Incidental Mutation 'R5801:Stk10'
ID 490738
Institutional Source Beutler Lab
Gene Symbol Stk10
Ensembl Gene ENSMUSG00000020272
Gene Name serine/threonine kinase 10
Synonyms Lok, Gek1
MMRRC Submission 043390-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R5801 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 32483305-32574587 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 32546748 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 335 (P335L)
Ref Sequence ENSEMBL: ENSMUSP00000099885 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102821]
AlphaFold O55098
Predicted Effect probably benign
Transcript: ENSMUST00000102821
AA Change: P335L

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000099885
Gene: ENSMUSG00000020272
AA Change: P335L

DomainStartEndE-ValueType
S_TKc 36 294 8.66e-92 SMART
low complexity region 316 334 N/A INTRINSIC
low complexity region 544 577 N/A INTRINSIC
Pfam:PKK 586 724 1.9e-41 PFAM
Pfam:PKK 754 894 2.2e-37 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143397
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 100% (75/75)
MGI Phenotype FUNCTION: This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Mice deficient for this gene product are viable, but exhibit altered integrin-mediated lymphocyte adhesion characteristics. The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted disruption of this gene results in enhanced cell adhesion in mitogen-stimulated T cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AAdacl4fm3 T A 4: 144,430,206 (GRCm39) D261V probably damaging Het
Adam15 C T 3: 89,249,668 (GRCm39) V667I probably damaging Het
Adamts14 T C 10: 61,038,775 (GRCm39) S912G probably damaging Het
Adamts20 C A 15: 94,245,551 (GRCm39) E584* probably null Het
Ago3 A T 4: 126,265,561 (GRCm39) N284K possibly damaging Het
Alx3 T A 3: 107,512,257 (GRCm39) Y298* probably null Het
Arhgap32 A G 9: 32,167,084 (GRCm39) I574V probably benign Het
Bsn C T 9: 107,990,208 (GRCm39) R1848Q possibly damaging Het
Caskin2 T C 11: 115,694,299 (GRCm39) D400G probably damaging Het
Cdc73 T A 1: 143,484,281 (GRCm39) H525L probably benign Het
Cep135 A G 5: 76,778,523 (GRCm39) E674G probably damaging Het
Cic G A 7: 24,970,863 (GRCm39) R198Q possibly damaging Het
Col5a2 T C 1: 45,428,641 (GRCm39) probably null Het
Col6a5 A G 9: 105,825,566 (GRCm39) V9A unknown Het
Cpsf7 A T 19: 10,516,996 (GRCm39) D366V probably benign Het
Cuedc2 T C 19: 46,319,796 (GRCm39) E173G probably damaging Het
D5Ertd579e T C 5: 36,761,913 (GRCm39) E1318G probably damaging Het
Ddx55 T C 5: 124,704,560 (GRCm39) probably null Het
Dennd1b T A 1: 138,967,727 (GRCm39) probably null Het
Dpy19l3 T C 7: 35,424,723 (GRCm39) T111A probably benign Het
Edn1 C A 13: 42,460,282 (GRCm39) A179E probably benign Het
Eif2b1 T C 5: 124,712,775 (GRCm39) probably null Het
Epha5 A G 5: 84,479,085 (GRCm39) probably null Het
Erc1 T A 6: 119,750,783 (GRCm39) N466I probably damaging Het
