Incidental Mutation 'PIT1430001:Igsf10'
| ID |
499834 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Igsf10
|
| Ensembl Gene |
ENSMUSG00000036334 |
| Gene Name |
immunoglobulin superfamily, member 10 |
| Synonyms |
6530405F15Rik, CMF608, Adlican2 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.193)
|
| Stock # |
PIT1430001 (G1)
|
| Quality Score |
100 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
59224156-59251815 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 59235579 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 1534
(D1534G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141391
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000039419]
[ENSMUST00000193455]
[ENSMUST00000194546]
|
| AlphaFold |
Q3V1M1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000039419
AA Change: D1534G
PolyPhen 2
Score 0.064 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000037246
Gene: ENSMUSG00000036334
AA Change: D1534G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
LRRNT
|
28 |
61 |
3.24e-4 |
SMART |
|
LRR
|
57 |
79 |
9.24e1 |
SMART |
|
LRR
|
80 |
103 |
2.02e-1 |
SMART |
|
LRR
|
104 |
127 |
7.16e0 |
SMART |
|
LRR_TYP
|
128 |
151 |
1.2e-3 |
SMART |
|
LRR
|
152 |
175 |
1.25e-1 |
SMART |
|
LRR
|
188 |
207 |
2.33e2 |
SMART |
|
LRRCT
|
219 |
280 |
4.19e-4 |
SMART |
|
IGc2
|
488 |
558 |
2.34e-4 |
SMART |
|
IGc2
|
586 |
652 |
7.88e-11 |
SMART |
|
low complexity region
|
917 |
930 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1185 |
N/A |
INTRINSIC |
|
low complexity region
|
1245 |
1263 |
N/A |
INTRINSIC |
|
low complexity region
|
1311 |
1321 |
N/A |
INTRINSIC |
|
low complexity region
|
1449 |
1465 |
N/A |
INTRINSIC |
|
IGc2
|
1632 |
1701 |
7.69e-14 |
SMART |
|
IGc2
|
1729 |
1798 |
5.07e-14 |
SMART |
|
IGc2
|
1826 |
1895 |
2.19e-9 |
SMART |
|
IGc2
|
1925 |
1994 |
4.59e-12 |
SMART |
|
IGc2
|
2022 |
2097 |
1.33e-8 |
SMART |
|
IGc2
|
2125 |
2191 |
2.96e-15 |
SMART |
|
IGc2
|
2223 |
2291 |
2.03e-4 |
SMART |
|
IGc2
|
2321 |
2389 |
9.99e-13 |
SMART |
|
IGc2
|
2416 |
2484 |
3.03e-12 |
SMART |
|
IGc2
|
2512 |
2583 |
7.76e-10 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193455
AA Change: D1534G
PolyPhen 2
Score 0.064 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000141971
Gene: ENSMUSG00000036334
AA Change: D1534G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
LRRNT
|
28 |
61 |
3.24e-4 |
SMART |
|
LRR
|
57 |
79 |
9.24e1 |
SMART |
|
LRR
|
80 |
103 |
2.02e-1 |
SMART |
|
LRR
|
104 |
127 |
7.16e0 |
SMART |
|
LRR_TYP
|
128 |
151 |
1.2e-3 |
SMART |
|
LRR
|
152 |
175 |
1.25e-1 |
SMART |
|
LRR
|
188 |
207 |
2.33e2 |
SMART |
|
LRRCT
|
219 |
280 |
4.19e-4 |
SMART |
|
IGc2
|
488 |
558 |
2.34e-4 |
SMART |
|
IGc2
|
586 |
652 |
7.88e-11 |
SMART |
|
low complexity region
|
917 |
930 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1185 |
N/A |
INTRINSIC |
|
low complexity region
|
1245 |
1263 |
N/A |
INTRINSIC |
|
low complexity region
|
1311 |
1321 |
N/A |
INTRINSIC |
|
low complexity region
|
1449 |
1465 |
N/A |
INTRINSIC |
|
IGc2
|
1632 |
1701 |
7.69e-14 |
SMART |
|
IGc2
|
1729 |
1798 |
5.07e-14 |
SMART |
|
IGc2
|
1826 |
1895 |
2.19e-9 |
SMART |
|
IGc2
|
1925 |
1994 |
4.59e-12 |
SMART |
|
IGc2
|
2022 |
2097 |
1.33e-8 |
SMART |
|
IGc2
|
2125 |
2191 |
2.96e-15 |
SMART |
|
IGc2
|
2223 |
2291 |
2.03e-4 |
SMART |
|
IGc2
|
2321 |
2389 |
9.99e-13 |
SMART |
|
IGc2
|
2416 |
2484 |
3.03e-12 |
SMART |
|
IGc2
|
2512 |
2583 |
7.76e-10 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194546
AA Change: D1534G
PolyPhen 2
Score 0.064 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000141391
