Mutagenetix > Incidental Mutation

Incidental Mutation 'R6159:Dnah2'

489764

Institutional Source

Beutler Lab

Gene Symbol

Dnah2

Ensembl Gene

ENSMUSG00000005237

Gene Name

dynein, axonemal, heavy chain 2

Synonyms

Dnahc2, Dnhd3, D330014H01Rik, 2900022L05Rik

MMRRC Submission

044306-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6159 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

69420809-69549110 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 69458542 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 2423 (I2423F)

Ref Sequence

ENSEMBL: ENSMUSP00000104299 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035539] [ENSMUST00000108659]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000035539
AA Change: I2417F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000047329
Gene: ENSMUSG00000005237
AA Change: I2417F

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	273	429	6.6e-37	PFAM
Pfam:DHC_N1	432	761	1.3e-54	PFAM
Pfam:DHC_N2	1253	1668	3.4e-144	PFAM
AAA	1826	1962	2.95e-1	SMART
Pfam:AAA_5	2108	2251	1.3e-5	PFAM
AAA	2437	2584	3.63e-5	SMART
Pfam:AAA_8	2752	3022	1.1e-75	PFAM
Pfam:MT	3034	3370	8.7e-55	PFAM
Pfam:AAA_9	3386	3616	7.4e-68	PFAM
Pfam:Dynein_heavy	3748	4453	1.2e-220	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000108659
AA Change: I2423F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000104299
Gene: ENSMUSG00000005237
AA Change: I2423F

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	274	429	1.1e-47	PFAM
Pfam:DHC_N1	438	760	1.5e-75	PFAM
Pfam:DHC_N2	1255	1666	4.4e-144	PFAM
low complexity region	1711	1720	N/A	INTRINSIC
AAA	1832	1968	2.95e-1	SMART
Blast:AAA	2111	2251	2e-86	BLAST
AAA	2443	2590	3.63e-5	SMART
Pfam:AAA_8	2758	3028	5.5e-77	PFAM
Pfam:MT	3040	3376	7.6e-55	PFAM
Pfam:AAA_9	3396	3621	7.5e-94	PFAM
Pfam:Dynein_heavy	3759	4458	4.9e-264	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124108

