Mutagenetix > Incidental Mutations

Incidental Mutation 'R0529:Vmn1r174'

49049

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r174

Ensembl Gene

ENSMUSG00000090411

Gene Name

vomeronasal 1 receptor 174

Synonyms

V1rd22

MMRRC Submission

038721-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.078) question?

Stock #

R0529 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

23752270-23762403 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 23754197 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Histidine at position 96 (R96H)

Ref Sequence

ENSEMBL: ENSMUSP00000154506 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167551] [ENSMUST00000228331]

Predicted Effect

probably benign
Transcript: ENSMUST00000167551
AA Change: R96H

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000126478
Gene: ENSMUSG00000090411
AA Change: R96H

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	300	4e-9	PFAM
Pfam:V1R	43	300	5e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000228331
AA Change: R96H

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.5%
20x: 93.3%

Validation Efficiency

97% (58/60)

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	G	A	17: 8,992,396	V126I	probably benign	Het
Aasdh	A	C	5: 76,876,267	Y179*	probably null	Het
Afp	A	G	5: 90,504,395	Y415C	probably damaging	Het
Aldh5a1	G	T	13: 24,913,873	T393K	probably benign	Het
Arhgef26	T	C	3: 62,339,725	S77P	probably benign	Het
Axl	A	G	7: 25,787,287		probably benign	Het
Card10	A	G	15: 78,780,475		probably null	Het
Ccdc71l	G	A	12: 32,379,252	S90N	probably damaging	Het
Cebpa	A	T	7: 35,120,199	T261S	probably benign	Het
Cnmd	T	C	14: 79,642,041	E219G	probably benign	Het
Cntln	T	A	4: 85,067,825	L1010H	probably damaging	Het
Cul9	A	G	17: 46,520,468		probably benign	Het
Cyld	A	G	8: 88,729,759	E479G	probably benign	Het
Dmp1	A	G	5: 104,212,226	E256G	probably benign	Het
Dnmt1	T	C	9: 20,911,550	D1140G	probably damaging	Het
Drd2	A	C	9: 49,407,074	M439L	probably benign	Het
Drd3	G	A	16: 43,822,714	V438M	probably damaging	Het
Dyrk3	A	G	1: 131,130,121	I70T	probably benign	Het
Fam46c	A	G	3: 100,472,370	Y357H	probably benign	Het
Fbxo38	T	C	18: 62,505,986	K1082E	probably damaging	Het
Fbxw10	A	C	11: 62,859,845	D428A	probably damaging	Het
Fmn1	T	A	2: 113,707,853		probably benign	Het
Fmnl2	A	T	2: 53,042,365	I119F	probably damaging	Het
Frmd4a	A	G	2: 4,606,023	T995A	probably damaging	Het
Gda	T	A	19: 21,425,537	I82F	probably damaging	Het
Gpatch4	T	A	3: 88,051,276	H22Q	probably damaging	Het
Gpr55	A	G	1: 85,941,503	F119L	probably benign	Het
Gtf2i	A	T	5: 134,261,869	L425*	probably null	Het
Knstrn	T	A	2: 118,830,980		probably benign	Het
Lipo2	T	A	19: 33,746,935	I144L	probably benign	Het
Lrp1	T	C	10: 127,541,594		probably null	Het
Mtmr14	T	C	6: 113,266,252		probably benign	Het
Nsmce4a	A	T	7: 130,533,806	S345R	probably benign	Het
Oacyl	T	A	18: 65,742,219	V385D	probably damaging	Het
Olfr421-ps1	G	A	1: 174,152,130	A205T	probably benign	Het
Olfr917	A	T	9: 38,665,512	C111S	probably benign	Het
Phlpp2	T	C	8: 109,876,971	S55P	probably benign	Het
Pkhd1l1	T	A	15: 44,526,754	V1422E	possibly damaging	Het
Plcd3	T	G	11: 103,080,187	H181P	probably benign	Het
Psmc5	G	A	11: 106,261,164		probably null	Het
Psmd11	T	C	11: 80,470,689		probably benign	Het
Rab39	T	C	9: 53,686,716	Y83C	probably damaging	Het
Ric8a	A	G	7: 140,860,893	E93G	probably damaging	Het
Rtp3	T	C	9: 110,987,084	E133G	possibly damaging	Het
Serpina1e	A	C	12: 103,949,104	L281R	probably damaging	Het
Slc35e1	T	C	8: 72,492,571		probably benign	Het
Tmem63a	A	T	1: 180,961,094	E332V	probably benign	Het
Tnk1	T	C	11: 69,855,164	T312A	probably damaging	Het
Traf3ip3	G	T	1: 193,194,811		probably benign	Het
Trappc11	A	G	8: 47,526,979	V174A	possibly damaging	Het
Vmn1r7	T	A	6: 57,024,465	Y270F	possibly damaging	Het
Vmn2r12	A	G	5: 109,092,848	V133A	probably benign	Het
Vmn2r18	T	A	5: 151,562,523	E502V	probably damaging	Het
Wipf3	C	A	6: 54,485,363	P186Q	probably damaging	Het
Yipf5	A	T	18: 40,212,162	M55K	probably benign	Het
Zbtb7a	G	A	10: 81,143,986	V5M	probably damaging	Het
Zfy1	G	T	Y: 726,040	S575Y	probably damaging	Het

