Mutagenetix > Incidental Mutation

Incidental Mutation 'PIT1430001:Ankrd17'

499850

Institutional Source

Beutler Lab

Gene Symbol

Ankrd17

Ensembl Gene

ENSMUSG00000055204

Gene Name

ankyrin repeat domain 17

Synonyms

Gtar, A130069E23Rik, 4933425K22Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

PIT1430001 (G1)

Quality Score

100

Status

Validated

Chromosome

Chromosomal Location

90375025-90514436 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 90400832 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 1687 (T1687A)

Ref Sequence

ENSEMBL: ENSMUSP00000014421 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000014421] [ENSMUST00000081914] [ENSMUST00000168058] [ENSMUST00000197021] [ENSMUST00000218526]

AlphaFold

Q99NH0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000014421
AA Change: T1687A

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000014421
Gene: ENSMUSG00000055204
AA Change: T1687A

Domain	Start	End	E-Value	Type
low complexity region	6	40	N/A	INTRINSIC
low complexity region	55	71	N/A	INTRINSIC
low complexity region	82	130	N/A	INTRINSIC
ANK	229	258	8.62e1	SMART
ANK	262	291	3.31e-1	SMART
ANK	296	325	3.51e-5	SMART
ANK	329	358	1.33e-5	SMART
ANK	362	391	3.46e-4	SMART
ANK	396	425	3.23e-4	SMART
ANK	429	458	1.61e-4	SMART
ANK	462	491	1.46e-2	SMART
ANK	495	524	3.88e-7	SMART
ANK	529	558	4.19e-3	SMART
ANK	559	588	1.76e-5	SMART
ANK	592	621	3.51e-5	SMART
ANK	625	654	5.62e-4	SMART
ANK	659	688	1.29e-3	SMART
ANK	692	721	1.44e-1	SMART
coiled coil region	800	883	N/A	INTRINSIC
low complexity region	890	903	N/A	INTRINSIC
low complexity region	955	968	N/A	INTRINSIC
low complexity region	986	997	N/A	INTRINSIC
low complexity region	1046	1060	N/A	INTRINSIC
ANK	1078	1107	2.13e-4	SMART
ANK	1111	1140	8.19e-6	SMART
ANK	1145	1174	1.68e-2	SMART
ANK	1178	1207	1.61e-4	SMART
ANK	1213	1242	1.43e-5	SMART
ANK	1247	1276	1.83e-3	SMART
ANK	1280	1309	3.91e-3	SMART
ANK	1315	1344	1.93e-2	SMART
ANK	1348	1377	8.78e-6	SMART
ANK	1381	1410	7.59e-1	SMART
coiled coil region	1454	1522	N/A	INTRINSIC
low complexity region	1597	1611	N/A	INTRINSIC
low complexity region	1616	1636	N/A	INTRINSIC
KH	1720	1790	8.31e-14	SMART
low complexity region	1816	1827	N/A	INTRINSIC
low complexity region	1834	1850	N/A	INTRINSIC
low complexity region	1946	1989	N/A	INTRINSIC
low complexity region	1996	2024	N/A	INTRINSIC
low complexity region	2035	2052	N/A	INTRINSIC
low complexity region	2068	2077	N/A	INTRINSIC
low complexity region	2086	2110	N/A	INTRINSIC
low complexity region	2175	2189	N/A	INTRINSIC
low complexity region	2348	2365	N/A	INTRINSIC
low complexity region	2392	2411	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000081914
AA Change: T1436A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000080587
Gene: ENSMUSG00000055204
AA Change: T1436A