Meta Mutation Damage Score

0.1680

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 98.0%
20x: 94.2%

Validation Efficiency

96% (54/56)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahcyl2	A	C	6: 29,908,458 (GRCm38)	N609T	possibly damaging	Het
Ankzf1	G	A	1: 75,194,244 (GRCm38)	C98Y	probably damaging	Het
Atg101	T	A	15: 101,290,638 (GRCm38)	M208K	possibly damaging	Het
Baiap2l2	A	G	15: 79,259,730 (GRCm38)	I388T	probably benign	Het
Cabs1	C	T	5: 87,979,754 (GRCm38)	T88I	possibly damaging	Het
Chrnd	T	A	1: 87,191,090 (GRCm38)	D56E	probably benign	Het
Col28a1	A	T	6: 8,162,247 (GRCm38)		probably null	Het
Col4a1	G	T	8: 11,220,007 (GRCm38)	P899Q	probably damaging	Het
Cts3	C	A	13: 61,566,841 (GRCm38)	A217S	probably damaging	Het
Dab2	A	G	15: 6,436,460 (GRCm38)	N495S	possibly damaging	Het
Dock6	T	C	9: 21,821,745 (GRCm38)	H1053R	probably benign	Het
Fam184a	G	A	10: 53,698,773 (GRCm38)	L191F	probably damaging	Het
Fip1l1	C	T	5: 74,591,947 (GRCm38)	R472W	probably damaging	Het
Gbp2	T	C	3: 142,632,257 (GRCm38)	F378S	probably damaging	Het
Ggt1	A	T	10: 75,584,965 (GRCm38)	E388V	probably damaging	Het
Gm14496	A	G	2: 181,996,257 (GRCm38)	T375A	probably benign	Het
Gm2035	G	A	12: 87,919,751 (GRCm38)	A36V	probably damaging	Het
Gm43302	A	G	5: 105,289,028 (GRCm38)	S71P	probably benign	Het
Gnrhr	G	T	5: 86,182,357 (GRCm38)	T268K	probably damaging	Het
Htt	T	C	5: 34,804,676 (GRCm38)	V335A	probably benign	Het
Klhl20	A	T	1: 161,105,467 (GRCm38)	L257H	probably damaging	Het
Lrrc29	T	C	8: 105,323,293 (GRCm38)	Y33C	probably damaging	Het
Med27	C	A	2: 29,524,364 (GRCm38)		probably null	Het
Muc5ac	T	A	7: 141,815,586 (GRCm38)	C2433S	possibly damaging	Het
Nasp	A	G	4: 116,603,889 (GRCm38)		probably null	Het
Nipal2	A	C	15: 34,600,026 (GRCm38)	V215G	probably damaging	Het
Olfr121	A	T	17: 37,752,147 (GRCm38)	I98F	probably damaging	Het
Olfr1505	C	T	19: 13,919,740 (GRCm38)	T240I	probably damaging	Het
Oxct2b	G	A	4: 123,117,451 (GRCm38)	R388H	probably damaging	Het
Pbrm1	A	G	14: 31,052,283 (GRCm38)	I469V	possibly damaging	Het
Phyhip	A	G	14: 70,466,854 (GRCm38)	H171R	possibly damaging	Het
Pigs	C	T	11: 78,328,500 (GRCm38)	T9M	probably benign	Het
Plek	T	C	11: 16,985,539 (GRCm38)	D256G	probably damaging	Het
Prss50	T	C	9: 110,864,303 (GRCm38)	V369A	probably benign	Het
Psmc5	A	G	11: 106,261,262 (GRCm38)	K82E	possibly damaging	Het
Qrsl1	A	T	10: 43,882,193 (GRCm38)	F301L	probably benign	Het
Rasal1	T	C	5: 120,659,608 (GRCm38)	L135P	probably damaging	Het
Rbm47	A	G	5: 66,026,816 (GRCm38)	V148A	probably damaging	Het
Scyl1	T	A	19: 5,764,757 (GRCm38)	D381V	probably benign	Het
Selplg	G	T	5: 113,819,101 (GRCm38)	D381E	probably benign	Het
Sh3rf2	C	A	18: 42,156,135 (GRCm38)	Q674K	probably damaging	Het
Sned1	A	G	1: 93,282,937 (GRCm38)	T987A	probably benign	Het
Sntb1	A	G	15: 55,676,302 (GRCm38)		probably null	Het
Synj2	A	T	17: 5,986,052 (GRCm38)	I14F	probably damaging	Het
Taf2	A	T	15: 55,063,044 (GRCm38)	M170K	possibly damaging	Het
Tg	A	G	15: 66,735,247 (GRCm38)	E211G	possibly damaging	Het
Thnsl1	G	T	2: 21,212,205 (GRCm38)	E257*	probably null	Het
Tlr4	A	G	4: 66,839,833 (GRCm38)	R288G	possibly damaging	Het
Trbc1	T	C	6: 41,538,451 (GRCm38)		probably benign	Het
Trim37	G	A	11: 87,216,548 (GRCm38)		probably null	Het
Txnrd3	T	C	6: 89,663,194 (GRCm38)		probably null	Het
Tyk2	C	A	9: 21,110,504 (GRCm38)	Q875H	probably damaging	Het
Vmn2r55	A	G	7: 12,651,771 (GRCm38)	Y761H	probably damaging	Het
Zswim5	T	C	4: 116,979,679 (GRCm38)	L720P	probably damaging	Het

