Incidental Mutation 'R6163:Vmn2r58'
| ID |
489969 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r58
|
| Ensembl Gene |
ENSMUSG00000090383 |
| Gene Name |
vomeronasal 2, receptor 58 |
| Synonyms |
EG628422 |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.377)
|
| Stock # |
R6163 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
41486305-41522094 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 41486825 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 690
(M690T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126966
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171671]
|
| AlphaFold |
K7N6V2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171671
AA Change: M690T
PolyPhen 2
Score 0.305 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000126966
Gene: ENSMUSG00000090383
AA Change: M690T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
8e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.8e-23 |
PFAM |
|
Pfam:7tm_3
|
597 |
835 |
2.9e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.0%
- 20x: 94.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700018F24Rik |
C |
T |
5: 144,982,098 (GRCm39) |
Q228* |
probably null |
Het |
| Asic5 |
A |
G |
3: 81,913,833 (GRCm39) |
N169S |
probably damaging |
Het |
| Atad2b |
T |
A |
12: 5,004,593 (GRCm39) |
L374H |
probably benign |
Het |
| Birc2 |
G |
A |
9: 7,819,036 (GRCm39) |
T544I |
probably benign |
Het |
| Blm |
GCCTCCTCCTCCTCCTCCTCCTCCTCCTCC |
GCCTCCTCCTCCTCCTCCTCCTCCTCC |
7: 80,162,652 (GRCm39) |
|
probably benign |
Het |
| Cc2d2b |
C |
T |
19: 40,744,950 (GRCm39) |
T23I |
probably benign |
Het |
| Ccdc137 |
G |
T |
11: 120,350,927 (GRCm39) |
R108L |
possibly damaging |
Het |
| Cenpe |
T |
C |
3: 134,974,764 (GRCm39) |
I2308T |
probably damaging |
Het |
| Clec2m |
C |
T |
6: 129,303,710 (GRCm39) |
R85H |
probably benign |
Het |
| Cpt1b |
T |
C |
15: 89,308,620 (GRCm39) |
T103A |
probably benign |
Het |
| Cpvl |
C |
A |
6: 53,850,503 (GRCm39) |
V445F |
probably damaging |
Het |
| Cttnbp2 |
A |
G |
6: 18,434,950 (GRCm39) |
S303P |
possibly damaging |
Het |
| Cyp17a1 |
T |
A |
19: 46,657,761 (GRCm39) |
I264F |
possibly damaging |
Het |
| Cyp51 |
T |
A |
5: 4,150,199 (GRCm39) |
I175F |
probably damaging |
Het |
| Dennd4c |
C |
T |
4: 86,723,828 (GRCm39) |
P695S |
possibly damaging |
Het |
| Dlgap2 |
A |
T |
8: 14,896,641 (GRCm39) |
Q1039L |
probably damaging |
Het |
| Dnah14 |
T |
C |
1: 181,493,926 (GRCm39) |
L1694P |
probably benign |
Het |
| Dnah2 |
G |
A |
11: 69,411,729 (GRCm39) |
Q298* |
probably null |
Het |
| Dsg2 |
G |
T |
18: 20,731,726 (GRCm39) |
|
probably null |
Het |
| Esr2 |
A |
C |
12: 76,168,643 (GRCm39) |
V522G |
probably damaging |
Het |
| Fmo9 |
T |
A |
1: 166,494,962 (GRCm39) |
H262L |
probably benign |
Het |
| Glb1l |
T |
A |
1: 75,178,051 (GRCm39) |
M373L |
probably benign |
Het |
| Gls |
A |
G |
1: 52,254,735 (GRCm39) |
S247P |
probably benign |
Het |
| Gm37240 |
T |
A |
3: 84,423,092 (GRCm39) |
E213D |
probably damaging |
Het |
| Gmip |
T |
A |
8: 70,270,022 (GRCm39) |
V675E |
probably benign |
Het |
| Grb10 |
C |
A |
11: 11,893,932 (GRCm39) |
E330* |
probably null |
Het |
| H2ac13 |
A |
T |
13: 21,900,859 (GRCm39) |
N90Y |
probably damaging |
Het |
| Hivep2 |
A |
G |
10: 14,005,736 (GRCm39) |
K778R |
probably damaging |
Het |
| Ighv1-26 |
T |
C |
12: 114,752,416 (GRCm39) |
S4G |
