Incidental Mutation 'R6162:Dnai3'
ID 489913
Institutional Source Beutler Lab
Gene Symbol Dnai3
Ensembl Gene ENSMUSG00000043020
Gene Name dynein axonemal intermediate chain 3
Synonyms 4931433A13Rik, Wdr63, Ida7, IC140
MMRRC Submission 044309-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R6162 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 145746281-145813855 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 145750617 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 821 (I821F)
Ref Sequence ENSEMBL: ENSMUSP00000124475 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000160285]
AlphaFold B2RY71
Predicted Effect probably damaging
Transcript: ENSMUST00000160285
AA Change: I821F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000124475
Gene: ENSMUSG00000043020
AA Change: I821F

DomainStartEndE-ValueType
low complexity region 3 22 N/A INTRINSIC
low complexity region 26 35 N/A INTRINSIC
low complexity region 133 150 N/A INTRINSIC
low complexity region 165 180 N/A INTRINSIC
Blast:WD40 321 367 6e-19 BLAST
low complexity region 375 383 N/A INTRINSIC
WD40 390 429 6.34e-2 SMART
WD40 470 527 1.15e-4 SMART
low complexity region 536 553 N/A INTRINSIC
WD40 693 732 1.07e1 SMART
WD40 737 776 1.1e2 SMART
coiled coil region 867 902 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161104
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162572
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 98% (40/41)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T G 11: 9,259,047 (GRCm39) C2924W probably damaging Het
Adh4 T A 3: 138,121,250 (GRCm39) probably null Het
Aox3 A T 1: 58,198,890 (GRCm39) D695V possibly damaging Het
Ccnj A G 19: 40,833,606 (GRCm39) Y221C probably damaging Het
Cct2 T A 10: 116,894,091 (GRCm39) D221V probably damaging Het
Cd5 G A 19: 10,703,244 (GRCm39) T138M probably damaging Het
Cep78 A T 19: 15,952,304 (GRCm39) M307K probably benign Het
Dclk1 C A 3: 55,163,575 (GRCm39) D222E probably benign Het
Dhrs11 C T 11: 84,719,605 (GRCm39) G40D probably damaging Het
Dnah10 A G 5: 124,900,382 (GRCm39) S3823G probably benign Het
Dock3 A T 9: 106,841,998 (GRCm39) Y944N possibly damaging Het
Dst A G 1: 34,045,318 (GRCm39) D17G probably damaging Het
Ehmt2 C T 17: 35,118,067 (GRCm39) R40* probably null Het
Fam20a G T 11: 109,573,696 (GRCm39) S229* probably null Het
Fbn1 T C 2: 125,202,147 (GRCm39) D1242G probably damaging Het
Ggt5 T A 10: 75,425,626 (GRCm39) V28D possibly damaging Het
Gimap4 A T 6: 48,667,655 (GRCm39) I137F probably damaging Het
Git2 T A 5: 114,899,717 (GRCm39) H212L probably damaging Het
Gprc6a T A 10: 51,491,008 (GRCm39) I739F probably benign Het
Il1rl2 A G 1: 40,391,038 (GRCm39) Y327C probably damaging Het
Lmf1 A G 17: 25,831,368 (GRCm39) I205V probably benign Het
Mipep C A 14: 61,024,853 (GRCm39) P98Q probably damaging Het
Mroh2b A G 15: 4,944,707 (GRCm39) D436G probably damaging Het
Mtcl2 T A 2: 156,881,784 (GRCm39) E756V possibly damaging Het
Myorg A G 4: 41,497,899 (GRCm39) V577A possibly damaging Het
Notch1 C T 2: 26,352,207 (GRCm39) V2035I probably benign Het
Or1e28-ps1 T A 11: 73,615,713 (GRCm39) I46F probably damaging Het
Or2ag16 A T 7: 106,352,227 (GRCm39) Y123N probably damaging Het
Or4c118 G T 2: 88,975,114 (GRCm39) F84L probably benign Het
Oxa1l A G 14: 54,605,789 (GRCm39) T395A probably damaging Het
Phospho2 T A 2: 69,626,375 (GRCm39) I177K probably damaging Het
Prpf40a T C 2: 53,049,317 (GRCm39) T224A probably benign Het
Reln T A 5: 22,116,048 (GRCm39) T2987S probably damaging Het
Scn5a T A 9: 119,351,621 (GRCm39) I787F probably damaging Het
Sgsm2 A T 11: 74,782,847 (GRCm39) D36E probably damaging Het
Slc12a3 A G 8: 95,072,401 (GRCm39) probably null Het
Tas2r134 T C 2: 51,517,571 (GRCm39) S17P probably damaging Het
Top3a T C 11: 60,636,763 (GRCm39) Y609C probably damaging Het
Trem2 A G 17: 48,655,694 (GRCm39) I84V probably damaging Het