Other mutations in Dnah2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00087:Dnah2	APN	11	69,492,672 (GRCm38)	missense	possibly damaging	0.93
IGL00418:Dnah2	APN	11	69,495,066 (GRCm38)	splice site	probably benign
IGL00772:Dnah2	APN	11	69,451,257 (GRCm38)	missense	probably damaging	0.97
IGL00819:Dnah2	APN	11	69,473,350 (GRCm38)	critical splice donor site	probably null
IGL00827:Dnah2	APN	11	69,448,457 (GRCm38)	missense	probably damaging	1.00
IGL01060:Dnah2	APN	11	69,478,092 (GRCm38)	missense	possibly damaging	0.86
IGL01340:Dnah2	APN	11	69,493,184 (GRCm38)	missense	probably damaging	0.99
IGL01349:Dnah2	APN	11	69,475,606 (GRCm38)	missense	probably damaging	0.99
IGL01413:Dnah2	APN	11	69,432,964 (GRCm38)	missense	probably damaging	0.99
IGL01451:Dnah2	APN	11	69,474,191 (GRCm38)	splice site	probably benign
IGL01480:Dnah2	APN	11	69,458,371 (GRCm38)	missense	possibly damaging	0.91
IGL01537:Dnah2	APN	11	69,516,080 (GRCm38)	missense	probably benign	0.17
IGL01592:Dnah2	APN	11	69,431,087 (GRCm38)	missense	probably benign	0.14
IGL01612:Dnah2	APN	11	69,465,063 (GRCm38)	splice site	probably benign
IGL01667:Dnah2	APN	11	69,544,395 (GRCm38)	missense	probably benign
IGL01667:Dnah2	APN	11	69,520,941 (GRCm38)	missense	probably damaging	0.98
IGL01691:Dnah2	APN	11	69,539,443 (GRCm38)	missense	probably benign
IGL02019:Dnah2	APN	11	69,474,285 (GRCm38)	missense	probably damaging	1.00
IGL02039:Dnah2	APN	11	69,499,212 (GRCm38)	missense	probably damaging	1.00
IGL02076:Dnah2	APN	11	69,422,559 (GRCm38)	missense	probably damaging	0.99
IGL02085:Dnah2	APN	11	69,458,185 (GRCm38)	missense	probably benign	0.07
IGL02158:Dnah2	APN	11	69,458,123 (GRCm38)	missense	probably benign
IGL02381:Dnah2	APN	11	69,446,292 (GRCm38)	missense	probably benign	0.25
IGL02681:Dnah2	APN	11	69,452,933 (GRCm38)	missense	probably benign	0.40
IGL02957:Dnah2	APN	11	69,448,507 (GRCm38)	missense	possibly damaging	0.96
IGL02961:Dnah2	APN	11	69,518,414 (GRCm38)	missense	probably damaging	1.00
IGL02969:Dnah2	APN	11	69,521,187 (GRCm38)	missense	possibly damaging	0.80
IGL03117:Dnah2	APN	11	69,436,291 (GRCm38)	splice site	probably benign
IGL03120:Dnah2	APN	11	69,421,848 (GRCm38)	missense	probably damaging	1.00
IGL03183:Dnah2	APN	11	69,458,488 (GRCm38)	missense	possibly damaging	0.94
IGL03197:Dnah2	APN	11	69,459,263 (GRCm38)	missense	probably damaging	1.00
IGL03263:Dnah2	APN	11	69,529,381 (GRCm38)	critical splice donor site	probably null
IGL03333:Dnah2	APN	11	69,495,123 (GRCm38)	missense	probably damaging	1.00
IGL03338:Dnah2	APN	11	69,496,577 (GRCm38)	missense	probably benign	0.13
argyrios	UTSW	11	69,516,590 (GRCm38)	missense	possibly damaging	0.47
Aureus	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
platinum	UTSW	11	69,458,042 (GRCm38)	missense	probably damaging	0.96
R0334_dnah2_144	UTSW	11	69,436,836 (GRCm38)	missense	probably damaging	1.00
R2150_dnah2_212	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
BB005:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
BB015:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
E0370:Dnah2	UTSW	11	69,515,615 (GRCm38)	splice site	probably null
P0026:Dnah2	UTSW	11	69,464,947 (GRCm38)	missense	probably damaging	1.00
