Incidental Mutation 'R0532:Tiam2'
| ID |
49288 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tiam2
|
| Ensembl Gene |
ENSMUSG00000023800 |
| Gene Name |
T cell lymphoma invasion and metastasis 2 |
| Synonyms |
STEF, 3000002F19Rik |
| MMRRC Submission |
038724-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0532 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
3376675-3569672 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 3471921 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Arginine
at position 521
(K521R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125842
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072156]
[ENSMUST00000169838]
|
| AlphaFold |
Q6ZPF3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000072156
AA Change: K521R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000072020
Gene: ENSMUSG00000023800
AA Change: K521R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169838
AA Change: K521R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000125842
Gene: ENSMUSG00000023800
AA Change: K521R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226905
|
| Meta Mutation Damage Score |
0.2901 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.2%
|
| Validation Efficiency |
100% (90/90) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921524L21Rik |
A |
T |
18: 6,638,618 (GRCm39) |
E339V |
possibly damaging |
Het |
| 9230009I02Rik |
A |
T |
11: 50,982,405 (GRCm39) |
|
noncoding transcript |
Het |
| 9230112D13Rik |
A |
T |
14: 34,234,054 (GRCm39) |
I79K |
unknown |
Het |
| Adam25 |
C |
T |
8: 41,208,987 (GRCm39) |
T751I |
probably benign |
Het |
| Adgrv1 |
C |
A |
13: 81,727,015 (GRCm39) |
V446L |
probably damaging |
Het |
| Afap1 |
C |
A |
5: 36,125,944 (GRCm39) |
A313D |
possibly damaging |
Het |
| Akap6 |
A |
G |
12: 52,934,766 (GRCm39) |
T753A |
probably benign |
Het |
| Aldh16a1 |
G |
T |
7: 44,792,262 (GRCm39) |
T730N |
probably damaging |
Het |
| Amfr |
A |
T |
8: 94,725,736 (GRCm39) |
M215K |
probably damaging |
Het |
| Apob |
A |
G |
12: 8,066,188 (GRCm39) |
R4386G |
possibly damaging |
Het |
| Arhgap45 |
A |
T |
10: 79,857,917 (GRCm39) |
M217L |
possibly damaging |
Het |
| Baiap2l2 |
C |
T |
15: 79,168,276 (GRCm39) |
E49K |
possibly damaging |
Het |
| Baz1a |
C |
T |
12: 54,981,605 (GRCm39) |
E350K |
possibly damaging |
Het |
| Bbx |
A |
T |
16: 50,086,647 (GRCm39) |
V83D |
probably damaging |
Het |
| Btaf1 |
T |
C |
19: 36,928,586 (GRCm39) |
|
probably benign |
Het |
| Cacna2d1 |
G |
A |
5: 16,567,271 (GRCm39) |
E942K |
probably benign |
Het |
| Cad |
T |
C |
5: 31,219,531 (GRCm39) |
|
probably benign |
Het |
| Ccdc96 |
A |
G |
5: 36,643,710 (GRCm39) |
K572R |
probably benign |
Het |
| Cdc5l |
G |
A |
17: 45,726,610 (GRCm39) |
R321W |
probably damaging |
Het |
| Cep164 |
G |
A |
9: 45,721,124 (GRCm39) |
R93* |
probably null |
Het |
| Cir1 |
A |
G |
2: 73,140,799 (GRCm39) |
|
probably null |
Het |
| Crocc |
A |
G |
4: 140,757,558 (GRCm39) |
S912P |
possibly damaging |
Het |
| Cwf19l2 |
T |
C |
9: 3,431,057 (GRCm39) |
L463P |
probably benign |
Het |
| Cyp3a59 |
C |
T |
5: 146,033,463 (GRCm39) |
Q200* |
probably null |
Het |
| Cyp4b1 |
G |
T |
4: 115,484,073 (GRCm39) |
P303T |
probably damaging |
Het |
| Dcbld1 |
C |
A |
10: 52,193,173 (GRCm39) |
T306K |
probably benign |
Het |
| Dgat2 |
A |
G |
7: 98,818,988 (GRCm39) |
V56A |
possibly damaging |
Het |
| Dnajc16 |
A |
C |
4: 141,516,320 (GRCm39) |
L16R |
probably damaging |
Het |
| Dnmt1 |
A |
C |
9: 20,829,852 (GRCm39) |
|
probably benign |
Het |
| Dus3l |
A |
G |
17: 57,076,308 (GRCm39) |
I528V |