Other mutations in Vmn1r174

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00331:Vmn1r174	APN	7	23754533	missense	possibly damaging	0.77
IGL00950:Vmn1r174	APN	7	23754486	missense	possibly damaging	0.96
IGL01484:Vmn1r174	APN	7	23754324	nonsense	probably null
IGL02014:Vmn1r174	APN	7	23754158	missense	probably damaging	1.00
IGL02190:Vmn1r174	APN	7	23754827	missense	unknown
IGL03265:Vmn1r174	APN	7	23754473	nonsense	probably null
IGL03335:Vmn1r174	APN	7	23754512	missense	probably benign	0.41
R1489:Vmn1r174	UTSW	7	23754556	nonsense	probably null
R1645:Vmn1r174	UTSW	7	23754352	missense	possibly damaging	0.87
R1691:Vmn1r174	UTSW	7	23753912	start codon destroyed	probably null	1.00
R1753:Vmn1r174	UTSW	7	23754197	missense	probably benign	0.00
R1939:Vmn1r174	UTSW	7	23754107	missense	probably damaging	0.99
R1988:Vmn1r174	UTSW	7	23754625	missense	probably damaging	0.98
R2299:Vmn1r174	UTSW	7	23754004	missense	probably benign	0.08
R4429:Vmn1r174	UTSW	7	23754140	missense	probably benign	0.02
R4516:Vmn1r174	UTSW	7	23754343	missense	probably benign	0.01
R4589:Vmn1r174	UTSW	7	23754779	nonsense	probably null
R5175:Vmn1r174	UTSW	7	23754728	missense	probably benign	0.03
R5392:Vmn1r174	UTSW	7	23754802	missense	unknown
R5503:Vmn1r174	UTSW	7	23754137	missense	probably benign	0.03
R5568:Vmn1r174	UTSW	7	23754494	missense	probably damaging	0.96
R6705:Vmn1r174	UTSW	7	23754426	missense	probably benign	0.25
R8168:Vmn1r174	UTSW	7	23754671	missense	probably damaging	0.99
R8190:Vmn1r174	UTSW	7	23754143	missense	probably damaging	1.00
R8523:Vmn1r174	UTSW	7	23754757	missense	probably damaging	1.00
R8555:Vmn1r174	UTSW	7	23754545	missense	possibly damaging	0.84
X0011:Vmn1r174	UTSW	7	23754481	missense	probably benign	0.03

Predicted Primers

PCR Primer
(F):5'- TTTGCTGGCCCTCAACTGAGAC -3'
(R):5'- TGCTGATGAATATGGCATCGTGGAC -3'

Sequencing Primer
(F):5'- GAGACCAAAACATGTCATTCTTGC -3'
(R):5'- GAGTTAGAACATACCCACTTGCTG -3'

Posted On

2013-06-12