R0133:Dnah2	UTSW	11	69,421,009 (GRCm38)	missense	probably damaging	1.00
R0190:Dnah2	UTSW	11	69,435,249 (GRCm38)	missense	probably damaging	1.00
R0334:Dnah2	UTSW	11	69,436,836 (GRCm38)	missense	probably damaging	1.00
R0359:Dnah2	UTSW	11	69,529,531 (GRCm38)	missense	probably benign	0.00
R0386:Dnah2	UTSW	11	69,447,861 (GRCm38)	missense	probably damaging	1.00
R0414:Dnah2	UTSW	11	69,499,238 (GRCm38)	missense	probably benign	0.26
R0427:Dnah2	UTSW	11	69,452,879 (GRCm38)	missense	probably damaging	0.99
R0433:Dnah2	UTSW	11	69,459,288 (GRCm38)	missense	probably damaging	1.00
R0442:Dnah2	UTSW	11	69,448,542 (GRCm38)	missense	probably damaging	1.00
R0462:Dnah2	UTSW	11	69,459,201 (GRCm38)	missense	probably damaging	1.00
R0463:Dnah2	UTSW	11	69,423,126 (GRCm38)	missense	probably damaging	1.00
R0611:Dnah2	UTSW	11	69,499,194 (GRCm38)	missense	probably damaging	1.00
R0626:Dnah2	UTSW	11	69,477,683 (GRCm38)	missense	probably benign	0.07
R0924:Dnah2	UTSW	11	69,421,308 (GRCm38)	missense	probably damaging	1.00
R0968:Dnah2	UTSW	11	69,448,519 (GRCm38)	missense	possibly damaging	0.67
R1066:Dnah2	UTSW	11	69,447,819 (GRCm38)	missense	probably damaging	1.00
R1183:Dnah2	UTSW	11	69,446,648 (GRCm38)	missense	possibly damaging	0.95
R1184:Dnah2	UTSW	11	69,499,190 (GRCm38)	missense	probably damaging	1.00
R1186:Dnah2	UTSW	11	69,515,700 (GRCm38)	missense	probably damaging	0.99
R1453:Dnah2	UTSW	11	69,451,050 (GRCm38)	missense	probably damaging	0.99
R1498:Dnah2	UTSW	11	69,520,667 (GRCm38)	splice site	probably null
R1538:Dnah2	UTSW	11	69,477,202 (GRCm38)	missense	probably benign	0.17
R1574:Dnah2	UTSW	11	69,514,688 (GRCm38)	missense	probably benign	0.26
R1574:Dnah2	UTSW	11	69,514,688 (GRCm38)	missense	probably benign	0.26
R1590:Dnah2	UTSW	11	69,521,198 (GRCm38)	missense	probably benign	0.00
R1590:Dnah2	UTSW	11	69,422,754 (GRCm38)	critical splice donor site	probably null
R1655:Dnah2	UTSW	11	69,473,854 (GRCm38)	missense	probably damaging	1.00
R1695:Dnah2	UTSW	11	69,514,691 (GRCm38)	missense	possibly damaging	0.74
R1726:Dnah2	UTSW	11	69,497,889 (GRCm38)	missense	probably damaging	1.00
R1764:Dnah2	UTSW	11	69,423,543 (GRCm38)	missense	probably damaging	1.00
R1815:Dnah2	UTSW	11	69,475,574 (GRCm38)	missense	probably damaging	1.00
R1822:Dnah2	UTSW	11	69,514,804 (GRCm38)	missense	probably damaging	1.00
R1859:Dnah2	UTSW	11	69,437,886 (GRCm38)	missense	probably damaging	0.99
R1911:Dnah2	UTSW	11	69,515,752 (GRCm38)	missense	possibly damaging	0.64
R1913:Dnah2	UTSW	11	69,464,930 (GRCm38)	missense	probably damaging	1.00
R1981:Dnah2	UTSW	11	69,474,325 (GRCm38)	missense	probably damaging	1.00
R2010:Dnah2	UTSW	11	69,458,358 (GRCm38)	critical splice donor site	probably null
R2016:Dnah2	UTSW	11	69,437,070 (GRCm38)	missense	probably damaging	0.97
R2017:Dnah2	UTSW	11	69,437,070 (GRCm38)	missense	probably damaging	0.97
R2044:Dnah2	UTSW	11	69,524,240 (GRCm38)	missense	probably benign	0.14
R2077:Dnah2	UTSW	11	69,496,606 (GRCm38)	missense	possibly damaging	0.73
R2096:Dnah2	UTSW	11	69,455,916 (GRCm38)	missense	probably damaging	0.98
R2099:Dnah2	UTSW	11	69,493,237 (GRCm38)	missense	probably damaging	1.00
R2127:Dnah2	UTSW	11	69,458,185 (GRCm38)	missense	probably benign	0.02
