Incidental Mutation 'R0538:Igsf10'
| ID |
49550 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Igsf10
|
| Ensembl Gene |
ENSMUSG00000036334 |
| Gene Name |
immunoglobulin superfamily, member 10 |
| Synonyms |
Adlican2, CMF608, 6530405F15Rik |
| MMRRC Submission |
038730-MU
|
| Accession Numbers |
Genbank: NM_001162884; MGI: 1923481 |
| Essential gene? |
Possibly non essential
(E-score: 0.279)
|
| Stock # |
R0538 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
59316735-59344394 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 59320106 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 2049
(T2049A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141391
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000039419]
[ENSMUST00000040325]
[ENSMUST00000164225]
[ENSMUST00000193455]
[ENSMUST00000194546]
[ENSMUST00000199659]
|
| AlphaFold |
Q3V1M1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000039419
AA Change: T2049A
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000037246
Gene: ENSMUSG00000036334
AA Change: T2049A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
LRRNT
|
28 |
61 |
3.24e-4 |
SMART |
|
LRR
|
57 |
79 |
9.24e1 |
SMART |
|
LRR
|
80 |
103 |
2.02e-1 |
SMART |
|
LRR
|
104 |
127 |
7.16e0 |
SMART |
|
LRR_TYP
|
128 |
151 |
1.2e-3 |
SMART |
|
LRR
|
152 |
175 |
1.25e-1 |
SMART |
|
LRR
|
188 |
207 |
2.33e2 |
SMART |
|
LRRCT
|
219 |
280 |
4.19e-4 |
SMART |
|
IGc2
|
488 |
558 |
2.34e-4 |
SMART |
|
IGc2
|
586 |
652 |
7.88e-11 |
SMART |
|
low complexity region
|
917 |
930 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1185 |
N/A |
INTRINSIC |
|
low complexity region
|
1245 |
1263 |
N/A |
INTRINSIC |
|
low complexity region
|
1311 |
1321 |
N/A |
INTRINSIC |
|
low complexity region
|
1449 |
1465 |
N/A |
INTRINSIC |
|
IGc2
|
1632 |
1701 |
7.69e-14 |
SMART |
|
IGc2
|
1729 |
1798 |
5.07e-14 |
SMART |
|
IGc2
|
1826 |
1895 |
2.19e-9 |
SMART |
|
IGc2
|
1925 |
1994 |
4.59e-12 |
SMART |
|
IGc2
|
2022 |
2097 |
1.33e-8 |
SMART |
|
IGc2
|
2125 |
2191 |
2.96e-15 |
SMART |
|
IGc2
|
2223 |
2291 |
2.03e-4 |
SMART |
|
IGc2
|
2321 |
2389 |
9.99e-13 |
SMART |
|
IGc2
|
2416 |
2484 |
3.03e-12 |
SMART |
|
IGc2
|
2512 |
2583 |
7.76e-10 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000040325
|
| SMART Domains |
Protein: ENSMUSP00000042269
Gene: ENSMUSG00000056476
| Domain | Start | End | E-Value | Type |
|---|
|
Med12
|
101 |
161 |
1.71e-24 |
SMART |
|
low complexity region
|
216 |
224 |
N/A |
INTRINSIC |
|
low complexity region
|
269 |
278 |
N/A |
INTRINSIC |
|
Pfam:Med12-LCEWAV
|
282 |
730 |
2.6e-207 |
PFAM |
|
low complexity region
|
744 |
758 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
872 |
N/A |
INTRINSIC |
|
low complexity region
|
1455 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1728 |
1742 |
N/A |
INTRINSIC |
|
low complexity region
|
1769 |
1783 |
N/A |
INTRINSIC |
|
Pfam:Med12-PQL
|
1803 |
2029 |
2.3e-14 |
PFAM |
|
low complexity region
|
2055 |
2076 |
N/A |
INTRINSIC |
|
low complexity region
|
2083 |
2101 |
N/A |
INTRINSIC |
|
low complexity region
|
2116 |
2136 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164225
|
| SMART Domains |
Protein: ENSMUSP00000127038
Gene: ENSMUSG00000056476
| Domain | Start | End | E-Value | Type |
|---|
|
Med12
|
101 |
161 |
1.71e-24 |
SMART |
|
low complexity region
|
216 |
224 |
N/A |
INTRINSIC |
|
low complexity region
|
269 |
278 |
N/A |
INTRINSIC |
|
Pfam:Med12-LCEWAV
|
283 |
765 |
5e-187 |
PFAM |
|
low complexity region
|
779 |
793 |
N/A |
INTRINSIC |
|
low complexity region
|
888 |
907 |
N/A |
INTRINSIC |
|
low complexity region
|
1490 |
1501 |
N/A |
INTRINSIC |
|
low complexity region
|
1763 |
1777 |
N/A |
INTRINSIC |
|
low complexity region
|
1804 |
1818 |
N/A |
INTRINSIC |
|
Pfam:Med12-PQL
|
1840 |
2063 |
9.7e-66 |
PFAM |
|
low complexity region
|
2090 |
2111 |
N/A |
INTRINSIC |
|
low complexity region
