Incidental Mutation 'R6158:Aurka'
ID 489685
Institutional Source Beutler Lab
Gene Symbol Aurka
Ensembl Gene ENSMUSG00000027496
Gene Name aurora kinase A
Synonyms Stk6, IAK1, IAK, AIRK1, Aurora-A, Ark1, Ayk1, aurora A
MMRRC Submission 044305-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6158 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 172198110-172212455 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to C at 172205516 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000104768 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028997] [ENSMUST00000109139] [ENSMUST00000109140]
AlphaFold P97477
Predicted Effect probably null
Transcript: ENSMUST00000028997
SMART Domains Protein: ENSMUSP00000028997
Gene: ENSMUSG00000027496

DomainStartEndE-ValueType
S_TKc 146 396 2.25e-99 SMART
Predicted Effect probably null
Transcript: ENSMUST00000109139
SMART Domains Protein: ENSMUSP00000104767
Gene: ENSMUSG00000027496

DomainStartEndE-ValueType
S_TKc 124 374 2.25e-99 SMART
Predicted Effect probably null
Transcript: ENSMUST00000109140
SMART Domains Protein: ENSMUSP00000104768
Gene: ENSMUSG00000027496

DomainStartEndE-ValueType
S_TKc 124 374 2.25e-99 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126107
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128004
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 97.5%
  • 20x: 92.6%
Validation Efficiency 98% (65/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele display embryonic lethality before implantation, early embryonic growth arrest, and impaired mitosis. Heterozygous null mice display increased incidence of tumors primarily lymphomas and chromosomal instability. [provided by MGI curators]
Allele List at MGI

All alleles(25) : Targeted(4) Gene trapped(21)

Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T C 12: 71,217,410 (GRCm39) V793A possibly damaging Het
2900092C05Rik A G 7: 12,246,599 (GRCm39) T32A probably benign Het
Adprhl1 C T 8: 13,274,977 (GRCm39) V594M possibly damaging Het
Ano3 A T 2: 110,496,220 (GRCm39) Y845N probably damaging Het
Arhgap24 A T 5: 103,040,778 (GRCm39) I575L probably benign Het
C1qtnf5 A T 9: 44,020,267 (GRCm39) probably benign Het
Cacnb2 A G 2: 14,990,412 (GRCm39) D454G possibly damaging Het
Chchd5 T C 2: 128,972,437 (GRCm39) L87P probably damaging Het
Col7a1 G T 9: 108,793,671 (GRCm39) R1377L unknown Het
Cpne8 A C 15: 90,456,191 (GRCm39) S191A probably damaging Het
Dhx30 A T 9: 109,916,098 (GRCm39) I671N probably damaging Het
Dnah12 A T 14: 26,495,642 (GRCm39) K1423N possibly damaging Het
Dnm3 T C 1: 162,148,556 (GRCm39) M272V probably damaging Het
Fat4 A T 3: 39,037,411 (GRCm39) S3688C possibly damaging Het
Frmpd1 A T 4: 45,285,401 (GRCm39) L1407F probably damaging Het
Fry T C 5: 150,378,037 (GRCm39) S410P probably damaging Het
Gm11565 T A 11: 99,805,744 (GRCm39) C45* probably null Het
Gngt1 A T 6: 3,994,311 (GRCm39) R30* probably null Het
Htt T C 5: 35,064,430 (GRCm39) I2943T possibly damaging Het
Kl T A 5: 150,912,318 (GRCm39) M689K possibly damaging Het
Lmo7 T A 14: 102,137,573 (GRCm39) D247E probably benign Het
Mastl G T 2: 23,022,784 (GRCm39) N646K possibly damaging Het
Mei4 G T 9: 81,809,629 (GRCm39) L237F probably damaging Het
Mettl27 C T 5: 134,969,430 (GRCm39) P170S possibly damaging Het
Mgam T A 6: 40,734,648 (GRCm39) I896K probably damaging Het
Mix23 T A 16: 35,910,299 (GRCm39) V118D probably damaging Het
Moxd1 T A 10: 24,160,675 (GRCm39) C443S probably damaging Het
Myo18b A T 5: 113,022,038 (GRCm39) N451K probably benign Het
Myo7b T C 18: 32,121,602 (GRCm39) I768V probably benign Het
Nos1 A C 5: 118,005,639 (GRCm39) I120L probably benign Het
Nsd1 T C 13: 55,393,434 (GRCm39) V345A probably benign Het
Or1j15 A T 2: 36,459,128 (GRCm39) T173S probably benign Het
Or2aj5 C A 16: 19,424,675 (GRCm39) V248F probably damaging Het
Or4c11c T C 2: 88,661,490 (GRCm39) F10L probably damaging Het
Or5t15 A G 2: 86,681,859 (GRCm39) L61P possibly damaging Het
Or8g50 C T 9: 39,648,372 (GRCm39) T87I probably benign Het
Pdzph1 T G 17: 59,280,622 (GRCm39) Q553H probably damaging Het
Piwil1 T A 5: 128,824,940 (GRCm39) L546* probably null Het
Pla2g4f T C 2: 120,131,552 (GRCm39) T724A probably benign Het
Ralgapa2 A T 2: 146,266,596 (GRCm39) M660K possibly damaging Het
Rgsl1 T C 1: 153,679,767 (GRCm39) D103G possibly damaging Het
Rnf186 A G 4: 138,694,565 (GRCm39) D35G probably damaging Het
Rock2 A G 12: 17,004,919 (GRCm39) D424G probably benign Het
Scg2 A T 1: 79,413,117 (GRCm39) D495E probably damaging Het
Slc39a2 G A 14: 52,131,681 (GRCm39) probably null Het
Snrnp48 T A 13: 38,394,212 (GRCm39) Y100* probably null Het
Spaca1 A G 4: 34,029,176 (GRCm39) M99T probably damaging Het
Specc1 T G 11: 62,008,950 (GRCm39) F235L probably damaging Het
St13 A T 15: 81,283,802 (GRCm39) probably null Het
Swap70 T A 7: 109,869,230 (GRCm39) M341K probably damaging Het
Synj2 A G 17: 6,036,487 (GRCm39) D67G probably benign Het
Tmem135 T A 7: 88,805,652 (GRCm39) I251F probably benign Het
Tmem87a A T 2: 120,190,584 (GRCm39) probably null Het
Tom1l2 C T 11: 60,123,753 (GRCm39) D128N probably damaging Het
Tpx2 C A 2: 152,715,024 (GRCm39) H82N probably benign Het
Trip12 A T 1: 84,738,733 (GRCm39) C738S possibly damaging Het
Ttyh1 A G 7: 4,128,561 (GRCm39) T153A probably benign Het
Utrn C T 10: 12,566,566 (GRCm39) G1199S probably benign Het
Vmn1r8 T A 6: 57,013,274 (GRCm39) N108K probably benign Het
Vmn2r63 T A 7: 42,583,104 (GRCm39) D37V probably damaging Het
Vwce C T 19: 10,621,585 (GRCm39) R206C possibly damaging Het
Wrn G T 8: 33,809,200 (GRCm39) F265L probably damaging Het
Zfp472 T A 17: 33,197,363 (GRCm39) C479* probably null Het
Zfp831 A T 2: 174,485,651 (GRCm39) T109S possibly damaging Het
Znfx1 G T 2: 166,898,646 (GRCm39) Q93K probably benign Het
Other mutations in Aurka
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01458:Aurka APN 2 172,210,899 (GRCm39) unclassified probably benign
IGL02338:Aurka APN 2 172,201,778 (GRCm39) missense probably benign 0.00
IGL02894:Aurka APN 2 172,208,868 (GRCm39) splice site probably null
IGL03188:Aurka APN 2 172,205,688 (GRCm39) missense possibly damaging 0.60
G1Funyon:Aurka UTSW 2 172,198,850 (GRCm39) missense probably damaging 0.99
PIT4585001:Aurka UTSW 2 172,199,117 (GRCm39) missense probably benign 0.01
R0006:Aurka UTSW 2 172,201,673 (GRCm39) critical splice donor site probably null
R0006:Aurka UTSW 2 172,201,673 (GRCm39) critical splice donor site probably null
R0458:Aurka UTSW 2 172,212,366 (GRCm39) nonsense probably null
R0555:Aurka UTSW 2 172,209,067 (GRCm39) missense probably benign 0.07
R1130:Aurka UTSW 2 172,199,178 (GRCm39) splice site probably null
R1140:Aurka UTSW 2 172,199,149 (GRCm39) missense probably damaging 1.00
R2507:Aurka UTSW 2 172,212,365 (GRCm39) missense probably benign 0.00
R2887:Aurka UTSW 2 172,209,040 (GRCm39) missense probably benign 0.01
R2889:Aurka UTSW 2 172,209,040 (GRCm39) missense probably benign 0.01
R3772:Aurka UTSW 2 172,208,880 (GRCm39) missense probably benign
R4929:Aurka UTSW 2 172,212,326 (GRCm39) missense probably benign 0.05
R5409:Aurka UTSW 2 172,209,036 (GRCm39) missense possibly damaging 0.78
R6689:Aurka UTSW 2 172,212,313 (GRCm39) critical splice donor site probably null
R6828:Aurka UTSW 2 172,199,172 (GRCm39) missense probably damaging 1.00
R7912:Aurka UTSW 2 172,210,949 (GRCm39) missense probably benign 0.00
R8066:Aurka UTSW 2 172,212,338 (GRCm39) missense probably benign 0.00
R8301:Aurka UTSW 2 172,198,850 (GRCm39) missense probably damaging 0.99
R9764:Aurka UTSW 2 172,201,760 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTGTCAAACTCAGAAACACTG -3'
(R):5'- GATTTTGACATTGGCCGCCC -3'

Sequencing Primer
(F):5'- TACCAACTCACCCAGTGTCTC -3'
(R):5'- TTGGCCGCCCACTAGGAAAAG -3'
Posted On 2017-10-10