Domain	Start	End	E-Value	Type
low complexity region	6	40	N/A	INTRINSIC
low complexity region	55	71	N/A	INTRINSIC
low complexity region	82	130	N/A	INTRINSIC
ANK	229	258	8.62e1	SMART
ANK	262	291	3.31e-1	SMART
ANK	296	325	3.51e-5	SMART
ANK	329	358	1.33e-5	SMART
ANK	362	391	3.46e-4	SMART
ANK	396	425	3.23e-4	SMART
ANK	429	458	1.61e-4	SMART
ANK	462	491	1.46e-2	SMART
ANK	495	524	3.88e-7	SMART
ANK	529	558	4.19e-3	SMART
ANK	559	588	1.76e-5	SMART
ANK	592	621	3.51e-5	SMART
ANK	625	654	5.62e-4	SMART
ANK	659	688	1.29e-3	SMART
ANK	692	721	1.44e-1	SMART
low complexity region	795	809	N/A	INTRINSIC
ANK	827	856	2.13e-4	SMART
ANK	860	889	8.19e-6	SMART
ANK	894	923	1.68e-2	SMART
ANK	927	956	1.61e-4	SMART
ANK	962	991	1.43e-5	SMART
ANK	996	1025	1.83e-3	SMART
ANK	1029	1058	3.91e-3	SMART
ANK	1064	1093	1.93e-2	SMART
ANK	1097	1126	8.78e-6	SMART
ANK	1130	1159	7.59e-1	SMART
coiled coil region	1203	1271	N/A	INTRINSIC
low complexity region	1346	1360	N/A	INTRINSIC
low complexity region	1365	1385	N/A	INTRINSIC
KH	1469	1539	8.31e-14	SMART
low complexity region	1565	1576	N/A	INTRINSIC
low complexity region	1583	1599	N/A	INTRINSIC
low complexity region	1695	1738	N/A	INTRINSIC
low complexity region	1745	1773	N/A	INTRINSIC
low complexity region	1784	1801	N/A	INTRINSIC
low complexity region	1817	1826	N/A	INTRINSIC
low complexity region	1835	1859	N/A	INTRINSIC
low complexity region	1924	1938	N/A	INTRINSIC
low complexity region	2097	2114	N/A	INTRINSIC
low complexity region	2141	2160	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000168058
AA Change: T1686A

PolyPhen 2 Score 0.226 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000128960
Gene: ENSMUSG00000055204
AA Change: T1686A

Domain	Start	End	E-Value	Type
low complexity region	6	40	N/A	INTRINSIC
low complexity region	55	71	N/A	INTRINSIC
low complexity region	82	130	N/A	INTRINSIC
ANK	229	258	8.62e1	SMART
ANK	262	291	3.31e-1	SMART
ANK	296	325	3.51e-5	SMART
ANK	329	358	1.33e-5	SMART
ANK	362	391	3.46e-4	SMART
ANK	396	425	3.23e-4	SMART
ANK	429	458	1.61e-4	SMART
ANK	462	491	1.46e-2	SMART
ANK	495	524	3.88e-7	SMART
ANK	529	558	4.19e-3	SMART
ANK	559	588	1.76e-5	SMART
ANK	592	621	3.51e-5	SMART
ANK	625	654	5.62e-4	SMART
ANK	659	688	1.29e-3	SMART
ANK	692	721	1.44e-1	SMART
coiled coil region	800	883	N/A	INTRINSIC
low complexity region	890	903	N/A	INTRINSIC
low complexity region	955	968	N/A	INTRINSIC
low complexity region	986	997	N/A	INTRINSIC
low complexity region	1046	1060	N/A	INTRINSIC
ANK	1078	1107	2.13e-4	SMART
ANK	1111	1140	8.19e-6	SMART
ANK	1145	1174	1.68e-2	SMART
ANK	1178	1207	1.61e-4	SMART
ANK	1213	1242	1.43e-5	SMART
ANK	1247	1276	1.83e-3	SMART
ANK	1280	1309	3.91e-3	SMART
ANK	1315	1344	1.93e-2	SMART
ANK	1348	1377	8.78e-6	SMART
ANK	1381	1410	7.59e-1	SMART
coiled coil region	1454	1522	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000197021
AA Change: T1578A

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000142575
Gene: ENSMUSG00000055204
AA Change: T1578A

