Incidental Mutation 'R6160:Myo1f'
ID 489840
Institutional Source Beutler Lab
Gene Symbol Myo1f
Ensembl Gene ENSMUSG00000024300
Gene Name myosin IF
Synonyms C330006B10Rik
MMRRC Submission 044307-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.143) question?
Stock # R6160 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 33774681-33826738 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 33823318 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Glutamine at position 981 (P981Q)
Ref Sequence ENSEMBL: ENSMUSP00000084887 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087605] [ENSMUST00000173372]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000087605
AA Change: P981Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000084887
Gene: ENSMUSG00000024300
AA Change: P981Q

DomainStartEndE-ValueType
MYSc 11 691 N/A SMART
IQ 692 714 7.57e0 SMART
Pfam:Myosin_TH1 717 909 1.7e-51 PFAM
low complexity region 939 952 N/A INTRINSIC
low complexity region 973 987 N/A INTRINSIC
low complexity region 991 1001 N/A INTRINSIC
SH3 1044 1098 2.09e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173372
SMART Domains Protein: ENSMUSP00000134715
Gene: ENSMUSG00000024300

DomainStartEndE-ValueType
MYSc 11 691 N/A SMART
IQ 692 714 7.57e0 SMART
Pfam:Myosin_TH1 716 780 6e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173426
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 94% (62/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired neutrophil migration and adhesion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930433I11Rik T A 7: 40,642,950 (GRCm39) S297R possibly damaging Het
5530400C23Rik A G 6: 133,271,289 (GRCm39) E111G possibly damaging Het
8030423J24Rik T A 13: 71,032,029 (GRCm39) S34T unknown Het
Ace3 T A 11: 105,885,558 (GRCm39) W20R possibly damaging Het
Adgrf1 A G 17: 43,621,578 (GRCm39) E605G probably damaging Het
Arhgap44 G A 11: 65,053,375 (GRCm39) probably benign Het
Atm A C 9: 53,402,259 (GRCm39) H1404Q probably benign Het
AW209491 A G 13: 14,811,306 (GRCm39) E53G probably damaging Het
Bhmt1b G A 18: 87,775,245 (GRCm39) C256Y probably damaging Het
Cdt1 C T 8: 123,298,107 (GRCm39) T366I probably benign Het
Cerk A T 15: 86,026,974 (GRCm39) C179S probably benign Het
Cldn10 T C 14: 119,099,255 (GRCm39) V123A possibly damaging Het
Clip1 T C 5: 123,751,604 (GRCm39) K726E possibly damaging Het
Dcaf12 A T 4: 41,294,043 (GRCm39) Y365N probably damaging Het
Dennd6b A G 15: 89,073,024 (GRCm39) L171P probably damaging Het
Dip2c G A 13: 9,583,290 (GRCm39) V91I probably benign Het
Dlec1 A G 9: 118,972,387 (GRCm39) I1431V probably benign Het
Egln1 T C 8: 125,675,231 (GRCm39) D188G probably damaging Het
Enpp5 T A 17: 44,392,259 (GRCm39) N229K possibly damaging Het
Fmo1 T G 1: 162,663,867 (GRCm39) I221L probably benign Het
Fsip2 G A 2: 82,818,289 (GRCm39) W4674* probably null Het
Gm12185 G A 11: 48,799,255 (GRCm39) Q413* probably null Het
Gm7298 A T 6: 121,741,886 (GRCm39) H436L probably benign Het
Gucy2c G A 6: 136,717,684 (GRCm39) Q430* probably null Het
Hgd A G 16: 37,433,660 (GRCm39) H134R probably damaging Het
Hoxd8 A G 2: 74,536,343 (GRCm39) E151G probably damaging Het
Il15ra A G 2: 11,724,827 (GRCm39) D99G probably damaging Het
Ints4 T A 7: 97,158,790 (GRCm39) probably null Het