Gene: ENSMUSG00000036334
AA Change: D1534G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
LRRNT
|
28 |
61 |
3.24e-4 |
SMART |
|
LRR
|
57 |
79 |
9.24e1 |
SMART |
|
LRR
|
80 |
103 |
2.02e-1 |
SMART |
|
LRR
|
104 |
127 |
7.16e0 |
SMART |
|
LRR_TYP
|
128 |
151 |
1.2e-3 |
SMART |
|
LRR
|
152 |
175 |
1.25e-1 |
SMART |
|
LRR
|
188 |
207 |
2.33e2 |
SMART |
|
LRRCT
|
219 |
280 |
4.19e-4 |
SMART |
|
IGc2
|
488 |
558 |
2.34e-4 |
SMART |
|
IGc2
|
586 |
652 |
7.88e-11 |
SMART |
|
low complexity region
|
917 |
930 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1185 |
N/A |
INTRINSIC |
|
low complexity region
|
1245 |
1263 |
N/A |
INTRINSIC |
|
low complexity region
|
1311 |
1321 |
N/A |
INTRINSIC |
|
low complexity region
|
1449 |
1465 |
N/A |
INTRINSIC |
|
IGc2
|
1632 |
1701 |
7.69e-14 |
SMART |
|
IGc2
|
1729 |
1798 |
5.07e-14 |
SMART |
|
IGc2
|
1826 |
1895 |
2.19e-9 |
SMART |
|
IGc2
|
1925 |
1994 |
4.59e-12 |
SMART |
|
IGc2
|
2022 |
2097 |
1.33e-8 |
SMART |
|
IGc2
|
2125 |
2191 |
2.96e-15 |
SMART |
|
IGc2
|
2223 |
2291 |
2.03e-4 |
SMART |
|
IGc2
|
2321 |
2389 |
9.99e-13 |
SMART |
|
IGc2
|
2416 |
2484 |
3.03e-12 |
SMART |
|
IGc2
|
2512 |
2583 |
7.76e-10 |
SMART |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 0.0%
- 3x: 0.0%
- 10x: 0.0%
- 20x: 0.0%
|
| Validation Efficiency |
99% (136/137) |
| Allele List at MGI |
All alleles(2) : Targeted, other(2) |
| Other mutations in this stock |
Total: 139 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
A |
T |
12: 71,207,160 (GRCm39) |
I524F |
possibly damaging |
Het |
| 4930511M06Rik |
T |
C |
18: 57,517,241 (GRCm39) |
|
probably benign |
Het |
| 9330159F19Rik |
T |
A |
10: 29,100,711 (GRCm39) |
N361K |
probably damaging |
Het |
| Adgra2 |
A |
G |
8: 27,604,216 (GRCm39) |
M469V |
possibly damaging |
Het |
| Akap9 |
A |
G |
5: 4,079,849 (GRCm39) |
D1867G |
probably damaging |
Het |
| Ankrd17 |
T |
C |
5: 90,400,832 (GRCm39) |
T1687A |
possibly damaging |
Het |
| Ap1m2 |
G |
A |
9: 21,209,548 (GRCm39) |
P376L |
probably damaging |
Het |
| Bicc1 |
A |
G |
10: 70,793,511 (GRCm39) |
S196P |
possibly damaging |
Het |
| Cacnb2 |
C |
T |
2: 14,976,412 (GRCm39) |
R228* |
probably null |
Het |
| Ccdc43 |
A |
G |
11: 102,582,976 (GRCm39) |
S83P |
probably damaging |
Het |
| Cdc42bpg |
T |
A |
19: 6,372,582 (GRCm39) |
|
probably null |
Het |
| Cdh16 |
C |
A |
8: 105,344,271 (GRCm39) |
M89I |
probably benign |
Het |
| Cecr2 |
A |
C |
6: 120,735,440 (GRCm39) |
H892P |
probably benign |
Het |
| Chd5 |
T |
A |
4: 152,455,094 (GRCm39) |
S859T |
probably damaging |
Het |
| Chrd |
G |
A |
16: 20,557,748 (GRCm39) |
|
probably null |
Het |
| Chrna2 |
T |
A |
14: 66,387,186 (GRCm39) |
L444Q |
probably benign |
Het |
| Ckap4 |
A |
G |
10: 84,363,630 (GRCm39) |
S478P |
probably damaging |
Het |
| Cldn4 |
A |
T |
5: 134,975,514 (GRCm39) |
M29K |
possibly damaging |
Het |
| Clpb |
T |
C |
7: 101,435,926 (GRCm39) |
V615A |
possibly damaging |
Het |
| Cyb5r4 |
G |
A |
9: 86,920,791 (GRCm39) |
G142E |
probably benign |
Het |
| Cyp1a1 |
A |
G |
9: 57,608,194 (GRCm39) |
Y274C |
probably benign |
Het |
| D2hgdh |
T |
C |
1: 93,754,001 (GRCm39) |
|
probably benign |
Het |
| Dgkh |
T |
A |
14: 78,818,953 (GRCm39) |
E919V |
probably damaging |
Het |
| Dnah1 |
A |
G |
14: 30,984,537 (GRCm39) |
Y3916H |
probably damaging |
Het |
| Dpp10 |
A |
G |
1: 123,268,911 (GRCm39) |
|
probably benign |
Het |
| Dync2i2 |
T |
C |
2: 29,922,147 (GRCm39) |
Y438C |
probably damaging |
Het |
| Egfr |
A |
G |
11: 16,860,214 (GRCm39) |
T1043A |
probably benign |
Het |
| Elp5 |
T |
G |