|
2118 |
2136 |
N/A |
INTRINSIC |
|
low complexity region
|
2151 |
2171 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000193455
AA Change: T2049A
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000141971
Gene: ENSMUSG00000036334
AA Change: T2049A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
LRRNT
|
28 |
61 |
3.24e-4 |
SMART |
|
LRR
|
57 |
79 |
9.24e1 |
SMART |
|
LRR
|
80 |
103 |
2.02e-1 |
SMART |
|
LRR
|
104 |
127 |
7.16e0 |
SMART |
|
LRR_TYP
|
128 |
151 |
1.2e-3 |
SMART |
|
LRR
|
152 |
175 |
1.25e-1 |
SMART |
|
LRR
|
188 |
207 |
2.33e2 |
SMART |
|
LRRCT
|
219 |
280 |
4.19e-4 |
SMART |
|
IGc2
|
488 |
558 |
2.34e-4 |
SMART |
|
IGc2
|
586 |
652 |
7.88e-11 |
SMART |
|
low complexity region
|
917 |
930 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1185 |
N/A |
INTRINSIC |
|
low complexity region
|
1245 |
1263 |
N/A |
INTRINSIC |
|
low complexity region
|
1311 |
1321 |
N/A |
INTRINSIC |
|
low complexity region
|
1449 |
1465 |
N/A |
INTRINSIC |
|
IGc2
|
1632 |
1701 |
7.69e-14 |
SMART |
|
IGc2
|
1729 |
1798 |
5.07e-14 |
SMART |
|
IGc2
|
1826 |
1895 |
2.19e-9 |
SMART |
|
IGc2
|
1925 |
1994 |
4.59e-12 |
SMART |
|
IGc2
|
2022 |
2097 |
1.33e-8 |
SMART |
|
IGc2
|
2125 |
2191 |
2.96e-15 |
SMART |
|
IGc2
|
2223 |
2291 |
2.03e-4 |
SMART |
|
IGc2
|
2321 |
2389 |
9.99e-13 |
SMART |
|
IGc2
|
2416 |
2484 |
3.03e-12 |
SMART |
|
IGc2
|
2512 |
2583 |
7.76e-10 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000194546
AA Change: T2049A
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000141391
Gene: ENSMUSG00000036334
AA Change: T2049A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
LRRNT
|
28 |
61 |
3.24e-4 |
SMART |
|
LRR
|
57 |
79 |
9.24e1 |
SMART |
|
LRR
|
80 |
103 |
2.02e-1 |
SMART |
|
LRR
|
104 |
127 |
7.16e0 |
SMART |
|
LRR_TYP
|
128 |
151 |
1.2e-3 |
SMART |
|
LRR
|
152 |
175 |
1.25e-1 |
SMART |
|
LRR
|
188 |
207 |
2.33e2 |
SMART |
|
LRRCT
|
219 |
280 |
4.19e-4 |
SMART |
|
IGc2
|
488 |
558 |
2.34e-4 |
SMART |
|
IGc2
|
586 |
652 |
7.88e-11 |
SMART |
|
low complexity region
|
917 |
930 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1185 |
N/A |
INTRINSIC |
|
low complexity region
|
1245 |
1263 |
N/A |
INTRINSIC |
|
low complexity region
|
1311 |
1321 |
N/A |
INTRINSIC |
|
low complexity region
|
1449 |
1465 |
N/A |
INTRINSIC |
|
IGc2
|
1632 |
1701 |
7.69e-14 |
SMART |
|
IGc2
|
1729 |
1798 |
5.07e-14 |
SMART |
|
IGc2
|
1826 |
1895 |
2.19e-9 |
SMART |
|
IGc2
|
1925 |
1994 |
4.59e-12 |
SMART |
|
IGc2
|
2022 |
2097 |
1.33e-8 |
SMART |
|
IGc2
|
2125 |
2191 |
2.96e-15 |
SMART |
|
IGc2
|
2223 |
2291 |
2.03e-4 |
SMART |
|
IGc2
|
2321 |
2389 |
9.99e-13 |
SMART |
|
IGc2
|
2416 |
2484 |
3.03e-12 |
SMART |
|
IGc2
|
2512 |
2583 |
7.76e-10 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197374
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199659
|
| SMART Domains |
Protein: ENSMUSP00000142903
Gene: ENSMUSG00000056476
| Domain | Start | End | E-Value | Type |
|---|
|
Med12
|
101 |
161 |
1.71e-24 |
SMART |
|
low complexity region
|
216 |
224 |
N/A |
INTRINSIC |
|
low complexity region
|
269 |
278 |
N/A |
INTRINSIC |
|
Pfam:Med12-LCEWAV
|
282 |
765 |
5.5e-209 |
PFAM |
|
low complexity region
|
779 |
793 |
N/A |
INTRINSIC |
|
low complexity region
|
888 |
907 |
N/A |
INTRINSIC |
|
low complexity region
|
1490 |
1501 |
N/A |
INTRINSIC |
|
low complexity region
|
1761 |
1775 |
N/A |
INTRINSIC |
|
low complexity region
|
1802 |
1816 |
N/A |
INTRINSIC |
|
Pfam:Med12-PQL
|
1836 |
2062 |
1.7e-15 |
PFAM |
|
low complexity region
|
2088 |
2130 |
N/A |
INTRINSIC |
|
low complexity region
|
2144 |
2164 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.2607 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.7%
|
| Validation Efficiency |
98% (126/129) |
| Allele List at MGI |
All alleles(2) : Targeted, other(2) |
| Other mutations in this stock |
