Incidental Mutation 'R6166:Or6k2'
ID 490124
Institutional Source Beutler Lab
Gene Symbol Or6k2
Ensembl Gene ENSMUSG00000055033
Gene Name olfactory receptor family 6 subfamily K member 2
Synonyms GA_x6K02T2P20D-20995211-20994246, MOR105-10, Olfr420
MMRRC Submission 044312-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # R6166 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 173986288-173987333 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 173986659 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 107 (T107A)
Ref Sequence ENSEMBL: ENSMUSP00000149052 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068403] [ENSMUST00000213748]
AlphaFold E9Q4G0
Predicted Effect probably benign
Transcript: ENSMUST00000068403
AA Change: T107A

PolyPhen 2 Score 0.429 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000069662
Gene: ENSMUSG00000055033
AA Change: T107A

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 9.9e-60 PFAM
Pfam:7tm_1 41 292 4.1e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213748
AA Change: T107A

PolyPhen 2 Score 0.429 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.7%
Validation Efficiency 97% (57/59)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot2 A T 12: 84,039,378 (GRCm39) N296Y probably damaging Het
Ago2 T A 15: 72,996,089 (GRCm39) I347L probably benign Het
Aldh1l2 C T 10: 83,329,288 (GRCm39) probably null Het
Ap1ar A G 3: 127,606,177 (GRCm39) probably null Het
Arap3 T C 18: 38,107,423 (GRCm39) T1365A probably damaging Het
Arhgef17 A T 7: 100,525,699 (GRCm39) H1966Q probably damaging Het
Arpp21 T C 9: 111,948,266 (GRCm39) T668A probably benign Het
Atg13 G T 2: 91,506,736 (GRCm39) Q479K probably damaging Het
Bmp8a T C 4: 123,218,471 (GRCm39) T183A probably benign Het
Camta2 G C 11: 70,565,087 (GRCm39) probably null Het
Catspere2 A G 1: 177,931,403 (GRCm39) T441A unknown Het
Ccdc40 T C 11: 119,122,827 (GRCm39) S210P probably benign Het
Cnn2 A G 10: 79,824,561 (GRCm39) E17G possibly damaging Het
Cnot6l T C 5: 96,227,799 (GRCm39) D478G possibly damaging Het
Cplane1 A G 15: 8,216,044 (GRCm39) H478R probably benign Het
Csf2rb A G 15: 78,228,766 (GRCm39) Y369C probably damaging Het
Dll4 A G 2: 119,165,107 (GRCm39) probably null Het
Efcab6 A G 15: 83,780,316 (GRCm39) V1039A probably benign Het
Fam117a T C 11: 95,271,607 (GRCm39) M393T possibly damaging Het
Fancd2 T A 6: 113,532,212 (GRCm39) N508K possibly damaging Het
Fat1 T C 8: 45,405,522 (GRCm39) S758P probably damaging Het
Fgf20 T C 8: 40,732,881 (GRCm39) K186E probably damaging Het
Filip1 T C 9: 79,726,736 (GRCm39) K628E probably damaging Het
Fsip2 G T 2: 82,811,071 (GRCm39) K2463N probably benign Het
Gm15446 T A 5: 110,090,646 (GRCm39) Y299* probably null Het
Gm7363 A T 7: 3,986,784 (GRCm39) noncoding transcript Het
Gpx5 A T 13: 21,473,435 (GRCm39) F104I probably damaging Het
Grip1 A T 10: 119,908,623 (GRCm39) I618F probably damaging Het
Hmcn2 G A 2: 31,259,274 (GRCm39) G1038D probably damaging Het
Lgals9 C T 11: 78,862,184 (GRCm39) A134T probably benign Het
Lrba G A 3: 86,261,614 (GRCm39) probably null Het
Lypd10 A T 7: 24,413,644 (GRCm39) Q220L probably benign Het
Naprt T C 15: 75,763,326 (GRCm39) Q439R possibly damaging Het
Ndufs6 G A 13: 73,466,060 (GRCm39) probably benign Het
Nodal C A 10: 61,260,337 (GRCm39) S329R probably damaging Het
Olfm3 T A 3: 114,916,074 (GRCm39) N315K probably damaging Het
Or4k2 C T 14: 50,424,225 (GRCm39) V150I probably benign Het
Or6c3b A T 10: 129,527,148 (GRCm39) I254K probably damaging Het
Plg T A 17: 12,617,001 (GRCm39) V373E probably damaging Het