R2128:Dnah2	UTSW	11	69,458,185 (GRCm38)	missense	probably benign	0.02
R2146:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2147:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2150:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2404:Dnah2	UTSW	11	69,437,221 (GRCm38)	missense	probably damaging	0.99
R2510:Dnah2	UTSW	11	69,524,206 (GRCm38)	nonsense	probably null
R2517:Dnah2	UTSW	11	69,516,644 (GRCm38)	missense	probably damaging	1.00
R3014:Dnah2	UTSW	11	69,430,478 (GRCm38)	missense	probably benign
R3741:Dnah2	UTSW	11	69,448,469 (GRCm38)	missense	probably damaging	1.00
R3814:Dnah2	UTSW	11	69,492,650 (GRCm38)	splice site	probably null
R3872:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3873:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3874:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3875:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3881:Dnah2	UTSW	11	69,451,347 (GRCm38)	missense	possibly damaging	0.94
R3953:Dnah2	UTSW	11	69,454,103 (GRCm38)	missense	probably damaging	1.00
R3956:Dnah2	UTSW	11	69,484,021 (GRCm38)	missense	probably benign	0.00
R4501:Dnah2	UTSW	11	69,477,659 (GRCm38)	missense	probably benign
R4515:Dnah2	UTSW	11	69,465,631 (GRCm38)	missense	possibly damaging	0.61
R4612:Dnah2	UTSW	11	69,483,367 (GRCm38)	missense	possibly damaging	0.93
R4625:Dnah2	UTSW	11	69,463,661 (GRCm38)	missense	probably damaging	1.00
R4627:Dnah2	UTSW	11	69,465,376 (GRCm38)	missense	probably damaging	1.00
R4642:Dnah2	UTSW	11	69,496,559 (GRCm38)	missense	probably benign	0.00
R4683:Dnah2	UTSW	11	69,458,942 (GRCm38)	missense	probably damaging	1.00
R4698:Dnah2	UTSW	11	69,498,532 (GRCm38)	missense	probably damaging	1.00
R4710:Dnah2	UTSW	11	69,478,077 (GRCm38)	missense	probably damaging	1.00
R4712:Dnah2	UTSW	11	69,516,590 (GRCm38)	missense	possibly damaging	0.47
R4713:Dnah2	UTSW	11	69,476,688 (GRCm38)	missense	probably damaging	1.00
R4717:Dnah2	UTSW	11	69,429,357 (GRCm38)	missense	probably benign	0.00
R4740:Dnah2	UTSW	11	69,458,042 (GRCm38)	missense	probably damaging	0.96
R4780:Dnah2	UTSW	11	69,473,871 (GRCm38)	missense	probably damaging	0.97
R4825:Dnah2	UTSW	11	69,423,205 (GRCm38)	missense	probably damaging	1.00
R4864:Dnah2	UTSW	11	69,422,590 (GRCm38)	missense	probably damaging	0.98
R4868:Dnah2	UTSW	11	69,463,648 (GRCm38)	missense	probably damaging	1.00
R4879:Dnah2	UTSW	11	69,476,691 (GRCm38)	missense	probably damaging	1.00
R4908:Dnah2	UTSW	11	69,521,147 (GRCm38)	missense	probably benign	0.00
R4911:Dnah2	UTSW	11	69,499,104 (GRCm38)	critical splice donor site	probably null
R4954:Dnah2	UTSW	11	69,539,496 (GRCm38)	missense	possibly damaging	0.61
R4962:Dnah2	UTSW	11	69,455,973 (GRCm38)	nonsense	probably null
R5015:Dnah2	UTSW	11	69,497,882 (GRCm38)	missense	possibly damaging	0.89
R5049:Dnah2	UTSW	11	69,448,166 (GRCm38)	missense	probably damaging	1.00
R5055:Dnah2	UTSW	11	69,520,773 (GRCm38)	missense	possibly damaging	0.67
R5153:Dnah2	UTSW	11	69,520,933 (GRCm38)	missense	possibly damaging	0.84
R5155:Dnah2	UTSW	11	69,422,536 (GRCm38)	missense	probably damaging	1.00
R5186:Dnah2	UTSW	11	69,435,884 (GRCm38)	missense	probably damaging	1.00