Total: 129 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930578I07Rik |
A |
T |
14: 66,938,374 (GRCm38) |
H6L |
unknown |
Het |
| Abca13 |
G |
A |
11: 9,267,622 (GRCm38) |
|
probably null |
Het |
| Acad12 |
C |
T |
5: 121,607,448 (GRCm38) |
R260Q |
possibly damaging |
Het |
| Actn1 |
G |
A |
12: 80,260,100 (GRCm38) |
|
probably benign |
Het |
| Acvrl1 |
A |
G |
15: 101,136,149 (GRCm38) |
T182A |
probably damaging |
Het |
| Adam23 |
T |
C |
1: 63,567,844 (GRCm38) |
|
probably benign |
Het |
| Adamtsl1 |
A |
T |
4: 86,343,121 (GRCm38) |
T1190S |
probably benign |
Het |
| Adh6b |
A |
T |
3: 138,357,650 (GRCm38) |
Y330F |
probably benign |
Het |
| Ak7 |
A |
G |
12: 105,766,617 (GRCm38) |
E540G |
probably damaging |
Het |
| Akr1c19 |
T |
A |
13: 4,237,100 (GRCm38) |
L106Q |
probably damaging |
Het |
| Ankrd12 |
A |
T |
17: 66,049,852 (GRCm38) |
S57T |
probably damaging |
Het |
| Aoc3 |
G |
A |
11: 101,332,138 (GRCm38) |
R400Q |
possibly damaging |
Het |
| Arel1 |
A |
T |
12: 84,941,837 (GRCm38) |
I46N |
probably damaging |
Het |
| Armc5 |
A |
G |
7: 128,244,291 (GRCm38) |
D752G |
probably damaging |
Het |
| Atp11b |
T |
C |
3: 35,837,014 (GRCm38) |
V812A |
probably damaging |
Het |
| Axin1 |
A |
G |
17: 26,184,241 (GRCm38) |
H131R |
possibly damaging |
Het |
| Bpifb3 |
A |
G |
2: 153,923,869 (GRCm38) |
E184G |
probably benign |
Het |
| Cacna2d2 |
T |
C |
9: 107,524,383 (GRCm38) |
|
probably benign |
Het |
| Catsperd |
T |
C |
17: 56,662,828 (GRCm38) |
F641L |
probably benign |
Het |
| Ccdc83 |
A |
C |
7: 90,228,383 (GRCm38) |
L284V |
probably damaging |
Het |
| Ccnt2 |
T |
A |
1: 127,803,165 (GRCm38) |
V593E |
probably damaging |
Het |
| Cd53 |
T |
A |
3: 106,762,128 (GRCm38) |
I185F |
probably benign |
Het |
| Cep350 |
A |
T |
1: 155,848,620 (GRCm38) |
D3077E |
possibly damaging |
Het |
| Ces1h |
C |
A |
8: 93,357,000 (GRCm38) |
|
probably null |
Het |
| Chrna3 |
T |
A |
9: 55,016,006 (GRCm38) |
T173S |
probably benign |
Het |
| Clca4b |
T |
C |
3: 144,921,956 (GRCm38) |
D418G |
probably benign |
Het |
| Col11a2 |
T |
C |
17: 34,051,328 (GRCm38) |
|
probably benign |
Het |
| Coq2 |
T |
A |
5: 100,668,023 (GRCm38) |
I97F |
possibly damaging |
Het |
| Cr2 |
A |
G |
1: 195,160,359 (GRCm38) |
|
probably benign |
Het |
| Ctgf |
T |
A |
10: 24,596,466 (GRCm38) |
C136S |
probably damaging |
Het |
| D2hgdh |
A |
G |
1: 93,826,377 (GRCm38) |
Y24C |
probably damaging |
Het |
| D630045J12Rik |
G |
A |
6: 38,191,693 (GRCm38) |
R974C |
probably damaging |
Het |
| Dach1 |
A |
G |
14: 97,903,279 (GRCm38) |
V429A |
possibly damaging |
Het |
| Ddr1 |
G |
A |
17: 35,685,007 (GRCm38) |
T660I |
probably damaging |
Het |
| Dlg1 |
A |
C |
16: 31,796,864 (GRCm38) |
|
probably null |
Het |
| Dmbt1 |
T |
C |
7: 131,049,901 (GRCm38) |
|
probably benign |
Het |
| Dmxl2 |
A |
T |
9: 54,393,836 (GRCm38) |
D2330E |
probably benign |
Het |
| Doc2a |
A |
G |
7: 126,848,811 (GRCm38) |
T5A |
probably benign |
Het |
| Dock2 |
G |
A |
11: 34,704,718 (GRCm38) |
|
probably benign |
Het |
| Dok4 |
T |
A |
8: 94,865,238 (GRCm38) |
Y290F |
probably damaging |
Het |
| Dopey1 |
A |
G |
9: 86,485,497 (GRCm38) |
D11G |
probably damaging |
Het |
| E230025N22Rik |
T |
C |
18: 36,688,934 (GRCm38) |
H235R |
probably benign |
Het |
| Ear6 |
A |
G |
14: 51,854,452 (GRCm38) |
D152G |
probably damaging |
Het |
| Ecscr |
T |
A |
18: 35,713,636 (GRCm38) |
|
probably benign |
Het |
| Eml6 |
A |
T |
11: 29,760,010 (GRCm38) |
|
probably benign |
Het |
| Epha4 |
T |
A |
1: 77,388,541 (GRCm38) |
Q607L |
probably damaging |
Het |
| Exoc4 |
A |
G |
6: 33,972,063 (GRCm38) |
N947S |
probably benign |
Het |
| Flg |
A |
G |
3: 93,279,460 (GRCm38) |
E73G |
probably damaging |
Het |
| Fndc1 |
C |
T |
17: 7,784,341 (GRCm38) |
|
probably benign |
Het |
| Gad1-ps |
T |
C |
10: 99,444,992 (GRCm38) |
|
noncoding transcript |
Het |
| Gata6 |
A |
G |
18: 11,064,771 (GRCm38) |
