Mutagenetix > Incidental Mutations

Incidental Mutation 'R6156:Olfr936'

489591

Institutional Source

Beutler Lab

Gene Symbol

Olfr936

Ensembl Gene

ENSMUSG00000095194

Gene Name

olfactory receptor 936

Synonyms

EG628171, GA_x6K02T2PVTD-32743332-32742397, MOR171-37

MMRRC Submission

044303-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

R6156 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

39046614-39047549 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 39047375 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 15 (M15L)

Ref Sequence

ENSEMBL: ENSMUSP00000137209 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000178303] [ENSMUST00000216912]

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000104850

Predicted Effect

possibly damaging
Transcript: ENSMUST00000178303
AA Change: M15L

PolyPhen 2 Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000137209
Gene: ENSMUSG00000095194
AA Change: M15L

Domain	Start	End	E-Value	Type
Pfam:7tm_1	1	246	6e-21	PFAM
Pfam:7tm_4	1	264	6.9e-49	PFAM

Predicted Effect

unknown
Transcript: ENSMUST00000216912
AA Change: H59L

Meta Mutation Damage Score

0.0895

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.9%
20x: 93.9%

Validation Efficiency

97% (68/70)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Feb 2010]

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy8	T	G	15: 64,817,639		probably null	Het
Ank2	T	C	3: 126,944,237	D2579G	probably damaging	Het
Atp6v1b1	G	C	6: 83,758,133	G423R	probably damaging	Het
B4galnt3	T	C	6: 120,214,840	N644S	probably benign	Het
Capsl	T	G	15: 9,465,834	M132R	probably damaging	Het
Cep120	A	G	18: 53,703,223	Y797H	probably benign	Het
Clec2e	T	A	6: 129,095,098	D106V	possibly damaging	Het
Col6a2	C	T	10: 76,604,170	V634I	possibly damaging	Het
Dis3	T	C	14: 99,098,779	E97G	probably benign	Het
Dlec1	T	C	9: 119,110,213		probably null	Het
Dock2	C	A	11: 34,247,789	V1484F	possibly damaging	Het
Ephb2	T	A	4: 136,661,505	M593L	probably benign	Het
Fcgrt	T	C	7: 45,102,060	T125A	probably benign	Het
Gabbr1	T	C	17: 37,048,427	I98T	probably benign	Het
Gbp10	G	A	5: 105,236,149		probably benign	Het
Gfod1	T	C	13: 43,201,038	S154G	possibly damaging	Het
Ggt5	C	T	10: 75,609,326	T389I	probably damaging	Het
Gm5096	C	A	18: 87,757,107	Y251*	probably null	Het
Got2	A	G	8: 95,872,268	F169L	probably benign	Het
Gse1	A	G	8: 120,489,127	K5E	possibly damaging	Het
Hyal5	T	C	6: 24,891,438	I417T	possibly damaging	Het
Igkv4-91	G	T	6: 68,768,623	T97K	probably damaging	Het
Il4i1	T	C	7: 44,840,184	Y458H	possibly damaging	Het
Impg1	A	T	9: 80,322,824	C740S	probably damaging	Het
Itgb1	C	G	8: 128,732,054	T788R	possibly damaging	Het
Lman2l	A	G	1: 36,438,826	V143A	probably damaging	Het
Ltbp4	G	T	7: 27,330,162	T136K	unknown	Het
Macf1	A	G	4: 123,472,280	I1331T	probably benign	Het
Mmp11	G	A	10: 75,926,491	A336V	probably damaging	Het
Myh2	A	T	11: 67,181,053	I536F	probably damaging	Het
Myh4	A	G	11: 67,250,792	M826V	probably benign	Het
Naca	T	C	10: 128,039,291		probably benign	Het
Nr4a2	A	G	2: 57,112,352	Y30H	probably damaging	Het
Olfr1200	T	A	2: 88,767,590	I242L	probably benign	Het
Olfr1290	A	T	2: 111,489,750	M136K	probably damaging	Het
Olfr1316	A	T	2: 112,130,100	L237Q	probably damaging	Het
Olfr136	T	A	17: 38,335,173	N5K	probably damaging	Het
Olfr1427	A	G	19: 12,099,120	V173A	possibly damaging	Het
Olfr395	A	T	11: 73,906,621	Y290*	probably null	Het
Olfr533	A	G	7: 140,466,845	T215A	probably benign	Het
Paqr3	A	C	5: 97,108,269	L82R	probably damaging	Het
Pex6	C	T	17: 46,720,641	P456S	probably benign	Het
Pih1d2	A	T	9: 50,621,152	K186I	possibly damaging	Het
Plekhh3	A	G	11: 101,170,187		probably benign	Het
Ptpn23	C	A	9: 110,387,781		probably benign	Het
Rcor3	T	A	1: 192,127,842		probably benign	Het
Rgs11	T	A	17: 26,210,465	Y403*	probably null	Het
Scn10a	T	C	9: 119,635,583	N984D	probably benign	Het
Snx14	C	T	9: 88,407,339	A287T	possibly damaging	Het
Stx3	T	C	19: 11,803,510	D33G	probably damaging	Het
Tacc2	A	G	7: 130,625,764	K1393R	probably damaging	Het
Tas2r129	T	C	6: 132,951,492	S131P	probably benign	Het
Tbx15	G	T	3: 99,313,115		probably null	Het
Tex33	T	C	15: 78,378,813	T214A	probably damaging	Het
Thada	A	G	17: 84,393,367	V1237A	probably damaging	Het
Tnc	A	G	4: 63,970,352	Y1735H	probably damaging	Het
Ttc22	A	G	4: 106,638,583	K378R	probably benign	Het
Tubg2	A	G	11: 101,160,809	K287E	possibly damaging	Het
Ugt3a1	T	C	15: 9,310,676	I348T	possibly damaging	Het
Unc79	A	G	12: 103,061,458	N436S	probably damaging	Het
Unc80	A	T	1: 66,612,250	I1585F	probably benign	Het
Vmn2r104	T	C	17: 20,041,647	Y407C	probably damaging	Het
Vmn2r108	T	A	17: 20,472,185	L136F	probably benign	Het
Vmn2r38	A	G	7: 9,094,612	S161P	probably damaging	Het
Vmn2r90	T	C	17: 17,733,344	I590T	probably benign	Het
Washc5	T	C	15: 59,345,399	E323G	probably damaging	Het
Wdhd1	C	T	14: 47,268,196	G273D	probably damaging	Het
Xpo6	G	T	7: 126,108,844	Q851K	probably damaging	Het
Zfp386	T	C	12: 116,059,906	S380P	probably damaging	Het
Zfp536	A	G	7: 37,473,856	C274R	unknown	Het
Zfp64	A	G	2: 168,926,168	I508T	probably benign	Het

