Incidental Mutation 'R0530:Prdx6b'
ID 49089
Institutional Source Beutler Lab
Gene Symbol Prdx6b
Ensembl Gene ENSMUSG00000050114
Gene Name peroxiredoxin 6B
Synonyms Aop2-rs1, 4930414C22Rik, Prdx6-ps1, 1-cysPrx-P1
MMRRC Submission 038722-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R0530 (G1)
Quality Score 114
Status Validated
Chromosome 2
Chromosomal Location 80122816-80125700 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 80123659 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 156 (N156S)
Ref Sequence ENSEMBL: ENSMUSP00000133276 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057072]
AlphaFold Q8BG37
Predicted Effect probably damaging
Transcript: ENSMUST00000057072
AA Change: N156S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000133276
Gene: ENSMUSG00000050114
AA Change: N156S

DomainStartEndE-ValueType
Pfam:Redoxin 6 164 6.9e-10 PFAM
Pfam:AhpC-TSA 7 146 3.7e-30 PFAM
Pfam:1-cysPrx_C 166 205 4.2e-14 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.7%
  • 10x: 96.6%
  • 20x: 93.1%
Validation Efficiency 96% (51/53)
MGI Phenotype FUNCTION: This intronless gene is similar to the multi-exon peroxiredoxin 6 gene located on chromosome 1. It is transcribed and the ORF is intact compared to that of the peroxiredoxin 6 gene. This gene could be considered a transcribed pseudogene based on a failure to detect the protein in vivo in PMID:14644414. However, NCBI is representing the protein due to mass spectrometry data in PMID:18614015, which detected at least one peptide that is specific for this protein. [provided by RefSeq, Mar 2011]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg3 A G 5: 105,083,920 (GRCm39) W617R probably damaging Het
Adam34l A T 8: 44,079,568 (GRCm39) C219S probably benign Het
Cep83 A T 10: 94,555,450 (GRCm39) probably benign Het
Ces1e G A 8: 93,946,149 (GRCm39) probably benign Het
Ckap2 A G 8: 22,665,988 (GRCm39) probably benign Het
Clip1 C A 5: 123,778,594 (GRCm39) R443L probably damaging Het
Clmp A G 9: 40,672,302 (GRCm39) D44G probably benign Het
Cntnap2 G A 6: 46,506,839 (GRCm39) Q304* probably null Het
Cst7 A T 2: 150,412,435 (GRCm39) probably benign Het
Dclk3 A T 9: 111,311,789 (GRCm39) Y677F probably damaging Het
Dlat G T 9: 50,548,869 (GRCm39) N562K probably damaging Het
Elmod1 A T 9: 53,833,260 (GRCm39) Y182N probably damaging Het
Fzd10 T C 5: 128,679,077 (GRCm39) F266L probably damaging Het
Gm8258 A G 5: 104,923,952 (GRCm39) noncoding transcript Het
Gm9742 T A 13: 8,080,041 (GRCm39) noncoding transcript Het
Hdlbp T C 1: 93,358,039 (GRCm39) probably benign Het
Itga8 A G 2: 12,196,627 (GRCm39) S597P probably damaging Het
Kndc1 A T 7: 139,481,153 (GRCm39) I80F probably damaging Het
Ktn1 A G 14: 47,970,700 (GRCm39) N1192S probably benign Het
Ldha G A 7: 46,503,417 (GRCm39) V270M probably damaging Het
Lyst T C 13: 13,931,891 (GRCm39) probably benign Het
Map3k9 A T 12: 81,769,256 (GRCm39) F954I probably benign Het
Mroh2b A G 15: 4,963,877 (GRCm39) N823S probably damaging Het
Mycbp2 A T 14: 103,419,895 (GRCm39) N2480K probably damaging Het
Nat1 A G 8: 67,943,977 (GRCm39) K121E probably benign Het
Neurl1b T A 17: 26,660,519 (GRCm39) probably null Het
Nnt C A 13: 119,531,257 (GRCm39) L163F probably damaging Het
Or10v5 A G 19: 11,805,556 (GRCm39) V278A probably benign Het
Otog A G 7: 45,947,668 (GRCm39) T2274A probably damaging Het
Pde4b G A 4: 102,459,848 (GRCm39) R561Q probably damaging Het
Pitpnm2 A G 5: 124,269,264 (GRCm39) F453L probably damaging Het
Pms1 T C 1: 53,235,972 (GRCm39) probably null Het
Pot1a A G 6: 25,771,540 (GRCm39) V227A possibly damaging Het
Ptpn9 A G 9: 56,968,417 (GRCm39) S586G probably benign Het
Serpina6 A T 12: 103,618,053 (GRCm39) N253K probably damaging Het
Slc12a2 T A 18: 58,052,608 (GRCm39) V809D possibly damaging Het
Slc2a8 C T 2: 32,863,696 (GRCm39) A449T probably benign Het
Slc6a6 A G 6: 91,701,939 (GRCm39) I116V probably null Het
Synj2 T A 17: 6,058,380 (GRCm39) S58R possibly damaging Het
Tafa3 T C 3: 104,679,487 (GRCm39) probably benign Het
Tktl2 T C 8: 66,965,831 (GRCm39) V463A probably damaging Het
Uchl5 T C 1: 143,670,082 (GRCm39) V105A possibly damaging Het
Usp9y T C Y: 1,333,600 (GRCm39) probably benign Het
Vmn1r200 T C 13: 22,579,667 (GRCm39) S148P probably damaging Het
Vmn2r50 A T 7: 9,781,644 (GRCm39) M367K possibly damaging Het
Vps13a T C 19: 16,632,570 (GRCm39) probably benign Het
Wdr26 A T 1: 181,013,635 (GRCm39) probably null Het
Wdr87-ps A G 7: 29,229,545 (GRCm39) noncoding transcript Het
Ythdc2 T A 18: 44,983,465 (GRCm39) M544K probably damaging Het
Zpld2 A G 4: 133,930,221 (GRCm39) I28T probably benign Het
Other mutations in Prdx6b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00983:Prdx6b APN 2 80,123,539 (GRCm39) missense probably damaging 1.00
IGL01710:Prdx6b APN 2 80,123,490 (GRCm39) missense probably damaging 1.00
R0410:Prdx6b UTSW 2 80,123,373 (GRCm39) missense probably damaging 1.00
R1237:Prdx6b UTSW 2 80,123,520 (GRCm39) missense probably benign 0.04
R1797:Prdx6b UTSW 2 80,123,546 (GRCm39) missense possibly damaging 0.94
R2136:Prdx6b UTSW 2 80,123,507 (GRCm39) missense probably damaging 0.99
R4707:Prdx6b UTSW 2 80,123,404 (GRCm39) missense probably damaging 1.00
R7440:Prdx6b UTSW 2 80,123,560 (GRCm39) missense probably damaging 0.99
R7565:Prdx6b UTSW 2 80,123,334 (GRCm39) missense probably damaging 0.99
R7724:Prdx6b UTSW 2 80,123,746 (GRCm39) missense probably benign 0.01
R7814:Prdx6b UTSW 2 80,123,304 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- TGCCTGGAGCAAGGACATCAATG -3'
(R):5'- TGCAGCCCCAATTCCTGCAAAG -3'

Sequencing Primer
(F):5'- TGCTTACAATGGTGCAACAC -3'
(R):5'- TCCTGCAAAGACTTAAGGCTG -3'
Posted On 2013-06-12