Mutagenetix > Incidental Mutation

Incidental Mutation 'R0539:Hydin'

49709

Institutional Source

Beutler Lab

Gene Symbol

Hydin

Ensembl Gene

ENSMUSG00000059854

Gene Name

HYDIN, axonemal central pair apparatus protein

Synonyms

hy-3, hyrh, hy3, 1700034M11Rik, 4930545D19Rik

MMRRC Submission

038731-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.797) question?

Stock #

R0539 (G1)

Quality Score

191

Status

Validated

Chromosome

Chromosomal Location

110266977-110610253 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 110523072 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 2216 (I2216V)

Ref Sequence

ENSEMBL: ENSMUSP00000046204 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043141]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000043141
AA Change: I2216V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000046204
Gene: ENSMUSG00000059854
AA Change: I2216V

Domain	Start	End	E-Value	Type
Pfam:Motile_Sperm	246	325	5.6e-8	PFAM
Pfam:ASH	559	659	9.4e-17	PFAM
low complexity region	788	798	N/A	INTRINSIC
Pfam:PapD-like	848	906	1.2e-6	PFAM
low complexity region	998	1024	N/A	INTRINSIC
low complexity region	1279	1292	N/A	INTRINSIC
internal_repeat_6	1317	1549	5.96e-5	PROSPERO
internal_repeat_5	1355	1502	3.23e-5	PROSPERO
low complexity region	1574	1590	N/A	INTRINSIC
internal_repeat_4	1712	1940	5.14e-6	PROSPERO
coiled coil region	1947	1977	N/A	INTRINSIC
low complexity region	2009	2020	N/A	INTRINSIC
low complexity region	2034	2049	N/A	INTRINSIC
SCOP:d1eq1a_	2305	2403	3e-4	SMART
low complexity region	2404	2419	N/A	INTRINSIC
coiled coil region	2543	2588	N/A	INTRINSIC
low complexity region	2636	2656	N/A	INTRINSIC
internal_repeat_7	2772	3008	8.1e-5	PROSPERO
low complexity region	3660	3670	N/A	INTRINSIC
low complexity region	3919	3934	N/A	INTRINSIC
internal_repeat_5	4046	4190	3.23e-5	PROSPERO
internal_repeat_2	4106	4251	6.03e-7	PROSPERO
internal_repeat_4	4317	4532	5.14e-6	PROSPERO
internal_repeat_3	4403	4689	2.05e-6	PROSPERO
internal_repeat_2	4549	4697	6.03e-7	PROSPERO
low complexity region	4951	4964	N/A	INTRINSIC

Meta Mutation Damage Score

0.0599

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.3%

Validation Efficiency

100% (107/107)

MGI Phenotype

Strain: 1856913; 3801608
Lethality: D28-D42
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that may be involved in cilia motility. Mutations in this gene cause of autosomal recessive primary ciliary dyskinesia-5, a disorder characterized by the accumulation of cerebrospinal fluid within the ventricles of the brain. A duplicate copy of this gene has been found in humans on chromosome 1. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for a mutation in this gene develop hydrocephaly after birth. Symptoms develop after 3-5 days. Affected animals usually die before 2 months of age. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted(1) Gene trapped(3) Transgenic(1) Spontaneous(2)

