|Institutional Source||Beutler Lab|
|Gene Name||wingless-type MMTV integration site family, member 8A|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6161 (G1)|
|Chromosomal Location||34542313-34548273 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 34545546 bp (GRCm38)|
|Amino Acid Change||Phenylalanine to Leucine at position 138 (F138L)|
|Ref Sequence||ENSEMBL: ENSMUSP00000012426 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000012426]|
AA Change: F138L
PolyPhen 2 Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)
AA Change: F138L
|Meta Mutation Damage Score||0.7466|
|Coding Region Coverage||
|Validation Efficiency||100% (54/54)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Wnt8a||
(F):5'- CCTGTGGGTAGAGAGAACCTAG -3'
(R):5'- TCTTCCTGAACGGCTTTGGG -3'
(F):5'- CTAGCAGCCGAGAGACAGC -3'
(R):5'- CTGAACGGCTTTGGGGATGAG -3'