11: 69,857,935 (GRCm39) |
|
probably null |
Het |
| Emilin3 |
A |
T |
2: 160,750,402 (GRCm39) |
M449K |
possibly damaging |
Het |
| Epb41l4a |
T |
G |
18: 33,930,400 (GRCm39) |
T686P |
probably damaging |
Het |
| Eppk1 |
A |
G |
15: 76,105,236 (GRCm38) |
C2482R |
probably benign |
Het |
| Eps8l3 |
T |
C |
3: 107,792,183 (GRCm39) |
L370P |
probably damaging |
Het |
| Erbin |
A |
T |
13: 103,996,017 (GRCm39) |
S228R |
probably damaging |
Het |
| Fam149a |
C |
T |
8: 45,804,743 (GRCm39) |
E280K |
probably benign |
Het |
| Fam78b |
T |
C |
1: 166,829,313 (GRCm39) |
I60T |
probably benign |
Het |
| Fank1 |
A |
T |
7: 133,478,529 (GRCm39) |
R197* |
probably null |
Het |
| Fbxo21 |
C |
T |
5: 118,115,931 (GRCm39) |
S83F |
possibly damaging |
Het |
| Fbxo4 |
G |
C |
15: 4,008,782 (GRCm39) |
T42R |
probably benign |
Het |
| Fhad1 |
C |
G |
4: 141,637,060 (GRCm39) |
E1135D |
probably damaging |
Het |
| Fmo1 |
T |
A |
1: 162,657,622 (GRCm39) |
E506D |
probably benign |
Het |
| Glipr1l2 |
A |
T |
10: 111,942,745 (GRCm39) |
T231S |
probably benign |
Het |
| Gm11651 |
C |
G |
11: 105,863,917 (GRCm39) |
|
probably benign |
Het |
| Gm16043 |
A |
G |
6: 8,426,969 (GRCm39) |
|
probably null |
Het |
| Gm572 |
T |
G |
4: 148,755,850 (GRCm39) |
W389G |
unknown |
Het |
| Gpc6 |
G |
A |
14: 118,188,594 (GRCm39) |
W409* |
probably null |
Het |
| Gpr155 |
T |
C |
2: 73,200,482 (GRCm39) |
T342A |
probably benign |
Het |
| Hcn4 |
A |
C |
9: 58,766,833 (GRCm39) |
H798P |
unknown |
Het |
| Herc2 |
T |
C |
7: 55,876,702 (GRCm39) |
S4513P |
probably damaging |
Het |
| Hmcn1 |
G |
A |
1: 150,684,488 (GRCm39) |
R361C |
probably benign |
Het |
| Hoxa4 |
G |
T |
6: 52,168,199 (GRCm39) |
P157Q |
possibly damaging |
Het |
| Ift122 |
A |
C |
6: 115,902,705 (GRCm39) |
|
probably benign |
Het |
| Igfbpl1 |
G |
A |
4: 45,826,756 (GRCm39) |
S13L |
unknown |
Het |
| Il1rap |
T |
G |
16: 26,529,343 (GRCm39) |
L339V |
possibly damaging |
Het |
| Irf2bpl |
C |
T |
12: 86,930,229 (GRCm39) |
R148H |
possibly damaging |
Het |
| Ivns1abp |
A |
T |
1: 151,237,356 (GRCm39) |
R58W |
probably damaging |
Het |
| Kcnq5 |
C |
T |
1: 21,605,405 (GRCm39) |
V167M |
probably damaging |
Het |
| Lrrcc1 |
G |
A |
3: 14,610,656 (GRCm39) |
C337Y |
probably damaging |
Het |
| Lrriq3 |
A |
G |
3: 154,804,507 (GRCm39) |
I56V |
probably benign |
Het |
| Masp1 |
C |
A |
16: 23,332,694 (GRCm39) |
S47I |
probably damaging |
Het |
| Mcm7 |
A |
T |
5: 138,165,708 (GRCm39) |
|
probably benign |
Het |
| Mdm2 |
G |
T |
10: 117,530,840 (GRCm39) |
S210R |
probably damaging |
Het |
| Mical1 |
A |
G |
10: 41,359,492 (GRCm39) |
R500G |
possibly damaging |
Het |
| Mtarc1 |
T |
G |
1: 184,539,246 (GRCm39) |
T37P |
probably benign |
Het |
| Myc |
A |
C |
15: 61,859,542 (GRCm39) |
T73P |
probably damaging |
Het |
| Myh15 |
G |
A |
16: 49,017,254 (GRCm39) |
|
probably null |
Het |
| Myh4 |
A |
G |
11: 67,149,658 (GRCm39) |
M1768V |
probably benign |
Het |
| Nap1l1 |
T |
C |
10: 111,322,597 (GRCm39) |
Y66H |
probably damaging |
Het |
| Ncoa1 |
C |
T |
12: 4,373,005 (GRCm39) |
R132K |
probably benign |
Het |
| Nfatc3 |
C |
T |
8: 106,786,605 (GRCm39) |
S28F |
possibly damaging |
Het |
| Nhlrc3 |
T |
A |
3: 53,361,050 (GRCm39) |
K235M |
probably damaging |
Het |
| Nrk |
G |
A |
X: 137,879,463 (GRCm39) |
E757K |
probably damaging |
Het |
| Obsl1 |
G |
A |
1: 75,482,811 (GRCm39) |
P20S |
probably damaging |
Het |
| P2rx7 |
C |
T |
5: 122,819,279 (GRCm39) |
A567V |
probably damaging |
Het |
| Pate9 |
A |
T |
9: 36,446,295 (GRCm39) |
L39* |
probably null |
Het |
| Pcdhb15 |
G |
A |
18: 37,608,724 (GRCm39) |