T528A |
probably benign |
Het |
| Gjd4 |
T |
C |
18: 9,280,244 (GRCm38) |
E278G |
probably benign |
Het |
| Gm13101 |
T |
A |
4: 143,965,083 (GRCm38) |
T357S |
possibly damaging |
Het |
| Gm20091 |
T |
A |
10: 96,409,002 (GRCm38) |
|
noncoding transcript |
Het |
| Gnb3 |
G |
A |
6: 124,835,696 (GRCm38) |
Q266* |
probably null |
Het |
| Grm3 |
A |
G |
5: 9,512,446 (GRCm38) |
V468A |
possibly damaging |
Het |
| Igf1r |
C |
T |
7: 68,207,826 (GRCm38) |
R1085C |
probably damaging |
Het |
| Jak3 |
A |
T |
8: 71,685,482 (GRCm38) |
D859V |
probably benign |
Het |
| Kcnb2 |
G |
T |
1: 15,712,884 (GRCm38) |
|
probably benign |
Het |
| Kcnh3 |
G |
A |
15: 99,240,958 (GRCm38) |
G858D |
probably benign |
Het |
| Kif1a |
C |
A |
1: 93,043,638 (GRCm38) |
R1006L |
probably damaging |
Het |
| Klhl23 |
C |
T |
2: 69,824,413 (GRCm38) |
A209V |
probably benign |
Het |
| Mapk13 |
T |
C |
17: 28,775,255 (GRCm38) |
Y104H |
probably damaging |
Het |
| Mbd4 |
A |
G |
6: 115,849,482 (GRCm38) |
S183P |
probably damaging |
Het |
| Mga |
T |
C |
2: 119,919,706 (GRCm38) |
|
probably null |
Het |
| Mipol1 |
G |
A |
12: 57,414,411 (GRCm38) |
|
probably null |
Het |
| Mmp14 |
A |
G |
14: 54,438,709 (GRCm38) |
T299A |
possibly damaging |
Het |
| Mmrn1 |
A |
G |
6: 60,976,469 (GRCm38) |
E578G |
probably benign |
Het |
| Mov10l1 |
G |
A |
15: 88,994,860 (GRCm38) |
C193Y |
possibly damaging |
Het |
| Mppe1 |
A |
G |
18: 67,237,477 (GRCm38) |
C50R |
probably damaging |
Het |
| Msantd1 |
C |
A |
5: 34,917,725 (GRCm38) |
R44S |
probably damaging |
Het |
| Myt1l |
T |
C |
12: 29,842,571 (GRCm38) |
V69A |
possibly damaging |
Het |
| Nav1 |
A |
T |
1: 135,464,692 (GRCm38) |
|
probably benign |
Het |
| Ncan |
A |
G |
8: 70,108,602 (GRCm38) |
S572P |
possibly damaging |
Het |
| Nck2 |
T |
C |
1: 43,569,144 (GRCm38) |
|
probably benign |
Het |
| Nemf |
A |
T |
12: 69,356,314 (GRCm38) |
D31E |
probably damaging |
Het |
| Nlrp12 |
T |
C |
7: 3,249,262 (GRCm38) |
D93G |
possibly damaging |
Het |
| Nsmaf |
A |
T |
4: 6,419,930 (GRCm38) |
|
probably null |
Het |
| Nup98 |
T |
C |
7: 102,186,685 (GRCm38) |
T184A |
probably damaging |
Het |
| Olfr1415 |
A |
T |
1: 92,491,333 (GRCm38) |
C141S |
possibly damaging |
Het |
| Olfr46 |
A |
T |
7: 140,610,384 (GRCm38) |
N73Y |
probably damaging |
Het |
| Olfr522 |
A |
T |
7: 140,162,231 (GRCm38) |
S240T |
probably damaging |
Het |
| Oog2 |
C |
A |
4: 144,196,084 (GRCm38) |
Y306* |
probably null |
Het |
| Osmr |
A |
G |
15: 6,841,938 (GRCm38) |
|
probably benign |
Het |
| P2rx6 |
A |
G |
16: 17,568,298 (GRCm38) |
N275S |
probably benign |
Het |
| Papd4 |
A |
T |
13: 93,175,615 (GRCm38) |
|
probably benign |
Het |
| Pbxip1 |
G |
T |
3: 89,447,619 (GRCm38) |
G482W |
possibly damaging |
Het |
| Pcsk4 |
T |
G |
10: 80,325,334 (GRCm38) |
I249L |
probably damaging |
Het |
| Pou4f2 |
C |
T |
8: 78,435,662 (GRCm38) |
G104E |
probably damaging |
Het |
| Prkdc |
G |
T |
16: 15,833,788 (GRCm38) |
R3763L |
probably damaging |
Het |
| Ptpre |
A |
T |
7: 135,663,315 (GRCm38) |
I207F |
probably damaging |
Het |
| Rapgef3 |
A |
T |
15: 97,757,817 (GRCm38) |
|
probably benign |
Het |
| Rasgrp1 |
T |
G |
2: 117,284,947 (GRCm38) |
K685T |
probably benign |
Het |
| Rnf148 |
C |
T |
6: 23,654,238 (GRCm38) |
R253Q |
probably damaging |
Het |
| Rock1 |
T |
C |
18: 10,132,227 (GRCm38) |
I241V |
possibly damaging |
Het |
| Rp1l1 |
T |
G |
14: 64,022,092 (GRCm38) |
V61G |
probably damaging |
Het |
| Scin |
A |
C |
12: 40,081,771 (GRCm38) |
S255A |
probably damaging |
Het |
| Scn8a |
A |
T |
15: 101,035,624 (GRCm38) |
K1570* |
probably null |
Het |
| Sec14l4 |
A |
C |
11: 4,040,018 (GRCm38) |
M106L |
probably benign |
Het |
| Sec63 |
G |
A |
10: 42,798,799 (GRCm38) |
R226H |
probably benign |
Het |
| Sept2 |
T |
A |
1: 93,501,623 (GRCm38) |
N271K |
probably damaging |
Het |
| Serac1 |
G |
T |
17: 6,048,826 (GRCm38) |
|
probably benign |
