Incidental Mutation 'R0526:Cd200r2'
ID48953
Institutional Source Beutler Lab
Gene Symbol Cd200r2
Ensembl Gene ENSMUSG00000090176
Gene NameCd200 receptor 2
SynonymsCD200 cell surface glycoprotein receptor isoform 2
MMRRC Submission 038719-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.085) question?
Stock #R0526 (G1)
Quality Score209
Status Not validated
Chromosome16
Chromosomal Location44867097-44915840 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 44915047 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Serine at position 248 (R248S)
Ref Sequence ENSEMBL: ENSMUSP00000099869 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102805]
Predicted Effect probably damaging
Transcript: ENSMUST00000102805
AA Change: R248S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000099869
Gene: ENSMUSG00000090176
AA Change: R248S

DomainStartEndE-ValueType
IG 23 126 1.06e-2 SMART
IG_like 128 249 1.85e2 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 92.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik A T 4: 137,455,224 N230I possibly damaging Het
4933427D14Rik G T 11: 72,169,783 Q687K probably damaging Het
Actrt2 A G 4: 154,667,412 L89P probably damaging Het
Adamts1 A C 16: 85,802,372 S113R probably benign Het
Agxt2 G T 15: 10,373,862 C118F probably damaging Het
Akap8 G A 17: 32,317,292 T49I probably benign Het
Alk A T 17: 71,869,753 W1519R probably damaging Het
Atf7ip T A 6: 136,559,805 F12Y probably damaging Het
Atp13a5 A G 16: 29,348,740 C131R probably damaging Het
Atp8b4 A G 2: 126,427,363 L168P probably damaging Het
Blm G T 7: 80,505,893 S346* probably null Het
Ccnt2 T G 1: 127,799,445 C199G probably damaging Het
Cd151 A T 7: 141,470,591 H219L probably damaging Het
Cdh3 A G 8: 106,555,446 D822G possibly damaging Het
Clec4b1 T C 6: 123,069,770 probably null Het
Cluh C A 11: 74,665,986 L951I probably benign Het
Cog7 A T 7: 121,963,271 probably null Het
Col25a1 C A 3: 130,476,394 P197Q probably damaging Het
Csde1 T A 3: 103,056,426 S636R possibly damaging Het
Ect2l C A 10: 18,199,940 C66F possibly damaging Het
Elac2 T C 11: 64,999,436 M671T probably benign Het
Evi5 T C 5: 107,821,748 N143S probably benign Het
Ext2 A G 2: 93,806,085 V228A probably damaging Het
Fbxo38 A G 18: 62,505,980 Y1084H probably damaging Het
Fcgr4 T A 1: 171,029,191 L209Q probably damaging Het
Fgd3 C T 13: 49,296,524 S83N probably benign Het
Gigyf2 T A 1: 87,421,493 M664K probably benign Het
Gm38394 T C 1: 133,658,734 I288M probably damaging Het
Il27ra A T 8: 84,039,499 S219T probably benign Het
Kif15 T C 9: 122,997,797 V800A probably damaging Het
Lmo7 T A 14: 101,900,560 D666E probably damaging Het
Lrp5 T C 19: 3,628,295 D520G probably damaging Het
Lrriq3 T A 3: 155,188,297 M545K probably benign Het
Lsm5 T A 6: 56,703,325 D44V probably damaging Het
Man1c1 G T 4: 134,569,068 Y430* probably null Het
Map4 T A 9: 110,037,278 probably null Het
Megf6 A G 4: 154,258,941 K561R probably benign Het
Myo1e T C 9: 70,322,398 Y173H probably damaging Het
Myo6 T A 9: 80,283,541 S791R possibly damaging Het
Nol11 C A 11: 107,184,771 E144* probably null Het
Ntng2 C T 2: 29,197,062 R416Q probably damaging Het
Nxpe3 T A 16: 55,866,517 I43F possibly damaging Het
Olfr1093 A T 2: 86,786,347 T206S possibly damaging Het
Olfr1284 T A 2: 111,379,492 V164E possibly damaging Het
Pkd1l2 T C 8: 117,082,260 I64V probably damaging Het
Prf1 G A 10: 61,300,254 R103H probably benign Het
Rest A G 5: 77,281,027 D431G probably damaging Het
Serpina10 A T 12: 103,616,868 L439Q probably damaging Het
Sgk3 T G 1: 9,881,579 V176G probably damaging Het
Slc19a3 A G 1: 83,022,733 S188P probably damaging Het
Sorbs1 A G 19: 40,349,948 I336T probably damaging Het
Ssfa2 A G 2: 79,657,346 D591G probably benign Het
Strip1 C T 3: 107,620,039 probably null Het
Syt4 T C 18: 31,443,746 E185G possibly damaging Het
Tcaf3 T A 6: 42,589,804 I784F probably damaging Het
Tgfbr3l G T 8: 4,249,439 R74L possibly damaging Het
Thoc7 A G 14: 13,949,282 M194T probably benign Het
Thsd7b T C 1: 129,951,392 Y989H probably damaging Het
Tmem156 C T 5: 65,075,818 V134I probably benign Het
Tnks A T 8: 34,853,303 V738E probably benign Het
Trpm6 A T 19: 18,792,876 I342F probably damaging Het
Vmn2r69 A T 7: 85,411,503 V291D probably damaging Het
Wdr59 GGGTGGTG GGGTG 8: 111,480,540 probably benign Het
Wnk1 T C 6: 119,951,992 T1292A probably damaging Het
Yes1 T A 5: 32,655,240 C285S probably benign Het
Zbtb49 T C 5: 38,213,919 N206S probably benign Het
Other mutations in Cd200r2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Cd200r2 APN 16 44909288 missense probably damaging 1.00
IGL01019:Cd200r2 APN 16 44909469 splice site probably benign
IGL01480:Cd200r2 APN 16 44909266 missense probably null 1.00
IGL01510:Cd200r2 APN 16 44909311 missense probably benign 0.03
IGL02202:Cd200r2 APN 16 44909360 missense probably damaging 1.00
IGL02492:Cd200r2 APN 16 44909540 missense probably damaging 1.00
IGL02499:Cd200r2 APN 16 44914585 missense possibly damaging 0.47
R0066:Cd200r2 UTSW 16 44909674 missense possibly damaging 0.94
R0066:Cd200r2 UTSW 16 44909674 missense possibly damaging 0.94
R0503:Cd200r2 UTSW 16 44877962 start codon destroyed probably null 0.93
R1118:Cd200r2 UTSW 16 44909606 missense probably damaging 1.00
R1119:Cd200r2 UTSW 16 44909606 missense probably damaging 1.00
R2393:Cd200r2 UTSW 16 44909267 missense probably damaging 1.00
R5450:Cd200r2 UTSW 16 44909571 missense probably benign 0.04
R7466:Cd200r2 UTSW 16 44909174 missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- CCTTTGTGAACGACAGAGCCCA -3'
(R):5'- AGACAGGAGCCCTTCTCAGTTAAGAAT -3'

Sequencing Primer
(F):5'- CAGCTCTGTGAGAGATTCTGCC -3'
(R):5'- TTTGGAGGTGAGTGTCTAACAAAC -3'
Posted On2013-06-12