Mutagenetix > Incidental Mutation

Incidental Mutation 'R4578:Ptprd'

500000

Institutional Source

Beutler Lab

Gene Symbol

Ptprd

Ensembl Gene

ENSMUSG00000028399

Gene Name

protein tyrosine phosphatase receptor type D

Synonyms

1110002J03Rik, B230219D21Rik, 3000002J10Rik

MMRRC Submission

041800-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4578 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

75859475-78130198 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 76162023 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 78 (V78I)

Ref Sequence

ENSEMBL: ENSMUSP00000133468 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050757] [ENSMUST00000098005] [ENSMUST00000107289] [ENSMUST00000173376] [ENSMUST00000174023] [ENSMUST00000174180] [ENSMUST00000174531] [ENSMUST00000174831]

AlphaFold

Q64487

Predicted Effect

probably benign
Transcript: ENSMUST00000050757
AA Change: V71I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000058466
Gene: ENSMUSG00000028399
AA Change: V71I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	208	1.38e-15	SMART
IGc2	238	299	8.13e-4	SMART
FN3	313	392	7.92e-14	SMART
FN3	408	491	5.73e-11	SMART
IG_like	499	593	8.34e1	SMART
FN3	506	584	9.1e-14	SMART
FN3	597	674	1.21e0	SMART
transmembrane domain	847	869	N/A	INTRINSIC
low complexity region	870	882	N/A	INTRINSIC
PTPc	949	1207	6.38e-134	SMART
PTPc	1236	1498	9.17e-135	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000084467

Predicted Effect

possibly damaging
Transcript: ENSMUST00000098005
AA Change: V71I

PolyPhen 2 Score 0.497 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000095614
Gene: ENSMUSG00000028399
AA Change: V71I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	214	8.5e-16	SMART
low complexity region	225	237	N/A	INTRINSIC
IGc2	248	309	8.13e-4	SMART
FN3	323	402	7.92e-14	SMART
FN3	418	501	5.73e-11	SMART
IG_like	509	603	8.34e1	SMART
FN3	516	594	9.1e-14	SMART
FN3	607	684	1.21e0	SMART
transmembrane domain	857	879	N/A	INTRINSIC
low complexity region	886	897	N/A	INTRINSIC
PTPc	950	1208	6.38e-134	SMART
PTPc	1237	1499	9.17e-135	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000107287

Predicted Effect

probably benign
Transcript: ENSMUST00000107289
AA Change: V71I

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000102910
Gene: ENSMUSG00000028399
AA Change: V71I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	214	8.5e-16	SMART
low complexity region	225	237	N/A	INTRINSIC
IGc2	248	309	8.13e-4	SMART
FN3	323	402	7.92e-14	SMART
FN3	418	501	5.73e-11	SMART
IG_like	509	603	8.34e1	SMART
FN3	516	594	9.1e-14	SMART
FN3	609	696	2.72e-12	SMART
FN3	712	809	2.87e-11	SMART
FN3	824	904	4.96e-6	SMART
FN3	919	1003	4.12e-12	SMART
FN3	1018	1095	1.95e0	SMART
transmembrane domain	1268	1290	N/A	INTRINSIC
low complexity region	1291	1303	N/A	INTRINSIC
PTPc	1356	1614	6.38e-134	SMART
PTPc	1643	1905	9.17e-135	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000173376
AA Change: V78I

PolyPhen 2 Score 0.546 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000133468
Gene: ENSMUSG00000028399
AA Change: V78I

Domain	Start	End	E-Value	Type
IGc2	43	112	8.57e-12	SMART
IGc2	145	221	8.5e-16	SMART
low complexity region	232	244	N/A	INTRINSIC
IGc2	255	316	8.13e-4	SMART
FN3	330	409	7.92e-14	SMART
FN3	425	508	5.73e-11	SMART
IG_like	516	610	8.34e1	SMART
FN3	523	601	9.1e-14	SMART
FN3	614	691	1.21e0	SMART
transmembrane domain	864	886	N/A	INTRINSIC
low complexity region	887	899	N/A	INTRINSIC
PTPc	952	1210	6.38e-134	SMART
PTPc	1239	1501	9.17e-135	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000174023
AA Change: V71I

PolyPhen 2 Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000133562
Gene: ENSMUSG00000028399
AA Change: V71I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	211	4.88e-16	SMART
low complexity region	222	234	N/A	INTRINSIC
IGc2	245	306	8.13e-4	SMART
FN3	320	399	7.92e-14	SMART
FN3	415	498	5.73e-11	SMART
IG_like	506	600	8.34e1	SMART
FN3	513	591	9.1e-14	SMART
FN3	604	681	1.21e0	SMART
transmembrane domain	853	875	N/A	INTRINSIC
low complexity region	882	893	N/A	INTRINSIC
PTPc	946	1204	6.38e-134	SMART
PTPc	1233	1495	9.17e-135	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000174180
AA Change: V71I

PolyPhen 2 Score 0.492 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000133973
Gene: ENSMUSG00000028399
AA Change: V71I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	205	2.09e-15	SMART
IGc2	235	296	8.13e-4	SMART
FN3	310	389	7.92e-14	SMART
FN3	405	488	5.73e-11	SMART
IG_like	496	590	8.34e1	SMART
FN3	503	581	9.1e-14	SMART
FN3	596	683	2.72e-12	SMART
FN3	699	787	6.15e-11	SMART
FN3	802	882	4.96e-6	SMART
FN3	897	981	4.12e-12	SMART
FN3	996	1073	1.95e0	SMART
transmembrane domain	1246	1268	N/A	INTRINSIC
low complexity region	1269	1281	N/A	INTRINSIC
PTPc	1334	1592	6.38e-134	SMART
PTPc	1621	1883	9.17e-135	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000174531
AA Change: V71I

PolyPhen 2 Score 0.376 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000134229
Gene: ENSMUSG00000028399
AA Change: V71I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	208	1.38e-15	SMART
low complexity region	219	231	N/A	INTRINSIC
IGc2	242	303	8.13e-4	SMART
FN3	317	396	7.92e-14	SMART
FN3	412	495	5.73e-11	SMART
IG_like	503	597	8.34e1	SMART
FN3	510	588	9.1e-14	SMART
FN3	601	678	1.21e0	SMART
transmembrane domain	851	873	N/A	INTRINSIC
low complexity region	874	886	N/A	INTRINSIC
PTPc	939	1197	6.38e-134	SMART
PTPc	1226	1488	9.17e-135	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000174831
AA Change: V71I

SMART Domains

Protein: ENSMUSP00000133328
Gene: ENSMUSG00000028399
AA Change: V71I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	214	8.5e-16	SMART
low complexity region	225	237	N/A	INTRINSIC
IGc2	248	309	8.13e-4	SMART
FN3	323	402	7.92e-14	SMART
FN3	418	501	5.73e-11	SMART
IG_like	509	603	8.34e1	SMART
FN3	516	594	9.1e-14	SMART
FN3	607	684	1.21e0	SMART
transmembrane domain	856	878	N/A	INTRINSIC
low complexity region	885	896	N/A	INTRINSIC
PTPc	949	1207	6.38e-134	SMART
PTPc	1236	1498	9.17e-135	SMART

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.2%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygotes for a targeted null mutation exhibit impaired learning of spatial tasks, enhanced long-term potentiation at hippocampal synapses, and high mortality associated with reduced food intake. [provided by MGI curators]

Allele List at MGI

All alleles(9) : Targeted(4) Gene trapped(5)

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930522L14Rik	A	T	5: 109,884,537 (GRCm39)	Y440*	probably null	Het
Aldh3b3	A	T	19: 4,014,832 (GRCm39)	T110S	probably benign	Het
Atp2b2	T	C	6: 113,737,672 (GRCm39)	T901A	probably damaging	Het
Auts2	C	T	5: 132,287,773 (GRCm39)	G70E	probably benign	Het
Bfar	A	T	16: 13,505,307 (GRCm39)	I106F	probably benign	Het
Btbd10	T	G	7: 112,921,959 (GRCm39)	I301L	possibly damaging	Het
Card14	G	A	11: 119,217,567 (GRCm39)	R400H	probably benign	Het
Ccdc80	A	G	16: 44,915,849 (GRCm39)	R202G	probably damaging	Het
Cimip2a	T	C	2: 25,110,300 (GRCm39)	S71P	probably benign	Het
Cmtm7	A	C	9: 114,592,351 (GRCm39)	I82S	probably benign	Het
Cngb3	T	A	4: 19,425,613 (GRCm39)	W474R	probably damaging	Het
Coq9	T	C	8: 95,580,234 (GRCm39)	V285A	probably benign	Het
Cp	A	G	3: 20,028,052 (GRCm39)	E486G	probably damaging	Het
Crybg3	C	T	16: 59,350,564 (GRCm39)	C892Y	probably damaging	Het
Cttn	A	T	7: 144,008,453 (GRCm39)	F176L	probably damaging	Het
Cytip	T	A	2: 58,050,024 (GRCm39)	N15I	possibly damaging	Het
Dgkb	A	G	12: 38,477,492 (GRCm39)	E634G	possibly damaging	Het
Duox1	A	G	2: 122,164,258 (GRCm39)	E906G	probably benign	Het
Efcab6	A	T	15: 83,817,369 (GRCm39)	S735T	probably benign	Het
Elfn1	T	C	5: 139,957,808 (GRCm39)	S271P	probably benign	Het
Ep300	T	C	15: 81,533,210 (GRCm39)	S1756P	unknown	Het
Ep300	T	A	15: 81,495,611 (GRCm39)		probably benign	Het
Ercc5	T	A	1: 44,187,308 (GRCm39)	V29E	probably benign	Het
Frmd4a	C	A	2: 4,608,490 (GRCm39)	A786E	possibly damaging	Het
Ftcd	A	C	10: 76,425,092 (GRCm39)	E524D	probably benign	Het
Gfod2	T	C	8: 106,454,878 (GRCm39)	M1V	probably null	Het
Gm12790	T	C	4: 101,825,324 (GRCm39)	D30G	probably benign	Het
Gsta4	A	T	9: 78,113,302 (GRCm39)	R127S	probably benign	Het
Hcn2	G	A	10: 79,560,282 (GRCm39)		probably null	Het
Hectd1	A	G	12: 51,798,715 (GRCm39)	V2135A	probably damaging	Het
Hoxc6	A	G	15: 102,918,093 (GRCm39)	D19G	probably benign	Het
Hydin	A	T	8: 110,993,971 (GRCm39)	T2S	unknown	Het
Ifna14	A	T	4: 88,489,747 (GRCm39)	S97T	possibly damaging	Het
Igkv17-127	T	C	6: 67,838,183 (GRCm39)	L14P	unknown	Het
Il17rb	A	G	14: 29,724,356 (GRCm39)	V166A	probably damaging	Het
Iqca1	T	A	1: 90,001,472 (GRCm39)	I520F	probably damaging	Het
Kcnv2	G	T	19: 27,300,994 (GRCm39)	V282L	probably benign	Het
Klk12	A	G	7: 43,422,667 (GRCm39)	D198G	probably damaging	Het
Kntc1	T	G	5: 123,904,018 (GRCm39)	L345R	probably damaging	Het
Lrfn5	A	G	12: 61,890,763 (GRCm39)	D684G	probably benign	Het
Mef2a	T	C	7: 66,890,187 (GRCm39)	N131S	probably benign	Het
Mis18bp1	T	C	12: 65,200,655 (GRCm39)	Y124C	probably damaging	Het
Mplkipl1	C	T	19: 61,164,364 (GRCm39)	G24R	unknown	Het
Myh2	T	A	11: 67,064,084 (GRCm39)	V48D	possibly damaging	Het
Nat10	A	G	2: 103,584,417 (GRCm39)	M120T	probably damaging	Het
Nf1	T	C	11: 79,336,585 (GRCm39)	S1065P	probably damaging	Het
Nfib	A	T	4: 82,215,048 (GRCm39)	S518R	probably damaging	Het
Pced1a	A	C	2: 130,264,596 (GRCm39)	L78R	probably damaging	Het
Peli3	T	C	19: 4,984,486 (GRCm39)	D192G	probably benign	Het
Plb1	C	T	5: 32,404,901 (GRCm39)	Q20*	probably null	Het
Pomgnt2	G	A	9: 121,812,131 (GRCm39)	R217C	probably damaging	Het
Rngtt	A	G	4: 33,339,050 (GRCm39)	E285G	probably benign	Het
Sclt1	G	A	3: 41,625,900 (GRCm39)	Q356*	probably null	Het
Scn2b	T	C	9: 45,037,460 (GRCm39)	F169S	possibly damaging	Het
Sfta2	C	T	17: 35,960,775 (GRCm39)		probably benign	Het
Srpra	T	C	9: 35,125,904 (GRCm39)	I394T	possibly damaging	Het
Sspo	A	C	6: 48,440,307 (GRCm39)	D1541A	possibly damaging	Het
Strc	G	A	2: 121,208,484 (GRCm39)	L296F	possibly damaging	Het
Svop	C	T	5: 114,203,743 (GRCm39)	V13M	probably damaging	Het
Taf6l	C	A	19: 8,761,335 (GRCm39)	R10L	possibly damaging	Het
Tbx3	G	T	5: 119,820,841 (GRCm39)	R617L	probably damaging	Het
Tnrc6a	A	G	7: 122,783,444 (GRCm39)	R1471G	possibly damaging	Het
Togaram1	T	C	12: 65,067,100 (GRCm39)	L1714P	probably damaging	Het
Traf3ip2	A	G	10: 39,510,650 (GRCm39)	N308D	probably damaging	Het
Trim30b	T	C	7: 104,006,538 (GRCm39)	Y106C	possibly damaging	Het
Vcp	A	T	4: 42,984,565 (GRCm39)	M442K	probably benign	Het
Vmn2r16	A	T	5: 109,511,665 (GRCm39)	Y624F	possibly damaging	Het
Vmn2r52	A	T	7: 9,904,617 (GRCm39)	H407Q	probably damaging	Het
Vps13a	A	T	19: 16,659,474 (GRCm39)	D1684E	probably damaging	Het
Wdr49	T	C	3: 75,242,550 (GRCm39)	M380V	probably benign	Het

Other mutations in Ptprd

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00964:Ptprd	APN	4	75,916,793 (GRCm39)	nonsense	probably null
IGL01067:Ptprd	APN	4	75,977,922 (GRCm39)	missense	probably damaging	1.00
IGL01121:Ptprd	APN	4	75,872,438 (GRCm39)	splice site	probably benign
IGL01531:Ptprd	APN	4	76,003,757 (GRCm39)	missense	probably damaging	0.98
IGL01661:Ptprd	APN	4	75,872,320 (GRCm39)	missense	probably damaging	1.00
IGL01723:Ptprd	APN	4	76,161,910 (GRCm39)	missense	probably damaging	1.00
IGL01735:Ptprd	APN	4	76,055,057 (GRCm39)	splice site	probably null
IGL01810:Ptprd	APN	4	76,058,744 (GRCm39)	splice site	probably benign
IGL01834:Ptprd	APN	4	76,046,832 (GRCm39)	missense	probably damaging	1.00
IGL01835:Ptprd	APN	4	76,165,058 (GRCm39)	missense	probably benign	0.02
IGL01867:Ptprd	APN	4	76,161,884 (GRCm39)	missense	probably damaging	1.00
IGL02582:Ptprd	APN	4	75,865,361 (GRCm39)	missense	probably damaging	1.00
IGL02591:Ptprd	APN	4	75,900,287 (GRCm39)	missense	probably damaging	1.00
IGL02741:Ptprd	APN	4	76,051,521 (GRCm39)	missense	probably damaging	1.00
IGL02866:Ptprd	APN	4	75,968,674 (GRCm39)	missense	probably damaging	1.00
IGL02960:Ptprd	APN	4	76,047,105 (GRCm39)	missense	probably damaging	1.00
IGL03155:Ptprd	APN	4	75,984,456 (GRCm39)	missense	possibly damaging	0.95
IGL03230:Ptprd	APN	4	75,968,654 (GRCm39)	nonsense	probably null
IGL03343:Ptprd	APN	4	75,977,966 (GRCm39)	missense	probably damaging	1.00
unhurried	UTSW	4	76,018,870 (GRCm39)	nonsense	probably null
ANU22:Ptprd	UTSW	4	76,018,693 (GRCm39)	missense	probably damaging	0.99
F5493:Ptprd	UTSW	4	76,002,645 (GRCm39)	missense	probably damaging	1.00
P0033:Ptprd	UTSW	4	76,047,091 (GRCm39)	nonsense	probably null
R0044:Ptprd	UTSW	4	76,004,566 (GRCm39)	missense	probably benign	0.08
R0044:Ptprd	UTSW	4	76,004,566 (GRCm39)	missense	probably benign	0.08
R0076:Ptprd	UTSW	4	75,865,276 (GRCm39)	splice site	probably benign
R0137:Ptprd	UTSW	4	76,055,140 (GRCm39)	missense	probably benign	0.24
R0358:Ptprd	UTSW	4	75,863,226 (GRCm39)	missense	probably damaging	1.00
R0365:Ptprd	UTSW	4	76,055,083 (GRCm39)	missense	probably damaging	1.00
R0385:Ptprd	UTSW	4	76,046,902 (GRCm39)	missense	probably damaging	1.00
R0601:Ptprd	UTSW	4	76,018,711 (GRCm39)	missense	probably benign
R0646:Ptprd	UTSW	4	76,002,640 (GRCm39)	missense	probably damaging	0.99
R0667:Ptprd	UTSW	4	75,875,583 (GRCm39)	missense	probably damaging	1.00
R0707:Ptprd	UTSW	4	75,875,476 (GRCm39)	missense	probably damaging	1.00
R0734:Ptprd	UTSW	4	76,058,834 (GRCm39)	missense	probably damaging	1.00
R0827:Ptprd	UTSW	4	76,047,152 (GRCm39)	missense	probably damaging	0.98
R0932:Ptprd	UTSW	4	76,055,122 (GRCm39)	missense	probably damaging	1.00
R1069:Ptprd	UTSW	4	76,018,870 (GRCm39)	nonsense	probably null
R1069:Ptprd	UTSW	4	75,916,724 (GRCm39)	splice site	probably benign
R1086:Ptprd	UTSW	4	76,051,495 (GRCm39)	missense	probably damaging	1.00
R1439:Ptprd	UTSW	4	75,984,437 (GRCm39)	missense	probably damaging	1.00
R1440:Ptprd	UTSW	4	76,002,789 (GRCm39)	missense	probably damaging	0.98
R1688:Ptprd	UTSW	4	75,900,921 (GRCm39)	missense	probably damaging	1.00
R1858:Ptprd	UTSW	4	75,865,384 (GRCm39)	missense	probably damaging	1.00
R2001:Ptprd	UTSW	4	75,872,359 (GRCm39)	missense	probably damaging	1.00
R2020:Ptprd	UTSW	4	76,051,398 (GRCm39)	missense	probably damaging	1.00
R2023:Ptprd	UTSW	4	75,875,341 (GRCm39)	missense	probably damaging	1.00
R2413:Ptprd	UTSW	4	76,051,437 (GRCm39)	missense	probably damaging	1.00
R2510:Ptprd	UTSW	4	76,004,248 (GRCm39)	critical splice donor site	probably null
R2914:Ptprd	UTSW	4	75,865,338 (GRCm39)	missense	probably damaging	1.00
R2971:Ptprd	UTSW	4	76,025,561 (GRCm39)	missense	probably benign	0.10
R3051:Ptprd	UTSW	4	76,018,867 (GRCm39)	missense	probably damaging	1.00
R3433:Ptprd	UTSW	4	76,004,248 (GRCm39)	critical splice donor site	probably null
R3964:Ptprd	UTSW	4	75,978,073 (GRCm39)	splice site	probably benign
R4009:Ptprd	UTSW	4	75,874,634 (GRCm39)	missense	possibly damaging	0.94
R4394:Ptprd	UTSW	4	76,046,922 (GRCm39)	missense	probably damaging	1.00
R4420:Ptprd	UTSW	4	75,957,614 (GRCm39)	missense	possibly damaging	0.92
R4424:Ptprd	UTSW	4	76,021,200 (GRCm39)	missense	probably benign	0.22
R4575:Ptprd	UTSW	4	76,162,023 (GRCm39)	missense	possibly damaging	0.55
R4715:Ptprd	UTSW	4	76,025,570 (GRCm39)	missense	probably benign	0.03
R4782:Ptprd	UTSW	4	76,009,769 (GRCm39)	missense	probably benign	0.01
R4785:Ptprd	UTSW	4	76,058,790 (GRCm39)	missense	probably benign	0.05
R4799:Ptprd	UTSW	4	76,009,769 (GRCm39)	missense	probably benign	0.01
R4944:Ptprd	UTSW	4	76,047,136 (GRCm39)	missense	probably damaging	1.00
R4950:Ptprd	UTSW	4	76,058,752 (GRCm39)	splice site	probably null
R4969:Ptprd	UTSW	4	76,051,542 (GRCm39)	missense	probably damaging	1.00
R5153:Ptprd	UTSW	4	75,930,339 (GRCm39)	missense	probably damaging	1.00
R5164:Ptprd	UTSW	4	76,018,995 (GRCm39)	splice site	probably null
R5287:Ptprd	UTSW	4	75,872,405 (GRCm39)	nonsense	probably null
R5305:Ptprd	UTSW	4	75,900,863 (GRCm39)	missense	probably damaging	1.00
R5362:Ptprd	UTSW	4	76,047,050 (GRCm39)	missense	probably damaging	1.00
R5403:Ptprd	UTSW	4	75,872,405 (GRCm39)	nonsense	probably null
R5531:Ptprd	UTSW	4	75,977,904 (GRCm39)	critical splice donor site	probably null
R5543:Ptprd	UTSW	4	75,977,990 (GRCm39)	missense	probably damaging	1.00
R5634:Ptprd	UTSW	4	75,990,255 (GRCm39)	missense	probably benign	0.01
R5719:Ptprd	UTSW	4	75,972,839 (GRCm39)	critical splice acceptor site	probably null
R5884:Ptprd	UTSW	4	75,900,927 (GRCm39)	missense	probably damaging	1.00
R6247:Ptprd	UTSW	4	75,984,528 (GRCm39)	missense	probably benign	0.06
R6250:Ptprd	UTSW	4	76,047,232 (GRCm39)	missense	probably damaging	1.00
R6335:Ptprd	UTSW	4	75,872,420 (GRCm39)	missense	probably damaging	1.00
R6352:Ptprd	UTSW	4	76,009,789 (GRCm39)	splice site	probably null
R6533:Ptprd	UTSW	4	76,046,765 (GRCm39)	missense	probably damaging	1.00
R6756:Ptprd	UTSW	4	75,873,536 (GRCm39)	missense	probably damaging	1.00
R6782:Ptprd	UTSW	4	76,243,377 (GRCm39)	splice site	probably null
R7131:Ptprd	UTSW	4	75,984,577 (GRCm39)	missense	probably damaging	1.00
R7170:Ptprd	UTSW	4	75,990,199 (GRCm39)	missense	probably benign	0.06
R7233:Ptprd	UTSW	4	75,978,020 (GRCm39)	missense	probably benign	0.00
R7246:Ptprd	UTSW	4	76,046,913 (GRCm39)	missense	probably damaging	1.00
R7413:Ptprd	UTSW	4	76,165,076 (GRCm39)	missense	probably benign	0.00
R7428:Ptprd	UTSW	4	76,004,705 (GRCm39)	missense	probably benign	0.03
R7442:Ptprd	UTSW	4	75,978,058 (GRCm39)	nonsense	probably null
R7491:Ptprd	UTSW	4	76,051,392 (GRCm39)	missense	probably benign	0.23
R7526:Ptprd	UTSW	4	75,984,564 (GRCm39)	missense	probably benign	0.00
R7609:Ptprd	UTSW	4	75,990,240 (GRCm39)	missense	probably benign	0.03
R7612:Ptprd	UTSW	4	76,004,696 (GRCm39)	missense	probably benign	0.45
R7659:Ptprd	UTSW	4	76,047,153 (GRCm39)	missense	probably benign	0.03
R7743:Ptprd	UTSW	4	76,004,326 (GRCm39)	missense	probably damaging	1.00
R7748:Ptprd	UTSW	4	76,017,741 (GRCm39)	missense	probably null	0.39
R7788:Ptprd	UTSW	4	75,916,841 (GRCm39)	missense	probably damaging	1.00
R7836:Ptprd	UTSW	4	75,900,881 (GRCm39)	missense	probably damaging	0.99
R7937:Ptprd	UTSW	4	76,013,772 (GRCm39)	missense	probably benign	0.00
R8000:Ptprd	UTSW	4	75,984,479 (GRCm39)	missense	possibly damaging	0.95
R8018:Ptprd	UTSW	4	76,003,757 (GRCm39)	missense	probably damaging	0.98
R8072:Ptprd	UTSW	4	76,004,273 (GRCm39)	missense	probably benign	0.01
R8119:Ptprd	UTSW	4	76,047,263 (GRCm39)	missense	probably benign	0.00
R8350:Ptprd	UTSW	4	75,868,898 (GRCm39)	missense	probably damaging	1.00
R8387:Ptprd	UTSW	4	75,873,526 (GRCm39)	missense	probably damaging	1.00
R8458:Ptprd	UTSW	4	75,984,496 (GRCm39)	missense	probably benign	0.00
R8529:Ptprd	UTSW	4	76,047,262 (GRCm39)	missense	probably damaging	1.00
R8699:Ptprd	UTSW	4	75,959,629 (GRCm39)	missense	probably benign
R8924:Ptprd	UTSW	4	75,916,736 (GRCm39)	critical splice donor site	probably null
R8984:Ptprd	UTSW	4	75,863,251 (GRCm39)	missense	probably damaging	1.00
R9024:Ptprd	UTSW	4	75,874,567 (GRCm39)	missense	probably damaging	1.00
R9204:Ptprd	UTSW	4	75,872,315 (GRCm39)	missense	possibly damaging	0.46
R9206:Ptprd	UTSW	4	75,872,315 (GRCm39)	missense	possibly damaging	0.46
R9259:Ptprd	UTSW	4	75,990,200 (GRCm39)	missense	probably damaging	0.99
R9311:Ptprd	UTSW	4	76,051,320 (GRCm39)	missense	probably benign	0.25
R9417:Ptprd	UTSW	4	75,865,335 (GRCm39)	missense	probably damaging	0.99
R9427:Ptprd	UTSW	4	76,051,440 (GRCm39)	missense	probably benign	0.01
R9579:Ptprd	UTSW	4	75,872,315 (GRCm39)	missense	possibly damaging	0.46
R9580:Ptprd	UTSW	4	75,872,315 (GRCm39)	missense	possibly damaging	0.46
R9701:Ptprd	UTSW	4	75,916,896 (GRCm39)	missense	probably damaging	1.00
RF016:Ptprd	UTSW	4	76,046,892 (GRCm39)	missense	probably benign	0.01
RF023:Ptprd	UTSW	4	76,046,802 (GRCm39)	missense	probably damaging	0.98
Z1176:Ptprd	UTSW	4	76,051,451 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TGTGATCATACCACAACCCTGC -3'
(R):5'- ACATTCGATCAAGTGTTCTCCTG -3'

Sequencing Primer
(F):5'- TTGACAGACAGAACTGCAGC -3'
(R):5'- GTCCCACTTTATTAGAATTCAGTGC -3'

Posted On

2017-11-30