Ermp1 A G 19: 29,590,228 (GRCm39) F825L probably damaging Het
Fbh1 T C 2: 11,774,637 (GRCm39) D36G probably damaging Het
Fbxo41 G T 6: 85,461,515 (GRCm39) F64L probably damaging Het
Gabrb2 T C 11: 42,312,216 (GRCm39) S14P probably benign Het
Gm6505 A T 3: 28,819,116 (GRCm39) noncoding transcript Het
Ighv1-18 T A 12: 114,646,328 (GRCm39) D91V probably damaging Het
Imp3 A G 9: 56,845,086 (GRCm39) D99G probably benign Het
Iqub T C 6: 24,449,768 (GRCm39) K699R probably benign Het
Itpk1 A G 12: 102,540,204 (GRCm39) V293A probably damaging Het
Lrrc49 A T 9: 60,509,916 (GRCm39) F157L probably damaging Het
Mapk1ip1 T A 7: 138,438,239 (GRCm39) T64S possibly damaging Het
Mrpl9 T C 3: 94,355,103 (GRCm39) L225P possibly damaging Het
Ms4a14 A G 19: 11,279,150 (GRCm39) L1136S possibly damaging Het
Ms4a14 A T 19: 11,279,246 (GRCm39) I1104K possibly damaging Het
Nkain2 T C 10: 32,278,264 (GRCm39) T54A probably damaging Het
Ociad2 A G 5: 73,483,642 (GRCm39) F60S probably damaging Het
Or1e1f T C 11: 73,855,772 (GRCm39) F113L probably benign Het
Polk T A 13: 96,620,094 (GRCm39) H723L probably damaging Het
Prickle4 C A 17: 47,999,698 (GRCm39) R285L possibly damaging Het
Psmd2 A G 16: 20,473,672 (GRCm39) N121S probably damaging Het
Rab11fip5 T A 6: 85,314,582 (GRCm39) S1212C probably damaging Het
Rasgef1c T G 11: 49,860,883 (GRCm39) M266R probably damaging Het
Rpusd4 A G 9: 35,181,369 (GRCm39) E155G possibly damaging Het
Rrbp1 A G 2: 143,831,703 (GRCm39) S155P probably damaging Het
Safb2 T C 17: 56,870,103 (GRCm39) Y991C possibly damaging Het
Shank1 G A 7: 44,006,240 (GRCm39) E1986K possibly damaging Het
Slc22a14 A G 9: 119,001,149 (GRCm39) F482L probably benign Het
Slc35e3 T A 10: 117,581,767 (GRCm39) M109L probably benign Het
Slco4c1 T C 1: 96,799,809 (GRCm39) N9S probably damaging Het
Slco6b1 C T 1: 96,875,356 (GRCm39) noncoding transcript Het
Sptan1 A G 2: 29,920,613 (GRCm39) probably null Het
Sptlc2 T C 12: 87,388,545 (GRCm39) probably null Het
Strip1 A C 3: 107,528,757 (GRCm39) L391R possibly damaging Het
Tacr1 T A 6: 82,534,134 (GRCm39) S387T probably benign Het
Thbs2 A T 17: 14,908,125 (GRCm39) F213I probably damaging Het
Thbs3 A T 3: 89,131,704 (GRCm39) Y692F probably benign Het
Tktl2 C A 8: 66,966,299 (GRCm39) A619E probably benign Het
Tmc3 A T 7: 83,271,686 (GRCm39) E946V possibly damaging Het
Tmem132d A G 5: 127,861,964 (GRCm39) V719A possibly damaging Het
Trpa1 T C 1: 14,968,302 (GRCm39) H488R probably damaging Het
Tsfm TCACTCC TCACTCCACTCC 10: 126,858,706 (GRCm39) probably null Het
Wdr35 A G 12: 9,056,723 (GRCm39) T503A possibly damaging Het
Zfp109 T C 7: 23,928,126 (GRCm39) K436E probably damaging Het
Zfp423 A G 8: 88,585,990 (GRCm39) Y78H probably damaging Het
Zfp970 A G 2: 177,165,151 (GRCm39) K26E probably damaging Het
Other mutations in Stk10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01105:Stk10 APN 11 32,527,740 (GRCm39) missense probably benign 0.33