Het |
| Shc2 |
T |
A |
10: 79,630,140 (GRCm38) |
|
probably benign |
Het |
| Sipa1l1 |
T |
A |
12: 82,425,099 (GRCm38) |
D1284E |
probably benign |
Het |
| Slc11a2 |
A |
G |
15: 100,408,216 (GRCm38) |
L105P |
probably damaging |
Het |
| Slc1a3 |
T |
A |
15: 8,650,922 (GRCm38) |
T151S |
probably benign |
Het |
| Smarca2 |
G |
T |
19: 26,691,362 (GRCm38) |
K920N |
probably damaging |
Het |
| Sugp2 |
G |
A |
8: 70,258,948 (GRCm38) |
E964K |
probably damaging |
Het |
| Tas2r122 |
A |
C |
6: 132,711,815 (GRCm38) |
N38K |
probably benign |
Het |
| Tecpr1 |
G |
A |
5: 144,206,274 (GRCm38) |
R730C |
probably damaging |
Het |
| Themis3 |
G |
T |
17: 66,593,270 (GRCm38) |
N34K |
possibly damaging |
Het |
| Traf3ip1 |
A |
G |
1: 91,499,619 (GRCm38) |
T104A |
unknown |
Het |
| Trappc11 |
A |
G |
8: 47,503,412 (GRCm38) |
V843A |
probably benign |
Het |
| Trmt61a |
T |
A |
12: 111,678,927 (GRCm38) |
L99Q |
probably damaging |
Het |
| Trp53tg5 |
T |
A |
2: 164,471,481 (GRCm38) |
K91N |
probably damaging |
Het |
| Ufsp2 |
T |
C |
8: 45,992,150 (GRCm38) |
S339P |
probably damaging |
Het |
| Usp20 |
T |
A |
2: 31,004,450 (GRCm38) |
V126E |
probably damaging |
Het |
| Vmn1r75 |
T |
A |
7: 11,880,870 (GRCm38) |
N176K |
probably damaging |
Het |
| Vmn2r24 |
A |
G |
6: 123,816,053 (GRCm38) |
S780G |
probably benign |
Het |
| Vmn2r89 |
A |
G |
14: 51,457,591 (GRCm38) |
|
probably null |
Het |
| Vps13d |
A |
T |
4: 145,045,095 (GRCm38) |
S4038T |
probably damaging |
Het |
| Vwa7 |
A |
G |
17: 35,022,651 (GRCm38) |
T421A |
probably damaging |
Het |
| Wdr78 |
T |
C |
4: 103,096,618 (GRCm38) |
N128S |
possibly damaging |
Het |
| Wdr95 |
C |
A |
5: 149,580,806 (GRCm38) |
L332I |
probably damaging |
Het |
| Wrn |
T |
A |
8: 33,336,091 (GRCm38) |
K181I |
probably damaging |
Het |
| Zc3h6 |
T |
A |
2: 129,017,223 (GRCm38) |
I1058N |
possibly damaging |
Het |
| Zfp423 |
T |
A |
8: 87,782,085 (GRCm38) |
I544F |
probably damaging |
Het |
| Zfp446 |
T |
A |
7: 12,979,589 (GRCm38) |
S161T |
possibly damaging |
Het |
| Zmym6 |
T |
A |
4: 127,123,369 (GRCm38) |
M889K |
probably benign |
Het |
|
| Other mutations in Igsf10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00773:Igsf10
|
APN |
3 |
59,331,539 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL00790:Igsf10
|
APN |
3 |
59,319,517 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00916:Igsf10
|
APN |
3 |
59,331,127 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL00928:Igsf10
|
APN |
3 |
59,330,597 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01066:Igsf10
|
APN |
3 |
59,327,782 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01107:Igsf10
|
APN |
3 |
59,331,524 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01420:Igsf10
|
APN |
3 |
59,319,650 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL01533:Igsf10
|
APN |
3 |
59,319,230 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01537:Igsf10
|
APN |
3 |
59,330,031 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01676:Igsf10
|
APN |
3 |
59,329,335 (GRCm38) |
missense |
probably benign |
0.17 |
|
IGL01676:Igsf10
|
APN |
3 |
59,326,011 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL01960:Igsf10
|
APN |
3 |
59,318,737 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02123:Igsf10
|
APN |
3 |
59,318,660 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02198:Igsf10
|
APN |
3 |
59,325,978 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL02268:Igsf10
|
APN |
3 |
59,331,152 (GRCm38) |
nonsense |
probably null |
|
|
IGL02313:Igsf10
|
APN |
3 |
59,330,690 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02368:Igsf10
|
APN |
3 |
59,328,231 (GRCm38) |
missense |
probably benign |
|
|
IGL02494:Igsf10
|
APN |
3 |
59,328,006 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02549:Igsf10
|
APN |
3 |
59,329,241 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02616:Igsf10