Other mutations in this stock

Total: 108 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5730480H06Rik	T	A	5: 48,379,350 (GRCm38)	H129Q	probably damaging	Het
Abca14	G	A	7: 120,207,797 (GRCm38)	R22Q	probably damaging	Het
Abcg5	T	A	17: 84,669,075 (GRCm38)	M445L	probably benign	Het
Abhd3	T	A	18: 10,645,208 (GRCm38)	N357I	possibly damaging	Het
Adamts5	C	T	16: 85,868,692 (GRCm38)	G574S	probably damaging	Het
Adgrg5	T	A	8: 94,938,632 (GRCm38)	N389K	probably damaging	Het
Ankk1	A	G	9: 49,418,030 (GRCm38)	V80A	probably benign	Het
Arhgap20	A	G	9: 51,850,155 (GRCm38)	Q1066R	probably benign	Het
Arhgap21	T	A	2: 20,914,799 (GRCm38)	K32*	probably null	Het
AW209491	T	C	13: 14,637,732 (GRCm38)	F390S	probably damaging	Het
Axl	A	T	7: 25,778,717 (GRCm38)		probably benign	Het
Bri3bp	A	G	5: 125,454,539 (GRCm38)	Y183C	probably damaging	Het
Cad	T	C	5: 31,075,457 (GRCm38)		probably benign	Het
Capns2	A	G	8: 92,901,732 (GRCm38)	Q83R	possibly damaging	Het
Ccdc180	G	T	4: 45,922,010 (GRCm38)	R1028L	probably damaging	Het
Cdh19	C	A	1: 110,925,162 (GRCm38)	V348F	possibly damaging	Het
Chrm2	T	C	6: 36,523,706 (GRCm38)	V166A	possibly damaging	Het
Clmp	A	G	9: 40,782,486 (GRCm38)	Y333C	probably benign	Het
Cntn3	A	G	6: 102,277,217 (GRCm38)		probably null	Het
Copz1	A	G	15: 103,291,365 (GRCm38)	Y69C	probably damaging	Het
Crybg1	T	C	10: 43,998,898 (GRCm38)	D738G	probably benign	Het
Ctnna2	T	A	6: 76,973,899 (GRCm38)	I165F	probably damaging	Het
Dcaf7	T	G	11: 106,051,826 (GRCm38)	S200A	probably damaging	Het
Deup1	T	A	9: 15,582,597 (GRCm38)	R416S	possibly damaging	Het
Dmxl1	T	A	18: 49,857,430 (GRCm38)		probably benign	Het
Dnaaf11	A	T	15: 66,447,606 (GRCm38)	V305D	probably damaging	Het
Dnase2b	A	T	3: 146,589,155 (GRCm38)		probably benign	Het
Dst	C	T	1: 34,189,119 (GRCm38)	P1606L	probably damaging	Het
Eef2	C	CN	10: 81,178,768 (GRCm38)		probably null	Het
Ephb2	T	C	4: 136,655,976 (GRCm38)	Y931C	probably damaging	Het
Fam83h	T	C	15: 76,003,227 (GRCm38)	S754G	possibly damaging	Het
Fibp	T	A	19: 5,463,188 (GRCm38)	V177D	probably damaging	Het
Gfpt2	T	C	11: 49,832,898 (GRCm38)	I571T	probably damaging	Het
Grm7	T	G	6: 111,359,094 (GRCm38)		probably benign	Het
Gsdma3	A	G	11: 98,635,919 (GRCm38)	Y335C	probably damaging	Het
H2-T23	A	T	17: 36,032,141 (GRCm38)		probably benign	Het
H4c3	A	G	13: 23,698,148 (GRCm38)	F101S	probably damaging	Het
Ipo8	A	G	6: 148,818,108 (GRCm38)	M113T	probably benign	Het
Kdm6a	A	G	X: 18,262,425 (GRCm38)	E1045G	probably damaging	Het
Kyat1	C	T	2: 30,188,217 (GRCm38)	E117K	probably damaging	Het
Lin7b	A	G	7: 45,369,902 (GRCm38)		probably benign	Het
Lipn	G	A	19: 34,084,603 (GRCm38)		probably benign	Het
Lrfn2	C	A	17: 49,071,044 (GRCm38)	N384K	probably damaging	Het
Map1b	T	C	13: 99,434,018 (GRCm38)	K732E	unknown	Het
Mpl	A	G	4: 118,443,508 (GRCm38)	M541T	possibly damaging	Het
Mprip	T	C	11: 59,741,117 (GRCm38)		probably benign	Het
Mrc1	T	C	2: 14,270,126 (GRCm38)		probably benign	Het
Ms4a13	T	C	19: 11,171,871 (GRCm38)		probably benign	Het
Myo18b	G	T	5: 112,723,868 (GRCm38)	R2116S	probably damaging	Het
Nav2	A	G	7: 49,461,938 (GRCm38)	T731A	probably damaging	Het
Ncoa6	G	T	2: 155,415,697 (GRCm38)	A642D	probably benign	Het
Ndufs7	T	A	10: 80,254,831 (GRCm38)		probably benign	Het
Nfkbiz	G	A	16: 55,817,879 (GRCm38)	T406M	probably benign	Het
Nr4a1	A	G	15: 101,270,884 (GRCm38)	E267G	probably damaging	Het
Nrxn2	T	G	19: 6,493,404 (GRCm38)	F1103V	probably damaging	Het
Or10ab4	C	T	7: 108,055,822 (GRCm38)	T280I	probably damaging	Het
Or10d3	A	T	9: 39,550,297 (GRCm38)	D191E	probably damaging	Het
Or1e22	T	C	11: 73,486,063 (GRCm38)	T254A	probably benign	Het
Or5a3	C	T	19: 12,422,809 (GRCm38)	L167F	probably damaging	Het
Or5g27	T	A	2: 85,579,775 (GRCm38)	C179S	probably damaging	Het
Or5m11	G	T	2: 85,952,009 (GRCm38)	M315I	probably benign	Het
Or8u9	A	T	2: 86,171,043 (GRCm38)	M258K	probably damaging	Het
Phf1	A	G	17: 26,934,458 (GRCm38)		probably null	Het
Pip	C	T	6: 41,849,885 (GRCm38)	Q53*	probably null	Het
Ppp2ca	T	C	11: 52,118,162 (GRCm38)		probably null	Het
Prl2c5	A	G	13: 13,189,321 (GRCm38)		probably null	Het
Psph	T	A	5: 129,766,577 (GRCm38)		probably benign	Het
Ptch1	C	T	13: 63,543,480 (GRCm38)		probably benign	Het
Ptprs	C	T	17: 56,458,255 (GRCm38)	V10M	probably damaging	Het
Rarg	T	C	15: 102,238,877 (GRCm38)	R358G	probably damaging	Het
Rbl2	T	C	8: 91,112,505 (GRCm38)		probably benign	Het
Robo2	A	T	16: 73,985,574 (GRCm38)		probably benign	Het
Scin	A	T	12: 40,081,766 (GRCm38)	D256E	possibly damaging	Het
Scn8a	T	C	15: 101,016,568 (GRCm38)	Y1152H	probably damaging	Het
Sh2b2	T	G	5: 136,225,301 (GRCm38)		probably benign	Het
Slc13a2	G	A	11: 78,399,138 (GRCm38)	P450L	probably damaging	Het
Slc2a12	A	G	10: 22,692,230 (GRCm38)	I519V	probably benign	Het
Slc30a9	C	T	5: 67,334,610 (GRCm38)	T260M	probably damaging	Het
Slc9a7	A	T	X: 20,202,762 (GRCm38)	F184Y	probably damaging	Het
Smc2	G	T	4: 52,458,558 (GRCm38)	K466N	probably benign	Het
Snx16	T	C	3: 10,426,218 (GRCm38)	E209G	probably damaging	Het
Sp3	A	T	2: 72,970,532 (GRCm38)	I423N	possibly damaging	Het
Ssh2	G	T	11: 77,454,794 (GRCm38)	V1202F	probably benign	Het
Stam2	A	T	2: 52,703,256 (GRCm38)		probably benign	Het
Stox2	T	C	8: 47,194,035 (GRCm38)	Y194C	probably damaging	Het
Sult3a1	A	G	10: 33,866,523 (GRCm38)	T49A	probably damaging	Het
Supt3	A	T	17: 45,003,131 (GRCm38)	I136F	possibly damaging	Het
Syne2	A	T	12: 76,024,121 (GRCm38)	R103S	possibly damaging	Het
Synj2	T	A	17: 5,996,888 (GRCm38)	M1K	probably null	Het
Tas2r110	T	C	6: 132,868,371 (GRCm38)	S122P	possibly damaging	Het
Tln1	A	G	4: 43,543,434 (GRCm38)		probably null	Het
Tmem117	A	G	15: 94,714,912 (GRCm38)	T110A	possibly damaging	Het
Tmem247	A	G	17: 86,917,478 (GRCm38)	D5G	probably benign	Het
Tmem39a	T	A	16: 38,590,975 (GRCm38)	F363I	probably benign	Het
Tmem80	G	A	7: 141,335,895 (GRCm38)	A73T	possibly damaging	Het
Trpm4	C	T	7: 45,305,472 (GRCm38)	G901S	probably damaging	Het
Upk3bl	T	C	5: 136,063,986 (GRCm38)		probably benign	Het
Vmn1r120	A	T	7: 21,053,472 (GRCm38)	C105S	probably damaging	Het
Vmn1r69	A	T	7: 10,580,947 (GRCm38)		probably benign	Het
Vmn2r95	T	C	17: 18,452,100 (GRCm38)	F700L	probably damaging	Het
Wdr70	G	A	15: 7,885,637 (GRCm38)	T550M	possibly damaging	Het
Zbtb22	A	G	17: 33,918,144 (GRCm38)	D421G	possibly damaging	Het
Zbtb45	G	A	7: 13,006,333 (GRCm38)	R452C	probably damaging	Het
Zfhx3	T	C	8: 108,800,509 (GRCm38)	Y1013H	probably damaging	Het
Zfp329	C	T	7: 12,806,593 (GRCm38)		probably null	Het
Zfp532	T	A	18: 65,623,766 (GRCm38)	S257T	probably benign	Het
Zfp933	G	A	4: 147,826,548 (GRCm38)	T197I	probably benign	Het
Zgrf1	T	A	3: 127,615,192 (GRCm38)	N1649K	probably damaging	Het

Other mutations in Hydin

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00338:Hydin	APN	8	110,569,802 (GRCm38)	missense	possibly damaging	0.69
IGL00432:Hydin	APN	8	110,601,252 (GRCm38)	missense	probably damaging	0.98
IGL01025:Hydin	APN	8	110,326,401 (GRCm38)	missense	probably benign	0.38
IGL01140:Hydin	APN	8	110,398,062 (GRCm38)	missense	probably benign	0.14
IGL01317:Hydin	APN	8	110,326,446 (GRCm38)	missense	probably damaging	0.98
IGL01473:Hydin	APN	8	110,312,160 (GRCm38)	missense	probably benign	0.08
IGL01473:Hydin	APN	8	110,354,953 (GRCm38)	missense	probably damaging	1.00
IGL01610:Hydin	APN	8	110,557,713 (GRCm38)	missense	probably benign	0.00
IGL01685:Hydin	APN	8	110,355,033 (GRCm38)	nonsense	probably null
IGL01734:Hydin	APN	8	110,490,789 (GRCm38)	nonsense	probably null
IGL01743:Hydin	APN	8	110,592,776 (GRCm38)	missense	possibly damaging	0.94
IGL01829:Hydin	APN	8	110,589,522 (GRCm38)	missense	possibly damaging	0.68
IGL01919:Hydin	APN	8	110,519,174 (GRCm38)	missense	possibly damaging	0.89
IGL01946:Hydin	APN	8	110,490,718 (GRCm38)	missense	possibly damaging	0.91
IGL01983:Hydin	APN	8	110,514,895 (GRCm38)	missense	probably benign	0.02
IGL02122:Hydin	APN	8	110,494,415 (GRCm38)	missense	possibly damaging	0.86
IGL02140:Hydin	APN	8	110,566,938 (GRCm38)	missense	probably benign
IGL02158:Hydin	APN	8	110,609,966 (GRCm38)	missense	possibly damaging	0.89
IGL02167:Hydin	APN	8	110,418,423 (GRCm38)	missense	possibly damaging	0.96
IGL02171:Hydin	APN	8	110,451,958 (GRCm38)	nonsense	probably null
IGL02185:Hydin	APN	8	110,506,476 (GRCm38)	missense	possibly damaging	0.86
IGL02517:Hydin	APN	8	110,566,972 (GRCm38)	missense	probably benign	0.01
IGL02639:Hydin	APN	8	110,538,449 (GRCm38)	missense	probably benign	0.01
IGL02644:Hydin	APN	8	110,538,468 (GRCm38)	missense	probably damaging	1.00
IGL02652:Hydin	APN	8	110,589,522 (GRCm38)	missense	possibly damaging	0.68
IGL02658:Hydin	APN	8	110,413,276 (GRCm38)	missense	possibly damaging	0.86
IGL02706:Hydin	APN	8	110,410,566 (GRCm38)	missense	probably damaging	0.99
IGL02892:Hydin	APN	8	110,598,959 (GRCm38)	missense	possibly damaging	0.89
IGL02947:Hydin	APN	8	110,418,462 (GRCm38)	missense	probably damaging	0.96
IGL03136:Hydin	APN	8	110,418,524 (GRCm38)	missense	probably benign	0.22
IGL03248:Hydin	APN	8	110,595,289 (GRCm38)	missense	probably damaging	0.97
IGL03251:Hydin	APN	8	110,490,596 (GRCm38)	missense	probably damaging	1.00
IGL03350:Hydin	APN	8	110,312,224 (GRCm38)	missense	possibly damaging	0.86
IGL03366:Hydin	APN	8	110,267,363 (GRCm38)	missense	unknown
IGL03404:Hydin	APN	8	110,569,777 (GRCm38)	missense	probably benign	0.06
Franz_joseph	UTSW	8	110,601,318 (GRCm38)	missense	probably damaging	1.00
jahreszeiten	UTSW	8	110,569,359 (GRCm38)	missense	probably damaging	1.00
maria	UTSW	8	110,509,127 (GRCm38)	splice site	probably benign
schoepfung	UTSW	8	110,600,245 (GRCm38)	missense	possibly damaging	0.68
surprise	UTSW	8	110,528,016 (GRCm38)	missense	probably benign
teresa	UTSW	8	110,609,671 (GRCm38)	missense	possibly damaging	0.79
BB001:Hydin	UTSW	8	110,418,471 (GRCm38)	missense	possibly damaging	0.93
BB004:Hydin	UTSW	8	110,580,844 (GRCm38)	missense	possibly damaging	0.89
BB011:Hydin	UTSW	8	110,418,471 (GRCm38)	missense	possibly damaging	0.93
BB014:Hydin	UTSW	8	110,580,844 (GRCm38)	missense	possibly damaging	0.89
P0005:Hydin	UTSW	8	110,494,289 (GRCm38)	critical splice acceptor site	probably null
R0099:Hydin	UTSW	8	110,589,561 (GRCm38)	missense	probably damaging	1.00
R0125:Hydin	UTSW	8	110,462,531 (GRCm38)	missense	probably benign	0.12
R0157:Hydin	UTSW	8	110,300,010 (GRCm38)	missense	possibly damaging	0.86
R0241:Hydin	UTSW	8	110,398,023 (GRCm38)	missense	probably benign	0.04
R0241:Hydin	UTSW	8	110,398,023 (GRCm38)	missense	probably benign	0.04
R0255:Hydin	UTSW	8	110,565,018 (GRCm38)	missense	probably benign	0.00
R0352:Hydin	UTSW	8	110,569,901 (GRCm38)	critical splice donor site	probably null
R0379:Hydin	UTSW	8	110,509,127 (GRCm38)	splice site	probably benign
R0468:Hydin	UTSW	8	110,413,223 (GRCm38)	missense	possibly damaging	0.96
R0477:Hydin	UTSW	8	110,418,498 (GRCm38)	missense	probably damaging	1.00
R0479:Hydin	UTSW	8	110,599,088 (GRCm38)	missense	probably damaging	1.00
R0550:Hydin	UTSW	8	110,587,775 (GRCm38)	missense	probably benign	0.01
R0571:Hydin	UTSW	8	110,514,103 (GRCm38)	splice site	probably null
R0606:Hydin	UTSW	8	110,549,798 (GRCm38)	splice site	probably benign
R0789:Hydin	UTSW	8	110,566,971 (GRCm38)	missense	possibly damaging	0.53
R0849:Hydin	UTSW	8	110,598,984 (GRCm38)	missense	probably damaging	1.00
R0946:Hydin	UTSW	8	110,531,053 (GRCm38)	missense	probably benign	0.25
R1201:Hydin	UTSW	8	110,569,855 (GRCm38)	missense	probably benign	0.01
R1375:Hydin	UTSW	8	110,506,222 (GRCm38)	critical splice donor site	probably null
R1385:Hydin	UTSW	8	110,523,204 (GRCm38)	missense	probably benign	0.40
R1411:Hydin	UTSW	8	110,575,031 (GRCm38)	missense	probably benign	0.04
R1437:Hydin	UTSW	8	110,581,985 (GRCm38)	nonsense	probably null
R1447:Hydin	UTSW	8	110,523,166 (GRCm38)	missense	probably damaging	1.00
R1448:Hydin	UTSW	8	110,446,585 (GRCm38)	missense	probably benign	0.27
R1466:Hydin	UTSW	8	110,532,953 (GRCm38)	missense	possibly damaging	0.47
R1466:Hydin	UTSW	8	110,532,953 (GRCm38)	missense	possibly damaging	0.47
R1523:Hydin	UTSW	8	110,533,271 (GRCm38)	missense	probably benign	0.05
R1544:Hydin	UTSW	8	110,574,854 (GRCm38)	missense	probably benign	0.30
R1581:Hydin	UTSW	8	110,410,460 (GRCm38)	missense	probably benign
R1584:Hydin	UTSW	8	110,580,815 (GRCm38)	missense	probably benign	0.27
R1598:Hydin	UTSW	8	110,410,674 (GRCm38)	missense	possibly damaging	0.96
R1633:Hydin	UTSW	8	110,506,982 (GRCm38)	missense	probably benign	0.10
R1777:Hydin	UTSW	8	110,589,571 (GRCm38)	missense	probably benign	0.14
R1817:Hydin	UTSW	8	110,532,827 (GRCm38)	missense	probably benign	0.00
R1828:Hydin	UTSW	8	110,510,894 (GRCm38)	missense	probably benign	0.03
R1837:Hydin	UTSW	8	110,569,625 (GRCm38)	missense	probably benign	0.20
R1848:Hydin	UTSW	8	110,569,808 (GRCm38)	missense	probably benign	0.19
R1869:Hydin	UTSW	8	110,500,705 (GRCm38)	missense	possibly damaging	0.94
R1909:Hydin	UTSW	8	110,587,772 (GRCm38)	missense	probably damaging	1.00
R1928:Hydin	UTSW	8	110,502,947 (GRCm38)	missense	possibly damaging	0.93
R1950:Hydin	UTSW	8	110,609,987 (GRCm38)	missense	possibly damaging	0.64
R2095:Hydin	UTSW	8	110,462,657 (GRCm38)	missense	probably damaging	0.96
R2172:Hydin	UTSW	8	110,582,049 (GRCm38)	missense	probably benign	0.42
R2217:Hydin	UTSW	8	110,418,506 (GRCm38)	missense	probably benign
R2248:Hydin	UTSW	8	110,578,203 (GRCm38)	missense	probably benign	0.09
R2272:Hydin	UTSW	8	110,309,132 (GRCm38)	missense	probably benign	0.01
R2294:Hydin	UTSW	8	110,299,959 (GRCm38)	missense	probably damaging	0.99
R2315:Hydin	UTSW	8	110,398,044 (GRCm38)	missense	probably benign	0.01
R2330:Hydin	UTSW	8	110,565,009 (GRCm38)	missense	probably benign	0.01
R2374:Hydin	UTSW	8	110,565,148 (GRCm38)	missense	probably damaging	1.00
R2446:Hydin	UTSW	8	110,587,715 (GRCm38)	missense	possibly damaging	0.82
R2484:Hydin	UTSW	8	110,513,115 (GRCm38)	missense	possibly damaging	0.76
R2698:Hydin	UTSW	8	110,609,929 (GRCm38)	missense	possibly damaging	0.70
R2843:Hydin	UTSW	8	110,519,114 (GRCm38)	missense	probably benign
R2844:Hydin	UTSW	8	110,519,114 (GRCm38)	missense	probably benign
R2846:Hydin	UTSW	8	110,519,114 (GRCm38)	missense	probably benign
R2882:Hydin	UTSW	8	110,566,923 (GRCm38)	missense	possibly damaging	0.92
R2937:Hydin	UTSW	8	110,404,295 (GRCm38)	missense	possibly damaging	0.88
R3031:Hydin	UTSW	8	110,603,216 (GRCm38)	missense	possibly damaging	0.83
R3038:Hydin	UTSW	8	110,582,689 (GRCm38)	missense	probably damaging	1.00
R3121:Hydin	UTSW	8	110,506,506 (GRCm38)	missense	probably benign
R3157:Hydin	UTSW	8	110,267,373 (GRCm38)	missense	unknown
R3547:Hydin	UTSW	8	110,582,067 (GRCm38)	missense	possibly damaging	0.85
R3696:Hydin	UTSW	8	110,603,279 (GRCm38)	missense	probably damaging	1.00
R3850:Hydin	UTSW	8	110,563,929 (GRCm38)	missense	probably damaging	0.99
R3896:Hydin	UTSW	8	110,509,079 (GRCm38)	missense	possibly damaging	0.93
R3983:Hydin	UTSW	8	110,392,325 (GRCm38)	missense	probably damaging	1.00
R4031:Hydin	UTSW	8	110,610,047 (GRCm38)	missense	probably benign	0.30
R4072:Hydin	UTSW	8	110,505,256 (GRCm38)	missense	possibly damaging	0.68
R4095:Hydin	UTSW	8	110,541,547 (GRCm38)	missense	probably damaging	0.98
R4176:Hydin	UTSW	8	110,593,820 (GRCm38)	missense	probably benign	0.00
R4213:Hydin	UTSW	8	110,456,507 (GRCm38)	missense	possibly damaging	0.91
R4412:Hydin	UTSW	8	110,415,736 (GRCm38)	missense	probably damaging	0.99
R4471:Hydin	UTSW	8	110,587,132 (GRCm38)	missense	probably damaging	1.00
R4474:Hydin	UTSW	8	110,563,865 (GRCm38)	missense	probably benign	0.11
R4495:Hydin	UTSW	8	110,595,402 (GRCm38)	missense	probably damaging	0.99
R4508:Hydin	UTSW	8	110,519,254 (GRCm38)	missense	possibly damaging	0.91
R4578:Hydin	UTSW	8	110,267,339 (GRCm38)	missense	unknown
R4583:Hydin	UTSW	8	110,595,225 (GRCm38)	missense	probably benign	0.36
R4600:Hydin	UTSW	8	110,566,950 (GRCm38)	missense	probably benign	0.04
R4681:Hydin	UTSW	8	110,506,471 (GRCm38)	missense	possibly damaging	0.85
R4685:Hydin	UTSW	8	110,462,522 (GRCm38)	missense	probably damaging	0.99
R4689:Hydin	UTSW	8	110,595,414 (GRCm38)	missense	probably benign	0.18
R4735:Hydin	UTSW	8	110,555,632 (GRCm38)	critical splice donor site	probably null
R4736:Hydin	UTSW	8	110,523,208 (GRCm38)	missense	probably benign	0.02
R4740:Hydin	UTSW	8	110,446,439 (GRCm38)	missense	probably benign	0.06
R4771:Hydin	UTSW	8	110,532,883 (GRCm38)	missense	probably benign
R4777:Hydin	UTSW	8	110,410,464 (GRCm38)	missense	probably damaging	0.98
R4859:Hydin	UTSW	8	110,506,494 (GRCm38)	missense	possibly damaging	0.93
R4911:Hydin	UTSW	8	110,595,438 (GRCm38)	missense	probably benign	0.01
R4964:Hydin	UTSW	8	110,490,673 (GRCm38)	missense	possibly damaging	0.86
R4965:Hydin	UTSW	8	110,398,095 (GRCm38)	missense	probably benign
R4989:Hydin	UTSW	8	110,563,922 (GRCm38)	missense	possibly damaging	0.84
R4995:Hydin	UTSW	8	110,569,642 (GRCm38)	missense	probably damaging	0.97
R5059:Hydin	UTSW	8	110,505,769 (GRCm38)	missense	probably damaging	0.96
R5071:Hydin	UTSW	8	110,538,473 (GRCm38)	missense	probably benign	0.03
R5073:Hydin	UTSW	8	110,538,473 (GRCm38)	missense	probably benign	0.03
R5092:Hydin	UTSW	8	110,582,668 (GRCm38)	missense	probably benign	0.16
R5156:Hydin	UTSW	8	110,609,701 (GRCm38)	missense	probably benign	0.00
R5166:Hydin	UTSW	8	110,523,142 (GRCm38)	missense	possibly damaging	0.89
R5189:Hydin	UTSW	8	110,413,211 (GRCm38)	critical splice acceptor site	probably null
R5243:Hydin	UTSW	8	110,505,748 (GRCm38)	missense	possibly damaging	0.92
R5244:Hydin	UTSW	8	110,532,819 (GRCm38)	missense	possibly damaging	0.77
R5256:Hydin	UTSW	8	110,587,223 (GRCm38)	missense	possibly damaging	0.92
R5266:Hydin	UTSW	8	110,334,784 (GRCm38)	missense	possibly damaging	0.87
R5283:Hydin	UTSW	8	110,451,980 (GRCm38)	missense	possibly damaging	0.96
R5343:Hydin	UTSW	8	110,485,419 (GRCm38)	missense	probably benign	0.40
R5359:Hydin	UTSW	8	110,538,372 (GRCm38)	missense	probably benign	0.00
R5390:Hydin	UTSW	8	110,595,467 (GRCm38)	missense	probably benign
R5394:Hydin	UTSW	8	110,539,842 (GRCm38)	splice site	probably null
R5441:Hydin	UTSW	8	110,565,109 (GRCm38)	missense	possibly damaging	0.72
R5461:Hydin	UTSW	8	110,519,231 (GRCm38)	missense	probably damaging	0.96
R5662:Hydin	UTSW	8	110,580,709 (GRCm38)	missense	probably benign	0.02
R5695:Hydin	UTSW	8	110,535,283 (GRCm38)	missense	probably benign	0.35
R5732:Hydin	UTSW	8	110,452,058 (GRCm38)	missense	probably benign	0.03
R5774:Hydin	UTSW	8	110,571,915 (GRCm38)	nonsense	probably null
R5780:Hydin	UTSW	8	110,586,080 (GRCm38)	missense	probably damaging	1.00
R5787:Hydin	UTSW	8	110,326,353 (GRCm38)	missense	probably damaging	0.99
R5802:Hydin	UTSW	8	110,452,060 (GRCm38)	missense	possibly damaging	0.86
R5841:Hydin	UTSW	8	110,533,214 (GRCm38)	missense	possibly damaging	0.76
R5856:Hydin	UTSW	8	110,541,842 (GRCm38)	missense	probably damaging	0.99
R5893:Hydin	UTSW	8	110,490,676 (GRCm38)	missense	probably benign	0.12
R5963:Hydin	UTSW	8	110,494,294 (GRCm38)	missense	possibly damaging	0.93
R6008:Hydin	UTSW	8	110,599,085 (GRCm38)	missense	probably benign	0.02
R6019:Hydin	UTSW	8	110,566,620 (GRCm38)	missense	probably benign
R6038:Hydin	UTSW	8	110,599,031 (GRCm38)	missense	probably benign	0.16
R6038:Hydin	UTSW	8	110,599,031 (GRCm38)	missense	probably benign	0.16
R6133:Hydin	UTSW	8	110,601,276 (GRCm38)	missense	probably benign	0.00
R6135:Hydin	UTSW	8	110,462,660 (GRCm38)	missense	possibly damaging	0.85
R6157:Hydin	UTSW	8	110,528,016 (GRCm38)	missense	probably benign
R6209:Hydin	UTSW	8	110,593,802 (GRCm38)	missense	probably benign	0.05
R6238:Hydin	UTSW	8	110,392,111 (GRCm38)	splice site	probably null
R6293:Hydin	UTSW	8	110,597,911 (GRCm38)	missense	possibly damaging	0.83
R6340:Hydin	UTSW	8	110,354,942 (GRCm38)	splice site	probably null
R6349:Hydin	UTSW	8	110,418,459 (GRCm38)	nonsense	probably null
R6357:Hydin	UTSW	8	110,541,657 (GRCm38)	missense	possibly damaging	0.86
R6385:Hydin	UTSW	8	110,312,224 (GRCm38)	missense	possibly damaging	0.86
R6396:Hydin	UTSW	8	110,506,889 (GRCm38)	missense	probably damaging	0.96
R6466:Hydin	UTSW	8	110,506,968 (GRCm38)	missense	possibly damaging	0.85
R6648:Hydin	UTSW	8	110,525,667 (GRCm38)	splice site	probably null
R6671:Hydin	UTSW	8	110,601,318 (GRCm38)	missense	probably damaging	1.00
R6695:Hydin	UTSW	8	110,326,460 (GRCm38)	missense	probably benign	0.05
R6800:Hydin	UTSW	8	110,597,971 (GRCm38)	missense	probably benign	0.09
R6841:Hydin	UTSW	8	110,538,375 (GRCm38)	missense	probably benign	0.09
R6867:Hydin	UTSW	8	110,539,802 (GRCm38)	missense	probably benign	0.08
R6889:Hydin	UTSW	8	110,532,856 (GRCm38)	missense	possibly damaging	0.79
R6895:Hydin	UTSW	8	110,312,251 (GRCm38)	missense	probably benign	0.00
R6940:Hydin	UTSW	8	110,490,611 (GRCm38)	missense	probably damaging	1.00
R6951:Hydin	UTSW	8	110,398,125 (GRCm38)	missense	probably benign
R6980:Hydin	UTSW	8	110,413,284 (GRCm38)	missense	possibly damaging	0.91
R6981:Hydin	UTSW	8	110,531,072 (GRCm38)	missense	possibly damaging	0.89
R7061:Hydin	UTSW	8	110,603,288 (GRCm38)	missense	possibly damaging	0.90
R7085:Hydin	UTSW	8	110,603,330 (GRCm38)	missense	probably benign	0.03
R7086:Hydin	UTSW	8	110,600,245 (GRCm38)	missense	possibly damaging	0.68
R7110:Hydin	UTSW	8	110,354,951 (GRCm38)	critical splice acceptor site	probably null
R7158:Hydin	UTSW	8	110,609,671 (GRCm38)	missense	possibly damaging	0.79
R7163:Hydin	UTSW	8	110,603,336 (GRCm38)	missense	probably benign	0.25
R7209:Hydin	UTSW	8	110,489,792 (GRCm38)	nonsense	probably null
R7244:Hydin	UTSW	8	110,549,675 (GRCm38)	missense	probably damaging	0.98
R7347:Hydin	UTSW	8	110,600,362 (GRCm38)	missense	probably benign	0.06
R7349:Hydin	UTSW	8	110,398,171 (GRCm38)	splice site	probably null
R7359:Hydin	UTSW	8	110,506,101 (GRCm38)	missense	probably damaging	0.98
R7365:Hydin	UTSW	8	110,601,273 (GRCm38)	missense	probably damaging	1.00
R7365:Hydin	UTSW	8	110,557,662 (GRCm38)	missense	probably damaging	0.99
R7436:Hydin	UTSW	8	110,583,914 (GRCm38)	missense	probably damaging	0.96
R7528:Hydin	UTSW	8	110,380,572 (GRCm38)	nonsense	probably null
R7544:Hydin	UTSW	8	110,589,525 (GRCm38)	missense	probably benign	0.35
R7625:Hydin	UTSW	8	110,541,844 (GRCm38)	missense	probably benign	0.01
R7713:Hydin	UTSW	8	110,593,812 (GRCm38)	missense	possibly damaging	0.69
R7763:Hydin	UTSW	8	110,505,843 (GRCm38)	missense	possibly damaging	0.92
R7771:Hydin	UTSW	8	110,565,085 (GRCm38)	missense	probably damaging	0.97
R7794:Hydin	UTSW	8	110,509,083 (GRCm38)	missense	probably damaging	1.00
R7833:Hydin	UTSW	8	110,589,460 (GRCm38)	missense	probably damaging	0.99
R7894:Hydin	UTSW	8	110,513,010 (GRCm38)	missense	possibly damaging	0.88
R7899:Hydin	UTSW	8	110,587,748 (GRCm38)	missense	probably benign	0.00
R7908:Hydin	UTSW	8	110,510,867 (GRCm38)	missense	probably benign	0.01
R7912:Hydin	UTSW	8	110,555,607 (GRCm38)	missense	possibly damaging	0.68
R7919:Hydin	UTSW	8	110,267,339 (GRCm38)	missense	unknown
R7924:Hydin	UTSW	8	110,418,471 (GRCm38)	missense	possibly damaging	0.93
R7927:Hydin	UTSW	8	110,580,844 (GRCm38)	missense	possibly damaging	0.89
R7970:Hydin	UTSW	8	110,309,091 (GRCm38)	missense	probably damaging	0.99
R7993:Hydin	UTSW	8	110,579,632 (GRCm38)	missense	probably benign
R8011:Hydin	UTSW	8	110,583,909 (GRCm38)	missense	probably damaging	1.00
R8041:Hydin	UTSW	8	110,574,994 (GRCm38)	missense	probably benign	0.02
R8080:Hydin	UTSW	8	110,535,231 (GRCm38)	missense	probably benign	0.32
R8081:Hydin	UTSW	8	110,365,469 (GRCm38)	missense	possibly damaging	0.93
R8095:Hydin	UTSW	8	110,569,359 (GRCm38)	missense	probably damaging	1.00
R8157:Hydin	UTSW	8	110,452,036 (GRCm38)	missense	probably benign	0.33
R8186:Hydin	UTSW	8	110,609,645 (GRCm38)	missense	probably benign	0.14
R8205:Hydin	UTSW	8	110,592,638 (GRCm38)	missense	possibly damaging	0.57
R8263:Hydin	UTSW	8	110,452,073 (GRCm38)	missense	probably benign	0.00
R8288:Hydin	UTSW	8	110,507,029 (GRCm38)	missense	probably damaging	0.96
R8298:Hydin	UTSW	8	110,600,383 (GRCm38)	missense	probably damaging	1.00
R8309:Hydin	UTSW	8	110,607,902 (GRCm38)	missense	probably benign	0.18
R8348:Hydin	UTSW	8	110,603,246 (GRCm38)	missense	possibly damaging	0.68
R8356:Hydin	UTSW	8	110,533,124 (GRCm38)	missense	possibly damaging	0.67
R8406:Hydin	UTSW	8	110,609,911 (GRCm38)	missense	possibly damaging	0.94
R8415:Hydin	UTSW	8	110,451,994 (GRCm38)	missense	probably damaging	1.00
R8417:Hydin	UTSW	8	110,569,392 (GRCm38)	missense	probably benign	0.28
R8432:Hydin	UTSW	8	110,597,951 (GRCm38)	missense	probably benign	0.02
R8437:Hydin	UTSW	8	110,462,735 (GRCm38)	missense	probably damaging	0.96
R8463:Hydin	UTSW	8	110,510,921 (GRCm38)	missense	probably benign	0.22
R8508:Hydin	UTSW	8	110,582,018 (GRCm38)	missense	probably benign	0.00
R8510:Hydin	UTSW	8	110,506,570 (GRCm38)	missense	probably damaging	1.00
R8560:Hydin	UTSW	8	110,538,474 (GRCm38)	missense	probably benign	0.09
R8682:Hydin	UTSW	8	110,309,166 (GRCm38)	missense	probably damaging	0.96
R8697:Hydin	UTSW	8	110,532,883 (GRCm38)	missense	probably benign
R8857:Hydin	UTSW	8	110,571,955 (GRCm38)	critical splice donor site	probably null
R8866:Hydin	UTSW	8	110,582,147 (GRCm38)	missense	possibly damaging	0.89
R8878:Hydin	UTSW	8	110,309,088 (GRCm38)	missense	probably benign	0.12
R8897:Hydin	UTSW	8	110,589,480 (GRCm38)	missense	probably benign
R8987:Hydin	UTSW	8	110,513,134 (GRCm38)	nonsense	probably null
R9072:Hydin	UTSW	8	110,267,451 (GRCm38)	critical splice donor site	probably null
R9073:Hydin	UTSW	8	110,267,451 (GRCm38)	critical splice donor site	probably null
R9102:Hydin	UTSW	8	110,508,914 (GRCm38)	missense	probably benign	0.33
R9224:Hydin	UTSW	8	110,532,884 (GRCm38)	missense	probably benign
R9255:Hydin	UTSW	8	110,535,340 (GRCm38)	missense	probably benign	0.23
R9257:Hydin	UTSW	8	110,575,016 (GRCm38)	missense	probably damaging	0.99
R9261:Hydin	UTSW	8	110,267,415 (GRCm38)	missense	unknown
R9273:Hydin	UTSW	8	110,506,948 (GRCm38)	missense	probably damaging	0.98
R9376:Hydin	UTSW	8	110,398,063 (GRCm38)	missense	possibly damaging	0.70
R9380:Hydin	UTSW	8	110,563,872 (GRCm38)	missense	probably benign	0.07
R9386:Hydin	UTSW	8	110,587,730 (GRCm38)	missense	probably benign
R9406:Hydin	UTSW	8	110,587,780 (GRCm38)	missense	probably null	0.96
R9492:Hydin	UTSW	8	110,600,245 (GRCm38)	missense	possibly damaging	0.68
R9513:Hydin	UTSW	8	110,595,482 (GRCm38)	missense	probably damaging	0.99
R9562:Hydin	UTSW	8	110,586,154 (GRCm38)	missense	probably benign	0.11
R9664:Hydin	UTSW	8	110,494,333 (GRCm38)	missense	probably benign	0.01
R9733:Hydin	UTSW	8	110,535,379 (GRCm38)	missense	probably benign
R9753:Hydin	UTSW	8	110,490,766 (GRCm38)	missense	possibly damaging	0.85
X0063:Hydin	UTSW	8	110,551,319 (GRCm38)	missense	probably damaging	1.00
Z1088:Hydin	UTSW	8	110,592,791 (GRCm38)	frame shift	probably null
Z1088:Hydin	UTSW	8	110,586,048 (GRCm38)	missense	probably benign	0.00
Z1088:Hydin	UTSW	8	110,299,973 (GRCm38)	missense	probably benign	0.12
Z1176:Hydin	UTSW	8	110,541,600 (GRCm38)	missense	possibly damaging	0.65
Z1177:Hydin	UTSW	8	110,587,142 (GRCm38)	frame shift	probably null
Z1177:Hydin	UTSW	8	110,450,232 (GRCm38)	missense	possibly damaging	0.47
Z1177:Hydin	UTSW	8	110,380,610 (GRCm38)	missense	probably damaging	1.00
Z1177:Hydin	UTSW	8	110,609,989 (GRCm38)	missense	probably benign	0.10
Z1188:Hydin	UTSW	8	110,415,787 (GRCm38)	missense	probably benign	0.40

Predicted Primers

PCR Primer
(F):5'- GTCCTCATTATTTAAGGAGCCTGCAAGA -3'
(R):5'- CTCTCAGCAAGGGTTCAGTGTGTG -3'

Sequencing Primer
(F):5'- tgtgtgtgtgtgtgtAGGCT -3'
(R):5'- CAGTGTGTGAGTTCCAAGCC -3'

Posted On

2013-06-12