R5187:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5208:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5252:Dnah2	UTSW	11	69,529,469 (GRCm38)	missense	probably damaging	0.98
R5296:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5298:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5299:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5301:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5324:Dnah2	UTSW	11	69,457,993 (GRCm38)	missense	probably benign	0.07
R5350:Dnah2	UTSW	11	69,516,036 (GRCm38)	missense	possibly damaging	0.48
R5377:Dnah2	UTSW	11	69,421,848 (GRCm38)	missense	probably damaging	1.00
R5393:Dnah2	UTSW	11	69,500,857 (GRCm38)	missense	probably benign
R5421:Dnah2	UTSW	11	69,435,636 (GRCm38)	missense	probably damaging	1.00
R5452:Dnah2	UTSW	11	69,524,383 (GRCm38)	missense	probably damaging	1.00
R5461:Dnah2	UTSW	11	69,473,351 (GRCm38)	critical splice donor site	probably null
R5474:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5476:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5477:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5510:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5527:Dnah2	UTSW	11	69,437,188 (GRCm38)	nonsense	probably null
R5566:Dnah2	UTSW	11	69,516,569 (GRCm38)	nonsense	probably null
R5587:Dnah2	UTSW	11	69,437,242 (GRCm38)	missense	probably damaging	1.00
R5628:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5688:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5690:Dnah2	UTSW	11	69,491,544 (GRCm38)	missense	probably benign	0.15
R5711:Dnah2	UTSW	11	69,435,390 (GRCm38)	missense	probably damaging	1.00
R5735:Dnah2	UTSW	11	69,430,817 (GRCm38)	missense	possibly damaging	0.93
R5826:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5913:Dnah2	UTSW	11	69,448,430 (GRCm38)	missense	probably damaging	1.00
R5914:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5960:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,431,148 (GRCm38)	missense	probably damaging	1.00
R5977:Dnah2	UTSW	11	69,520,881 (GRCm38)	missense	possibly damaging	0.79
R6020:Dnah2	UTSW	11	69,500,839 (GRCm38)	missense	probably benign
R6036:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6036:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6050:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6086:Dnah2	UTSW	11	69,516,008 (GRCm38)	missense	probably benign	0.30
R6115:Dnah2	UTSW	11	69,446,649 (GRCm38)	missense	probably damaging	1.00
R6123:Dnah2	UTSW	11	69,518,359 (GRCm38)	missense	probably benign	0.29
R6159:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6163:Dnah2	UTSW	11	69,520,903 (GRCm38)	nonsense	probably null
R6171:Dnah2	UTSW	11	69,423,042 (GRCm38)	missense	probably damaging	1.00
R6263:Dnah2	UTSW	11	69,457,412 (GRCm38)	missense	probably damaging	1.00
R6298:Dnah2	UTSW	11	69,491,641 (GRCm38)	missense	probably benign	0.25
R6352:Dnah2	UTSW	11	69,448,227 (GRCm38)	missense	probably damaging	1.00
R6399:Dnah2	UTSW	11	69,458,518 (GRCm38)	missense	probably damaging	0.98
R6466:Dnah2	UTSW	11	69,539,415 (GRCm38)	missense	probably benign
R6478:Dnah2	UTSW	11	69,516,010 (GRCm38)	missense	probably benign	0.01
R6516:Dnah2	UTSW	11	69,465,386 (GRCm38)	missense	probably benign	0.34