|
APN |
3 |
59,318,606 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL02957:Igsf10
|
APN |
3 |
59,330,864 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03067:Igsf10
|
APN |
3 |
59,318,918 (GRCm38) |
missense |
probably benign |
0.25 |
|
IGL03104:Igsf10
|
APN |
3 |
59,319,484 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03124:Igsf10
|
APN |
3 |
59,319,665 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL03212:Igsf10
|
APN |
3 |
59,328,165 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL03347:Igsf10
|
APN |
3 |
59,331,900 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL03357:Igsf10
|
APN |
3 |
59,336,211 (GRCm38) |
missense |
probably benign |
0.35 |
|
F6893:Igsf10
|
UTSW |
3 |
59,331,060 (GRCm38) |
missense |
probably damaging |
1.00 |
|
FR4449:Igsf10
|
UTSW |
3 |
59,319,110 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT1430001:Igsf10
|
UTSW |
3 |
59,328,158 (GRCm38) |
missense |
probably benign |
0.06 |
|
PIT4402001:Igsf10
|
UTSW |
3 |
59,325,579 (GRCm38) |
missense |
probably benign |
0.00 |
|
PIT4810001:Igsf10
|
UTSW |
3 |
59,318,482 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0068:Igsf10
|
UTSW |
3 |
59,330,624 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0095:Igsf10
|
UTSW |
3 |
59,331,196 (GRCm38) |
nonsense |
probably null |
|
|
R0095:Igsf10
|
UTSW |
3 |
59,331,196 (GRCm38) |
nonsense |
probably null |
|
|
R0112:Igsf10
|
UTSW |
3 |
59,326,008 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0141:Igsf10
|
UTSW |
3 |
59,330,832 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0551:Igsf10
|
UTSW |
3 |
59,328,668 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0556:Igsf10
|
UTSW |
3 |
59,328,875 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0582:Igsf10
|
UTSW |
3 |
59,319,767 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0630:Igsf10
|
UTSW |
3 |
59,326,062 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0675:Igsf10
|
UTSW |
3 |
59,328,594 (GRCm38) |
missense |
probably benign |
0.14 |
|
R0948:Igsf10
|
UTSW |
3 |
59,331,104 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1252:Igsf10
|
UTSW |
3 |
59,331,848 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1412:Igsf10
|
UTSW |
3 |
59,327,775 (GRCm38) |
splice site |
probably benign |
|
|
R1473:Igsf10
|
UTSW |
3 |
59,318,767 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1585:Igsf10
|
UTSW |
3 |
59,330,417 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1650:Igsf10
|
UTSW |
3 |
59,326,162 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1660:Igsf10
|
UTSW |
3 |
59,331,285 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1671:Igsf10
|
UTSW |
3 |
59,328,500 (GRCm38) |
nonsense |
probably null |
|
|
R1748:Igsf10
|
UTSW |
3 |
59,319,093 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1758:Igsf10
|
UTSW |
3 |
59,329,196 (GRCm38) |
missense |
probably benign |
0.09 |
|
R1856:Igsf10
|
UTSW |
3 |
59,331,272 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R1912:Igsf10
|
UTSW |
3 |
59,329,572 (GRCm38) |
missense |
probably benign |
0.40 |
|
R2148:Igsf10
|
UTSW |
3 |
59,336,577 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R2155:Igsf10
|
UTSW |
3 |
59,331,680 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2509:Igsf10
|
UTSW |
3 |
59,331,866 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2511:Igsf10
|
UTSW |
3 |
59,331,866 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2680:Igsf10
|
UTSW |
3 |
59,325,454 (GRCm38) |
missense |
probably benign |
0.14 |
|
R2913:Igsf10
|
UTSW |
3 |
59,331,736 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R2927:Igsf10
|
UTSW |
3 |
59,329,427 (GRCm38) |
missense |
probably benign |
|
|
R3547:Igsf10
|
UTSW |
3 |
59,336,514 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3547:Igsf10
|
UTSW |
3 |
59,330,541 (GRCm38) |
missense |
probably benign |