IGL01285:Stk10 APN 11 32,560,653 (GRCm39) missense possibly damaging 0.91
IGL01983:Stk10 APN 11 32,539,460 (GRCm39) missense probably benign 0.05
IGL03177:Stk10 APN 11 32,564,592 (GRCm39) missense probably damaging 1.00
IGL03183:Stk10 APN 11 32,554,143 (GRCm39) missense possibly damaging 0.50
coquet UTSW 11 32,527,764 (GRCm39) missense
legacy UTSW 11 32,554,166 (GRCm39) nonsense probably null
mignon UTSW 11 32,537,363 (GRCm39) missense probably damaging 1.00
R0481_stk10_383 UTSW 11 32,564,708 (GRCm39) missense probably damaging 1.00
FR4976:Stk10 UTSW 11 32,564,520 (GRCm39) critical splice acceptor site probably benign
R0003:Stk10 UTSW 11 32,539,460 (GRCm39) missense probably benign 0.05
R0008:Stk10 UTSW 11 32,537,305 (GRCm39) splice site probably benign
R0056:Stk10 UTSW 11 32,567,851 (GRCm39) missense possibly damaging 0.95
R0076:Stk10 UTSW 11 32,553,722 (GRCm39) missense probably benign
R0227:Stk10 UTSW 11 32,567,859 (GRCm39) missense probably damaging 1.00
R0440:Stk10 UTSW 11 32,554,190 (GRCm39) missense probably damaging 1.00
R0454:Stk10 UTSW 11 32,546,724 (GRCm39) missense probably damaging 0.99
R0481:Stk10 UTSW 11 32,564,708 (GRCm39) missense probably damaging 1.00
R0504:Stk10 UTSW 11 32,567,882 (GRCm39) missense probably benign 0.04
R0790:Stk10 UTSW 11 32,548,653 (GRCm39) missense probably benign 0.00
R1439:Stk10 UTSW 11 32,567,919 (GRCm39) missense probably damaging 0.98
R1539:Stk10 UTSW 11 32,483,440 (GRCm39) missense possibly damaging 0.85
R1770:Stk10 UTSW 11 32,572,464 (GRCm39) missense possibly damaging 0.94
R4304:Stk10 UTSW 11 32,560,634 (GRCm39) missense probably damaging 0.97
R4430:Stk10 UTSW 11 32,483,552 (GRCm39) missense possibly damaging 0.81
R4702:Stk10 UTSW 11 32,505,172 (GRCm39) missense probably benign 0.28
R4797:Stk10 UTSW 11 32,548,471 (GRCm39) missense probably benign 0.01
R5447:Stk10 UTSW 11 32,554,166 (GRCm39) nonsense probably null
R5802:Stk10 UTSW 11 32,546,748 (GRCm39) missense probably benign 0.01
R6129:Stk10 UTSW 11 32,565,871 (GRCm39) missense probably damaging 1.00
R6154:Stk10 UTSW 11 32,553,654 (GRCm39) splice site probably null
R6175:Stk10 UTSW 11 32,553,761 (GRCm39) missense possibly damaging 0.46
R6185:Stk10 UTSW 11 32,527,749 (GRCm39) missense probably benign 0.13
R6520:Stk10 UTSW 11 32,538,839 (GRCm39) missense probably damaging 1.00
R6824:Stk10 UTSW 11 32,537,363 (GRCm39) missense probably damaging 1.00
R7259:Stk10 UTSW 11 32,548,497 (GRCm39) missense probably benign 0.00
R7649:Stk10 UTSW 11 32,527,764 (GRCm39) missense
R8331:Stk10 UTSW 11 32,538,928 (GRCm39) missense
R8847:Stk10 UTSW 11 32,539,427 (GRCm39) missense
R9252:Stk10 UTSW 11 32,538,915 (GRCm39) missense
R9367:Stk10 UTSW 11 32,538,878 (GRCm39) missense
X0027:Stk10 UTSW 11 32,537,361 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ACCAGAGTTGTTCCTCGTTG -3'
(R):5'- GCTCCAGAACTTAGACCTGG -3'

Sequencing Primer
(F):5'- TCGTTGCTTCAGGACCAAG -3'
(R):5'- AACTTAGACCTGGCCAGTTG -3'
Posted On 2017-10-24