Mutagenetix > Incidental Mutations

Incidental Mutation 'R0543:Olfr1141'

50030

Institutional Source

Beutler Lab

Gene Symbol

Olfr1141

Ensembl Gene

ENSMUSG00000075148

Gene Name

olfactory receptor 1141

Synonyms

MOR177-10, GA_x6K02T2Q125-49257818-49256883

MMRRC Submission

038735-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.103) question?

Stock #

R0543 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

87753056-87753991 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 87753650 bp

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 114 (L114F)

Ref Sequence

ENSEMBL: ENSMUSP00000097433 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099846]

Predicted Effect

probably damaging
Transcript: ENSMUST00000099846
AA Change: L114F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000097433
Gene: ENSMUSG00000075148
AA Change: L114F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	2.8e-28	PFAM
Pfam:7tm_1	41	290	1.5e-6	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.5%
20x: 93.3%

Validation Efficiency

99% (69/70)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1500015O10Rik	C	A	1: 43,742,289	N110K	possibly damaging	Het
4930444G20Rik	T	C	10: 22,066,924	S386G	possibly damaging	Het
4932438A13Rik	G	A	3: 36,996,458	S2981N	probably benign	Het
Alox5	T	A	6: 116,454,317		probably null	Het
Apol9b	A	G	15: 77,735,640	N212S	probably damaging	Het
Ash1l	T	A	3: 89,063,778		probably null	Het
Ccdc180	A	T	4: 45,900,041	K200*	probably null	Het
Ccser2	A	T	14: 36,940,192	M345K	probably benign	Het
Cdcp2	A	T	4: 107,097,676		probably null	Het
Clca3a1	T	C	3: 144,748,394		probably benign	Het
Cntn3	G	A	6: 102,269,090		probably benign	Het
Col28a1	T	A	6: 8,075,326		probably benign	Het
Dock2	A	G	11: 34,294,325	F1035S	probably damaging	Het
Dsg1a	A	T	18: 20,340,863	S998C	probably damaging	Het
Enox1	T	C	14: 77,506,959		probably benign	Het
Fgfr3	A	G	5: 33,729,710	M1V	probably null	Het
Fuca2	T	A	10: 13,503,126	Y5N	probably damaging	Het
Git2	G	T	5: 114,745,531	H42Q	probably damaging	Het
Gm7964	G	A	7: 83,756,394		noncoding transcript	Het
Hars2	G	A	18: 36,789,424	E337K	probably damaging	Het
Hells	A	G	19: 38,967,750	R797G	probably benign	Het
Hnf1a	G	A	5: 114,950,744	S571L	probably benign	Het
Hoxa5	T	C	6: 52,204,340	Y4C	probably damaging	Het
Inpp4a	G	A	1: 37,369,492		probably benign	Het
Ints6	T	C	14: 62,696,611	I816V	probably damaging	Het
Itpr1	T	C	6: 108,515,748		probably benign	Het
Kcnt2	C	A	1: 140,609,614	P1037T	probably damaging	Het
Lyg2	T	A	1: 37,911,107	M47L	possibly damaging	Het
Macf1	G	T	4: 123,376,378	A4648D	probably damaging	Het
Mcf2l	T	C	8: 12,996,728		probably null	Het
Mcm9	C	T	10: 53,541,598	R3H	probably damaging	Het
Met	T	A	6: 17,491,970	Y244N	probably damaging	Het
Mettl14	A	T	3: 123,374,762	C210S	possibly damaging	Het
Mrgpra4	T	C	7: 47,981,310	Y181C	probably benign	Het
Mtch2	T	C	2: 90,849,682	V86A	possibly damaging	Het
Mttp	A	T	3: 138,111,696	I446N	possibly damaging	Het
Muc4	T	A	16: 32,756,746	S2207T	unknown	Het
Muc5b	A	G	7: 141,851,785	T944A	unknown	Het
Myo15	A	T	11: 60,479,051	H879L	probably benign	Het
Nkiras2	G	A	11: 100,624,192		probably benign	Het
Nostrin	T	G	2: 69,189,131	*507E	probably null	Het
Nup205	T	C	6: 35,198,969	V589A	probably benign	Het
Olfr1444	G	T	19: 12,861,888	V38F	probably benign	Het
Olfr530	A	G	7: 140,373,394	I72T	probably benign	Het
Oxct2b	T	A	4: 123,116,989	M234K	possibly damaging	Het
Park2	G	A	17: 11,067,179	D20N	probably damaging	Het
Pcdha1	A	T	18: 37,185,068	I945F	probably damaging	Het
Pdzd3	A	C	9: 44,248,934	H324Q	probably damaging	Het
Pik3ca	G	A	3: 32,450,261		probably null	Het
Pkhd1l1	A	G	15: 44,523,491		probably null	Het
Plscr1	A	T	9: 92,258,046		probably null	Het
Psd	T	C	19: 46,319,517	E684G	possibly damaging	Het
Rab11fip3	T	C	17: 25,994,225	E870G	probably damaging	Het
Rpl22l1	C	A	3: 28,807,274	Y103*	probably null	Het
Slc38a4	A	T	15: 97,016,839	N44K	possibly damaging	Het
Slco6c1	T	A	1: 97,127,898	I93F	probably damaging	Het
Ssfa2	T	A	2: 79,644,506	S270T	possibly damaging	Het
Strip1	G	A	3: 107,626,775	T181M	possibly damaging	Het
Stxbp5l	G	A	16: 37,208,096	A535V	probably damaging	Het
Tg	A	T	15: 66,729,597	Q152L	probably benign	Het
Thada	T	C	17: 84,423,163	T1036A	probably damaging	Het
Tnfrsf21	C	T	17: 43,038,213	H239Y	probably benign	Het
Tns1	T	A	1: 73,952,697	T941S	probably benign	Het
Tppp3	T	C	8: 105,468,208	D97G	probably benign	Het
Trp53bp1	C	A	2: 121,251,868	A317S	probably null	Het
Trpm7	T	C	2: 126,848,529	I210V	probably damaging	Het
Ubr1	A	G	2: 120,881,093	L1440P	probably damaging	Het
Utp18	A	T	11: 93,875,835	Y317N	probably damaging	Het
Zdhhc5	T	A	2: 84,692,480		probably benign	Het
Zfp719	A	G	7: 43,589,253		probably null	Het