Itgb1 T A 8: 129,446,764 (GRCm39) F426L possibly damaging Het
Itpr1 A C 6: 108,495,716 (GRCm39) I2534L probably benign Het
Kcnq4 T A 4: 120,573,756 (GRCm39) H235L probably damaging Het
Kcnt1 T A 2: 25,782,395 (GRCm39) I178N probably damaging Het
Kidins220 A G 12: 25,047,310 (GRCm39) D252G probably damaging Het
Krt23 A G 11: 99,376,544 (GRCm39) I204T probably damaging Het
Lipo4 A G 19: 33,480,693 (GRCm39) L225P probably damaging Het
Lrp3 T C 7: 34,903,548 (GRCm39) D245G possibly damaging Het
Mmp16 A G 4: 18,051,857 (GRCm39) D282G probably damaging Het
Myo1c A T 11: 75,541,568 (GRCm39) H18L probably benign Het
Nle1 A T 11: 82,798,983 (GRCm39) F33I probably benign Het
Nlrp4e T G 7: 23,020,731 (GRCm39) M406R probably damaging Het
Obscn A T 11: 58,942,611 (GRCm39) V4857E probably damaging Het
Palb2 A T 7: 121,727,643 (GRCm39) probably null Het
Phospho1 A T 11: 95,721,450 (GRCm39) E22V probably damaging Het
Pom121l2 C T 13: 22,167,838 (GRCm39) S703L possibly damaging Het
Prex2 T C 1: 11,064,075 (GRCm39) L20P probably damaging Het
Psmb7 T C 2: 38,533,393 (GRCm39) T45A probably damaging Het
R3hdm2 T C 10: 127,320,376 (GRCm39) I532T probably damaging Het
Rcn1 T C 2: 105,222,362 (GRCm39) D208G probably damaging Het
Recql5 A G 11: 115,823,613 (GRCm39) probably null Het
Resf1 G A 6: 149,233,005 (GRCm39) probably null Het
Rfc4 A T 16: 22,933,433 (GRCm39) I242N probably damaging Het
Rims1 T C 1: 22,503,235 (GRCm39) Y650C probably damaging Het
Shc2 C T 10: 79,462,853 (GRCm39) probably null Het
Slc14a2 A T 18: 78,202,190 (GRCm39) probably null Het
Slc6a6 A T 6: 91,716,995 (GRCm39) probably null Het
Synj2 C A 17: 6,058,336 (GRCm39) H275N possibly damaging Het
T A T 17: 8,660,618 (GRCm39) T410S probably benign Het
Tars3 A G 7: 65,332,527 (GRCm39) I543V probably benign Het
Tbc1d8 T A 1: 39,411,484 (GRCm39) K1117N probably damaging Het
Tm7sf3 A T 6: 146,507,787 (GRCm39) L425* probably null Het
Trav14-3 A G 14: 54,000,978 (GRCm39) Y63C probably damaging Het
Tyro3 A C 2: 119,633,751 (GRCm39) D133A probably damaging Het
Vmn1r119 T G 7: 20,745,740 (GRCm39) H214P possibly damaging Het
Vmn2r120 G A 17: 57,816,418 (GRCm39) P646S probably benign Het
Zbtb7c A T 18: 76,278,904 (GRCm39) Y454F probably benign Het
Zmym2 T C 14: 57,187,766 (GRCm39) L1144P probably damaging Het
Other mutations in Myo1f
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00851:Myo1f APN 17 33,800,938 (GRCm39) missense probably benign 0.01
IGL01019:Myo1f APN 17 33,811,977 (GRCm39) missense possibly damaging 0.93
IGL01524:Myo1f APN 17 33,798,857 (GRCm39) missense probably damaging 1.00
IGL01744:Myo1f APN 17 33,802,654 (GRCm39) splice site probably benign
IGL01951:Myo1f APN 17 33,816,991 (GRCm39) missense possibly damaging 0.64
IGL02132:Myo1f APN 17 33,798,945 (GRCm39) missense probably benign 0.10
IGL02170:Myo1f APN 17 33,797,246 (GRCm39) missense probably benign 0.14
IGL02173:Myo1f APN 17 33,826,318 (GRCm39) missense probably damaging 1.00
IGL02277:Myo1f APN 17 33,798,835 (GRCm39) splice site probably null
IGL02550:Myo1f APN 17 33,799,124 (GRCm39) unclassified probably benign
IGL02550:Myo1f APN 17 33,807,116 (GRCm39) missense probably damaging 1.00
IGL02615:Myo1f APN 17 33,823,630 (GRCm39) missense probably benign
IGL02801:Myo1f APN 17 33,797,111 (GRCm39) missense probably damaging 1.00
