Incidental Mutation 'R4561:Ipo4'
ID 499997
Institutional Source Beutler Lab
Gene Symbol Ipo4
Ensembl Gene ENSMUSG00000002319
Gene Name importin 4
Synonyms 8430408O15Rik
MMRRC Submission 041786-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.169) question?
Stock # R4561 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 55862857-55873321 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) C to T at 55867546 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000002395] [ENSMUST00000047131] [ENSMUST00000125133] [ENSMUST00000135221] [ENSMUST00000148351] [ENSMUST00000141499]
AlphaFold Q8VI75
Predicted Effect probably benign
Transcript: ENSMUST00000002395
SMART Domains Protein: ENSMUSP00000002395
Gene: ENSMUSG00000002324

DomainStartEndE-ValueType
Pfam:Rad21_Rec8_N 1 117 2.2e-26 PFAM
low complexity region 235 249 N/A INTRINSIC
low complexity region 329 347 N/A INTRINSIC
coiled coil region 423 458 N/A INTRINSIC
low complexity region 497 521 N/A INTRINSIC
Pfam:Rad21_Rec8 536 590 9.2e-23 PFAM
Predicted Effect silent
Transcript: ENSMUST00000047131
SMART Domains Protein: ENSMUSP00000036555
Gene: ENSMUSG00000002319

DomainStartEndE-ValueType
IBN_N 24 90 4.4e-7 SMART
Blast:IBN_N 101 170 4e-20 BLAST
Blast:IBN_N 224 293 4e-31 BLAST
low complexity region 307 321 N/A INTRINSIC
Pfam:HEAT 395 425 7.7e-7 PFAM
Blast:ARM 465 499 8e-13 BLAST
low complexity region 500 511 N/A INTRINSIC
low complexity region 636 660 N/A INTRINSIC
low complexity region 733 743 N/A INTRINSIC
low complexity region 811 830 N/A INTRINSIC
low complexity region 851 864 N/A INTRINSIC
Pfam:HEAT 901 931 1.9e-5 PFAM
Pfam:HEAT_EZ 914 969 2.3e-9 PFAM
low complexity region 1043 1053 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000125133
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126064
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127773
Predicted Effect silent
Transcript: ENSMUST00000135221
SMART Domains Protein: ENSMUSP00000123692
Gene: ENSMUSG00000002319

DomainStartEndE-ValueType
IBN_N 24 90 4.4e-7 SMART
Blast:IBN_N 101 170 3e-20 BLAST
Blast:IBN_N 224 293 2e-31 BLAST
low complexity region 307 321 N/A INTRINSIC
Pfam:HEAT 395 425 7.4e-7 PFAM
Blast:ARM 465 499 7e-13 BLAST
low complexity region 500 511 N/A INTRINSIC
low complexity region 636 660 N/A INTRINSIC
low complexity region 733 743 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000156420
Predicted Effect probably benign
Transcript: ENSMUST00000148351
SMART Domains Protein: ENSMUSP00000117543
Gene: ENSMUSG00000002319

DomainStartEndE-ValueType
IBN_N 24 90 4.4e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155464
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141848
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228754
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146528
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150951
Predicted Effect probably benign
Transcript: ENSMUST00000141499
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148942
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155193
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ank3 T C 10: 69,837,848 (GRCm39) S1601P probably damaging Het
Arnt A G 3: 95,359,924 (GRCm39) N56D probably damaging Het
Atad5 A G 11: 79,986,715 (GRCm39) T601A probably benign Het
Calr4 A G 4: 109,103,379 (GRCm39) N163S probably damaging Het
Cenpc1 C A 5: 86,195,491 (GRCm39) A93S probably damaging Het
Cep135 C T 5: 76,786,040 (GRCm39) H1048Y possibly damaging Het
Ctnna2 A G 6: 77,613,696 (GRCm39) probably null Het
Ddx60 T C 8: 62,395,495 (GRCm39) L144P probably damaging Het
Dera A T 6: 137,757,736 (GRCm39) T96S possibly damaging Het
Dock9 T A 14: 121,796,419 (GRCm39) M1853L probably benign Het
Erbb4 G A 1: 68,383,080 (GRCm39) R306* probably null Het
Glyat G T 19: 12,628,644 (GRCm39) L146F possibly damaging Het
Grk4 C A 5: 34,852,157 (GRCm39) Q134K probably benign Het
Hkdc1 T C 10: 62,245,618 (GRCm39) Q181R probably benign Het
Huwe1 A T X: 150,646,955 (GRCm39) I682F probably damaging Het
Ivl CCTGCTGCTGCT CCTGCTGCTGCTGCT 3: 92,479,262 (GRCm39) probably benign Het
Kcnd2 A G 6: 21,216,395 (GRCm39) Q33R probably benign Het
Kdm7a C T 6: 39,129,757 (GRCm39) R473Q probably damaging Het
Klhl30 A T 1: 91,288,753 (GRCm39) H504L probably damaging Het
Map4 A G 9: 109,881,439 (GRCm39) Y101C possibly damaging Het
Mfn2 C A 4: 147,961,492 (GRCm39) R707L probably damaging Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Myof T C 19: 37,911,438 (GRCm39) N1511D probably benign Het
Neb A T 2: 52,176,167 (GRCm39) Y1431N probably damaging Het
Nlrc5 A G 8: 95,203,774 (GRCm39) T625A probably damaging Het
Or5g27 G T 2: 85,409,964 (GRCm39) C127F probably damaging Het
Pax2 A G 19: 44,824,402 (GRCm39) Y374C unknown Het
Pde8a T A 7: 80,958,568 (GRCm39) Y315* probably null Het
Pkhd1 A T 1: 20,604,943 (GRCm39) L1124Q possibly damaging Het
Ppp1r3a A G 6: 14,754,681 (GRCm39) F189L probably damaging Het
Prex2 G A 1: 11,254,769 (GRCm39) probably null Het
Robo4 CGG CG 9: 37,322,786 (GRCm39) probably null Het
Slc22a22 T A 15: 57,126,781 (GRCm39) Q77L probably damaging Het
Slc24a2 A T 4: 87,145,634 (GRCm39) V140D probably damaging Het
Slc35g2 C A 9: 100,435,287 (GRCm39) R128L probably damaging Het
Slco1b2 A G 6: 141,616,893 (GRCm39) T409A probably benign Het
Spag7 T C 11: 70,555,816 (GRCm39) I80M probably damaging Het
Srgap3 A G 6: 112,758,015 (GRCm39) M164T probably damaging Het
Sspo A T 6: 48,452,468 (GRCm39) probably null Het
Tcte2 T C 17: 13,942,864 (GRCm39) probably benign Het
Tmem117 A T 15: 94,992,677 (GRCm39) M446L probably benign Het
Tmtc4 T C 14: 123,200,710 (GRCm39) T194A probably benign Het
Ttc21b T C 2: 66,016,562 (GRCm39) Y1269C probably damaging Het
Zfp236 A T 18: 82,638,531 (GRCm39) I1363N probably damaging Het
Zfp760 T A 17: 21,942,648 (GRCm39) S608T probably benign Het
Zfp947 G T 17: 22,365,124 (GRCm39) Y183* probably null Het
Other mutations in Ipo4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0268:Ipo4 UTSW 14 55,863,399 (GRCm39) missense possibly damaging 0.92
R0277:Ipo4 UTSW 14 55,869,572 (GRCm39) missense probably benign 0.03
R0344:Ipo4 UTSW 14 55,863,399 (GRCm39) missense possibly damaging 0.92
R0467:Ipo4 UTSW 14 55,872,983 (GRCm39) start codon destroyed probably null
R1167:Ipo4 UTSW 14 55,872,477 (GRCm39) missense probably damaging 1.00
R1217:Ipo4 UTSW 14 55,871,816 (GRCm39) missense probably damaging 0.98
R1804:Ipo4 UTSW 14 55,866,913 (GRCm39) missense probably damaging 1.00
R2270:Ipo4 UTSW 14 55,871,557 (GRCm39) missense probably damaging 1.00
R3551:Ipo4 UTSW 14 55,870,560 (GRCm39) missense probably benign 0.10
R4801:Ipo4 UTSW 14 55,868,671 (GRCm39) missense probably damaging 1.00
R4802:Ipo4 UTSW 14 55,868,671 (GRCm39) missense probably damaging 1.00
R4804:Ipo4 UTSW 14 55,868,313 (GRCm39) missense possibly damaging 0.80
R5384:Ipo4 UTSW 14 55,863,653 (GRCm39) missense probably benign 0.28
R5493:Ipo4 UTSW 14 55,868,327 (GRCm39) missense probably benign 0.00
R5527:Ipo4 UTSW 14 55,869,507 (GRCm39) splice site probably null
R5631:Ipo4 UTSW 14 55,870,838 (GRCm39) missense probably benign 0.08
R5631:Ipo4 UTSW 14 55,869,526 (GRCm39) missense probably damaging 1.00
R5788:Ipo4 UTSW 14 55,866,277 (GRCm39) missense probably benign 0.02
R5929:Ipo4 UTSW 14 55,868,646 (GRCm39) missense probably benign 0.03
R6018:Ipo4 UTSW 14 55,863,609 (GRCm39) critical splice donor site probably null
R6031:Ipo4 UTSW 14 55,869,596 (GRCm39) missense probably damaging 1.00
R6031:Ipo4 UTSW 14 55,869,596 (GRCm39) missense probably damaging 1.00
R6707:Ipo4 UTSW 14 55,866,361 (GRCm39) missense possibly damaging 0.82
R7344:Ipo4 UTSW 14 55,872,988 (GRCm39) missense probably benign 0.00
R7345:Ipo4 UTSW 14 55,872,988 (GRCm39) missense probably benign 0.00
R7702:Ipo4 UTSW 14 55,869,787 (GRCm39) missense probably damaging 1.00
R9028:Ipo4 UTSW 14 55,866,408 (GRCm39) missense probably damaging 1.00
R9197:Ipo4 UTSW 14 55,870,840 (GRCm39) missense probably damaging 1.00
R9202:Ipo4 UTSW 14 55,868,597 (GRCm39) critical splice donor site probably null
R9244:Ipo4 UTSW 14 55,871,799 (GRCm39) missense probably damaging 1.00
R9547:Ipo4 UTSW 14 55,870,789 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CTGTGGCTAGATAAAGCAAGC -3'
(R):5'- CTGCCGCCTACTCACTAGATTG -3'

Sequencing Primer
(F):5'- CAAGCAGATCGGGGACTTTGC -3'
(R):5'- GCCTACTCACTAGATTGACAGTC -3'
Posted On 2017-11-30