R6538:Dnah2	UTSW	11	69,437,197 (GRCm38)	missense	possibly damaging	0.87
R6802:Dnah2	UTSW	11	69,423,690 (GRCm38)	missense	probably damaging	1.00
R6861:Dnah2	UTSW	11	69,455,963 (GRCm38)	missense	possibly damaging	0.64
R6869:Dnah2	UTSW	11	69,429,471 (GRCm38)	missense	probably damaging	1.00
R6894:Dnah2	UTSW	11	69,484,260 (GRCm38)	missense	probably benign	0.12
R6935:Dnah2	UTSW	11	69,421,741 (GRCm38)	missense	probably damaging	1.00
R7017:Dnah2	UTSW	11	69,491,547 (GRCm38)	nonsense	probably null
R7073:Dnah2	UTSW	11	69,430,492 (GRCm38)	nonsense	probably null
R7111:Dnah2	UTSW	11	69,446,753 (GRCm38)	splice site	probably null
R7125:Dnah2	UTSW	11	69,436,182 (GRCm38)	missense	probably damaging	0.99
R7137:Dnah2	UTSW	11	69,491,555 (GRCm38)	missense	probably damaging	1.00
R7190:Dnah2	UTSW	11	69,549,097 (GRCm38)	splice site	probably null
R7214:Dnah2	UTSW	11	69,431,109 (GRCm38)	missense	probably damaging	1.00
R7227:Dnah2	UTSW	11	69,421,396 (GRCm38)	missense	probably damaging	0.99
R7238:Dnah2	UTSW	11	69,459,146 (GRCm38)	critical splice donor site	probably null
R7256:Dnah2	UTSW	11	69,431,094 (GRCm38)	missense	probably damaging	1.00
R7267:Dnah2	UTSW	11	69,500,817 (GRCm38)	missense	probably damaging	1.00
R7420:Dnah2	UTSW	11	69,478,797 (GRCm38)	missense	possibly damaging	0.94
R7421:Dnah2	UTSW	11	69,492,805 (GRCm38)	missense	probably benign	0.25
R7437:Dnah2	UTSW	11	69,498,627 (GRCm38)	missense	probably damaging	1.00
R7461:Dnah2	UTSW	11	69,548,990 (GRCm38)	critical splice donor site	probably null
R7473:Dnah2	UTSW	11	69,491,658 (GRCm38)	missense	probably damaging	0.99
R7528:Dnah2	UTSW	11	69,500,796 (GRCm38)	missense	probably damaging	0.99
R7613:Dnah2	UTSW	11	69,548,990 (GRCm38)	critical splice donor site	probably null
R7615:Dnah2	UTSW	11	69,435,304 (GRCm38)	missense	probably damaging	0.99
R7626:Dnah2	UTSW	11	69,498,685 (GRCm38)	missense	probably damaging	0.99
R7745:Dnah2	UTSW	11	69,451,318 (GRCm38)	nonsense	probably null
R7764:Dnah2	UTSW	11	69,458,158 (GRCm38)	missense	probably benign	0.29
R7793:Dnah2	UTSW	11	69,495,214 (GRCm38)	missense	probably benign	0.00
R7819:Dnah2	UTSW	11	69,516,593 (GRCm38)	missense	probably benign	0.01
R7881:Dnah2	UTSW	11	69,431,238 (GRCm38)	missense	probably damaging	1.00
R7900:Dnah2	UTSW	11	69,518,428 (GRCm38)	missense	probably damaging	1.00
R7916:Dnah2	UTSW	11	69,421,148 (GRCm38)	critical splice acceptor site	probably null
R7921:Dnah2	UTSW	11	69,520,834 (GRCm38)	missense	probably benign
R7928:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
R7937:Dnah2	UTSW	11	69,517,685 (GRCm38)	nonsense	probably null
R7995:Dnah2	UTSW	11	69,520,737 (GRCm38)	missense	possibly damaging	0.77
R8202:Dnah2	UTSW	11	69,478,823 (GRCm38)	missense	probably benign	0.00
R8208:Dnah2	UTSW	11	69,520,852 (GRCm38)	missense	probably benign	0.05
R8215:Dnah2	UTSW	11	69,435,367 (GRCm38)	missense	probably damaging	1.00
R8279:Dnah2	UTSW	11	69,475,573 (GRCm38)	missense	probably damaging	1.00
R8338:Dnah2	UTSW	11	69,487,296 (GRCm38)	missense	probably damaging	1.00
R8348:Dnah2	UTSW	11	69,429,447 (GRCm38)	missense	possibly damaging	0.95
R8405:Dnah2	UTSW	11	69,458,463 (GRCm38)	missense	probably damaging	1.00
R8407:Dnah2	UTSW	11	69,459,278 (GRCm38)	missense	probably benign	0.00
