Incidental Mutation 'IGL00309:Or10d4c'
ID 4907
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10d4c
Ensembl Gene ENSMUSG00000059106
Gene Name olfactory receptor family 10 subfamily D member 4C
Synonyms GA_x6K02T2PVTD-33343617-33344561, MOR224-5, Olfr961
Accession Numbers
Essential gene? Probably non essential (E-score: 0.180) question?
Stock # IGL00309
Quality Score
Status
Chromosome 9
Chromosomal Location 39558024-39558968 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 39558636 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 205 (S205T)
Ref Sequence ENSEMBL: ENSMUSP00000151840 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076548] [ENSMUST00000219295]
AlphaFold Q9EQ84
Predicted Effect probably benign
Transcript: ENSMUST00000076548
AA Change: S205T

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000075863
Gene: ENSMUSG00000059106
AA Change: S205T

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 1.1e-50 PFAM
Pfam:7tm_1 39 286 4.5e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000219295
AA Change: S205T

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933430I17Rik T C 4: 62,450,903 (GRCm39) probably benign Het
Abca9 T A 11: 110,051,342 (GRCm39) D118V probably benign Het
Adgrb2 T A 4: 129,912,598 (GRCm39) I1241N probably damaging Het
Arsb A G 13: 93,926,608 (GRCm39) D126G probably benign Het
BB014433 G T 8: 15,092,510 (GRCm39) N114K probably benign Het
Ccne2 T A 4: 11,199,322 (GRCm39) V241E probably benign Het
Ccnjl A T 11: 43,474,023 (GRCm39) K199N probably benign Het
Cyp2c55 A G 19: 39,000,190 (GRCm39) T130A probably benign Het
Cyp2c70 A T 19: 40,145,270 (GRCm39) N395K probably benign Het
Dst T C 1: 34,199,733 (GRCm39) V67A probably damaging Het
Dysf G A 6: 84,085,081 (GRCm39) R806H probably damaging Het
Extl3 G A 14: 65,314,438 (GRCm39) P248L probably benign Het
Fcgbp A G 7: 27,784,555 (GRCm39) D205G probably damaging Het
Gga1 G T 15: 78,767,555 (GRCm39) V98L possibly damaging Het
Gpr6 C T 10: 40,946,812 (GRCm39) A257T probably damaging Het
Mex3c C T 18: 73,722,960 (GRCm39) T351M probably damaging Het
Or10g3b A G 14: 52,587,167 (GRCm39) V112A probably benign Het
Or5ar1 A T 2: 85,671,706 (GRCm39) V143D probably benign Het
Or5g26 A T 2: 85,494,700 (GRCm39) V26D probably benign Het
Prex1 A G 2: 166,451,743 (GRCm39) Y412H probably damaging Het
Slc25a25 A T 2: 32,309,172 (GRCm39) V75E probably benign Het
Sv2c A G 13: 96,184,937 (GRCm39) C247R probably damaging Het
Trpm5 A T 7: 142,636,728 (GRCm39) V403E probably benign Het
Wdr17 A G 8: 55,140,746 (GRCm39) V202A probably damaging Het
Zscan25 A G 5: 145,220,559 (GRCm39) E118G probably damaging Het
Other mutations in Or10d4c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01792:Or10d4c APN 9 39,558,955 (GRCm39) missense probably benign 0.07
R0344:Or10d4c UTSW 9 39,558,646 (GRCm39) missense probably damaging 1.00
R0503:Or10d4c UTSW 9 39,558,772 (GRCm39) missense probably damaging 1.00
R0525:Or10d4c UTSW 9 39,558,767 (GRCm39) missense probably damaging 1.00
R0531:Or10d4c UTSW 9 39,558,168 (GRCm39) missense probably benign
R1188:Or10d4c UTSW 9 39,558,772 (GRCm39) missense probably damaging 1.00
R1453:Or10d4c UTSW 9 39,558,459 (GRCm39) missense probably benign 0.01
R2970:Or10d4c UTSW 9 39,558,195 (GRCm39) missense probably damaging 1.00
R3883:Or10d4c UTSW 9 39,558,420 (GRCm39) missense probably benign 0.07
R4423:Or10d4c UTSW 9 39,558,412 (GRCm39) missense probably damaging 1.00
R5129:Or10d4c UTSW 9 39,558,790 (GRCm39) missense probably benign 0.03
R6148:Or10d4c UTSW 9 39,558,555 (GRCm39) missense probably damaging 1.00
R6738:Or10d4c UTSW 9 39,557,957 (GRCm39) start gained probably benign
R6778:Or10d4c UTSW 9 39,558,043 (GRCm39) missense probably damaging 1.00
R7194:Or10d4c UTSW 9 39,558,387 (GRCm39) missense probably benign 0.15
R7545:Or10d4c UTSW 9 39,558,403 (GRCm39) missense probably damaging 0.97
R8547:Or10d4c UTSW 9 39,558,798 (GRCm39) nonsense probably null
R8956:Or10d4c UTSW 9 39,558,496 (GRCm39) missense probably damaging 1.00
R9081:Or10d4c UTSW 9 39,558,196 (GRCm39) missense probably damaging 1.00
R9098:Or10d4c UTSW 9 39,558,379 (GRCm39) missense probably damaging 1.00
R9734:Or10d4c UTSW 9 39,558,202 (GRCm39) missense probably damaging 1.00
RF008:Or10d4c UTSW 9 39,558,559 (GRCm39) missense probably benign 0.09
Posted On 2012-04-20