Incidental Mutation 'R6159:Trbc1'
ID 489751
Institutional Source Beutler Lab
Gene Symbol Trbc1
Ensembl Gene ENSMUSG00000076490
Gene Name T cell receptor beta, constant region 1
Synonyms Gm16802, Tcrb-C1
MMRRC Submission 044306-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.176) question?
Stock # R6159 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 41515153-41516599 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 41515385 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103296] [ENSMUST00000193061] [ENSMUST00000178862] [ENSMUST00000103295]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000103284
Predicted Effect probably benign
Transcript: ENSMUST00000103285
Predicted Effect noncoding transcript
Transcript: ENSMUST00000103286
Predicted Effect probably benign
Transcript: ENSMUST00000103287
Predicted Effect probably benign
Transcript: ENSMUST00000103288
Predicted Effect probably benign
Transcript: ENSMUST00000103289
Predicted Effect unknown
Transcript: ENSMUST00000103291
AA Change: S78P
SMART Domains Protein: ENSMUSP00000100099
Gene: ENSMUSG00000076490
AA Change: S78P

DomainStartEndE-ValueType
IGc1 26 102 9.51e-28 SMART
transmembrane domain 142 164 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000192856
AA Change: S78P
Predicted Effect noncoding transcript
Transcript: ENSMUST00000103290
Predicted Effect probably benign
Transcript: ENSMUST00000103293
Predicted Effect probably benign
Transcript: ENSMUST00000103296
Predicted Effect probably benign
Transcript: ENSMUST00000192366
Predicted Effect probably benign
Transcript: ENSMUST00000193061
Predicted Effect probably benign
Transcript: ENSMUST00000178862
Predicted Effect probably benign
Transcript: ENSMUST00000103295
Predicted Effect probably benign
Transcript: ENSMUST00000103294
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 98.0%
  • 20x: 94.2%
Validation Efficiency 96% (54/56)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahcyl2 A C 6: 29,908,457 (GRCm39) N609T possibly damaging Het
Ankzf1 G A 1: 75,170,888 (GRCm39) C98Y probably damaging Het
Atg101 T A 15: 101,188,519 (GRCm39) M208K possibly damaging Het
Baiap2l2 A G 15: 79,143,930 (GRCm39) I388T probably benign Het
Cabs1 C T 5: 88,127,613 (GRCm39) T88I possibly damaging Het
Chrnd T A 1: 87,118,812 (GRCm39) D56E probably benign Het
Col28a1 A T 6: 8,162,247 (GRCm39) probably null Het
Col4a1 G T 8: 11,270,007 (GRCm39) P899Q probably damaging Het
Cts3 C A 13: 61,714,655 (GRCm39) A217S probably damaging Het
Dab2 A G 15: 6,465,941 (GRCm39) N495S possibly damaging Het
Dnah2 T A 11: 69,349,368 (GRCm39) I2423F probably damaging Het
Dnah2 C T 11: 69,349,746 (GRCm39) R2399Q probably benign Het
Dock6 T C 9: 21,733,041 (GRCm39) H1053R probably benign Het
Eif1ad14 G A 12: 87,886,521 (GRCm39) A36V probably damaging Het
Fam184a G A 10: 53,574,869 (GRCm39) L191F probably damaging Het
Fbxl9 T C 8: 106,049,925 (GRCm39) Y33C probably damaging Het
Fip1l1 C T 5: 74,752,608 (GRCm39) R472W probably damaging Het
Gbp2 T C 3: 142,338,018 (GRCm39) F378S probably damaging Het