R652H |
probably benign |
Het |
| Pcdhga4 |
T |
C |
18: 37,819,267 (GRCm39) |
V272A |
probably benign |
Het |
| Pcdhgb1 |
T |
G |
18: 37,814,472 (GRCm39) |
V321G |
probably damaging |
Het |
| Pde2a |
C |
G |
7: 101,100,684 (GRCm39) |
|
probably benign |
Het |
| Pdhb |
C |
T |
14: 8,170,425 (GRCm38) |
E109K |
probably damaging |
Het |
| Pkd1 |
C |
A |
17: 24,788,485 (GRCm39) |
L748M |
probably damaging |
Het |
| Pkd2 |
A |
T |
5: 104,607,654 (GRCm39) |
E51V |
probably damaging |
Het |
| Pkdrej |
A |
G |
15: 85,705,493 (GRCm39) |
Y148H |
probably damaging |
Het |
| Polr3gl |
C |
G |
3: 96,488,228 (GRCm39) |
|
probably benign |
Het |
| Ppfia1 |
A |
T |
7: 144,052,073 (GRCm39) |
L882Q |
probably damaging |
Het |
| Ppp4r3b |
G |
T |
11: 29,159,434 (GRCm39) |
R596L |
probably benign |
Het |
| Ppp6r3 |
G |
A |
19: 3,521,059 (GRCm39) |
Q85* |
probably null |
Het |
| Prss8 |
A |
G |
7: 127,521,424 (GRCm39) |
|
probably benign |
Het |
| Qng1 |
T |
A |
13: 58,532,827 (GRCm39) |
K48* |
probably null |
Het |
| Rab22a |
A |
G |
2: 173,536,963 (GRCm39) |
I87V |
probably benign |
Het |
| Rev1 |
A |
C |
1: 38,095,337 (GRCm39) |
|
probably benign |
Het |
| Rnase13 |
A |
G |
14: 52,159,987 (GRCm39) |
Y51H |
probably damaging |
Het |
| Rnf26 |
T |
C |
9: 44,023,942 (GRCm39) |
H102R |
probably damaging |
Het |
| Rnf5 |
T |
C |
17: 34,822,341 (GRCm39) |
E36G |
probably damaging |
Het |
| Rplp1 |
T |
G |
9: 61,821,658 (GRCm39) |
D18A |
probably benign |
Het |
| Rrs1 |
C |
A |
1: 9,616,150 (GRCm39) |
D134E |
probably damaging |
Het |
| Sec14l1 |
A |
G |
11: 117,034,629 (GRCm39) |
Y166C |
probably damaging |
Het |
| Sec14l2 |
A |
T |
11: 4,059,209 (GRCm39) |
Y153* |
probably null |
Het |
| Senp1 |
A |
G |
15: 97,982,870 (GRCm39) |
L39P |
probably damaging |
Het |
| Senp2 |
T |
A |
16: 21,832,864 (GRCm39) |
|
probably benign |
Het |
| Sh3bp1 |
G |
A |
15: 78,798,224 (GRCm39) |
A19T |
probably benign |
Het |
| Sis |
G |
A |
3: 72,830,162 (GRCm39) |
P1130S |
probably damaging |
Het |
| Slc16a12 |
C |
T |
19: 34,654,759 (GRCm39) |
A95T |
possibly damaging |
Het |
| Slc22a4 |
A |
G |
11: 53,918,783 (GRCm39) |
V7A |
probably benign |
Het |
| Slc35c2 |
C |
T |
2: 165,119,452 (GRCm39) |
S296N |
probably benign |
Het |
| Slf1 |
A |
G |
13: 77,198,169 (GRCm39) |
|
probably benign |
Het |
| Slitrk6 |
A |
T |
14: 110,987,859 (GRCm39) |
V616E |
possibly damaging |
Het |
| Smarca2 |
T |
A |
19: 26,626,493 (GRCm39) |
M439K |
probably benign |
Het |
| Snx29 |
G |
A |
16: 11,221,488 (GRCm39) |
A305T |
probably benign |
Het |
| Socs5 |
C |
T |
17: 87,441,044 (GRCm39) |
|
probably benign |
Het |
| Spata31d1a |
G |
T |
13: 59,849,010 (GRCm39) |
H1039Q |
probably benign |
Het |
| Srgap1 |
G |
A |
10: 121,732,658 (GRCm39) |
|
probably benign |
Het |
| Synj1 |
A |
T |
16: 90,761,396 (GRCm39) |
I650N |
probably damaging |
Het |
| Tac4 |
A |
C |
11: 95,158,190 (GRCm39) |
|
probably benign |
Het |
| Tbck |
A |
C |
3: 132,428,487 (GRCm39) |
T281P |
probably benign |
Het |
| Tbx22 |
T |
C |
X: 106,720,611 (GRCm39) |
L62P |
probably damaging |
Het |
| Terf2 |
G |
C |
8: 107,822,934 (GRCm39) |
R70G |
probably damaging |
Het |
| Tfdp1 |
C |
T |
8: 13,422,526 (GRCm39) |
P138S |
probably benign |
Het |
| Tigd2 |
T |
C |
6: 59,188,233 (GRCm39) |
Y367H |
probably damaging |
Het |
| Tmprss15 |
A |
T |
16: 78,821,640 (GRCm39) |
|
probably null |
Het |
| Tmprss6 |
C |
T |
15: 78,324,827 (GRCm39) |
G741D |
probably damaging |
Het |
| Tnrc6b |
A |
C |
15: 80,813,387 (GRCm39) |
T1715P |
probably damaging |
Het |
| Tpcn1 |
T |
C |
5: 120,686,388 (GRCm39) |
|
probably benign |
Het |
| Trappc2l |
T |
C |
8: 123,339,874 (GRCm39) |
S35P |
probably damaging |
Het |
| Trim63 |
T |
C |
4: 134,048,484 (GRCm39) |
|
probably benign |
Het |
| Trim66 |
G |
T |
7: 109,074,454 (GRCm39) |
D602E |
probably damaging |
Het |
| Trp53bp1 |
G |
A |
2: 121,101,756 (GRCm39) |
P2S |
probably damaging |
Het |
| Tspan14 |
A |
G |
14: 40,637,488 (GRCm39) |
L100P |
probably damaging |
Het |
| Tspan15 |
C |
T |
10: 62,023,899 (GRCm39) |
E260K |
probably damaging |
Het |
| Ubxn10 |
T |
C |
4: 138,448,199 (GRCm39) |
D159G |
probably benign |
Het |
| Unc5a |
T |
G |
13: 55,151,709 (GRCm39) |
V713G |
probably damaging |
Het |
| Usp16 |
C |
T |
16: 87,270,020 (GRCm39) |
A324V |
probably damaging |
Het |
| Uvssa |
G |
A |
5: 33,559,914 (GRCm39) |
R422Q |
possibly damaging |
Het |
| Wipf1 |
A |
C |
2: 73,267,946 (GRCm39) |
F151V |
probably damaging |
Het |
| Xpo1 |
A |
T |
11: 23,226,437 (GRCm39) |
K104N |
possibly damaging |
Het |
| Ybx3 |
T |
C |
6: 131,356,422 (GRCm39) |
T150A |
probably damaging |
Het |
| Yju2 |
C |
T |
17: 56,271,479 (GRCm39) |
|
probably benign |
Het |
| Zap70 |
T |
A |
1: 36,818,250 (GRCm39) |
S312R |
possibly damaging |
Het |
| Zfp534 |
T |
G |
4: 147,759,880 (GRCm39) |
K263T |
probably benign |
Het |
| Zfp534 |
T |
G |
4: 147,759,917 (GRCm39) |
N251H |
probably benign |
Het |
|
| Other mutations in Igsf10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00773:Igsf10
|
APN |
3 |
59,238,960 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00790:Igsf10
|
APN |
3 |
59,226,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00916:Igsf10
|
APN |
3 |
59,238,548 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL00928:Igsf10
|
APN |
3 |
59,238,018 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01066:Igsf10
|
APN |
3 |
59,235,203 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01107:Igsf10
|
APN |
3 |
59,238,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01420:Igsf10
|
APN |
3 |
59,227,071 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01533:Igsf10
|
APN |
3 |
59,226,651 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01537:Igsf10
|
APN |
3 |
59,237,452 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01676:Igsf10
|
APN |
3 |
59,236,756 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01676:Igsf10
|
APN |
3 |
59,233,432 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01960:Igsf10
|
APN |
3 |
59,226,158 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02123:Igsf10
|
APN |
3 |
59,226,081 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02198:Igsf10
|
APN |
3 |
59,233,399 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02268:Igsf10
|
APN |
3 |
59,238,573 (GRCm39) |
nonsense |
probably null |
|
|
IGL02313:Igsf10
|
APN |
3 |
59,238,111 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02368:Igsf10
|
APN |
3 |
59,235,652 (GRCm39) |
missense |
probably benign |
|
|
IGL02494:Igsf10
|
APN |
3 |
59,235,427 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02549:Igsf10
|
APN |
3 |
59,236,662 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02616:Igsf10
|
APN |
3 |
59,226,027 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02957:Igsf10
|
APN |
3 |
59,238,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03067:Igsf10
|
APN |
3 |
59,226,339 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL03104:Igsf10
|
APN |
3 |
59,226,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03124:Igsf10
|
APN |
3 |
59,227,086 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03212:Igsf10
|
APN |
3 |
59,235,586 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03347:Igsf10
|
APN |
3 |
59,239,321 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03357:Igsf10
|
APN |
3 |
59,243,632 (GRCm39) |
missense |
probably benign |
0.35 |
|
F6893:Igsf10
|
UTSW |
3 |
59,238,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
FR4449:Igsf10
|
UTSW |
3 |
59,226,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4402001:Igsf10
|
UTSW |
3 |
59,233,000 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4810001:Igsf10
|
UTSW |
3 |
59,225,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0068:Igsf10
|
UTSW |
3 |
59,238,045 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0095:Igsf10
|
UTSW |
3 |
59,238,617 (GRCm39) |
nonsense |
probably null |
|
|
R0095:Igsf10
|
UTSW |
3 |
59,238,617 (GRCm39) |
nonsense |
probably null |
|
|
R0112:Igsf10
|
UTSW |
3 |
59,233,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0141:Igsf10
|
UTSW |
3 |
59,238,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0538:Igsf10
|
UTSW |
3 |
59,227,527 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0551:Igsf10
|
UTSW |
3 |
59,236,089 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0556:Igsf10
|
UTSW |
3 |
59,236,296 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0582:Igsf10
|
UTSW |
3 |
59,227,188 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0630:Igsf10
|
UTSW |
3 |
59,233,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0675:Igsf10
|
UTSW |
3 |
59,236,015 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0948:Igsf10
|
UTSW |
3 |
59,238,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1252:Igsf10
|
UTSW |
3 |
59,239,269 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1412:Igsf10
|
UTSW |
3 |
59,235,196 (GRCm39) |
splice site |
probably benign |
|
|
R1473:Igsf10
|
UTSW |
3 |
59,226,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1585:Igsf10
|
UTSW |
3 |
59,237,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1650:Igsf10
|
UTSW |
3 |
59,233,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1660:Igsf10
|
UTSW |
3 |
59,238,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1671:Igsf10
|
UTSW |
3 |
59,235,921 (GRCm39) |
nonsense |
probably null |
|
|
R1748:Igsf10
|
UTSW |
3 |
59,226,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Igsf10
|
UTSW |
3 |
59,236,617 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1856:Igsf10
|
UTSW |
3 |
59,238,693 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1912:Igsf10
|
UTSW |
3 |
59,236,993 (GRCm39) |
missense |
probably benign |
0.40 |
|
R2148:Igsf10
|
UTSW |
3 |
59,243,998 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R2155:Igsf10
|
UTSW |
3 |
59,239,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2509:Igsf10
|
UTSW |
3 |
59,239,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2511:Igsf10
|
UTSW |
3 |
59,239,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2680:Igsf10
|
UTSW |
3 |
59,232,875 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2913:Igsf10
|
UTSW |
3 |
59,239,157 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R2927:Igsf10
|
UTSW |
3 |
59,236,848 (GRCm39) |
missense |
probably benign |
|
|
R3547:Igsf10
|
UTSW |
3 |
59,243,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3547:Igsf10
|
UTSW |
3 |
59,237,962 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3548:Igsf10
|
UTSW |
3 |
59,243,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3620:Igsf10
|
UTSW |
3 |
59,243,752 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3732:Igsf10
|
UTSW |
3 |
59,233,135 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3743:Igsf10
|
UTSW |
3 |
59,233,546 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3973:Igsf10
|
UTSW |
3 |
59,239,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4005:Igsf10
|
UTSW |
3 |
59,235,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4184:Igsf10
|
UTSW |
3 |
59,227,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Igsf10
|
UTSW |
3 |
59,226,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4404:Igsf10
|
UTSW |
3 |
59,236,972 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4575:Igsf10
|
UTSW |
3 |
59,237,521 (GRCm39) |
missense |
probably benign |
|
|
R4676:Igsf10
|
UTSW |
3 |
59,233,370 (GRCm39) |
missense |
probably benign |
0.23 |
|
R4700:Igsf10
|
UTSW |
3 |
59,227,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4765:Igsf10
|
UTSW |
3 |
59,237,126 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4986:Igsf10
|
UTSW |
3 |
59,236,027 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5012:Igsf10
|
UTSW |
3 |
59,226,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5070:Igsf10
|
UTSW |
3 |
59,235,714 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5083:Igsf10
|
UTSW |
3 |
59,233,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5336:Igsf10
|
UTSW |
3 |
59,227,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5462:Igsf10
|
UTSW |
3 |
59,233,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5648:Igsf10
|
UTSW |
3 |
59,235,574 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5810:Igsf10
|
UTSW |
3 |
59,226,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5871:Igsf10
|
UTSW |
3 |
59,237,832 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5880:Igsf10
|
UTSW |
3 |
59,238,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5935:Igsf10
|
UTSW |
3 |
59,235,578 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5979:Igsf10
|
UTSW |
3 |
59,243,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6145:Igsf10
|
UTSW |
3 |
59,239,077 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6222:Igsf10
|
UTSW |
3 |
59,226,336 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6224:Igsf10
|
UTSW |
3 |
59,232,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6264:Igsf10
|
UTSW |
3 |
59,235,928 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6283:Igsf10
|
UTSW |
3 |
59,226,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6336:Igsf10
|
UTSW |
3 |
59,237,760 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6490:Igsf10
|
UTSW |
3 |
59,236,992 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6785:Igsf10
|
UTSW |
3 |
59,226,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6873:Igsf10
|
UTSW |
3 |
59,235,865 (GRCm39) |
missense |
probably benign |
|
|
R6889:Igsf10
|
UTSW |
3 |
59,239,354 (GRCm39) |
missense |
probably benign |
|
|
R7024:Igsf10
|
UTSW |
3 |
59,239,122 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7056:Igsf10
|
UTSW |
3 |
59,238,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7128:Igsf10
|
UTSW |
3 |
59,236,326 (GRCm39) |
missense |
probably benign |
|
|
R7251:Igsf10
|
UTSW |
3 |
59,226,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7313:Igsf10
|
UTSW |
3 |
59,236,837 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7340:Igsf10
|
UTSW |
3 |
59,233,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7447:Igsf10
|
UTSW |
3 |
59,239,222 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7506:Igsf10
|
UTSW |
3 |
59,226,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7678:Igsf10
|
UTSW |
3 |
59,226,761 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7695:Igsf10
|
UTSW |
3 |
59,233,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7709:Igsf10
|
UTSW |
3 |
59,238,964 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7749:Igsf10
|
UTSW |
3 |
59,236,549 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7808:Igsf10
|
UTSW |
3 |
59,235,489 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7850:Igsf10
|
UTSW |
3 |
59,227,053 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7879:Igsf10
|
UTSW |
3 |
59,238,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7886:Igsf10
|
UTSW |
3 |
59,235,748 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7891:Igsf10
|
UTSW |
3 |
59,235,832 (GRCm39) |
nonsense |
probably null |
|
|
R7946:Igsf10
|
UTSW |
3 |
59,227,125 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7948:Igsf10
|
UTSW |
3 |
59,239,279 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8004:Igsf10
|
UTSW |
3 |
59,237,130 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8096:Igsf10
|
UTSW |
3 |
59,236,380 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8141:Igsf10
|
UTSW |
3 |
59,237,949 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8183:Igsf10
|
UTSW |
3 |
59,238,036 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8203:Igsf10
|
UTSW |
3 |
59,236,254 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8325:Igsf10
|
UTSW |
3 |
59,225,954 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8350:Igsf10
|
UTSW |
3 |
59,238,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8387:Igsf10
|
UTSW |
3 |
59,236,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8488:Igsf10
|
UTSW |
3 |
59,227,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8697:Igsf10
|
UTSW |
3 |
59,226,308 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8786:Igsf10
|
UTSW |
3 |
59,238,063 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8804:Igsf10
|
UTSW |
3 |
59,243,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8886:Igsf10
|
UTSW |
3 |
59,237,410 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8902:Igsf10
|
UTSW |
3 |
59,243,633 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8906:Igsf10
|
UTSW |
3 |
59,233,739 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8917:Igsf10
|
UTSW |
3 |
59,226,888 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9051:Igsf10
|
UTSW |
3 |
59,236,668 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9178:Igsf10
|
UTSW |
3 |
59,233,480 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9228:Igsf10
|
UTSW |
3 |
59,243,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9230:Igsf10
|
UTSW |
3 |
59,243,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9231:Igsf10
|
UTSW |
3 |
59,243,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9232:Igsf10
|
UTSW |
3 |
59,243,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9417:Igsf10
|
UTSW |
3 |
59,236,526 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9609:Igsf10
|
UTSW |
3 |
59,226,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9631:Igsf10
|
UTSW |
3 |
59,237,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9689:Igsf10
|
UTSW |
3 |
59,233,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9762:Igsf10
|
UTSW |
3 |
59,237,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9770:Igsf10
|
UTSW |
3 |
59,227,199 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9798:Igsf10
|
UTSW |
3 |
59,239,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Igsf10
|
UTSW |
3 |
59,237,359 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
Z1177:Igsf10
|
UTSW |
3 |
59,237,026 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
|
| Posted On |
2017-11-21 |
Incidental Mutation