R8493:Dnah2	UTSW	11	69,452,978 (GRCm38)	missense	probably damaging	1.00
R8673:Dnah2	UTSW	11	69,514,697 (GRCm38)	missense	probably benign	0.23
R8725:Dnah2	UTSW	11	69,524,179 (GRCm38)	missense	probably damaging	1.00
R8727:Dnah2	UTSW	11	69,524,179 (GRCm38)	missense	probably damaging	1.00
R8730:Dnah2	UTSW	11	69,493,261 (GRCm38)	missense	possibly damaging	0.73
R8804:Dnah2	UTSW	11	69,465,685 (GRCm38)	missense	probably benign	0.01
R8876:Dnah2	UTSW	11	69,491,522 (GRCm38)	missense	probably damaging	1.00
R8894:Dnah2	UTSW	11	69,492,222 (GRCm38)	missense	probably benign	0.01
R8938:Dnah2	UTSW	11	69,437,928 (GRCm38)	missense	probably damaging	0.99
R9044:Dnah2	UTSW	11	69,529,421 (GRCm38)	missense	probably benign
R9085:Dnah2	UTSW	11	69,429,398 (GRCm38)	missense	possibly damaging	0.69
R9110:Dnah2	UTSW	11	69,544,382 (GRCm38)	missense	probably benign
R9156:Dnah2	UTSW	11	69,422,861 (GRCm38)	missense
R9251:Dnah2	UTSW	11	69,515,793 (GRCm38)	missense	probably damaging	1.00
R9258:Dnah2	UTSW	11	69,477,253 (GRCm38)	missense	probably damaging	1.00
R9279:Dnah2	UTSW	11	69,518,278 (GRCm38)	missense	probably benign	0.01
R9318:Dnah2	UTSW	11	69,484,329 (GRCm38)	missense	probably benign	0.07
R9321:Dnah2	UTSW	11	69,448,113 (GRCm38)	critical splice donor site	probably null
R9350:Dnah2	UTSW	11	69,493,247 (GRCm38)	missense	probably benign	0.10
R9358:Dnah2	UTSW	11	69,515,766 (GRCm38)	missense	probably damaging	0.99
R9417:Dnah2	UTSW	11	69,436,164 (GRCm38)	missense	probably damaging	1.00
R9420:Dnah2	UTSW	11	69,478,116 (GRCm38)	missense	probably benign	0.09
R9438:Dnah2	UTSW	11	69,473,394 (GRCm38)	missense	probably damaging	1.00
R9469:Dnah2	UTSW	11	69,431,070 (GRCm38)	missense	probably damaging	1.00
R9487:Dnah2	UTSW	11	69,515,791 (GRCm38)	missense	possibly damaging	0.47
R9495:Dnah2	UTSW	11	69,454,382 (GRCm38)	missense	possibly damaging	0.89
R9579:Dnah2	UTSW	11	69,477,215 (GRCm38)	missense	probably damaging	1.00
R9608:Dnah2	UTSW	11	69,454,062 (GRCm38)	missense	probably null	1.00
R9651:Dnah2	UTSW	11	69,450,998 (GRCm38)	critical splice donor site	probably null
R9662:Dnah2	UTSW	11	69,452,937 (GRCm38)	missense	probably benign
RF004:Dnah2	UTSW	11	69,437,187 (GRCm38)	missense	probably benign	0.24
U24488:Dnah2	UTSW	11	69,483,822 (GRCm38)	missense	probably damaging	0.99
X0021:Dnah2	UTSW	11	69,448,562 (GRCm38)	missense	possibly damaging	0.81
Z1088:Dnah2	UTSW	11	69,430,793 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,421,821 (GRCm38)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,516,523 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,516,481 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,498,667 (GRCm38)	missense	probably benign	0.12
Z1176:Dnah2	UTSW	11	69,487,054 (GRCm38)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,451,120 (GRCm38)	missense	probably benign
Z1177:Dnah2	UTSW	11	69,544,557 (GRCm38)	critical splice acceptor site	probably null
Z1177:Dnah2	UTSW	11	69,463,453 (GRCm38)	missense	possibly damaging	0.63

Predicted Primers

PCR Primer
(F):5'- CAGGGAGCTAATTGGTGGTC -3'
(R):5'- TCAAGGAGAATGCCACGCTC -3'

Sequencing Primer
(F):5'- ACCTGTGCGGACATGTTGAC -3'
(R):5'- GAGAATGCCACGCTCCCAAG -3'

Posted On

2017-10-10