probably damaging |
Het |
| Egflam |
T |
C |
15: 7,263,718 (GRCm39) |
D744G |
probably benign |
Het |
| Epb41 |
A |
C |
4: 131,706,106 (GRCm39) |
|
probably benign |
Het |
| Eri2 |
C |
T |
7: 119,385,206 (GRCm39) |
V432I |
probably benign |
Het |
| Esyt2 |
A |
G |
12: 116,320,818 (GRCm39) |
|
probably benign |
Het |
| Extl3 |
A |
T |
14: 65,315,122 (GRCm39) |
M20K |
probably benign |
Het |
| Fam32a |
A |
G |
8: 72,976,063 (GRCm39) |
Y103C |
probably damaging |
Het |
| Fat4 |
T |
C |
3: 39,035,870 (GRCm39) |
V3174A |
probably benign |
Het |
| Fbxo40 |
T |
A |
16: 36,789,984 (GRCm39) |
E375D |
possibly damaging |
Het |
| Frrs1 |
A |
G |
3: 116,676,813 (GRCm39) |
T182A |
probably benign |
Het |
| Fry |
A |
G |
5: 150,357,172 (GRCm39) |
|
probably benign |
Het |
| Fry |
T |
C |
5: 150,402,226 (GRCm39) |
|
probably benign |
Het |
| Fsip2 |
A |
G |
2: 82,808,129 (GRCm39) |
I1483V |
probably benign |
Het |
| Glra3 |
T |
A |
8: 56,578,111 (GRCm39) |
D389E |
probably benign |
Het |
| Gpr3 |
A |
T |
4: 132,937,796 (GRCm39) |
I292N |
probably damaging |
Het |
| Grina |
T |
C |
15: 76,133,045 (GRCm39) |
M230T |
probably damaging |
Het |
| Igkv11-125 |
G |
A |
6: 67,890,603 (GRCm39) |
W16* |
probably null |
Het |
| Il18r1 |
T |
C |
1: 40,514,061 (GRCm39) |
V89A |
probably damaging |
Het |
| Ino80 |
T |
C |
2: 119,212,464 (GRCm39) |
E1286G |
possibly damaging |
Het |
| Iqch |
G |
A |
9: 63,415,514 (GRCm39) |
|
probably benign |
Het |
| Itpr2 |
G |
T |
6: 146,013,898 (GRCm39) |
Q2666K |
probably damaging |
Het |
| Kcnh3 |
A |
G |
15: 99,130,844 (GRCm39) |
D487G |
probably damaging |
Het |
| Kdm1a |
A |
G |
4: 136,288,377 (GRCm39) |
L402P |
probably damaging |
Het |
| Klhl10 |
T |
G |
11: 100,337,937 (GRCm39) |
|
probably benign |
Het |
| Krt39 |
T |
C |
11: 99,405,617 (GRCm39) |
T428A |
possibly damaging |
Het |
| Mapk3 |
G |
A |
7: 126,362,558 (GRCm39) |
|
probably benign |
Het |
| Med13l |
T |
A |
5: 118,897,188 (GRCm39) |
S2089T |
possibly damaging |
Het |
| Mex3c |
G |
A |
18: 73,723,124 (GRCm39) |
D406N |
possibly damaging |
Het |
| Mki67 |
G |
A |
7: 135,299,893 (GRCm39) |
R1714* |
probably null |
Het |
| Mmp9 |
C |
A |
2: 164,791,740 (GRCm39) |
S211* |
probably null |
Het |
| Nat8f2 |
G |
T |
6: 85,844,784 (GRCm39) |
Q193K |
probably benign |
Het |
| Omt2a |
C |
A |
9: 78,220,187 (GRCm39) |
A71S |
possibly damaging |
Het |
| Or10ak11 |
T |
G |
4: 118,686,897 (GRCm39) |
T247P |
probably damaging |
Het |
| Or5ac22 |
T |
C |
16: 59,134,964 (GRCm39) |
K269E |
probably benign |
Het |
| Pdgfra |
G |
A |
5: 75,331,434 (GRCm39) |
V315I |
probably benign |
Het |
| Pdgfrb |
A |
G |
18: 61,216,337 (GRCm39) |
D1065G |
probably damaging |
Het |
| Pfas |
A |
T |
11: 68,893,455 (GRCm39) |
|
probably benign |
Het |
| Pramel5 |
T |
C |
4: 143,999,310 (GRCm39) |
E259G |
probably benign |
Het |
| Prpf6 |
A |
G |
2: 181,264,004 (GRCm39) |
Y222C |
possibly damaging |
Het |
| Rbck1 |
C |
A |
2: 152,166,250 (GRCm39) |
Q229H |
probably damaging |
Het |
| Rdm1 |
T |
A |
11: 101,526,661 (GRCm39) |
C278S |
probably benign |
Het |
| Sall1 |
T |
C |
8: 89,759,819 (GRCm39) |
D95G |
probably benign |
Het |
| Scn1a |
T |
A |
2: 66,148,167 (GRCm39) |
D1126V |
probably damaging |
Het |
| Scn4a |
C |
T |
11: 106,221,226 (GRCm39) |
G811D |
probably benign |
Het |
| Sh2b1 |
A |
G |
7: 126,071,444 (GRCm39) |
I247T |
probably benign |
Het |
| Shprh |
C |
A |
10: 11,038,556 (GRCm39) |
T437K |
possibly damaging |
Het |
| Slc13a4 |
A |
T |
6: 35,264,339 (GRCm39) |
|
probably null |
Het |
| Slc16a1 |
C |
A |
3: 104,560,734 (GRCm39) |
Y346* |
probably null |
Het |