Ggt1 A T 10: 75,420,799 (GRCm39) E388V probably damaging Het
Gm14496 A G 2: 181,638,050 (GRCm39) T375A probably benign Het
Gm43302 A G 5: 105,436,894 (GRCm39) S71P probably benign Het
Gnrhr G T 5: 86,330,216 (GRCm39) T268K probably damaging Het
Htt T C 5: 34,962,020 (GRCm39) V335A probably benign Het
Klhl20 A T 1: 160,933,037 (GRCm39) L257H probably damaging Het
Med27 C A 2: 29,414,376 (GRCm39) probably null Het
Muc5ac T A 7: 141,369,323 (GRCm39) C2433S possibly damaging Het
Nasp A G 4: 116,461,086 (GRCm39) probably null Het
Nipal2 A C 15: 34,600,172 (GRCm39) V215G probably damaging Het
Or10al5 A T 17: 38,063,038 (GRCm39) I98F probably damaging Het
Or9i1b C T 19: 13,897,104 (GRCm39) T240I probably damaging Het
Oxct2b G A 4: 123,011,244 (GRCm39) R388H probably damaging Het
Pbrm1 A G 14: 30,774,240 (GRCm39) I469V possibly damaging Het
Phyhip A G 14: 70,704,294 (GRCm39) H171R possibly damaging Het
Pigs C T 11: 78,219,326 (GRCm39) T9M probably benign Het
Plek T C 11: 16,935,539 (GRCm39) D256G probably damaging Het
Prss50 T C 9: 110,693,371 (GRCm39) V369A probably benign Het
Psmc5 A G 11: 106,152,088 (GRCm39) K82E possibly damaging Het
Qrsl1 A T 10: 43,758,189 (GRCm39) F301L probably benign Het
Rasal1 T C 5: 120,797,673 (GRCm39) L135P probably damaging Het
Rbm47 A G 5: 66,184,159 (GRCm39) V148A probably damaging Het
Scyl1 T A 19: 5,814,785 (GRCm39) D381V probably benign Het
Selplg G T 5: 113,957,162 (GRCm39) D381E probably benign Het
Sh3rf2 C A 18: 42,289,200 (GRCm39) Q674K probably damaging Het
Sned1 A G 1: 93,210,659 (GRCm39) T987A probably benign Het
Sntb1 A G 15: 55,539,698 (GRCm39) probably null Het
Synj2 A T 17: 6,036,327 (GRCm39) I14F probably damaging Het
Taf2 A T 15: 54,926,440 (GRCm39) M170K possibly damaging Het
Tg A G 15: 66,607,096 (GRCm39) E211G possibly damaging Het
Thnsl1 G T 2: 21,217,016 (GRCm39) E257* probably null Het
Tlr4 A G 4: 66,758,070 (GRCm39) R288G possibly damaging Het
Trim37 G A 11: 87,107,374 (GRCm39) probably null Het
Txnrd3 T C 6: 89,640,176 (GRCm39) probably null Het
Tyk2 C A 9: 21,021,800 (GRCm39) Q875H probably damaging Het
Vmn2r55 A G 7: 12,385,698 (GRCm39) Y761H probably damaging Het
Zswim5 T C 4: 116,836,876 (GRCm39) L720P probably damaging Het
Other mutations in Trbc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03077:Trbc1 APN 6 41,515,383 (GRCm39) unclassified probably benign
R1888:Trbc1 UTSW 6 41,512,570 (GRCm39) unclassified probably benign
R3552:Trbc1 UTSW 6 41,516,579 (GRCm39) unclassified probably benign
R4845:Trbc1 UTSW 6 41,516,169 (GRCm39) unclassified probably benign
R4998:Trbc1 UTSW 6 41,516,270 (GRCm39) unclassified probably benign
R5233:Trbc1 UTSW 6 41,515,383 (GRCm39) unclassified probably benign
R7800:Trbc1 UTSW 6 41,516,195 (GRCm39) missense
R7978:Trbc1 UTSW 6 41,515,236 (GRCm39) missense
R8334:Trbc1 UTSW 6 41,516,046 (GRCm39) critical splice acceptor site probably benign
Predicted Primers PCR Primer
(F):5'- AAGGTCTCCTTGTTTGAGCC -3'
(R):5'- TTGGCACGACTGATGCTTATTC -3'

Sequencing Primer
(F):5'- TTGAGCCATCAAAAGCAGAGATTGC -3'
(R):5'- GGCACGACTGATGCTTATTCTTCTTG -3'
Posted On 2017-10-10