probably benign |
Het |
| Igkv3-3 |
T |
A |
6: 70,664,257 (GRCm39) |
V33E |
possibly damaging |
Het |
| Itga2 |
C |
A |
13: 115,002,726 (GRCm39) |
G588V |
probably damaging |
Het |
| Itpr1 |
C |
T |
6: 108,365,245 (GRCm39) |
H58Y |
probably damaging |
Het |
| Jmjd1c |
T |
A |
10: 67,083,827 (GRCm39) |
D2365E |
possibly damaging |
Het |
| Limk1 |
T |
C |
5: 134,686,809 (GRCm39) |
Y518C |
probably damaging |
Het |
| Marchf6 |
G |
C |
15: 31,465,497 (GRCm39) |
H802Q |
probably benign |
Het |
| Mark2 |
A |
G |
19: 7,268,126 (GRCm39) |
S26P |
probably benign |
Het |
| Mdn1 |
T |
A |
4: 32,716,040 (GRCm39) |
L2074Q |
probably damaging |
Het |
| Mrpl37 |
T |
C |
4: 106,921,793 (GRCm39) |
E174G |
possibly damaging |
Het |
| Mtcl1 |
T |
C |
17: 66,686,326 (GRCm39) |
H860R |
probably benign |
Het |
| Neurod1 |
A |
G |
2: 79,284,505 (GRCm39) |
F293L |
probably benign |
Het |
| Nwd1 |
C |
T |
8: 73,388,814 (GRCm39) |
R81W |
probably damaging |
Het |
| Nwd2 |
C |
A |
5: 63,963,131 (GRCm39) |
A905E |
probably benign |
Het |
| Or14a260 |
A |
T |
7: 85,985,592 (GRCm39) |
I4N |
possibly damaging |
Het |
| Or1x6 |
T |
A |
11: 50,939,595 (GRCm39) |
Y220* |
probably null |
Het |
| Or5b12b |
A |
C |
19: 12,861,472 (GRCm39) |
T76P |
probably damaging |
Het |
| Or7e169 |
A |
G |
9: 19,757,024 (GRCm39) |
I297T |
probably benign |
Het |
| Otop1 |
C |
A |
5: 38,445,234 (GRCm39) |
|
probably null |
Het |
| Otp |
A |
G |
13: 95,012,288 (GRCm39) |
H4R |
probably damaging |
Het |
| P4htm |
A |
C |
9: 108,459,150 (GRCm39) |
Y261D |
probably damaging |
Het |
| Pcsk5 |
A |
T |
19: 17,450,405 (GRCm39) |
C1148S |
probably damaging |
Het |
| Plekhg1 |
A |
T |
10: 3,914,369 (GRCm39) |
R1419W |
probably damaging |
Het |
| Pramel20 |
A |
G |
4: 143,298,605 (GRCm39) |
K183E |
probably damaging |
Het |
| Prkd3 |
C |
A |
17: 79,273,784 (GRCm39) |
D491Y |
possibly damaging |
Het |
| Prr11 |
A |
C |
11: 86,994,454 (GRCm39) |
L64R |
possibly damaging |
Het |
| Pygo1 |
G |
T |
9: 72,851,980 (GRCm39) |
A56S |
probably damaging |
Het |
| Rexo5 |
A |
G |
7: 119,404,470 (GRCm39) |
T189A |
probably damaging |
Het |
| Rnf213 |
A |
T |
11: 119,349,254 (GRCm39) |
H3784L |
possibly damaging |
Het |
| Rps6ka5 |
T |
G |
12: 100,562,179 (GRCm39) |
|
probably null |
Het |
| Slco2b1 |
T |
A |
7: 99,338,106 (GRCm39) |
I93F |
probably damaging |
Het |
| Slfn8 |
T |
C |
11: 82,894,690 (GRCm39) |
*408W |
probably null |
Het |
| Sptbn1 |
C |
A |
11: 30,109,443 (GRCm39) |
E51* |
probably null |
Het |
| Ssc5d |
T |
A |
7: 4,930,253 (GRCm39) |
H111Q |
probably damaging |
Het |
| Sult1c2 |
T |
C |
17: 54,280,981 (GRCm39) |
N41D |
probably benign |
Het |
| Taar8c |
G |
A |
10: 23,977,116 (GRCm39) |
T232I |
probably benign |
Het |
| Tdo2 |
T |
C |
3: 81,882,710 (GRCm39) |
E2G |
possibly damaging |
Het |
| Tff2 |
T |
C |
17: 31,363,152 (GRCm39) |
E24G |
probably benign |
Het |
| Tjp2 |
C |
A |
19: 24,103,068 (GRCm39) |
|
probably null |
Het |
| Tnfrsf1b |
A |
T |
4: 144,946,477 (GRCm39) |
D311E |
probably benign |
Het |
| Usp15 |
G |
T |
10: 123,004,210 (GRCm39) |
N181K |
probably damaging |
Het |
| Vmn1r175 |
T |
G |
7: 23,508,591 (GRCm39) |
E12A |
possibly damaging |
Het |
| Vmn1r47 |
T |
C |
6: 89,999,773 (GRCm39) |
S302P |
probably damaging |
Het |
| Wee1 |
T |
A |
7: 109,734,858 (GRCm39) |
H465Q |
probably damaging |
Het |
| Zfr |
C |
T |
15: 12,146,331 (GRCm39) |