Prdm2 A C 4: 142,861,306 (GRCm39) S661R probably damaging Het
Psg21 A T 7: 18,390,664 (GRCm39) probably benign Het
Rhobtb2 T C 14: 70,035,627 (GRCm39) D148G probably damaging Het
Rsf1 GCG GCGACGGCGACG 7: 97,229,114 (GRCm39) probably benign Het
Scaf11 A T 15: 96,322,543 (GRCm39) N116K probably damaging Het
Sf3a3 T C 4: 124,617,177 (GRCm39) probably benign Homo
Slc38a9 T G 13: 112,831,801 (GRCm39) Y184D possibly damaging Het
Sowahc A G 10: 59,058,182 (GRCm39) D106G probably benign Het
Srbd1 T C 17: 86,406,696 (GRCm39) Y563C probably damaging Het
Src A G 2: 157,310,442 (GRCm39) Y359C probably damaging Het
Tbc1d9b A G 11: 50,026,673 (GRCm39) D47G probably damaging Het
Tctn3 T C 19: 40,585,923 (GRCm39) K541E possibly damaging Het
Tgm7 A G 2: 120,929,539 (GRCm39) V245A probably damaging Het
Thbs2 C T 17: 14,900,650 (GRCm39) R519H probably damaging Het
Tm4sf19 T C 16: 32,226,681 (GRCm39) S157P probably damaging Het
Trio C T 15: 27,818,157 (GRCm39) S507N probably damaging Het
Trrap T A 5: 144,718,791 (GRCm39) H152Q possibly damaging Het
Vmn2r56 A G 7: 12,427,947 (GRCm39) L773P probably damaging Het
Vmn2r70 A G 7: 85,215,189 (GRCm39) L115P probably benign Het
Wdr59 C T 8: 112,199,293 (GRCm39) R631H probably damaging Het
Other mutations in Or6k2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01394:Or6k2 APN 1 173,986,423 (GRCm39) missense probably damaging 1.00
IGL02479:Or6k2 APN 1 173,986,520 (GRCm39) nonsense probably null
IGL03190:Or6k2 APN 1 173,987,110 (GRCm39) missense probably damaging 0.99
IGL03270:Or6k2 APN 1 173,987,119 (GRCm39) missense probably benign 0.04
R0645:Or6k2 UTSW 1 173,986,920 (GRCm39) missense probably benign 0.00
R0834:Or6k2 UTSW 1 173,986,930 (GRCm39) missense possibly damaging 0.55
R1432:Or6k2 UTSW 1 173,986,483 (GRCm39) missense possibly damaging 0.67
R1508:Or6k2 UTSW 1 173,986,930 (GRCm39) missense possibly damaging 0.55
R2351:Or6k2 UTSW 1 173,986,486 (GRCm39) missense probably damaging 0.99
R3440:Or6k2 UTSW 1 173,986,746 (GRCm39) missense probably benign 0.14
R3441:Or6k2 UTSW 1 173,986,746 (GRCm39) missense probably benign 0.14
R4571:Or6k2 UTSW 1 173,986,494 (GRCm39) missense possibly damaging 0.77
R5072:Or6k2 UTSW 1 173,986,527 (GRCm39) missense probably damaging 1.00
R6060:Or6k2 UTSW 1 173,986,907 (GRCm39) nonsense probably null
R6228:Or6k2 UTSW 1 173,979,712 (GRCm39) missense probably benign 0.00
R6272:Or6k2 UTSW 1 173,986,741 (GRCm39) missense probably benign 0.02
R6298:Or6k2 UTSW 1 173,979,748 (GRCm39) missense probably benign 0.02
R6400:Or6k2 UTSW 1 173,986,830 (GRCm39) missense probably damaging 0.99
R7581:Or6k2 UTSW 1 173,986,337 (GRCm39) splice site probably null
R7677:Or6k2 UTSW 1 173,986,614 (GRCm39) missense probably damaging 1.00
R7823:Or6k2 UTSW 1 173,987,254 (GRCm39) missense probably benign 0.12
R7829:Or6k2 UTSW 1 173,986,425 (GRCm39) missense probably benign 0.00
R8077:Or6k2 UTSW 1 173,979,411 (GRCm39) unclassified probably benign
R8519:Or6k2 UTSW 1 173,986,614 (GRCm39) missense probably damaging 0.99
R9106:Or6k2 UTSW 1 173,986,369 (GRCm39) missense probably benign 0.00
R9205:Or6k2 UTSW 1 173,986,456 (GRCm39) missense probably benign 0.33
R9507:Or6k2 UTSW 1 173,986,552 (GRCm39) missense possibly damaging 0.94
R9797:Or6k2 UTSW 1 173,986,417 (GRCm39) missense probably benign
Z1187:Or6k2 UTSW 1 173,986,907 (GRCm39) nonsense probably null
Z1192:Or6k2 UTSW 1 173,986,907 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GGTTATCATCACAGTGGTCCAG -3'
(R):5'- ATGCTCAAGGTGATTAGAGCC -3'

Sequencing Primer
(F):5'- TCACAGTGGTCCAGCTCAACG -3'
(R):5'- CTCAAGGTGATTAGAGCCACAAAAAG -3'
Posted On 2017-10-10