Vmn2r12 A G 5: 109,234,430 (GRCm39) L594P probably damaging Het
Zdbf2 A T 1: 63,319,977 (GRCm39) probably benign Het
Zfr C T 15: 12,146,331 (GRCm39) A294V unknown Het
Other mutations in Dnai3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Dnai3 APN 3 145,788,759 (GRCm39) missense probably benign
IGL00565:Dnai3 APN 3 145,750,674 (GRCm39) splice site probably benign
IGL01339:Dnai3 APN 3 145,748,591 (GRCm39) missense probably benign 0.14
IGL01952:Dnai3 APN 3 145,802,918 (GRCm39) missense probably damaging 0.96
IGL02663:Dnai3 APN 3 145,760,312 (GRCm39) missense possibly damaging 0.53
IGL02710:Dnai3 APN 3 145,753,903 (GRCm39) missense possibly damaging 0.96
P0041:Dnai3 UTSW 3 145,786,997 (GRCm39) missense possibly damaging 0.96
R0014:Dnai3 UTSW 3 145,787,178 (GRCm39) splice site probably null
R0014:Dnai3 UTSW 3 145,787,178 (GRCm39) splice site probably null
R0498:Dnai3 UTSW 3 145,787,119 (GRCm39) missense possibly damaging 0.54
R0589:Dnai3 UTSW 3 145,768,086 (GRCm39) missense probably benign 0.01
R1484:Dnai3 UTSW 3 145,802,996 (GRCm39) missense probably benign 0.02
R1537:Dnai3 UTSW 3 145,748,504 (GRCm39) missense probably damaging 0.98
R1611:Dnai3 UTSW 3 145,801,113 (GRCm39) missense probably damaging 1.00
R1743:Dnai3 UTSW 3 145,803,017 (GRCm39) missense possibly damaging 0.81
R1861:Dnai3 UTSW 3 145,788,801 (GRCm39) missense probably damaging 1.00
R1991:Dnai3 UTSW 3 145,769,235 (GRCm39) missense possibly damaging 0.82
R2185:Dnai3 UTSW 3 145,772,619 (GRCm39) missense possibly damaging 0.76
R4299:Dnai3 UTSW 3 145,774,561 (GRCm39) missense probably damaging 1.00
R4620:Dnai3 UTSW 3 145,748,564 (GRCm39) missense probably damaging 1.00
R4649:Dnai3 UTSW 3 145,753,922 (GRCm39) missense probably damaging 1.00
R4914:Dnai3 UTSW 3 145,772,582 (GRCm39) missense probably damaging 0.98
R4948:Dnai3 UTSW 3 145,788,820 (GRCm39) nonsense probably null
R5578:Dnai3 UTSW 3 145,802,983 (GRCm39) nonsense probably null
R6130:Dnai3 UTSW 3 145,748,559 (GRCm39) missense probably benign 0.25
R6291:Dnai3 UTSW 3 145,772,648 (GRCm39) missense probably benign 0.00
R6390:Dnai3 UTSW 3 145,801,143 (GRCm39) missense probably damaging 1.00
R6560:Dnai3 UTSW 3 145,801,161 (GRCm39) missense possibly damaging 0.79
R6893:Dnai3 UTSW 3 145,786,184 (GRCm39) missense probably damaging 1.00
R7090:Dnai3 UTSW 3 145,746,582 (GRCm39) missense possibly damaging 0.80
R7102:Dnai3 UTSW 3 145,761,459 (GRCm39) missense possibly damaging 0.49
R7111:Dnai3 UTSW 3 145,803,028 (GRCm39) missense probably damaging 0.99
R7260:Dnai3 UTSW 3 145,752,295 (GRCm39) missense probably benign 0.01
R7288:Dnai3 UTSW 3 145,787,007 (GRCm39) missense probably damaging 0.97
R7411:Dnai3 UTSW 3 145,802,900 (GRCm39) missense probably damaging 0.98
R7417:Dnai3 UTSW 3 145,798,835 (GRCm39) splice site probably null
R7466:Dnai3 UTSW 3 145,761,373 (GRCm39) missense probably benign 0.01
R7860:Dnai3 UTSW 3 145,772,675 (GRCm39) missense probably damaging 0.99
R7964:Dnai3 UTSW 3 145,774,531 (GRCm39) missense probably benign 0.09
R8013:Dnai3 UTSW 3 145,787,040 (GRCm39) missense probably damaging 1.00
R8059:Dnai3 UTSW 3 145,752,428 (GRCm39) missense possibly damaging 0.75
R8191:Dnai3 UTSW 3 145,800,066 (GRCm39) missense probably damaging 1.00
R8354:Dnai3 UTSW 3 145,802,982 (GRCm39) missense probably damaging 1.00
R8454:Dnai3 UTSW 3 145,802,982 (GRCm39) missense probably damaging 1.00
R8770:Dnai3 UTSW 3 145,752,298 (GRCm39) missense probably benign 0.01
R8967:Dnai3 UTSW 3 145,761,395 (GRCm39) missense possibly damaging 0.95
R9135:Dnai3 UTSW 3 145,772,589 (GRCm39) missense probably benign 0.39
R9310:Dnai3 UTSW 3 145,802,895 (GRCm39) critical splice donor site probably null
R9664:Dnai3 UTSW 3 145,748,594 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ACACACTTTTAAGATCTGCCCC -3'
(R):5'- GGAATTGCAGCAGGCCTTCC -3'

Sequencing Primer
(F):5'- CAGCCTGGTCTACAAAGTGAGTTC -3'
(R):5'- AGCAGGCCTTCCCGGAAAC -3'
Posted On 2017-10-10