A294V |
unknown |
Het |
|
| Other mutations in Vmn2r58 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Vmn2r58
|
APN |
7 |
41,513,854 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL00924:Vmn2r58
|
APN |
7 |
41,486,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01291:Vmn2r58
|
APN |
7 |
41,513,935 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01480:Vmn2r58
|
APN |
7 |
41,514,116 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01551:Vmn2r58
|
APN |
7 |
41,514,703 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01591:Vmn2r58
|
APN |
7 |
41,514,753 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01940:Vmn2r58
|
APN |
7 |
41,487,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01994:Vmn2r58
|
APN |
7 |
41,486,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02041:Vmn2r58
|
APN |
7 |
41,514,703 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02222:Vmn2r58
|
APN |
7 |
41,513,449 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02317:Vmn2r58
|
APN |
7 |
41,486,765 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02614:Vmn2r58
|
APN |
7 |
41,486,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02673:Vmn2r58
|
APN |
7 |
41,514,082 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03323:Vmn2r58
|
APN |
7 |
41,511,295 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03337:Vmn2r58
|
APN |
7 |
41,513,810 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03380:Vmn2r58
|
APN |
7 |
41,513,874 (GRCm39) |
missense |
probably benign |
0.00 |
|
ANU05:Vmn2r58
|
UTSW |
7 |
41,513,935 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0138:Vmn2r58
|
UTSW |
7 |
41,487,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0141:Vmn2r58
|
UTSW |
7 |
41,511,309 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0421:Vmn2r58
|
UTSW |
7 |
41,514,628 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0604:Vmn2r58
|
UTSW |
7 |
41,510,000 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0854:Vmn2r58
|
UTSW |
7 |
41,486,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1413:Vmn2r58
|
UTSW |
7 |
41,513,387 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1441:Vmn2r58
|
UTSW |
7 |
41,486,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1678:Vmn2r58
|
UTSW |
7 |
41,513,480 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1691:Vmn2r58
|
UTSW |
7 |
41,486,913 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1699:Vmn2r58
|
UTSW |
7 |
41,509,951 (GRCm39) |
missense |
probably benign |
|
|
R1865:Vmn2r58
|
UTSW |
7 |
41,486,682 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2008:Vmn2r58
|
UTSW |
7 |
41,509,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2036:Vmn2r58
|
UTSW |
7 |
41,513,417 (GRCm39) |
missense |
probably benign |
|
|
R2202:Vmn2r58
|
UTSW |
7 |
41,513,594 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3787:Vmn2r58
|
UTSW |
7 |
41,513,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3883:Vmn2r58
|
UTSW |
7 |
41,513,914 (GRCm39) |
nonsense |
probably null |
|
|
R3944:Vmn2r58
|
UTSW |
7 |
41,513,885 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3949:Vmn2r58
|
UTSW |
7 |
41,513,348 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4232:Vmn2r58
|
UTSW |
7 |
41,487,011 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4409:Vmn2r58
|
UTSW |
7 |
41,522,051 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4411:Vmn2r58