| Slc25a38 |
G |
T |
9: 119,949,772 (GRCm39) |
A163S |
probably damaging |
Het |
| Slc6a12 |
G |
A |
6: 121,333,877 (GRCm39) |
V238I |
probably damaging |
Het |
| Slc8b1 |
C |
A |
5: 120,657,736 (GRCm39) |
D66E |
probably damaging |
Het |
| Snapin |
A |
G |
3: 90,396,893 (GRCm39) |
L106P |
probably damaging |
Het |
| Tas2r122 |
G |
A |
6: 132,688,791 (GRCm39) |
S34F |
possibly damaging |
Het |
| Tmem81 |
C |
G |
1: 132,435,567 (GRCm39) |
I124M |
probably damaging |
Het |
| Ttc3 |
T |
C |
16: 94,188,189 (GRCm39) |
|
probably benign |
Het |
| Uba1y |
T |
C |
Y: 820,911 (GRCm39) |
F31L |
probably benign |
Het |
| Ucp3 |
A |
G |
7: 100,131,186 (GRCm39) |
|
probably benign |
Het |
| Vcan |
T |
C |
13: 89,851,891 (GRCm39) |
E1023G |
probably damaging |
Het |
| Vmn2r45 |
A |
G |
7: 8,474,820 (GRCm39) |
I736T |
probably damaging |
Het |
| Vps36 |
T |
C |
8: 22,708,261 (GRCm39) |
F342L |
probably benign |
Het |
| Zc3hc1 |
A |
G |
6: 30,374,929 (GRCm39) |
|
probably benign |
Het |
| Zmym4 |
G |
A |
4: 126,792,194 (GRCm39) |
Q596* |
probably null |
Het |
|
| Other mutations in Tiam2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01011:Tiam2
|
APN |
17 |
3,465,303 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL01320:Tiam2
|
APN |
17 |
3,556,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01384:Tiam2
|
APN |
17 |
3,477,477 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01575:Tiam2
|
APN |
17 |
3,504,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01769:Tiam2
|
APN |
17 |
3,477,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02395:Tiam2
|
APN |
17 |
3,471,756 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02652:Tiam2
|
APN |
17 |
3,489,971 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Tiam2
|
APN |
17 |
3,559,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03222:Tiam2
|
APN |
17 |
3,488,983 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Feste_burg
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R0257:Tiam2
|
UTSW |
17 |
3,501,088 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0420:Tiam2
|
UTSW |
17 |
3,553,193 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0528:Tiam2
|
UTSW |
17 |
3,561,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0551:Tiam2
|
UTSW |
17 |
3,479,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0554:Tiam2
|
UTSW |
17 |
3,488,956 (GRCm39) |
nonsense |
probably null |
|
|
R0645:Tiam2
|
UTSW |
17 |
3,564,973 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0726:Tiam2
|
UTSW |
17 |
3,563,108 (GRCm39) |
unclassified |
probably benign |
|
|
R1139:Tiam2
|
UTSW |
17 |
3,527,542 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1529:Tiam2
|
UTSW |
17 |
3,566,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1671:Tiam2
|
UTSW |
17 |
3,557,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1731:Tiam2
|
UTSW |
17 |
3,568,698 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1759:Tiam2
|
UTSW |
17 |
3,566,278 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1850:Tiam2
|
UTSW |
17 |
3,487,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1853:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1931:Tiam2
|
UTSW |
17 |
3,565,000 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1932:Tiam2
|
UTSW |
17 |
3,565,000 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1993:Tiam2
|
UTSW |
17 |
3,465,401 (GRCm39) |
nonsense |
probably null |
|
|
R2211:Tiam2
|
UTSW |
17 |
3,465,193 (GRCm39) |
nonsense |
probably null |
|
|
R2217:Tiam2
|
UTSW |
17 |
3,465,389 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2278:Tiam2
|
UTSW |
17 |
