Incidental Mutation 'R5220:Dcaf10'
ID 499938
Institutional Source Beutler Lab
Gene Symbol Dcaf10
Ensembl Gene ENSMUSG00000035572
Gene Name DDB1 and CUL4 associated factor 10
Synonyms Wdr32
MMRRC Submission 042793-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5220 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 45342101-45379759 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 45373909 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 445 (W445R)
Ref Sequence ENSEMBL: ENSMUSP00000117082 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000153803] [ENSMUST00000155551]
AlphaFold A2AKB9
Predicted Effect noncoding transcript
Transcript: ENSMUST00000107798
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130821
Predicted Effect possibly damaging
Transcript: ENSMUST00000153803
AA Change: W104R

PolyPhen 2 Score 0.541 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000121616
Gene: ENSMUSG00000035572
AA Change: W104R

DomainStartEndE-ValueType
Blast:WD40 1 30 3e-11 BLAST
Blast:WD40 127 165 2e-10 BLAST
WD40 183 222 1.31e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000155551
AA Change: W445R

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000117082
Gene: ENSMUSG00000035572
AA Change: W445R

DomainStartEndE-ValueType
low complexity region 15 46 N/A INTRINSIC
low complexity region 80 107 N/A INTRINSIC
low complexity region 110 132 N/A INTRINSIC
WD40 166 203 1.71e1 SMART
WD40 206 245 7.85e-7 SMART
WD40 249 288 2.59e-7 SMART
WD40 295 334 2.05e1 SMART
low complexity region 352 374 N/A INTRINSIC
Blast:WD40 468 506 3e-10 BLAST
WD40 524 563 1.31e-3 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan A G 7: 78,738,045 (GRCm39) E250G probably damaging Het
Adgra1 A G 7: 139,455,512 (GRCm39) N380S probably benign Het
Ap3d1 G A 10: 80,563,001 (GRCm39) P160L probably damaging Het
Atg9a C T 1: 75,162,372 (GRCm39) V505M probably damaging Het
Chsy3 A T 18: 59,543,102 (GRCm39) I747F probably damaging Het
Clec2g A G 6: 128,958,269 (GRCm39) S100G probably benign Het
Cmya5 G T 13: 93,228,804 (GRCm39) P2095T probably damaging Het
Espl1 T A 15: 102,207,012 (GRCm39) L159M probably benign Het
Fbxw8 T C 5: 118,233,776 (GRCm39) D285G possibly damaging Het
Fras1 C T 5: 96,916,222 (GRCm39) R3419W probably damaging Het
Galc T A 12: 98,197,672 (GRCm39) probably null Het
Ghdc T C 11: 100,660,543 (GRCm39) E110G probably damaging Het
Gm4787 G C 12: 81,424,604 (GRCm39) T518S probably benign Het
H2-T24 T C 17: 36,325,562 (GRCm39) T309A probably benign Het
Helb A C 10: 119,937,391 (GRCm39) F618V probably damaging Het
Hycc1 A C 5: 24,170,220 (GRCm39) S376R possibly damaging Het
Ifi211 A G 1: 173,735,262 (GRCm39) F56L probably damaging Het
Kntc1 T C 5: 123,950,160 (GRCm39) F1988L probably damaging Het
Mapk13 G A 17: 28,997,465 (GRCm39) S361N probably benign Het
Mapk3 A G 7: 126,363,408 (GRCm39) I146V probably benign Het
Megf6 G A 4: 154,338,295 (GRCm39) probably null Het
Mug1 G T 6: 121,838,092 (GRCm39) V441F probably benign Het
Mymk A G 2: 26,952,226 (GRCm39) S173P probably benign Het
Nox4 A G 7: 87,023,616 (GRCm39) T501A possibly damaging Het
Or13c7 C A 4: 43,854,624 (GRCm39) S105Y possibly damaging Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or52n2 T C 7: 104,542,104 (GRCm39) T244A possibly damaging Het
Prkcb C A 7: 121,888,678 (GRCm39) H37Q probably damaging Het
Rabggtb A G 3: 153,615,024 (GRCm39) F189L probably damaging Het
Setd1b T C 5: 123,281,471 (GRCm39) I75T unknown Het
Slc10a5 T A 3: 10,400,148 (GRCm39) R171* probably null Het
Slc12a4 A G 8: 106,680,484 (GRCm39) F211L probably damaging Het
Slc1a5 T A 7: 16,527,759 (GRCm39) W352R probably damaging Het
Slc22a27 C G 19: 7,843,303 (GRCm39) A359P probably damaging Het
St8sia4 A G 1: 95,555,460 (GRCm39) M190T probably damaging Het
Tmeff2 A G 1: 51,018,476 (GRCm39) M153V probably benign Het
Trappc12 T C 12: 28,796,696 (GRCm39) T279A probably damaging Het
Ubn1 G T 16: 4,895,818 (GRCm39) A955S probably benign Het
Usp24 T A 4: 106,239,500 (GRCm39) H1147Q possibly damaging Het
Vrk1 T A 12: 106,039,865 (GRCm39) probably null Het
Zdhhc25 T A 15: 88,485,365 (GRCm39) Y233* probably null Het
Zfp109 A G 7: 23,928,179 (GRCm39) V418A probably benign Het
Other mutations in Dcaf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02431:Dcaf10 APN 4 45,342,630 (GRCm39) missense probably benign 0.01
IGL02660:Dcaf10 APN 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R0048:Dcaf10 UTSW 4 45,374,262 (GRCm39) nonsense probably null
R0550:Dcaf10 UTSW 4 45,372,753 (GRCm39) missense probably benign
R0611:Dcaf10 UTSW 4 45,373,011 (GRCm39) missense probably damaging 1.00
R2289:Dcaf10 UTSW 4 45,359,816 (GRCm39) missense probably damaging 1.00
R2973:Dcaf10 UTSW 4 45,373,957 (GRCm39) missense probably benign 0.04
R3610:Dcaf10 UTSW 4 45,372,962 (GRCm39) nonsense probably null
R3735:Dcaf10 UTSW 4 45,348,117 (GRCm39) missense probably benign 0.01
R4655:Dcaf10 UTSW 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R4665:Dcaf10 UTSW 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R4690:Dcaf10 UTSW 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R4724:Dcaf10 UTSW 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R4725:Dcaf10 UTSW 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R4735:Dcaf10 UTSW 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R4743:Dcaf10 UTSW 4 45,370,409 (GRCm39) missense probably damaging 0.98
R5254:Dcaf10 UTSW 4 45,370,415 (GRCm39) missense possibly damaging 0.94
R5855:Dcaf10 UTSW 4 45,342,558 (GRCm39) missense probably benign 0.18
R6833:Dcaf10 UTSW 4 45,373,043 (GRCm39) missense probably damaging 1.00
R7132:Dcaf10 UTSW 4 45,342,391 (GRCm39) missense probably benign
R7345:Dcaf10 UTSW 4 45,342,583 (GRCm39) missense probably damaging 0.98
R7366:Dcaf10 UTSW 4 45,373,919 (GRCm39) missense probably damaging 1.00
R7832:Dcaf10 UTSW 4 45,348,196 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCATCATAGTCCACAGTGACC -3'
(R):5'- TTTGTCAAATCCCAACAAGCG -3'

Sequencing Primer
(F):5'- GTCCACAGTGACCTTAGTTTATGAAG -3'
(R):5'- AGCGAATCCCATAGCCGTGTG -3'
Posted On 2017-11-30