Incidental Mutation 'R6157:Plaat1'
ID 489664
Institutional Source Beutler Lab
Gene Symbol Plaat1
Ensembl Gene ENSMUSG00000022525
Gene Name phospholipase A and acyltransferase 1
Synonyms 2810012B06Rik, A-C1, Hrasls
MMRRC Submission 044304-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R6157 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 29028447-29049283 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 29036501 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 46 (I46M)
Ref Sequence ENSEMBL: ENSMUSP00000123809 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089824] [ENSMUST00000161294] [ENSMUST00000162747]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000089824
AA Change: I46M

PolyPhen 2 Score 0.697 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000087257
Gene: ENSMUSG00000022525
AA Change: I46M

DomainStartEndE-ValueType
Pfam:LRAT 8 132 6.1e-44 PFAM
transmembrane domain 140 159 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160794
Predicted Effect unknown
Transcript: ENSMUST00000161294
AA Change: I46M
SMART Domains Protein: ENSMUSP00000124252
Gene: ENSMUSG00000022525
AA Change: I46M

DomainStartEndE-ValueType
Pfam:LRAT 8 50 8.5e-15 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000162747
AA Change: I46M

PolyPhen 2 Score 0.697 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000123809
Gene: ENSMUSG00000022525
AA Change: I46M

DomainStartEndE-ValueType
Pfam:LRAT 13 132 7.5e-41 PFAM
transmembrane domain 140 159 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 93.1%
Validation Efficiency 93% (40/43)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik A G 15: 81,947,617 (GRCm39) K505E possibly damaging Het
Abcb1b A T 5: 8,874,245 (GRCm39) N390I possibly damaging Het
Apob A T 12: 8,056,077 (GRCm39) M1520L probably benign Het
Atg4c C T 4: 99,123,400 (GRCm39) R396* probably null Het
Atp2a3 G A 11: 72,871,442 (GRCm39) V648M probably damaging Het
Blm T C 7: 80,162,733 (GRCm39) D203G probably benign Het
Csrnp3 A T 2: 65,779,363 (GRCm39) D13V probably damaging Het
Dnajc10 A T 2: 80,147,735 (GRCm39) probably benign Het
Dst A G 1: 34,250,253 (GRCm39) Y1729C probably damaging Het
Dynlt2b G A 16: 32,238,660 (GRCm39) A12T possibly damaging Het
Ecsit T C 9: 21,985,987 (GRCm39) Y213C probably damaging Het
Fer A G 17: 64,385,880 (GRCm39) K654R probably damaging Het
Hdac9 G T 12: 34,439,428 (GRCm39) A383E probably damaging Het
Hltf T A 3: 20,130,660 (GRCm39) S293T probably benign Het
Hydin T A 8: 111,254,648 (GRCm39) D2359E probably benign Het
Inf2 A G 12: 112,571,222 (GRCm39) probably benign Het
Kcns2 A G 15: 34,839,504 (GRCm39) N289S possibly damaging Het
Meioc T C 11: 102,559,227 (GRCm39) S50P probably damaging Het
Mocs1 G T 17: 49,761,764 (GRCm39) E619D probably benign Het
Nfatc2 A G 2: 168,361,371 (GRCm39) probably benign Het
Or51i1 T A 7: 103,671,105 (GRCm39) N140I possibly damaging Het
Pag1 A T 3: 9,758,896 (GRCm39) H407Q probably benign Het
Plcb3 G A 19: 6,943,533 (GRCm39) A122V probably damaging Het
Pld4 C T 12: 112,734,535 (GRCm39) T432I probably damaging Het
Psd3 T G 8: 68,574,179 (GRCm39) M1L probably benign Het
Rasgrp2 C A 19: 6,452,531 (GRCm39) L35I probably damaging Het
Ripor2 T C 13: 24,885,052 (GRCm39) L390P probably damaging Het
Rpgrip1 A T 14: 52,349,631 (GRCm39) E6D probably benign Het
Ryr3 A T 2: 112,672,244 (GRCm39) L1409Q probably damaging Het
Slc6a5 A G 7: 49,601,250 (GRCm39) T684A probably benign Het
Smpd4 G T 16: 17,458,930 (GRCm39) probably null Het
Snx18 T C 13: 113,753,725 (GRCm39) S403G probably damaging Het
Spsb4 G T 9: 96,878,160 (GRCm39) H54Q probably damaging Het
Ssrp1 A G 2: 84,871,072 (GRCm39) Y236C probably damaging Het
Tenm3 C T 8: 48,751,843 (GRCm39) S982N probably damaging Het
Tet1 A G 10: 62,675,749 (GRCm39) S776P probably damaging Het
Tln1 G A 4: 43,534,744 (GRCm39) P2166S probably benign Het
Ufl1 T A 4: 25,279,350 (GRCm39) Q83L possibly damaging Het
Unc80 A T 1: 66,693,188 (GRCm39) K2458* probably null Het
Ush2a A T 1: 188,460,467 (GRCm39) Y2576F probably benign Het
Xrcc6 C A 15: 81,913,305 (GRCm39) probably null Het
Zbtb48 A G 4: 152,106,064 (GRCm39) F380L probably damaging Het
Zfp534 C T 4: 147,758,947 (GRCm39) R574K probably benign Het
Other mutations in Plaat1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0487:Plaat1 UTSW 16 29,039,331 (GRCm39) splice site probably null
R1437:Plaat1 UTSW 16 29,046,922 (GRCm39) missense possibly damaging 0.78
R1707:Plaat1 UTSW 16 29,046,978 (GRCm39) missense probably damaging 0.96
R1858:Plaat1 UTSW 16 29,036,470 (GRCm39) missense probably damaging 1.00
R4450:Plaat1 UTSW 16 29,046,976 (GRCm39) missense possibly damaging 0.79
R4996:Plaat1 UTSW 16 29,036,456 (GRCm39) nonsense probably null
R5617:Plaat1 UTSW 16 29,039,162 (GRCm39) nonsense probably null
R5872:Plaat1 UTSW 16 29,039,189 (GRCm39) missense probably benign 0.27
R7502:Plaat1 UTSW 16 29,046,919 (GRCm39) missense probably benign 0.00
R8237:Plaat1 UTSW 16 29,039,106 (GRCm39) missense probably benign
R8804:Plaat1 UTSW 16 29,039,205 (GRCm39) missense probably benign 0.40
R8916:Plaat1 UTSW 16 29,039,259 (GRCm39) missense possibly damaging 0.56
Predicted Primers PCR Primer
(F):5'- CAGCAAGCTCATCTTTATGCCTG -3'
(R):5'- GTCATGTTTGGGGCCAATGC -3'

Sequencing Primer
(F):5'- GTCCTTACAGATGGCGGTAAATG -3'
(R):5'- AATGCCTCCCTCAAGTCATCATTAGG -3'
Posted On 2017-10-10