139168
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 92.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik A T 4: 137,182,535 (GRCm39) N230I possibly damaging Het
4933427D14Rik G T 11: 72,060,609 (GRCm39) Q687K probably damaging Het
Actrt2 A G 4: 154,751,869 (GRCm39) L89P probably damaging Het
Adamts1 A C 16: 85,599,260 (GRCm39) S113R probably benign Het
Agxt2 G T 15: 10,373,948 (GRCm39) C118F probably damaging Het
Akap8 G A 17: 32,536,266 (GRCm39) T49I probably benign Het
Alk A T 17: 72,176,748 (GRCm39) W1519R probably damaging Het
Atf7ip T A 6: 136,536,803 (GRCm39) F12Y probably damaging Het
Atp13a5 A G 16: 29,167,558 (GRCm39) C131R probably damaging Het
Atp8b4 A G 2: 126,269,283 (GRCm39) L168P probably damaging Het
Blm G T 7: 80,155,641 (GRCm39) S346* probably null Het
Ccnt2 T G 1: 127,727,182 (GRCm39) C199G probably damaging Het
Cd151 A T 7: 141,050,504 (GRCm39) H219L probably damaging Het
Cd200r2 A T 16: 44,735,410 (GRCm39) R248S probably damaging Het
Cdh3 A G 8: 107,282,078 (GRCm39) D822G possibly damaging Het
Clec4b1 T C 6: 123,046,729 (GRCm39) probably null Het
Cluh C A 11: 74,556,812 (GRCm39) L951I probably benign Het
Cog7 A T 7: 121,562,494 (GRCm39) probably null Het
Col25a1 C A 3: 130,270,043 (GRCm39) P197Q probably damaging Het
Csde1 T A 3: 102,963,742 (GRCm39) S636R possibly damaging Het
Ect2l C A 10: 18,075,688 (GRCm39) C66F possibly damaging Het
Elac2 T C 11: 64,890,262 (GRCm39) M671T probably benign Het
Evi5 T C 5: 107,969,614 (GRCm39) N143S probably benign Het
Ext2 A G 2: 93,636,430 (GRCm39) V228A probably damaging Het
Fbxo38 A G 18: 62,639,051 (GRCm39) Y1084H probably damaging Het
Fcgr4 T A 1: 170,856,760 (GRCm39) L209Q probably damaging Het
Fgd3 C T 13: 49,450,000 (GRCm39) S83N probably benign Het
Gigyf2 T A 1: 87,349,215 (GRCm39) M664K probably benign Het
Il27ra A T 8: 84,766,128 (GRCm39) S219T probably benign Het
Itprid2 A G 2: 79,487,690 (GRCm39) D591G probably benign Het
Kif15 T C 9: 122,826,862 (GRCm39) V800A probably damaging Het
Lmo7 T A 14: 102,137,996 (GRCm39) D666E probably damaging Het
Lrp5 T C 19: 3,678,295 (GRCm39) D520G probably damaging Het
Lrriq3 T A 3: 154,893,934 (GRCm39) M545K probably benign Het
Lsm5 T A 6: 56,680,310 (GRCm39) D44V probably damaging Het
Man1c1 G T 4: 134,296,379 (GRCm39) Y430* probably null Het
Map4 T A 9: 109,866,346 (GRCm39) probably null Het
Megf6 A G 4: 154,343,398 (GRCm39) K561R probably benign Het
Myo1e T C 9: 70,229,680 (GRCm39) Y173H probably damaging Het
Myo6 T A 9: 80,190,823 (GRCm39) S791R possibly damaging Het
Ntng2 C T 2: 29,087,074 (GRCm39) R416Q probably damaging Het
Nxpe3 T A 16: 55,686,880 (GRCm39) I43F possibly damaging Het
Or4g17 T A 2: 111,209,837 (GRCm39) V164E possibly damaging Het
Or5t5 A T 2: 86,616,691 (GRCm39) T206S possibly damaging Het
Pkd1l2 T C 8: 117,808,999 (GRCm39) I64V probably damaging Het
Prf1 G A 10: 61,136,033 (GRCm39) R103H probably benign Het
Rest A G 5: 77,428,874 (GRCm39) D431G probably damaging Het
Serpina10 A T 12: 103,583,127 (GRCm39) L439Q probably damaging Het
Sgk3 T G 1: 9,951,804 (GRCm39) V176G probably damaging Het
Slc19a3 A G 1: 83,000,454 (GRCm39) S188P probably damaging Het
Sorbs1 A G 19: 40,338,392 (GRCm39) I336T probably damaging Het
Strip1 C T 3: 107,527,355 (GRCm39) probably null Het
Syt4 T C 18: 31,576,799 (GRCm39) E185G possibly damaging Het
Tcaf3 T A 6: 42,566,738 (GRCm39) I784F probably damaging Het