IGL02817:Myo1f APN 17 33,823,532 (GRCm39) missense probably benign 0.06
IGL02904:Myo1f APN 17 33,804,632 (GRCm39) nonsense probably null
IGL03056:Myo1f APN 17 33,804,574 (GRCm39) missense probably damaging 1.00
IGL03334:Myo1f APN 17 33,817,168 (GRCm39) missense probably damaging 1.00
R0066:Myo1f UTSW 17 33,820,677 (GRCm39) missense probably damaging 0.98
R0066:Myo1f UTSW 17 33,820,677 (GRCm39) missense probably damaging 0.98
R0321:Myo1f UTSW 17 33,811,986 (GRCm39) missense probably benign 0.31
R0375:Myo1f UTSW 17 33,820,930 (GRCm39) missense probably benign 0.27
R0487:Myo1f UTSW 17 33,797,258 (GRCm39) missense probably damaging 1.00
R0925:Myo1f UTSW 17 33,797,107 (GRCm39) missense probably damaging 0.96
R1394:Myo1f UTSW 17 33,802,714 (GRCm39) missense probably damaging 0.96
R1395:Myo1f UTSW 17 33,802,714 (GRCm39) missense probably damaging 0.96
R1474:Myo1f UTSW 17 33,813,001 (GRCm39) missense possibly damaging 0.77
R1760:Myo1f UTSW 17 33,805,172 (GRCm39) missense probably benign 0.03
R1965:Myo1f UTSW 17 33,817,146 (GRCm39) nonsense probably null
R2409:Myo1f UTSW 17 33,795,641 (GRCm39) missense probably damaging 1.00
R2432:Myo1f UTSW 17 33,794,823 (GRCm39) missense probably damaging 1.00
R4610:Myo1f UTSW 17 33,801,306 (GRCm39) missense probably damaging 1.00
R4785:Myo1f UTSW 17 33,817,165 (GRCm39) missense possibly damaging 0.95
R5239:Myo1f UTSW 17 33,820,709 (GRCm39) missense probably benign 0.00
R5881:Myo1f UTSW 17 33,799,259 (GRCm39) missense possibly damaging 0.46
R5881:Myo1f UTSW 17 33,795,627 (GRCm39) missense probably damaging 1.00
R6210:Myo1f UTSW 17 33,820,044 (GRCm39) missense probably damaging 1.00
R6365:Myo1f UTSW 17 33,805,090 (GRCm39) missense probably benign
R6464:Myo1f UTSW 17 33,795,621 (GRCm39) missense probably damaging 1.00
R6532:Myo1f UTSW 17 33,794,820 (GRCm39) missense probably damaging 1.00
R6678:Myo1f UTSW 17 33,794,819 (GRCm39) missense probably damaging 1.00
R7241:Myo1f UTSW 17 33,798,902 (GRCm39) missense probably damaging 0.99
R7266:Myo1f UTSW 17 33,820,668 (GRCm39) missense probably benign
R7513:Myo1f UTSW 17 33,794,788 (GRCm39) missense probably damaging 1.00
R7606:Myo1f UTSW 17 33,795,424 (GRCm39) missense probably damaging 1.00
R7779:Myo1f UTSW 17 33,797,247 (GRCm39) missense probably benign 0.27
R7853:Myo1f UTSW 17 33,795,672 (GRCm39) missense probably damaging 1.00
R7884:Myo1f UTSW 17 33,817,270 (GRCm39) missense probably damaging 1.00
R8507:Myo1f UTSW 17 33,816,992 (GRCm39) missense probably benign 0.09
R8807:Myo1f UTSW 17 33,794,879 (GRCm39) missense probably damaging 1.00
R9009:Myo1f UTSW 17 33,823,662 (GRCm39) missense probably benign 0.12
R9083:Myo1f UTSW 17 33,813,036 (GRCm39) missense probably damaging 0.99
R9227:Myo1f UTSW 17 33,795,424 (GRCm39) missense probably damaging 1.00
R9230:Myo1f UTSW 17 33,795,424 (GRCm39) missense probably damaging 1.00
R9528:Myo1f UTSW 17 33,797,156 (GRCm39) critical splice donor site probably null
X0028:Myo1f UTSW 17 33,795,412 (GRCm39) missense possibly damaging 0.67
X0065:Myo1f UTSW 17 33,820,957 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CTGCATCTTCTGTCAGGCTTAG -3'
(R):5'- GCTTCCTTTGCATGCTGAAG -3'

Sequencing Primer
(F):5'- CTTCTGTCAGGCTTAGAACTTAGAG -3'
(R):5'- AACAGCATGGGTCTCAGC -3'
Posted On 2017-10-10