0.02 |
|
R3548:Igsf10
|
UTSW |
3 |
59,336,514 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3620:Igsf10
|
UTSW |
3 |
59,336,331 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3732:Igsf10
|
UTSW |
3 |
59,325,714 (GRCm38) |
missense |
probably benign |
0.29 |
|
R3743:Igsf10
|
UTSW |
3 |
59,326,125 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R3973:Igsf10
|
UTSW |
3 |
59,331,924 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4005:Igsf10
|
UTSW |
3 |
59,328,560 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4184:Igsf10
|
UTSW |
3 |
59,319,731 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4302:Igsf10
|
UTSW |
3 |
59,318,750 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4404:Igsf10
|
UTSW |
3 |
59,329,551 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4575:Igsf10
|
UTSW |
3 |
59,330,100 (GRCm38) |
missense |
probably benign |
|
|
R4676:Igsf10
|
UTSW |
3 |
59,325,949 (GRCm38) |
missense |
probably benign |
0.23 |
|
R4700:Igsf10
|
UTSW |
3 |
59,320,330 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4765:Igsf10
|
UTSW |
3 |
59,329,705 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4986:Igsf10
|
UTSW |
3 |
59,328,606 (GRCm38) |
missense |
probably benign |
0.24 |
|
R5012:Igsf10
|
UTSW |
3 |
59,318,722 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5070:Igsf10
|
UTSW |
3 |
59,328,293 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5083:Igsf10
|
UTSW |
3 |
59,326,273 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5336:Igsf10
|
UTSW |
3 |
59,320,132 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5462:Igsf10
|
UTSW |
3 |
59,325,754 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5648:Igsf10
|
UTSW |
3 |
59,328,153 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5810:Igsf10
|
UTSW |
3 |
59,319,071 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5871:Igsf10
|
UTSW |
3 |
59,330,411 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R5880:Igsf10
|
UTSW |
3 |
59,330,831 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5935:Igsf10
|
UTSW |
3 |
59,328,157 (GRCm38) |
missense |
probably benign |
0.12 |
|
R5979:Igsf10
|
UTSW |
3 |
59,336,473 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6145:Igsf10
|
UTSW |
3 |
59,331,656 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R6222:Igsf10
|
UTSW |
3 |
59,318,915 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R6224:Igsf10
|
UTSW |
3 |
59,325,510 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6264:Igsf10
|
UTSW |
3 |
59,328,507 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R6283:Igsf10
|
UTSW |
3 |
59,319,449 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6336:Igsf10
|
UTSW |
3 |
59,330,339 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6490:Igsf10
|
UTSW |
3 |
59,329,571 (GRCm38) |
missense |
probably benign |
0.06 |
|
R6785:Igsf10
|
UTSW |
3 |
59,319,244 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6873:Igsf10
|
UTSW |
3 |
59,328,444 (GRCm38) |
missense |
probably benign |
|
|
R6889:Igsf10
|
UTSW |
3 |
59,331,933 (GRCm38) |
missense |
probably benign |
|
|
R7024:Igsf10
|
UTSW |
3 |
59,331,701 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7056:Igsf10
|
UTSW |
3 |
59,331,080 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7128:Igsf10
|
UTSW |
3 |
59,328,905 (GRCm38) |
missense |
probably benign |
|
|
R7251:Igsf10
|
UTSW |
3 |
59,319,454 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7313:Igsf10
|
UTSW |
3 |
59,329,416 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7340:Igsf10
|
UTSW |
3 |
59,325,768 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7447:Igsf10
|
UTSW |
3 |
59,331,801 (GRCm38) |
missense |
probably benign |
0.39 |
|
R7506:Igsf10
|
UTSW |
3 |
59,319,354 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7678:Igsf10
|
UTSW |
3 |
59,319,340 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R7695:Igsf10