Tgfbr3l G T 8: 4,299,439 (GRCm39) R74L possibly damaging Het
Thoc7 A G 14: 13,949,282 (GRCm38) M194T probably benign Het
Thsd7b T C 1: 129,879,129 (GRCm39) Y989H probably damaging Het
Tmem156 C T 5: 65,233,161 (GRCm39) V134I probably benign Het
Tnks A T 8: 35,320,457 (GRCm39) V738E probably benign Het
Trpm6 A T 19: 18,770,240 (GRCm39) I342F probably damaging Het
Vmn2r69 A T 7: 85,060,711 (GRCm39) V291D probably damaging Het
Wdr59 GGGTGGTG GGGTG 8: 112,207,172 (GRCm39) probably benign Het
Wnk1 T C 6: 119,928,953 (GRCm39) T1292A probably damaging Het
Yes1 T A 5: 32,812,584 (GRCm39) C285S probably benign Het
Zbed6 T C 1: 133,586,472 (GRCm39) I288M probably damaging Het
Zbtb49 T C 5: 38,371,263 (GRCm39) N206S probably benign Het
Other mutations in Nol11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00646:Nol11 APN 11 107,064,286 (GRCm39) missense probably benign
IGL01656:Nol11 APN 11 107,079,998 (GRCm39) missense probably benign 0.00
IGL01687:Nol11 APN 11 107,077,695 (GRCm39) missense probably damaging 0.97
IGL02179:Nol11 APN 11 107,080,082 (GRCm39) start codon destroyed probably null 1.00
IGL02538:Nol11 APN 11 107,064,199 (GRCm39) missense probably benign 0.02
IGL03395:Nol11 APN 11 107,066,548 (GRCm39) missense probably benign 0.06
R1734:Nol11 UTSW 11 107,066,449 (GRCm39) missense possibly damaging 0.80
R2143:Nol11 UTSW 11 107,071,881 (GRCm39) missense probably benign 0.03
R2385:Nol11 UTSW 11 107,080,032 (GRCm39) missense probably benign 0.40
R3036:Nol11 UTSW 11 107,064,070 (GRCm39) missense possibly damaging 0.87
R3522:Nol11 UTSW 11 107,064,454 (GRCm39) missense possibly damaging 0.94
R3895:Nol11 UTSW 11 107,059,173 (GRCm39) missense probably damaging 1.00
R4404:Nol11 UTSW 11 107,064,551 (GRCm39) missense probably damaging 1.00
R4664:Nol11 UTSW 11 107,071,826 (GRCm39) missense possibly damaging 0.89
R4705:Nol11 UTSW 11 107,075,544 (GRCm39) intron probably benign
R5704:Nol11 UTSW 11 107,064,195 (GRCm39) missense probably benign 0.43
R5991:Nol11 UTSW 11 107,061,971 (GRCm39) missense probably benign 0.02
R6221:Nol11 UTSW 11 107,062,442 (GRCm39) missense possibly damaging 0.50
R6222:Nol11 UTSW 11 107,062,442 (GRCm39) missense possibly damaging 0.50
R6223:Nol11 UTSW 11 107,062,442 (GRCm39) missense possibly damaging 0.50
R6285:Nol11 UTSW 11 107,071,860 (GRCm39) missense probably benign 0.01
R6467:Nol11 UTSW 11 107,071,912 (GRCm39) missense possibly damaging 0.95
R7080:Nol11 UTSW 11 107,070,878 (GRCm39) missense probably damaging 1.00
R7679:Nol11 UTSW 11 107,064,142 (GRCm39) missense probably benign 0.00
R7767:Nol11 UTSW 11 107,069,908 (GRCm39) missense possibly damaging 0.67
R8831:Nol11 UTSW 11 107,067,662 (GRCm39) missense probably benign
R9063:Nol11 UTSW 11 107,069,857 (GRCm39) missense possibly damaging 0.62
R9063:Nol11 UTSW 11 107,064,240 (GRCm39) missense probably benign 0.04
R9329:Nol11 UTSW 11 107,071,765 (GRCm39) missense probably damaging 1.00
R9378:Nol11 UTSW 11 107,064,505 (GRCm39) missense probably benign 0.29
R9473:Nol11 UTSW 11 107,075,581 (GRCm39) missense probably null 0.81
R9515:Nol11 UTSW 11 107,064,278 (GRCm39) missense possibly damaging 0.76
R9771:Nol11 UTSW 11 107,069,914 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATCCTTCCACAGGCTCACAGGTTC -3'
(R):5'- CAGCCACTTAGGAAGCTAAGGCAC -3'

Sequencing Primer
(F):5'- cagggattaactctaggcttctaac -3'
(R):5'- GGCTAGACAGCTAAGCTAGATACC -3'
Posted On 2013-06-12