Incidental Mutation 'R6162:Cd5'
ID 489940
Institutional Source Beutler Lab
Gene Symbol Cd5
Ensembl Gene ENSMUSG00000024669
Gene Name CD5 antigen
Synonyms Ly-A, Ly-1, Ly-12, Lyt-1
MMRRC Submission 044309-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6162 (G1)
Quality Score 206.009
Status Validated
Chromosome 19
Chromosomal Location 10695471-10716390 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 10703244 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 138 (T138M)
Ref Sequence ENSEMBL: ENSMUSP00000025571 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025571]
AlphaFold P13379
Predicted Effect probably damaging
Transcript: ENSMUST00000025571
AA Change: T138M

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000025571
Gene: ENSMUSG00000024669
AA Change: T138M

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
SR 34 133 7.43e-19 SMART
low complexity region 138 157 N/A INTRINSIC
SR 276 367 7.27e-4 SMART
transmembrane domain 379 401 N/A INTRINSIC
low complexity region 402 415 N/A INTRINSIC
Meta Mutation Damage Score 0.6329 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 98% (40/41)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutation of this gene does not result in a phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T G 11: 9,259,047 (GRCm39) C2924W probably damaging Het
Adh4 T A 3: 138,121,250 (GRCm39) probably null Het
Aox3 A T 1: 58,198,890 (GRCm39) D695V possibly damaging Het
Ccnj A G 19: 40,833,606 (GRCm39) Y221C probably damaging Het
Cct2 T A 10: 116,894,091 (GRCm39) D221V probably damaging Het
Cep78 A T 19: 15,952,304 (GRCm39) M307K probably benign Het
Dclk1 C A 3: 55,163,575 (GRCm39) D222E probably benign Het
Dhrs11 C T 11: 84,719,605 (GRCm39) G40D probably damaging Het
Dnah10 A G 5: 124,900,382 (GRCm39) S3823G probably benign Het
Dnai3 T A 3: 145,750,617 (GRCm39) I821F probably damaging Het
Dock3 A T 9: 106,841,998 (GRCm39) Y944N possibly damaging Het
Dst A G 1: 34,045,318 (GRCm39) D17G probably damaging Het
Ehmt2 C T 17: 35,118,067 (GRCm39) R40* probably null Het
Fam20a G T 11: 109,573,696 (GRCm39) S229* probably null Het
Fbn1 T C 2: 125,202,147 (GRCm39) D1242G probably damaging Het
Ggt5 T A 10: 75,425,626 (GRCm39) V28D possibly damaging Het
Gimap4 A T 6: 48,667,655 (GRCm39) I137F probably damaging Het
Git2 T A 5: 114,899,717 (GRCm39) H212L probably damaging Het
Gprc6a T A 10: 51,491,008 (GRCm39) I739F probably benign Het
Il1rl2 A G 1: 40,391,038 (GRCm39) Y327C probably damaging Het
Lmf1 A G 17: 25,831,368 (GRCm39) I205V probably benign Het
Mipep C A 14: 61,024,853 (GRCm39) P98Q probably damaging Het
Mroh2b A G 15: 4,944,707 (GRCm39) D436G probably damaging Het
Mtcl2 T A 2: 156,881,784 (GRCm39) E756V possibly damaging Het
Myorg A G 4: 41,497,899 (GRCm39) V577A possibly damaging Het
Notch1 C T 2: 26,352,207 (GRCm39) V2035I probably benign Het
Or1e28-ps1 T A 11: 73,615,713 (GRCm39) I46F probably damaging Het
Or2ag16 A T 7: 106,352,227 (GRCm39) Y123N probably damaging Het
Or4c118 G T 2: 88,975,114 (GRCm39) F84L probably benign Het
Oxa1l A G 14: 54,605,789 (GRCm39) T395A probably damaging Het
Phospho2 T A 2: 69,626,375 (GRCm39) I177K probably damaging Het
Prpf40a T C 2: 53,049,317 (GRCm39) T224A probably benign Het
Reln T A 5: 22,116,048 (GRCm39) T2987S probably damaging Het
Scn5a T A 9: 119,351,621 (GRCm39) I787F probably damaging Het
Sgsm2 A T 11: 74,782,847 (GRCm39) D36E probably damaging Het
Slc12a3 A G 8: 95,072,401 (GRCm39) probably null Het
Tas2r134 T C 2: 51,517,571 (GRCm39) S17P probably damaging Het
Top3a T C 11: 60,636,763 (GRCm39) Y609C probably damaging Het
Trem2 A G 17: 48,655,694 (GRCm39) I84V probably damaging Het
Vmn2r12 A G 5: 109,234,430 (GRCm39) L594P probably damaging Het
Zdbf2 A T 1: 63,319,977 (GRCm39) probably benign Het
Zfr C T 15: 12,146,331 (GRCm39) A294V unknown Het
Other mutations in Cd5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01705:Cd5 APN 19 10,703,659 (GRCm39) critical splice donor site probably null
IGL03392:Cd5 APN 19 10,703,653 (GRCm39) splice site probably benign
PIT4305001:Cd5 UTSW 19 10,703,750 (GRCm39) missense possibly damaging 0.72
R0732:Cd5 UTSW 19 10,700,649 (GRCm39) missense probably damaging 1.00
R1831:Cd5 UTSW 19 10,696,933 (GRCm39) missense probably damaging 1.00
R2086:Cd5 UTSW 19 10,700,620 (GRCm39) missense probably benign 0.00
R4184:Cd5 UTSW 19 10,698,638 (GRCm39) missense probably damaging 1.00
R6894:Cd5 UTSW 19 10,716,203 (GRCm39) missense possibly damaging 0.91
R7138:Cd5 UTSW 19 10,697,668 (GRCm39) missense probably damaging 1.00
R7653:Cd5 UTSW 19 10,703,910 (GRCm39) missense probably benign 0.00
R8297:Cd5 UTSW 19 10,697,609 (GRCm39) missense probably damaging 1.00
R8408:Cd5 UTSW 19 10,700,469 (GRCm39) missense possibly damaging 0.89
R8411:Cd5 UTSW 19 10,697,585 (GRCm39) missense probably damaging 1.00
R8699:Cd5 UTSW 19 10,702,556 (GRCm39) missense possibly damaging 0.67
R9663:Cd5 UTSW 19 10,703,858 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- ATTCAGATGTAACTGGGCCTCTTAG -3'
(R):5'- CTCCTAGGGAGTTGAGAAGCAG -3'

Sequencing Primer
(F):5'- AGAATACTGACGGGCCTCATCTG -3'
(R):5'- CAGAATGGGAATGGAGGTCAAGTC -3'
Posted On 2017-10-10