|
UTSW |
3 |
59,326,191 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7709:Igsf10
|
UTSW |
3 |
59,331,543 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R7749:Igsf10
|
UTSW |
3 |
59,329,128 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R7808:Igsf10
|
UTSW |
3 |
59,328,068 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7850:Igsf10
|
UTSW |
3 |
59,319,632 (GRCm38) |
missense |
probably benign |
0.33 |
|
R7879:Igsf10
|
UTSW |
3 |
59,330,724 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7886:Igsf10
|
UTSW |
3 |
59,328,327 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7891:Igsf10
|
UTSW |
3 |
59,328,411 (GRCm38) |
nonsense |
probably null |
|
|
R7946:Igsf10
|
UTSW |
3 |
59,319,704 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R7948:Igsf10
|
UTSW |
3 |
59,331,858 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8004:Igsf10
|
UTSW |
3 |
59,329,709 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8096:Igsf10
|
UTSW |
3 |
59,328,959 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8141:Igsf10
|
UTSW |
3 |
59,330,528 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8183:Igsf10
|
UTSW |
3 |
59,330,615 (GRCm38) |
missense |
probably benign |
0.04 |
|
R8203:Igsf10
|
UTSW |
3 |
59,328,833 (GRCm38) |
missense |
probably benign |
0.11 |
|
R8325:Igsf10
|
UTSW |
3 |
59,318,533 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8350:Igsf10
|
UTSW |
3 |
59,331,528 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8387:Igsf10
|
UTSW |
3 |
59,329,143 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8488:Igsf10
|
UTSW |
3 |
59,320,010 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8697:Igsf10
|
UTSW |
3 |
59,318,887 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8786:Igsf10
|
UTSW |
3 |
59,330,642 (GRCm38) |
missense |
probably benign |
0.25 |
|
R8804:Igsf10
|
UTSW |
3 |
59,336,455 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8886:Igsf10
|
UTSW |
3 |
59,329,989 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8902:Igsf10
|
UTSW |
3 |
59,336,212 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8906:Igsf10
|
UTSW |
3 |
59,326,318 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8917:Igsf10
|
UTSW |
3 |
59,319,467 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R9051:Igsf10
|
UTSW |
3 |
59,329,247 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9178:Igsf10
|
UTSW |
3 |
59,326,059 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R9228:Igsf10
|
UTSW |
3 |
59,336,422 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9230:Igsf10
|
UTSW |
3 |
59,336,422 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9231:Igsf10
|
UTSW |
3 |
59,336,422 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9232:Igsf10
|
UTSW |
3 |
59,336,422 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9417:Igsf10
|
UTSW |
3 |
59,329,105 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9609:Igsf10
|
UTSW |
3 |
59,319,448 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9631:Igsf10
|
UTSW |
3 |
59,330,483 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9689:Igsf10
|
UTSW |
3 |
59,326,203 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9762:Igsf10
|
UTSW |
3 |
59,329,685 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9770:Igsf10
|
UTSW |
3 |
59,319,778 (GRCm38) |
missense |
probably benign |
0.07 |
|
R9798:Igsf10
|
UTSW |
3 |
59,331,705 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1088:Igsf10
|
UTSW |
3 |
59,329,938 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
Z1177:Igsf10
|
UTSW |
3 |
59,329,605 (GRCm38) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTCCCAGAGTCAAGCGGTTTCAC -3'
(R):5'- TGCATGTCCGCCTAAGACTGACAC -3'
Sequencing Primer
(F):5'- TGATGGACAAAGTTCCATTGGC -3'
(R):5'- GACTGACACCTGCCAAAATTG -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation