Incidental Mutation 'R0530:Fzd10'
ID 49097
Institutional Source Beutler Lab
Gene Symbol Fzd10
Ensembl Gene ENSMUSG00000081683
Gene Name frizzled class receptor 10
Synonyms Fz-10
MMRRC Submission 038722-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0530 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 128678170-128681157 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 128679077 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 266 (F266L)
Ref Sequence ENSEMBL: ENSMUSP00000114114 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117102]
AlphaFold Q8BKG4
Predicted Effect noncoding transcript
Transcript: ENSMUST00000091324
Predicted Effect probably damaging
Transcript: ENSMUST00000117102
AA Change: F266L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000114114
Gene: ENSMUSG00000081683
AA Change: F266L

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
FRI 34 153 7.83e-68 SMART
Frizzled 218 542 2.62e-207 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126472
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134673
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154305
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199981
Meta Mutation Damage Score 0.5029 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.7%
  • 10x: 96.6%
  • 20x: 93.1%
Validation Efficiency 96% (51/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene does not appear to result in a phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg3 A G 5: 105,083,920 (GRCm39) W617R probably damaging Het
Adam34l A T 8: 44,079,568 (GRCm39) C219S probably benign Het
Cep83 A T 10: 94,555,450 (GRCm39) probably benign Het
Ces1e G A 8: 93,946,149 (GRCm39) probably benign Het
Ckap2 A G 8: 22,665,988 (GRCm39) probably benign Het
Clip1 C A 5: 123,778,594 (GRCm39) R443L probably damaging Het
Clmp A G 9: 40,672,302 (GRCm39) D44G probably benign Het
Cntnap2 G A 6: 46,506,839 (GRCm39) Q304* probably null Het
Cst7 A T 2: 150,412,435 (GRCm39) probably benign Het
Dclk3 A T 9: 111,311,789 (GRCm39) Y677F probably damaging Het
Dlat G T 9: 50,548,869 (GRCm39) N562K probably damaging Het
Elmod1 A T 9: 53,833,260 (GRCm39) Y182N probably damaging Het
Gm8258 A G 5: 104,923,952 (GRCm39) noncoding transcript Het
Gm9742 T A 13: 8,080,041 (GRCm39) noncoding transcript Het
Hdlbp T C 1: 93,358,039 (GRCm39) probably benign Het
Itga8 A G 2: 12,196,627 (GRCm39) S597P probably damaging Het
Kndc1 A T 7: 139,481,153 (GRCm39) I80F probably damaging Het
Ktn1 A G 14: 47,970,700 (GRCm39) N1192S probably benign Het
Ldha G A 7: 46,503,417 (GRCm39) V270M probably damaging Het
Lyst T C 13: 13,931,891 (GRCm39) probably benign Het
Map3k9 A T 12: 81,769,256 (GRCm39) F954I probably benign Het
Mroh2b A G 15: 4,963,877 (GRCm39) N823S probably damaging Het
Mycbp2 A T 14: 103,419,895 (GRCm39) N2480K probably damaging Het
Nat1 A G 8: 67,943,977 (GRCm39) K121E probably benign Het
Neurl1b T A 17: 26,660,519 (GRCm39) probably null Het
Nnt C A 13: 119,531,257 (GRCm39) L163F probably damaging Het
Or10v5 A G 19: 11,805,556 (GRCm39) V278A probably benign Het
Otog A G 7: 45,947,668 (GRCm39) T2274A probably damaging Het
Pde4b G A 4: 102,459,848 (GRCm39) R561Q probably damaging Het
Pitpnm2 A G 5: 124,269,264 (GRCm39) F453L probably damaging Het
Pms1 T C 1: 53,235,972 (GRCm39) probably null Het
Pot1a A G 6: 25,771,540 (GRCm39) V227A possibly damaging Het
Prdx6b A G 2: 80,123,659 (GRCm39) N156S probably damaging Het
Ptpn9 A G 9: 56,968,417 (GRCm39) S586G probably benign Het
Serpina6 A T 12: 103,618,053 (GRCm39) N253K probably damaging Het
Slc12a2 T A 18: 58,052,608 (GRCm39) V809D possibly damaging Het
Slc2a8 C T 2: 32,863,696 (GRCm39) A449T probably benign Het
Slc6a6 A G 6: 91,701,939 (GRCm39) I116V probably null Het
Synj2 T A 17: 6,058,380 (GRCm39) S58R possibly damaging Het
Tafa3 T C 3: 104,679,487 (GRCm39) probably benign Het
Tktl2 T C 8: 66,965,831 (GRCm39) V463A probably damaging Het
Uchl5 T C 1: 143,670,082 (GRCm39) V105A possibly damaging Het
Usp9y T C Y: 1,333,600 (GRCm39) probably benign Het
Vmn1r200 T C 13: 22,579,667 (GRCm39) S148P probably damaging Het
Vmn2r50 A T 7: 9,781,644 (GRCm39) M367K possibly damaging Het
Vps13a T C 19: 16,632,570 (GRCm39) probably benign Het
Wdr26 A T 1: 181,013,635 (GRCm39) probably null Het
Wdr87-ps A G 7: 29,229,545 (GRCm39) noncoding transcript Het
Ythdc2 T A 18: 44,983,465 (GRCm39) M544K probably damaging Het
Zpld2 A G 4: 133,930,221 (GRCm39) I28T probably benign Het
Other mutations in Fzd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Fzd10 APN 5 128,678,592 (GRCm39) missense probably damaging 1.00
IGL02354:Fzd10 APN 5 128,678,932 (GRCm39) missense possibly damaging 0.89
IGL02361:Fzd10 APN 5 128,678,932 (GRCm39) missense possibly damaging 0.89
IGL03088:Fzd10 APN 5 128,679,669 (GRCm39) missense possibly damaging 0.81
R0645:Fzd10 UTSW 5 128,679,662 (GRCm39) missense possibly damaging 0.94
R1515:Fzd10 UTSW 5 128,679,623 (GRCm39) missense probably damaging 1.00
R3930:Fzd10 UTSW 5 128,679,476 (GRCm39) missense probably damaging 1.00
R4467:Fzd10 UTSW 5 128,678,340 (GRCm39) missense probably benign 0.01
R4976:Fzd10 UTSW 5 128,679,178 (GRCm39) nonsense probably null
R5156:Fzd10 UTSW 5 128,678,366 (GRCm39) missense possibly damaging 0.68
R5202:Fzd10 UTSW 5 128,679,180 (GRCm39) missense possibly damaging 0.78
R5874:Fzd10 UTSW 5 128,678,364 (GRCm39) missense probably benign 0.41
R6238:Fzd10 UTSW 5 128,679,995 (GRCm39) missense probably damaging 0.99
R6921:Fzd10 UTSW 5 128,678,646 (GRCm39) missense probably damaging 0.99
R7684:Fzd10 UTSW 5 128,678,480 (GRCm39) missense possibly damaging 0.73
R8093:Fzd10 UTSW 5 128,679,303 (GRCm39) missense probably benign 0.14
R9011:Fzd10 UTSW 5 128,679,369 (GRCm39) missense probably damaging 1.00
R9013:Fzd10 UTSW 5 128,679,369 (GRCm39) missense probably damaging 1.00
R9014:Fzd10 UTSW 5 128,679,369 (GRCm39) missense probably damaging 1.00
R9332:Fzd10 UTSW 5 128,678,316 (GRCm39) missense possibly damaging 0.92
R9603:Fzd10 UTSW 5 128,678,771 (GRCm39) missense probably benign 0.00
Z1088:Fzd10 UTSW 5 128,678,310 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGTGACAACCCAGGCAAGTTCC -3'
(R):5'- AGCATTGACATCCATGCTGCCC -3'

Sequencing Primer
(F):5'- CATGTGGAGAAGAGCGAATCTTG -3'
(R):5'- ATAGTCTTCACAGCCGGGATG -3'
Posted On 2013-06-12