|
UTSW |
7 |
41,511,360 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4413:Vmn2r58
|
UTSW |
7 |
41,511,360 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4600:Vmn2r58
|
UTSW |
7 |
41,522,046 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4610:Vmn2r58
|
UTSW |
7 |
41,487,117 (GRCm39) |
missense |
probably benign |
|
|
R4646:Vmn2r58
|
UTSW |
7 |
41,509,935 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4793:Vmn2r58
|
UTSW |
7 |
41,514,495 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4870:Vmn2r58
|
UTSW |
7 |
41,486,639 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R4981:Vmn2r58
|
UTSW |
7 |
41,486,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Vmn2r58
|
UTSW |
7 |
41,487,176 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5024:Vmn2r58
|
UTSW |
7 |
41,513,746 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5064:Vmn2r58
|
UTSW |
7 |
41,486,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5330:Vmn2r58
|
UTSW |
7 |
41,513,384 (GRCm39) |
nonsense |
probably null |
|
|
R5526:Vmn2r58
|
UTSW |
7 |
41,522,069 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5980:Vmn2r58
|
UTSW |
7 |
41,514,480 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6365:Vmn2r58
|
UTSW |
7 |
41,513,607 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6567:Vmn2r58
|
UTSW |
7 |
41,514,673 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6594:Vmn2r58
|
UTSW |
7 |
41,486,535 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6980:Vmn2r58
|
UTSW |
7 |
41,513,662 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7373:Vmn2r58
|
UTSW |
7 |
41,487,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7458:Vmn2r58
|
UTSW |
7 |
41,487,123 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7630:Vmn2r58
|
UTSW |
7 |
41,513,611 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7807:Vmn2r58
|
UTSW |
7 |
41,521,910 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8114:Vmn2r58
|
UTSW |
7 |
41,511,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8232:Vmn2r58
|
UTSW |
7 |
41,514,076 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8313:Vmn2r58
|
UTSW |
7 |
41,521,952 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8412:Vmn2r58
|
UTSW |
7 |
41,513,722 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8530:Vmn2r58
|
UTSW |
7 |
41,513,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8851:Vmn2r58
|
UTSW |
7 |
41,487,219 (GRCm39) |
missense |
probably benign |
|
|
R8881:Vmn2r58
|
UTSW |
7 |
41,486,609 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8936:Vmn2r58
|
UTSW |
7 |
41,513,981 (GRCm39) |
missense |
|
|
|
R9045:Vmn2r58
|
UTSW |
7 |
41,487,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9166:Vmn2r58
|
UTSW |
7 |
41,513,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9706:Vmn2r58
|
UTSW |
7 |
41,510,000 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF006:Vmn2r58
|
UTSW |
7 |
41,486,383 (GRCm39) |
frame shift |
probably null |
|
|
RF027:Vmn2r58
|
UTSW |
7 |
41,486,383 (GRCm39) |
frame shift |
probably null |
|
|
Z1176:Vmn2r58
|
UTSW |
7 |
41,513,789 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCCAGTACAGTGTGGAAGG -3'
(R):5'- GGCCAATAACAGGACTCTCAG -3'
Sequencing Primer
(F):5'- GCAACTGTTGAACCCATGTTG -3'
(R):5'- TAACAGGACTCTCAGTTACATCCTG -3'
|
| Posted On |
2017-10-10 |
Incidental Mutation