Other mutations in Olfr1141

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01143:Olfr1141	APN	2	87753934	missense	probably benign	0.00
IGL01412:Olfr1141	APN	2	87753117	missense	probably damaging	1.00
IGL01533:Olfr1141	APN	2	87753068	missense	probably benign	0.01
IGL02455:Olfr1141	APN	2	87753583	missense	possibly damaging	0.95
IGL02698:Olfr1141	APN	2	87753844	nonsense	probably null
PIT4480001:Olfr1141	UTSW	2	87753783	missense	possibly damaging	0.95
R1542:Olfr1141	UTSW	2	87753318	missense	probably damaging	0.99
R1750:Olfr1141	UTSW	2	87753186	missense	probably damaging	0.97
R1844:Olfr1141	UTSW	2	87753990	start codon destroyed	probably null	1.00
R2248:Olfr1141	UTSW	2	87753943	missense	probably null	0.05
R4064:Olfr1141	UTSW	2	87753789	missense	probably damaging	1.00
R5193:Olfr1141	UTSW	2	87753104	missense	possibly damaging	0.59
R5861:Olfr1141	UTSW	2	87753578	missense	probably benign	0.01
R6146:Olfr1141	UTSW	2	87753258	missense	probably damaging	1.00
R6197:Olfr1141	UTSW	2	87753352	missense	probably benign	0.15
R6481:Olfr1141	UTSW	2	87753468	missense	probably damaging	1.00
R6857:Olfr1141	UTSW	2	87753487	missense	probably damaging	1.00
R6904:Olfr1141	UTSW	2	87753879	missense	probably benign	0.00
R6962:Olfr1141	UTSW	2	87753727	missense	probably benign
R7014:Olfr1141	UTSW	2	87753871	missense	probably benign	0.00
R8229:Olfr1141	UTSW	2	87753064	missense	probably benign	0.00
T0722:Olfr1141	UTSW	2	87753123	missense	probably damaging	1.00
Z1177:Olfr1141	UTSW	2	87753190	missense	possibly damaging	0.95

Predicted Primers

PCR Primer
(F):5'- TCCCTTGGCAGAATGGATTTTCAAGAC -3'
(R):5'- ACAGCTCCAAACACCAATGTACTTCTTT -3'

Sequencing Primer
(F):5'- GACAAGGACTTCTGAAATAGTGCTC -3'
(R):5'- CAAACACCAATGTACTTCTTTCTCAG -3'

Posted On

2013-06-12