Domain	Start	End	E-Value	Type
ANK	120	149	5.4e-1	SMART
ANK	153	182	2e-3	SMART
ANK	187	216	2.2e-7	SMART
ANK	220	249	8.2e-8	SMART
ANK	253	282	2.2e-6	SMART
ANK	287	316	2.1e-6	SMART
ANK	320	349	9.9e-7	SMART
ANK	353	382	9.5e-5	SMART
ANK	386	415	2.4e-9	SMART
ANK	420	449	2.6e-5	SMART
ANK	450	479	1.1e-7	SMART
ANK	483	512	2.2e-7	SMART
ANK	516	545	3.5e-6	SMART
ANK	550	579	7.9e-6	SMART
ANK	583	612	8.9e-4	SMART
coiled coil region	691	774	N/A	INTRINSIC
low complexity region	781	794	N/A	INTRINSIC
low complexity region	846	859	N/A	INTRINSIC
low complexity region	877	888	N/A	INTRINSIC
low complexity region	937	951	N/A	INTRINSIC
ANK	969	998	1.4e-6	SMART
ANK	1002	1031	5.3e-8	SMART
ANK	1036	1065	1e-4	SMART
ANK	1069	1098	1e-6	SMART
ANK	1104	1133	9.1e-8	SMART
ANK	1138	1167	1.2e-5	SMART
ANK	1171	1200	2.5e-5	SMART
ANK	1206	1235	1.2e-4	SMART
ANK	1239	1268	5.5e-8	SMART
ANK	1272	1301	4.7e-3	SMART
coiled coil region	1345	1413	N/A	INTRINSIC
low complexity region	1488	1502	N/A	INTRINSIC
low complexity region	1507	1527	N/A	INTRINSIC
KH	1611	1681	5.1e-16	SMART
low complexity region	1707	1718	N/A	INTRINSIC
low complexity region	1725	1741	N/A	INTRINSIC
low complexity region	1837	1880	N/A	INTRINSIC
low complexity region	1887	1915	N/A	INTRINSIC
low complexity region	1926	1943	N/A	INTRINSIC
low complexity region	1959	1968	N/A	INTRINSIC
low complexity region	1977	2001	N/A	INTRINSIC
low complexity region	2066	2080	N/A	INTRINSIC
low complexity region	2239	2256	N/A	INTRINSIC
low complexity region	2283	2302	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000199096

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200012

Predicted Effect

probably benign
Transcript: ENSMUST00000218526

Meta Mutation Damage Score

0.0805

Coding Region Coverage

1x: 0.0%
3x: 0.0%
10x: 0.0%
20x: 0.0%

Validation Efficiency

99% (136/137)

MGI Phenotype

FUNCTION: This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies suggest that this protein is involved in liver development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality during organogenesis with hemorrhages, impaired vascular smooth muscle cell development, impaired vascular integrity, and growth retardation. [provided by MGI curators]

Allele List at MGI

All alleles(133) : Targeted(4) Gene trapped(129)

Other mutations in this stock

Total: 139 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	A	T	12: 71,207,160 (GRCm39)	I524F	possibly damaging	Het
4930511M06Rik	T	C	18: 57,517,241 (GRCm39)		probably benign	Het
9330159F19Rik	T	A	10: 29,100,711 (GRCm39)	N361K	probably damaging	Het
Adgra2	A	G	8: 27,604,216 (GRCm39)	M469V	possibly damaging	Het
Akap9	A	G	5: 4,079,849 (GRCm39)	D1867G	probably damaging	Het
Ap1m2	G	A	9: 21,209,548 (GRCm39)	P376L	probably damaging	Het
Bicc1	A	G	10: 70,793,511 (GRCm39)	S196P	possibly damaging	Het
Cacnb2	C	T	2: 14,976,412 (GRCm39)	R228*	probably null	Het
Ccdc43	A	G	11: 102,582,976 (GRCm39)	S83P	probably damaging	Het
Cdc42bpg	T	A	19: 6,372,582 (GRCm39)		probably null	Het
Cdh16	C	A	8: 105,344,271 (GRCm39)	M89I	probably benign	Het
Cecr2	A	C	6: 120,735,440 (GRCm39)	H892P	probably benign	Het
Chd5	T	A	4: 152,455,094 (GRCm39)	S859T	probably damaging	Het
Chrd	G	A	16: 20,557,748 (GRCm39)		probably null	Het
Chrna2	T	A	14: 66,387,186 (GRCm39)	L444Q	probably benign	Het
Ckap4	A	G	10: 84,363,630 (GRCm39)	S478P	probably damaging	Het
Cldn4	A	T	5: 134,975,514 (GRCm39)	M29K	possibly damaging	Het
Clpb	T	C	7: 101,435,926 (GRCm39)	V615A	possibly damaging	Het
Cyb5r4	G	A	9: 86,920,791 (GRCm39)	G142E	probably benign	Het
Cyp1a1	A	G	9: 57,608,194 (GRCm39)	Y274C	probably benign	Het
D2hgdh	T	C	1: 93,754,001 (GRCm39)		probably benign	Het
Dgkh	T	A	14: 78,818,953 (GRCm39)	E919V	probably damaging	Het
Dnah1	A	G	14: 30,984,537 (GRCm39)	Y3916H	probably damaging	Het
Dpp10	A	G	1: 123,268,911 (GRCm39)		probably benign	Het
Dync2i2	T	C	2: 29,922,147 (GRCm39)	Y438C	probably damaging	Het
Egfr	A	G	11: 16,860,214 (GRCm39)	T1043A	probably benign	Het
Elp5	T	G	11: 69,857,935 (GRCm39)		probably null	Het
Emilin3	A	T	2: 160,750,402 (GRCm39)	M449K	possibly damaging	Het
Epb41l4a	T	G	18: 33,930,400 (GRCm39)	T686P	probably damaging	Het
Eppk1	A	G	15: 76,105,236 (GRCm38)	C2482R	probably benign	Het
Eps8l3	T	C	3: 107,792,183 (GRCm39)	L370P	probably damaging	Het
Erbin	A	T	13: 103,996,017 (GRCm39)	S228R	probably damaging	Het
Fam149a	C	T	8: 45,804,743 (GRCm39)	E280K	probably benign	Het
Fam78b	T	C	1: 166,829,313 (GRCm39)	I60T	probably benign	Het
Fank1	A	T	7: 133,478,529 (GRCm39)	R197*	probably null	Het
Fbxo21	C	T	5: 118,115,931 (GRCm39)	S83F	possibly damaging	Het
Fbxo4	G	C	15: 4,008,782 (GRCm39)	T42R	probably benign	Het
Fhad1	C	G	4: 141,637,060 (GRCm39)	E1135D	probably damaging	Het
Fmo1	T	A	1: 162,657,622 (GRCm39)	E506D	probably benign	Het
Glipr1l2	A	T	10: 111,942,745 (GRCm39)	T231S	probably benign	Het
Gm11651	C	G	11: 105,863,917 (GRCm39)		probably benign	Het
Gm16043	A	G	6: 8,426,969 (GRCm39)		probably null	Het
Gm572	T	G	4: 148,755,850 (GRCm39)	W389G	unknown	Het
Gpc6	G	A	14: 118,188,594 (GRCm39)	W409*	probably null	Het
Gpr155	T	C	2: 73,200,482 (GRCm39)	T342A	probably benign	Het
Hcn4	A	C	9: 58,766,833 (GRCm39)	H798P	unknown	Het
Herc2	T	C	7: 55,876,702 (GRCm39)	S4513P	probably damaging	Het
Hmcn1	G	A	1: 150,684,488 (GRCm39)	R361C	probably benign	Het
Hoxa4	G	T	6: 52,168,199 (GRCm39)	P157Q	possibly damaging	Het
Ift122	A	C	6: 115,902,705 (GRCm39)		probably benign	Het
Igfbpl1	G	A	4: 45,826,756 (GRCm39)	S13L	unknown	Het
Igsf10	T	C	3: 59,235,579 (GRCm39)	D1534G	probably benign	Het
Il1rap	T	G	16: 26,529,343 (GRCm39)	L339V	possibly damaging	Het
Irf2bpl	C	T	12: 86,930,229 (GRCm39)	R148H	possibly damaging	Het
Ivns1abp	A	T	1: 151,237,356 (GRCm39)	R58W	probably damaging	Het
Kcnq5	C	T	1: 21,605,405 (GRCm39)	V167M	probably damaging	Het
Lrrcc1	G	A	3: 14,610,656 (GRCm39)	C337Y	probably damaging	Het
Lrriq3	A	G	3: 154,804,507 (GRCm39)	I56V	probably benign	Het
Masp1	C	A	16: 23,332,694 (GRCm39)	S47I	probably damaging	Het
Mcm7	A	T	5: 138,165,708 (GRCm39)		probably benign	Het
Mdm2	G	T	10: 117,530,840 (GRCm39)	S210R	probably damaging	Het
Mical1	A	G	10: 41,359,492 (GRCm39)	R500G	possibly damaging	Het
Mtarc1	T	G	1: 184,539,246 (GRCm39)	T37P	probably benign	Het
Myc	A	C	15: 61,859,542 (GRCm39)	T73P	probably damaging	Het
Myh15	G	A	16: 49,017,254 (GRCm39)		probably null	Het
Myh4	A	G	11: 67,149,658 (GRCm39)	M1768V	probably benign	Het
Nap1l1	T	C	10: 111,322,597 (GRCm39)	Y66H	probably damaging	Het
Ncoa1	C	T	12: 4,373,005 (GRCm39)	R132K	probably benign	Het
Nfatc3	C	T	8: 106,786,605 (GRCm39)	S28F	possibly damaging	Het
Nhlrc3	T	A	3: 53,361,050 (GRCm39)	K235M	probably damaging	Het
Nrk	G	A	X: 137,879,463 (GRCm39)	E757K	probably damaging	Het
Obsl1	G	A	1: 75,482,811 (GRCm39)	P20S	probably damaging	Het
P2rx7	C	T	5: 122,819,279 (GRCm39)	A567V	probably damaging	Het
Pate9	A	T	9: 36,446,295 (GRCm39)	L39*	probably null	Het
Pcdhb15	G	A	18: 37,608,724 (GRCm39)	R652H	probably benign	Het
Pcdhga4	T	C	18: 37,819,267 (GRCm39)	V272A	probably benign	Het
Pcdhgb1	T	G	18: 37,814,472 (GRCm39)	V321G	probably damaging	Het
Pde2a	C	G	7: 101,100,684 (GRCm39)		probably benign	Het
Pdhb	C	T	14: 8,170,425 (GRCm38)	E109K	probably damaging	Het
Pkd1	C	A	17: 24,788,485 (GRCm39)	L748M	probably damaging	Het
Pkd2	A	T	5: 104,607,654 (GRCm39)	E51V	probably damaging	Het
Pkdrej	A	G	15: 85,705,493 (GRCm39)	Y148H	probably damaging	Het
Polr3gl	C	G	3: 96,488,228 (GRCm39)		probably benign	Het
Ppfia1	A	T	7: 144,052,073 (GRCm39)	L882Q	probably damaging	Het
Ppp4r3b	G	T	11: 29,159,434 (GRCm39)	R596L	probably benign	Het
Ppp6r3	G	A	19: 3,521,059 (GRCm39)	Q85*	probably null	Het
Prss8	A	G	7: 127,521,424 (GRCm39)		probably benign	Het
Qng1	T	A	13: 58,532,827 (GRCm39)	K48*	probably null	Het
Rab22a	A	G	2: 173,536,963 (GRCm39)	I87V	probably benign	Het
Rev1	A	C	1: 38,095,337 (GRCm39)		probably benign	Het
Rnase13	A	G	14: 52,159,987 (GRCm39)	Y51H	probably damaging	Het
Rnf26	T	C	9: 44,023,942 (GRCm39)	H102R	probably damaging	Het
Rnf5	T	C	17: 34,822,341 (GRCm39)	E36G	probably damaging	Het
Rplp1	T	G	9: 61,821,658 (GRCm39)	D18A	probably benign	Het
Rrs1	C	A	1: 9,616,150 (GRCm39)	D134E	probably damaging	Het
Sec14l1	A	G	11: 117,034,629 (GRCm39)	Y166C	probably damaging	Het
Sec14l2	A	T	11: 4,059,209 (GRCm39)	Y153*	probably null	Het
Senp1	A	G	15: 97,982,870 (GRCm39)	L39P	probably damaging	Het
Senp2	T	A	16: 21,832,864 (GRCm39)		probably benign	Het
Sh3bp1	G	A	15: 78,798,224 (GRCm39)	A19T	probably benign	Het
Sis	G	A	3: 72,830,162 (GRCm39)	P1130S	probably damaging	Het
Slc16a12	C	T	19: 34,654,759 (GRCm39)	A95T	possibly damaging	Het
Slc22a4	A	G	11: 53,918,783 (GRCm39)	V7A	probably benign	Het
Slc35c2	C	T	2: 165,119,452 (GRCm39)	S296N	probably benign	Het
Slf1	A	G	13: 77,198,169 (GRCm39)		probably benign	Het
Slitrk6	A	T	14: 110,987,859 (GRCm39)	V616E	possibly damaging	Het
Smarca2	T	A	19: 26,626,493 (GRCm39)	M439K	probably benign	Het
Snx29	G	A	16: 11,221,488 (GRCm39)	A305T	probably benign	Het
Socs5	C	T	17: 87,441,044 (GRCm39)		probably benign	Het
Spata31d1a	G	T	13: 59,849,010 (GRCm39)	H1039Q	probably benign	Het
Srgap1	G	A	10: 121,732,658 (GRCm39)		probably benign	Het
Synj1	A	T	16: 90,761,396 (GRCm39)	I650N	probably damaging	Het
Tac4	A	C	11: 95,158,190 (GRCm39)		probably benign	Het
Tbck	A	C	3: 132,428,487 (GRCm39)	T281P	probably benign	Het
Tbx22	T	C	X: 106,720,611 (GRCm39)	L62P	probably damaging	Het
Terf2	G	C	8: 107,822,934 (GRCm39)	R70G	probably damaging	Het
Tfdp1	C	T	8: 13,422,526 (GRCm39)	P138S	probably benign	Het
Tigd2	T	C	6: 59,188,233 (GRCm39)	Y367H	probably damaging	Het
Tmprss15	A	T	16: 78,821,640 (GRCm39)		probably null	Het
Tmprss6	C	T	15: 78,324,827 (GRCm39)	G741D	probably damaging	Het
Tnrc6b	A	C	15: 80,813,387 (GRCm39)	T1715P	probably damaging	Het
Tpcn1	T	C	5: 120,686,388 (GRCm39)		probably benign	Het
Trappc2l	T	C	8: 123,339,874 (GRCm39)	S35P	probably damaging	Het
Trim63	T	C	4: 134,048,484 (GRCm39)		probably benign	Het
Trim66	G	T	7: 109,074,454 (GRCm39)	D602E	probably damaging	Het
Trp53bp1	G	A	2: 121,101,756 (GRCm39)	P2S	probably damaging	Het
Tspan14	A	G	14: 40,637,488 (GRCm39)	L100P	probably damaging	Het
Tspan15	C	T	10: 62,023,899 (GRCm39)	E260K	probably damaging	Het
Ubxn10	T	C	4: 138,448,199 (GRCm39)	D159G	probably benign	Het
Unc5a	T	G	13: 55,151,709 (GRCm39)	V713G	probably damaging	Het
Usp16	C	T	16: 87,270,020 (GRCm39)	A324V	probably damaging	Het
Uvssa	G	A	5: 33,559,914 (GRCm39)	R422Q	possibly damaging	Het
Wipf1	A	C	2: 73,267,946 (GRCm39)	F151V	probably damaging	Het
Xpo1	A	T	11: 23,226,437 (GRCm39)	K104N	possibly damaging	Het
Ybx3	T	C	6: 131,356,422 (GRCm39)	T150A	probably damaging	Het
Yju2	C	T	17: 56,271,479 (GRCm39)		probably benign	Het
Zap70	T	A	1: 36,818,250 (GRCm39)	S312R	possibly damaging	Het
Zfp534	T	G	4: 147,759,880 (GRCm39)	K263T	probably benign	Het
Zfp534	T	G	4: 147,759,917 (GRCm39)	N251H	probably benign	Het

Other mutations in Ankrd17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00236:Ankrd17	APN	5	90,381,787 (GRCm39)	missense	probably damaging	0.98
IGL00484:Ankrd17	APN	5	90,416,220 (GRCm39)	missense	probably damaging	0.99
IGL01320:Ankrd17	APN	5	90,407,988 (GRCm39)	missense	probably damaging	0.99
IGL01776:Ankrd17	APN	5	90,431,223 (GRCm39)	nonsense	probably null
IGL02093:Ankrd17	APN	5	90,390,822 (GRCm39)	missense	possibly damaging	0.93
IGL02292:Ankrd17	APN	5	90,400,718 (GRCm39)	unclassified	probably benign
IGL02302:Ankrd17	APN	5	90,431,057 (GRCm39)	missense	probably benign	0.23
IGL02472:Ankrd17	APN	5	90,412,010 (GRCm39)	missense	probably damaging	1.00
IGL02705:Ankrd17	APN	5	90,430,974 (GRCm39)	missense	probably benign	0.15
IGL02727:Ankrd17	APN	5	90,392,151 (GRCm39)	missense	possibly damaging	0.93
IGL02884:Ankrd17	APN	5	90,412,616 (GRCm39)	missense	probably damaging	1.00
3-1:Ankrd17	UTSW	5	90,391,013 (GRCm39)	missense	probably damaging	0.99
R0025:Ankrd17	UTSW	5	90,398,264 (GRCm39)	missense	probably damaging	0.99
R0076:Ankrd17	UTSW	5	90,392,265 (GRCm39)	nonsense	probably null
R0076:Ankrd17	UTSW	5	90,392,265 (GRCm39)	nonsense	probably null
R0271:Ankrd17	UTSW	5	90,402,658 (GRCm39)	missense	possibly damaging	0.90
R0684:Ankrd17	UTSW	5	90,411,857 (GRCm39)	missense	probably damaging	0.99
R1239:Ankrd17	UTSW	5	90,436,535 (GRCm39)	missense	probably damaging	0.99
R1457:Ankrd17	UTSW	5	90,433,705 (GRCm39)	missense	possibly damaging	0.92
R1505:Ankrd17	UTSW	5	90,447,885 (GRCm39)	missense	possibly damaging	0.53
R1766:Ankrd17	UTSW	5	90,412,656 (GRCm39)	missense	possibly damaging	0.95
R1770:Ankrd17	UTSW	5	90,391,235 (GRCm39)	missense	possibly damaging	0.84
R1780:Ankrd17	UTSW	5	90,380,274 (GRCm39)	missense	probably damaging	0.96
R1916:Ankrd17	UTSW	5	90,408,000 (GRCm39)	missense	probably damaging	1.00
R1926:Ankrd17	UTSW	5	90,392,028 (GRCm39)	missense	probably damaging	1.00
R2090:Ankrd17	UTSW	5	90,445,905 (GRCm39)	missense	possibly damaging	0.92
R2153:Ankrd17	UTSW	5	90,381,918 (GRCm39)	missense	probably damaging	0.98
R2279:Ankrd17	UTSW	5	90,412,576 (GRCm39)	missense	probably damaging	1.00
R2420:Ankrd17	UTSW	5	90,437,179 (GRCm39)	missense	possibly damaging	0.94
R3012:Ankrd17	UTSW	5	90,378,727 (GRCm39)	missense	probably damaging	1.00
R3417:Ankrd17	UTSW	5	90,391,772 (GRCm39)	missense	possibly damaging	0.86
R3704:Ankrd17	UTSW	5	90,391,828 (GRCm39)	missense	possibly damaging	0.72
R4581:Ankrd17	UTSW	5	90,430,979 (GRCm39)	missense	possibly damaging	0.67
R4850:Ankrd17	UTSW	5	90,412,645 (GRCm39)	missense	probably damaging	1.00
R4926:Ankrd17	UTSW	5	90,447,891 (GRCm39)	missense	probably damaging	1.00
R5023:Ankrd17	UTSW	5	90,430,727 (GRCm39)	missense	probably damaging	1.00
R5068:Ankrd17	UTSW	5	90,402,667 (GRCm39)	missense	probably damaging	0.96
R5109:Ankrd17	UTSW	5	90,391,395 (GRCm39)	missense	possibly damaging	0.83
R5111:Ankrd17	UTSW	5	90,390,858 (GRCm39)	missense	possibly damaging	0.85
R5214:Ankrd17	UTSW	5	90,431,319 (GRCm39)	missense	possibly damaging	0.48
R5362:Ankrd17	UTSW	5	90,413,404 (GRCm39)	missense	probably damaging	1.00
R5576:Ankrd17	UTSW	5	90,391,083 (GRCm39)	missense	probably benign	0.00
R5615:Ankrd17	UTSW	5	90,431,295 (GRCm39)	missense	possibly damaging	0.88
R5874:Ankrd17	UTSW	5	90,416,656 (GRCm39)	intron	probably benign
R5932:Ankrd17	UTSW	5	90,413,295 (GRCm39)	missense	probably damaging	1.00
R5944:Ankrd17	UTSW	5	90,433,702 (GRCm39)	missense	probably damaging	1.00
R5993:Ankrd17	UTSW	5	90,487,531 (GRCm39)	intron	probably benign
R6052:Ankrd17	UTSW	5	90,401,691 (GRCm39)	missense	probably benign	0.03
R6088:Ankrd17	UTSW	5	90,401,547 (GRCm39)	missense	possibly damaging	0.95
R6306:Ankrd17	UTSW	5	90,392,013 (GRCm39)	missense	probably benign	0.03
R6418:Ankrd17	UTSW	5	90,426,204 (GRCm39)	missense	possibly damaging	0.89
R6663:Ankrd17	UTSW	5	90,411,923 (GRCm39)	missense	probably damaging	1.00
R6758:Ankrd17	UTSW	5	90,411,172 (GRCm39)	missense	probably damaging	1.00
R6782:Ankrd17	UTSW	5	90,402,597 (GRCm39)	missense	possibly damaging	0.91
R6793:Ankrd17	UTSW	5	90,413,371 (GRCm39)	missense	probably damaging	1.00
R6929:Ankrd17	UTSW	5	90,433,384 (GRCm39)	missense	possibly damaging	0.86
R7008:Ankrd17	UTSW	5	90,407,955 (GRCm39)	missense	possibly damaging	0.93
R7051:Ankrd17	UTSW	5	90,514,310 (GRCm39)	unclassified	probably benign
R7077:Ankrd17	UTSW	5	90,433,723 (GRCm39)	missense	possibly damaging	0.92
R7134:Ankrd17	UTSW	5	90,433,382 (GRCm39)	missense	probably benign	0.03
R7134:Ankrd17	UTSW	5	90,380,173 (GRCm39)	missense	probably damaging	0.99
R7138:Ankrd17	UTSW	5	90,390,836 (GRCm39)	missense	probably benign	0.38
R7143:Ankrd17	UTSW	5	90,433,820 (GRCm39)	missense	possibly damaging	0.85
R7173:Ankrd17	UTSW	5	90,407,976 (GRCm39)	missense	possibly damaging	0.95
R7176:Ankrd17	UTSW	5	90,416,594 (GRCm39)	missense	probably damaging	0.99
R7365:Ankrd17	UTSW	5	90,439,010 (GRCm39)	missense	possibly damaging	0.45
R7390:Ankrd17	UTSW	5	90,430,779 (GRCm39)	missense	probably benign	0.13
R7430:Ankrd17	UTSW	5	90,443,516 (GRCm39)	missense	possibly damaging	0.80
R7468:Ankrd17	UTSW	5	90,390,902 (GRCm39)	missense	probably benign
R7483:Ankrd17	UTSW	5	90,447,855 (GRCm39)	missense	probably benign	0.00
R7492:Ankrd17	UTSW	5	90,381,807 (GRCm39)	missense	possibly damaging	0.85
R7610:Ankrd17	UTSW	5	90,380,222 (GRCm39)	missense	possibly damaging	0.93
R7636:Ankrd17	UTSW	5	90,380,239 (GRCm39)	missense	possibly damaging	0.53
R7790:Ankrd17	UTSW	5	90,408,011 (GRCm39)	missense	possibly damaging	0.61
R7839:Ankrd17	UTSW	5	90,411,213 (GRCm39)	missense	probably damaging	0.97
R7853:Ankrd17	UTSW	5	90,386,825 (GRCm39)	missense	possibly damaging	0.91
R7976:Ankrd17	UTSW	5	90,431,451 (GRCm39)	nonsense	probably null
R8054:Ankrd17	UTSW	5	90,438,914 (GRCm39)	missense	probably benign	0.43
R8230:Ankrd17	UTSW	5	90,391,835 (GRCm39)	missense	possibly damaging	0.86
R8274:Ankrd17	UTSW	5	90,430,718 (GRCm39)	missense	probably benign	0.15
R8365:Ankrd17	UTSW	5	90,398,378 (GRCm39)	missense	possibly damaging	0.95
R8532:Ankrd17	UTSW	5	90,412,679 (GRCm39)	missense	probably damaging	1.00
R8729:Ankrd17	UTSW	5	90,443,452 (GRCm39)	missense	probably benign
R8812:Ankrd17	UTSW	5	90,441,062 (GRCm39)	missense	probably benign	0.09
R8933:Ankrd17	UTSW	5	90,406,325 (GRCm39)	missense	probably damaging	0.99
R9051:Ankrd17	UTSW	5	90,411,134 (GRCm39)	missense	probably damaging	0.99
R9055:Ankrd17	UTSW	5	90,380,168 (GRCm39)	missense	probably benign	0.33
R9136:Ankrd17	UTSW	5	90,392,278 (GRCm39)	missense	probably damaging	0.96
R9158:Ankrd17	UTSW	5	90,416,575 (GRCm39)	missense	probably damaging	1.00
R9201:Ankrd17	UTSW	5	90,378,798 (GRCm39)	missense	possibly damaging	0.84
R9315:Ankrd17	UTSW	5	90,398,360 (GRCm39)	missense	probably damaging	0.97
R9364:Ankrd17	UTSW	5	90,416,508 (GRCm39)	missense	probably damaging	1.00
R9366:Ankrd17	UTSW	5	90,416,508 (GRCm39)	missense	probably damaging	1.00
R9368:Ankrd17	UTSW	5	90,416,508 (GRCm39)	missense	probably damaging	1.00
R9368:Ankrd17	UTSW	5	90,391,986 (GRCm39)	missense	possibly damaging	0.91
R9369:Ankrd17	UTSW	5	90,416,508 (GRCm39)	missense	probably damaging	1.00
R9381:Ankrd17	UTSW	5	90,416,508 (GRCm39)	missense	probably damaging	1.00
R9570:Ankrd17	UTSW	5	90,401,536 (GRCm39)	missense
X0019:Ankrd17	UTSW	5	90,446,513 (GRCm39)	missense	probably damaging	1.00
Z1177:Ankrd17	UTSW	5	90,437,184 (GRCm39)	missense	possibly damaging	0.86
Z1177:Ankrd17	UTSW	5	90,431,364 (GRCm39)	missense	possibly damaging	0.83

Predicted Primers

Posted On

2017-11-21