3,477,495 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2407:Tiam2
|
UTSW |
17 |
3,527,536 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2516:Tiam2
|
UTSW |
17 |
3,503,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2991:Tiam2
|
UTSW |
17 |
3,568,525 (GRCm39) |
missense |
probably benign |
|
|
R3086:Tiam2
|
UTSW |
17 |
3,471,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3121:Tiam2
|
UTSW |
17 |
3,489,977 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3686:Tiam2
|
UTSW |
17 |
3,471,959 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3740:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3742:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3826:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3829:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3844:Tiam2
|
UTSW |
17 |
3,471,926 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3970:Tiam2
|
UTSW |
17 |
3,479,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4060:Tiam2
|
UTSW |
17 |
3,479,255 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4296:Tiam2
|
UTSW |
17 |
3,501,120 (GRCm39) |
missense |
probably benign |
|
|
R4357:Tiam2
|
UTSW |
17 |
3,501,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4368:Tiam2
|
UTSW |
17 |
3,464,958 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4369:Tiam2
|
UTSW |
17 |
3,464,242 (GRCm39) |
start gained |
probably benign |
|
|
R4524:Tiam2
|
UTSW |
17 |
3,564,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4619:Tiam2
|
UTSW |
17 |
3,568,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4715:Tiam2
|
UTSW |
17 |
3,504,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4723:Tiam2
|
UTSW |
17 |
3,500,592 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4979:Tiam2
|
UTSW |
17 |
3,555,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5182:Tiam2
|
UTSW |
17 |
3,488,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5451:Tiam2
|
UTSW |
17 |
3,479,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5728:Tiam2
|
UTSW |
17 |
3,465,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5827:Tiam2
|
UTSW |
17 |
3,498,764 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5879:Tiam2
|
UTSW |
17 |
3,487,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5960:Tiam2
|
UTSW |
17 |
3,488,915 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5974:Tiam2
|
UTSW |
17 |
3,465,084 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6198:Tiam2
|
UTSW |
17 |
3,464,396 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6222:Tiam2
|
UTSW |
17 |
3,503,613 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6295:Tiam2
|
UTSW |
17 |
3,559,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6356:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6454:Tiam2
|
UTSW |
17 |
3,488,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6497:Tiam2
|
UTSW |
17 |
3,557,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6579:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6580:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6581:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6582:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6648:Tiam2
|
UTSW |
17 |
3,557,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6705:Tiam2
|
UTSW |
17 |
3,568,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6758:Tiam2
|
UTSW |
17 |
3,568,678 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6836:Tiam2
|
UTSW |
17 |
3,464,655 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6924:Tiam2
|
UTSW |
17 |
3,558,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Tiam2
|
UTSW |
17 |
3,568,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7051:Tiam2
|
UTSW |
17 |
3,498,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7151:Tiam2
|
UTSW |
17 |
3,498,660 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7214:Tiam2
|
UTSW |
17 |
3,568,687 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7332:Tiam2
|
UTSW |
17 |
3,503,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7334:Tiam2
|
UTSW |
17 |
3,553,283 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7414:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7660:Tiam2
|
UTSW |
17 |
3,532,880 (GRCm39) |
start codon destroyed |
probably null |
0.66 |
|
R7743:Tiam2
|
UTSW |
17 |
3,568,431 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7755:Tiam2
|
UTSW |
17 |
3,471,591 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7805:Tiam2
|
UTSW |
17 |
3,559,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7813:Tiam2
|
UTSW |
17 |
3,487,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7842:Tiam2
|
UTSW |
17 |
3,568,399 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7989:Tiam2
|
UTSW |
17 |
3,568,524 (GRCm39) |
nonsense |
probably null |
|
|
R8011:Tiam2
|
UTSW |
17 |
3,498,671 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8221:Tiam2
|
UTSW |
17 |
3,568,860 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8260:Tiam2
|
UTSW |
17 |
3,568,594 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8292:Tiam2
|
UTSW |
17 |
3,557,142 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8406:Tiam2
|
UTSW |
17 |
3,558,065 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8430:Tiam2
|
UTSW |
17 |
3,568,537 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8530:Tiam2
|
UTSW |
17 |
3,501,087 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8692:Tiam2
|
UTSW |
17 |
3,479,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8902:Tiam2
|
UTSW |
17 |
3,527,471 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9067:Tiam2
|
UTSW |
17 |
3,561,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9080:Tiam2
|
UTSW |
17 |
3,464,519 (GRCm39) |
missense |
probably benign |
|
|
R9090:Tiam2
|
UTSW |
17 |
3,465,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9211:Tiam2
|
UTSW |
17 |
3,498,729 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9271:Tiam2
|
UTSW |
17 |
3,465,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9347:Tiam2
|
UTSW |
17 |
3,471,923 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9353:Tiam2
|
UTSW |
17 |
3,558,074 (GRCm39) |
nonsense |
probably null |
|
|
R9407:Tiam2
|
UTSW |
17 |
3,553,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9460:Tiam2
|
UTSW |
17 |
3,487,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Tiam2
|
UTSW |
17 |
3,559,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9748:Tiam2
|
UTSW |
17 |
3,561,440 (GRCm39) |
missense |
probably benign |
0.20 |
|
X0027:Tiam2
|
UTSW |
17 |
3,464,275 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
X0060:Tiam2
|
UTSW |
17 |
3,500,629 (GRCm39) |
splice site |
probably null |
|
|
X0065:Tiam2
|
UTSW |
17 |
3,555,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Tiam2
|
UTSW |
17 |
3,465,294 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Tiam2
|
UTSW |
17 |
3,556,051 (GRCm39) |
missense |
probably null |
1.00 |
|
Z1177:Tiam2
|
UTSW |
17 |
3,477,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCACTCAGATGGACTGAATGCAGAAG -3'
(R):5'- CAATATTTACTCGACCATGCTGACCCC -3'
Sequencing Primer
(F):5'- CTATGAGAATTTCATGCGAGAGC -3'
(R):5'- CACCAGCACTTCCAGGTGAG -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation