Incidental Mutation 'R0131:Nin'
| ID |
500141 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nin
|
| Ensembl Gene |
ENSMUSG00000021068 |
| Gene Name |
ninein |
| Synonyms |
3110068G20Rik |
| MMRRC Submission |
038416-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0131 (G1)
|
| Quality Score |
168 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
70011435-70113717 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 70051141 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Threonine
at position 515
(K515T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152350
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021468]
[ENSMUST00000085314]
[ENSMUST00000095666]
[ENSMUST00000169074]
[ENSMUST00000220689]
[ENSMUST00000222237]
[ENSMUST00000222835]
[ENSMUST00000223257]
|
| AlphaFold |
Q61043 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000021468
AA Change: K515T
PolyPhen 2
Score 0.933 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000021468
Gene: ENSMUSG00000021068
AA Change: K515T
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000085314
AA Change: K515T
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000082422
Gene: ENSMUSG00000021068
AA Change: K515T
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1971 |
2045 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000095666
AA Change: K515T
PolyPhen 2
Score 0.933 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000093327
Gene: ENSMUSG00000021068
AA Change: K515T
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000169074
AA Change: K515T
PolyPhen 2
Score 0.933 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000129648
Gene: ENSMUSG00000021068
AA Change: K515T
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000220689
AA Change: K515T
PolyPhen 2
Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221486
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000222237
AA Change: K515T
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000222835
AA Change: K515T
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000223257
AA Change: K515T
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223316
|
| Meta Mutation Damage Score |
0.4087 |
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.2%
- 10x: 90.2%
- 20x: 71.5%
|
| Validation Efficiency |
87% (52/60) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9530053A07Rik |
A |
G |
7: 28,137,615 (GRCm38) |
R320G |
probably damaging |
Het |
| Abca8b |
T |
A |
11: 109,942,289 (GRCm38) |
Q1195L |
possibly damaging |
Het |
| Abcc12 |
A |
G |
8: 86,531,568 (GRCm38) |
I773T |
probably benign |
Het |
| Adamtsl1 |
T |
A |
4: 86,342,723 (GRCm38) |
I1057N |
possibly damaging |
Het |
| Adgrv1 |
A |
T |
13: 81,502,995 (GRCm38) |
|
probably benign |
Het |
| Anxa5 |
G |
A |
3: 36,450,672 (GRCm38) |
A247V |
probably damaging |
Het |
| Arntl2 |
C |
A |
6: 146,828,103 (GRCm38) |
H471N |
probably benign |
Het |
| Ascc3 |
T |
G |
10: 50,735,329 (GRCm38) |
W1589G |
probably damaging |
Het |
| Atp2b2 |
G |
A |
6: 113,793,782 (GRCm38) |
P389S |
probably damaging |
Het |
| Bicd1 |
A |
G |
6: 149,512,947 (GRCm38) |
E386G |
probably damaging |
Het |
| Bpifa6 |
T |
A |
2: 153,982,931 (GRCm38) |
S9T |
probably benign |
Het |
| Cacna1c |
T |
C |
6: 118,625,512 (GRCm38) |
I1428V |
probably damaging |
Het |
| Chd8 |
A |
G |
14: 52,205,326 (GRCm38) |
V589A |
probably benign |
Het |
| Chrnb2 |
T |
C |
3: 89,764,406 (GRCm38) |
M1V |
probably null |
Het |
| Cldnd1 |
T |
C |
16: 58,732,992 (GRCm38) |
L232P |
probably damaging |
Het |
| Col16a1 |
T |
A |
4: 130,067,096 (GRCm38) |
V449E |
unknown |
Het |
| Col3a1 |
T |
A |
1: 45,328,868 (GRCm38) |
|
probably benign |
Het |
| Cttnbp2nl |
T |
G |
3: 105,005,857 (GRCm38) |
K237T |
probably damaging |
Het |
| Cyc1 |
G |
A |
15: 76,344,959 (GRCm38) |
V142I |
probably benign |
Het |
| Dapk3 |
A |
G |
10: 81,192,307 (GRCm38) |
T265A |
probably benign |
Het |
| Ddx21 |
A |
T |
10: 62,584,752 (GRCm38) |
M711K |
possibly damaging |
Het |
| Dlg5 |
A |
T |
14: 24,138,649 (GRCm38) |
L1735Q |
probably damaging |
Het |
| Dse |
A |
G |
10: 34,153,664 (GRCm38) |
Y341H |
probably damaging |
Het |
| Elmod2 |
A |
G |
8: 83,319,504 (GRCm38) |
I148T |
probably damaging |
Het |
| Fam187b |
T |
A |
7: 30,989,120 (GRCm38) |
V22E |
probably damaging |
Het |
| Faxc |
A |
G |
4: 21,936,659 (GRCm38) |
D98G |
probably damaging |
Het |
| Fcrls |
A |
G |
3: 87,258,959 (GRCm38) |
S170P |
possibly damaging |
Het |
| Fsip2 |
G |
A |
2: 82,991,121 (GRCm38) |
D5733N |
probably benign |
Het |
| Gbe1 |
T |
C |
16: 70,360,852 (GRCm38) |
|
probably benign |
Het |
| Gm1141 |
T |
C |
X: 71,939,555 (GRCm38) |
C378R |
possibly damaging |
Het |
| Gm4788 |
T |
A |
1: 139,754,271 (GRCm38) |
T196S |
probably damaging |
Het |
| Gm6327 |
T |
C |
16: 12,761,045 (GRCm38) |
|
noncoding transcript |
Het |
| Gm9745 |
T |
A |
13: 8,940,527 (GRCm38) |
|
probably benign |
Het |
| H2-T24 |
T |
A |
17: 36,014,986 (GRCm38) |
I238F |
probably damaging |
Het |
| Hectd4 |
A |
G |
5: 121,333,024 (GRCm38) |
E2658G |
probably benign |
Het |
| Herc1 |
A |
C |
9: 66,480,910 (GRCm38) |
I3826L |
probably benign |
Het |
| Hinfp |
A |
G |
9: 44,299,763 (GRCm38) |
C67R |
probably damaging |
Het |
| Hp1bp3 |
C |
T |
4: 138,237,209 (GRCm38) |
S348F |
probably damaging |
Het |
| Hspg2 |
T |
C |
4: 137,551,887 (GRCm38) |
Y3094H |
probably damaging |
Het |
| Htr1f |
A |
G |
16: 64,926,728 (GRCm38) |
V67A |
probably damaging |
Het |
| Iqcc |
T |
G |
4: 129,616,599 (GRCm38) |
E374D |
probably damaging |
Het |
| Kcnj9 |
T |
C |
1: 172,326,198 (GRCm38) |
T120A |
probably damaging |
Het |
| Kitl |
C |
T |
10: 100,087,364 (GRCm38) |
P208S |
probably benign |
Het |
| Kmt2b |
A |
T |
7: 30,583,921 (GRCm38) |
C296S |
probably damaging |
Het |
| Lgals4 |
A |
G |
7: 28,834,232 (GRCm38) |
|
probably null |
Het |
| Lpcat4 |
A |
G |
2: 112,246,748 (GRCm38) |
Y479C |
probably damaging |
Het |
| Lrrc74b |
T |
C |
16: 17,553,152 (GRCm38) |
N227S |
probably damaging |
Het |
| Mdc1 |
T |
A |
17: 35,852,581 (GRCm38) |
V1007D |
probably damaging |
Het |
| Mocos |
T |
G |
18: 24,679,762 (GRCm38) |
I571S |
probably benign |
Het |
| Myh8 |
A |
G |
11: 67,292,188 (GRCm38) |
N659D |
probably damaging |
Het |
| Mylk |
T |
C |
16: 34,875,504 (GRCm38) |
V203A |
probably benign |
Het |
| Myom2 |
A |
G |
8: 15,083,329 (GRCm38) |
N407S |
probably damaging |
Het |
| Naip2 |
A |
G |
13: 100,183,788 (GRCm38) |
V240A |
probably benign |
Het |
| Nap1l1 |
T |
C |
10: 111,485,509 (GRCm38) |
S37P |
probably benign |
Het |
| Npl |
T |
A |
1: 153,509,118 (GRCm38) |
K258* |
probably null |
Het |
| Ntn4 |
T |
A |
10: 93,644,707 (GRCm38) |
S98T |
possibly damaging |
Het |
| Olfr1037 |
T |
C |
2: 86,085,500 (GRCm38) |
I92M |
probably damaging |
Het |
| Olfr177 |
C |
A |
16: 58,872,906 (GRCm38) |
M81I |
probably benign |
Het |
| Olfr372 |
C |
T |
8: 72,058,400 (GRCm38) |
T240M |
probably damaging |
Het |
| Olfr417 |
T |
C |
1: 174,369,586 (GRCm38) |
V223A |
probably damaging |
Het |
| Olfr720 |
T |
C |
14: 14,175,620 (GRCm38) |
D154G |
probably benign |
Het |
| Pate3 |
A |
G |
9: 35,646,157 (GRCm38) |
C68R |
probably damaging |
Het |
| Pcdh15 |
A |
G |
10: 74,170,608 (GRCm38) |
D106G |
probably null |
Het |
| Ppox |
C |
A |
1: 171,279,275 (GRCm38) |
A192S |
possibly damaging |
Het |
| Prkdc |
T |
C |
16: 15,713,653 (GRCm38) |
L1380S |
probably benign |
Het |
| Proc |
C |
T |
18: 32,135,898 (GRCm38) |
M11I |
probably benign |
Het |
| Psd4 |
C |
A |
2: 24,405,351 (GRCm38) |
A839E |
probably damaging |
Het |
| Psg21 |
A |
G |
7: 18,654,868 (GRCm38) |
Y100H |
probably benign |
Het |
| Pten |
T |
A |
19: 32,776,069 (GRCm38) |
V45E |
probably benign |
Het |
| Ptprn2 |
T |
G |
12: 116,722,091 (GRCm38) |
F57V |
probably damaging |
Het |
| Ptprt |
C |
T |
2: 162,278,110 (GRCm38) |
V146I |
probably benign |
Het |
| R3hdm2 |
T |
A |
10: 127,498,453 (GRCm38) |
M915K |
probably damaging |
Het |
| Rab26 |
C |
T |
17: 24,530,785 (GRCm38) |
|
probably null |
Het |
| Rab7b |
T |
C |
1: 131,698,555 (GRCm38) |
L107P |
probably damaging |
Het |
| Rbm47 |
T |
A |
5: 66,026,529 (GRCm38) |
T244S |
possibly damaging |
Het |
| Rhbdf2 |
C |
A |
11: 116,605,344 (GRCm38) |
G122C |
probably damaging |
Het |
| Rnf213 |
A |
G |
11: 119,430,361 (GRCm38) |
E1215G |
probably benign |
Het |
| Rprd2 |
T |
C |
3: 95,774,361 (GRCm38) |
K407E |
probably damaging |
Het |
| Siah3 |
G |
A |
14: 75,456,134 (GRCm38) |
V27I |
possibly damaging |
Het |
| Slc12a3 |
G |
A |
8: 94,340,883 (GRCm38) |
|
probably benign |
Het |
| Slc14a2 |
T |
A |
18: 78,192,123 (GRCm38) |
N280Y |
probably damaging |
Het |
| Slc17a3 |
C |
T |
13: 23,855,858 (GRCm38) |
S293F |
probably damaging |
Het |
| Slc25a35 |
A |
G |
11: 68,971,960 (GRCm38) |
Y247C |
probably damaging |
Het |
| Slc29a4 |
A |
G |
5: 142,705,530 (GRCm38) |
D55G |
probably benign |
Het |
| Slc35d1 |
C |
T |
4: 103,208,181 (GRCm38) |
V189I |
probably benign |
Het |
| Spg11 |
T |
C |
2: 122,070,968 (GRCm38) |
E1497G |
probably damaging |
Het |
| Srrm1 |
G |
A |
4: 135,340,573 (GRCm38) |
R322* |
probably null |
Het |
| Stac3 |
A |
T |
10: 127,503,650 (GRCm38) |
R138S |
probably damaging |
Het |
| Tet3 |
C |
G |
6: 83,368,788 (GRCm38) |
G1556R |
probably damaging |
Het |
| Tgfbr3 |
A |
G |
5: 107,132,816 (GRCm38) |
S693P |
probably benign |
Het |
| Tmcc2 |
C |
T |
1: 132,380,706 (GRCm38) |
G150D |
probably benign |
Het |
| Tmem216 |
T |
C |
19: 10,554,606 (GRCm38) |
Y44C |
probably damaging |
Het |
| Tmem260 |
T |
A |
14: 48,483,322 (GRCm38) |
C306* |
probably null |
Het |
| Tspyl1 |
A |
G |
10: 34,283,089 (GRCm38) |
N270S |
probably damaging |
Het |
| Ubr4 |
A |
G |
4: 139,464,051 (GRCm38) |
T4127A |
possibly damaging |
Het |
| Ugt2a2 |
T |
A |
5: 87,474,861 (GRCm38) |
K293* |
probably null |
Het |
| Vmn2r102 |
A |
C |
17: 19,678,763 (GRCm38) |
T456P |
probably benign |
Het |
| Vmn2r90 |
T |
A |
17: 17,712,249 (GRCm38) |
S139R |
probably benign |
Het |
| Wrnip1 |
G |
A |
13: 32,806,864 (GRCm38) |
V369I |
probably damaging |
Het |
| Zc3h12c |
T |
A |
9: 52,126,623 (GRCm38) |
I305F |
possibly damaging |
Het |
| Zmym2 |
A |
G |
14: 56,943,258 (GRCm38) |
N876D |
probably benign |
Het |
|
| Other mutations in Nin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00472:Nin
|
APN |
12 |
70,030,088 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL00677:Nin
|
APN |
12 |
70,026,860 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00823:Nin
|
APN |
12 |
70,014,793 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01103:Nin
|
APN |
12 |
70,056,758 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01113:Nin
|
APN |
12 |
70,031,779 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01420:Nin
|
APN |
12 |
70,045,414 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01556:Nin
|
APN |
12 |
70,043,188 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01663:Nin
|
APN |
12 |
70,043,665 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
IGL02002:Nin
|
APN |
12 |
70,062,699 (GRCm38) |
nonsense |
probably null |
|
|
IGL02030:Nin
|
APN |
12 |
70,045,268 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02202:Nin
|
APN |
12 |
70,055,436 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02207:Nin
|
APN |
12 |
70,056,657 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02257:Nin
|
APN |
12 |
70,102,691 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
IGL02394:Nin
|
APN |
12 |
70,044,031 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02531:Nin
|
APN |
12 |
70,020,932 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL03028:Nin
|
APN |
12 |
70,035,270 (GRCm38) |
missense |
probably benign |
0.13 |
|
IGL03155:Nin
|
APN |
12 |
70,031,770 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03197:Nin
|
APN |
12 |
70,026,810 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02835:Nin
|
UTSW |
12 |
70,056,738 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,051,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0132:Nin
|
UTSW |
12 |
70,051,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,014,875 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,014,875 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0734:Nin
|
UTSW |
12 |
70,030,113 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0947:Nin
|
UTSW |
12 |
70,061,186 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1085:Nin
|
UTSW |
12 |
70,020,962 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R1367:Nin
|
UTSW |
12 |
70,043,929 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1452:Nin
|
UTSW |
12 |
70,017,650 (GRCm38) |
nonsense |
probably null |
|
|
R1477:Nin
|
UTSW |
12 |
70,044,184 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1518:Nin
|
UTSW |
12 |
70,014,773 (GRCm38) |
missense |
probably benign |
0.27 |
|
R1566:Nin
|
UTSW |
12 |
70,054,479 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1572:Nin
|
UTSW |
12 |
70,038,750 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1583:Nin
|
UTSW |
12 |
70,031,738 (GRCm38) |
missense |
probably benign |
|
|
R1584:Nin
|
UTSW |
12 |
70,042,669 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1699:Nin
|
UTSW |
12 |
70,045,563 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1699:Nin
|
UTSW |
12 |
70,030,938 (GRCm38) |
missense |
probably benign |
0.40 |
|
R1765:Nin
|
UTSW |
12 |
70,042,891 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1794:Nin
|
UTSW |
12 |
70,043,795 (GRCm38) |
nonsense |
probably null |
|
|
R1952:Nin
|
UTSW |
12 |
70,030,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2004:Nin
|
UTSW |
12 |
70,025,477 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2025:Nin
|
UTSW |
12 |
70,030,008 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2060:Nin
|
UTSW |
12 |
70,042,418 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R2213:Nin
|
UTSW |
12 |
70,045,354 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2224:Nin
|
UTSW |
12 |
70,061,230 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2247:Nin
|
UTSW |
12 |
70,054,545 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2972:Nin
|
UTSW |
12 |
70,062,713 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3776:Nin
|
UTSW |
12 |
70,038,682 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R3881:Nin
|
UTSW |
12 |
70,042,541 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3930:Nin
|
UTSW |
12 |
70,078,242 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3959:Nin
|
UTSW |
12 |
70,050,752 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4229:Nin
|
UTSW |
12 |
70,051,210 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4359:Nin
|
UTSW |
12 |
70,014,938 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4423:Nin
|
UTSW |
12 |
70,042,978 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4461:Nin
|
UTSW |
12 |
70,042,585 (GRCm38) |
missense |
probably benign |
0.37 |
|
R4639:Nin
|
UTSW |
12 |
70,038,601 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4791:Nin
|
UTSW |
12 |
70,043,807 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4839:Nin
|
UTSW |
12 |
70,090,551 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R4912:Nin
|
UTSW |
12 |
70,044,063 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5712:Nin
|
UTSW |
12 |
70,042,769 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5726:Nin
|
UTSW |
12 |
70,078,179 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5804:Nin
|
UTSW |
12 |
70,045,601 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R5874:Nin
|
UTSW |
12 |
70,030,918 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5992:Nin
|
UTSW |
12 |
70,045,524 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R6077:Nin
|
UTSW |
12 |
70,019,232 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6184:Nin
|
UTSW |
12 |
70,043,737 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6307:Nin
|
UTSW |
12 |
70,014,857 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R6315:Nin
|
UTSW |
12 |
70,045,615 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6326:Nin
|
UTSW |
12 |
70,045,181 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R6492:Nin
|
UTSW |
12 |
70,054,534 (GRCm38) |
missense |
probably benign |
0.22 |
|
R6562:Nin
|
UTSW |
12 |
70,055,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6578:Nin
|
UTSW |
12 |
70,061,194 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6613:Nin
|
UTSW |
12 |
70,030,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7112:Nin
|
UTSW |
12 |
70,102,799 (GRCm38) |
missense |
|
|
|
R7170:Nin
|
UTSW |
12 |
70,044,239 (GRCm38) |
missense |
|
|
|
R7324:Nin
|
UTSW |
12 |
70,043,734 (GRCm38) |
missense |
|
|
|
R7338:Nin
|
UTSW |
12 |
70,044,064 (GRCm38) |
missense |
|
|
|
R7372:Nin
|
UTSW |
12 |
70,056,029 (GRCm38) |
missense |
|
|
|
R7431:Nin
|
UTSW |
12 |
70,078,223 (GRCm38) |
missense |
|
|
|
R7577:Nin
|
UTSW |
12 |
70,062,706 (GRCm38) |
missense |
|
|
|
R7655:Nin
|
UTSW |
12 |
70,042,768 (GRCm38) |
missense |
|
|
|
R7656:Nin
|
UTSW |
12 |
70,042,768 (GRCm38) |
missense |
|
|
|
R7683:Nin
|
UTSW |
12 |
70,078,182 (GRCm38) |
missense |
|
|
|
R7769:Nin
|
UTSW |
12 |
70,043,230 (GRCm38) |
missense |
|
|
|
R7981:Nin
|
UTSW |
12 |
70,042,817 (GRCm38) |
missense |
|
|
|
R8138:Nin
|
UTSW |
12 |
70,042,898 (GRCm38) |
missense |
|
|
|
R8141:Nin
|
UTSW |
12 |
70,030,021 (GRCm38) |
missense |
|
|
|
R8754:Nin
|
UTSW |
12 |
70,031,013 (GRCm38) |
intron |
probably benign |
|
|
R8790:Nin
|
UTSW |
12 |
70,021,019 (GRCm38) |
missense |
|
|
|
R8899:Nin
|
UTSW |
12 |
70,030,936 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8974:Nin
|
UTSW |
12 |
70,078,158 (GRCm38) |
missense |
|
|
|
R9085:Nin
|
UTSW |
12 |
70,030,012 (GRCm38) |
nonsense |
probably null |
|
|
R9143:Nin
|
UTSW |
12 |
70,090,575 (GRCm38) |
missense |
|
|
|
R9380:Nin
|
UTSW |
12 |
70,028,031 (GRCm38) |
missense |
|
|
|
R9496:Nin
|
UTSW |
12 |
70,055,988 (GRCm38) |
missense |
|
|
|
R9638:Nin
|
UTSW |
12 |
70,020,844 (GRCm38) |
missense |
|
|
|
R9709:Nin
|
UTSW |
12 |
70,102,694 (GRCm38) |
missense |
|
|
|
R9745:Nin
|
UTSW |
12 |
70,043,125 (GRCm38) |
missense |
|
|
|
R9792:Nin
|
UTSW |
12 |
70,047,235 (GRCm38) |
missense |
|
|
|
Z1176:Nin
|
UTSW |
12 |
70,049,164 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
Z1177:Nin
|
UTSW |
12 |
70,054,426 (GRCm38) |
missense |
|
|
|
Z1177:Nin
|
UTSW |
12 |
70,044,095 (GRCm38) |
missense |
|
|
|
| Predicted Primers |
|
| Posted On |
2017-12-01 |
Incidental Mutation