Other mutations in Olfr936

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01928:Olfr936	APN	9	39047413	missense	unknown
R0086:Olfr936	UTSW	9	39046895	missense	probably benign	0.00
R0561:Olfr936	UTSW	9	39047373	missense	probably damaging	0.99
R0650:Olfr936	UTSW	9	39046700	missense	probably benign	0.01
R1221:Olfr936	UTSW	9	39047187	missense	probably damaging	1.00
R1384:Olfr936	UTSW	9	39046904	missense	possibly damaging	0.70
R1680:Olfr936	UTSW	9	39047000	missense	probably benign	0.43
R1733:Olfr936	UTSW	9	39047382	missense	unknown
R3767:Olfr936	UTSW	9	39047411	missense	unknown
R4786:Olfr936	UTSW	9	39047487	nonsense	probably null
R4944:Olfr936	UTSW	9	39046862	missense	probably damaging	1.00
R5186:Olfr936	UTSW	9	39046969	nonsense	probably null
R5403:Olfr936	UTSW	9	39046703	missense	probably damaging	1.00
R6037:Olfr936	UTSW	9	39047107	missense	probably damaging	1.00
R6037:Olfr936	UTSW	9	39047107	missense	probably damaging	1.00
R6217:Olfr936	UTSW	9	39046743	makesense	probably null
R6711:Olfr936	UTSW	9	39046866	makesense	probably null
R6919:Olfr936	UTSW	9	39047531	utr 5 prime	probably benign
R7022:Olfr936	UTSW	9	39047083	nonsense	probably null
R7275:Olfr936	UTSW	9	39047519	utr 5 prime	probably benign
R7290:Olfr936	UTSW	9	39047398	missense	unknown
R7644:Olfr936	UTSW	9	39047342	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CAGCCAGCATGAAACATTCTG -3'
(R):5'- AGCAACTGTGTCCCTCTAAATC -3'

Sequencing Primer
(F):5'- GCCAGCATGAAACATTCTGAAACAAC -3'
(R):5'- CCTTTCAGAATCTGACTGAGAACATG -3'

Posted On

2017-10-10