Mutagenetix > Incidental Mutation

Incidental Mutation 'R4193:Vmn2r57'

500496

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r57

Ensembl Gene

ENSMUSG00000066537

Gene Name

vomeronasal 2, receptor 57

Synonyms

EG269902

MMRRC Submission

041024-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R4193 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

41399732-41448641 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 41428239 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 168 (F168L)

Ref Sequence

ENSEMBL: ENSMUSP00000125817 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094532] [ENSMUST00000165029]

AlphaFold

L7N269

Predicted Effect

probably benign
Transcript: ENSMUST00000094532

Predicted Effect

probably benign
Transcript: ENSMUST00000165029
AA Change: F168L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000125817
Gene: ENSMUSG00000066537
AA Change: F168L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	1.4e-44	PFAM
Pfam:NCD3G	514	567	2.7e-23	PFAM
Pfam:7tm_3	600	835	1.8e-52	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930474N05Rik	G	T	14: 36,096,579 (GRCm38)	R178L	possibly damaging	Het
Abcb1a	G	A	5: 8,715,068 (GRCm38)		probably null	Het
Acap3	A	G	4: 155,901,777 (GRCm38)	T285A	probably benign	Het
Adam20	A	T	8: 40,795,315 (GRCm38)	N154I	probably damaging	Het
Adamts8	A	T	9: 30,959,308 (GRCm38)	D693V	probably damaging	Het
Ak9	A	G	10: 41,335,945 (GRCm38)	H226R	probably benign	Het
Atp6v1b1	A	G	6: 83,743,103 (GRCm38)	S7G	probably benign	Het
Atxn7l3b	C	A	10: 112,928,705 (GRCm38)	L6F	probably damaging	Het
Bco1	C	T	8: 117,113,469 (GRCm38)	T242M	probably damaging	Het
Btla	A	G	16: 45,250,482 (GRCm38)	N268S	probably benign	Het
Capn9	A	G	8: 124,600,486 (GRCm38)	S292G	probably null	Het
Col7a1	G	A	9: 108,956,672 (GRCm38)	S403N	unknown	Het
Ctps	A	G	4: 120,548,138 (GRCm38)	V369A	probably damaging	Het
Ddx19b	A	T	8: 111,011,348 (GRCm38)	L256Q	probably damaging	Het
Dnah7a	T	C	1: 53,447,334 (GRCm38)	K3356R	probably benign	Het
Dpf2	G	A	19: 5,907,016 (GRCm38)	R60*	probably null	Het
Eif3h	A	T	15: 51,799,299 (GRCm38)	V117E	probably damaging	Het
Fam234a	A	T	17: 26,213,860 (GRCm38)	L467Q	probably damaging	Het
Fez1	T	A	9: 36,843,727 (GRCm38)	S7R	probably damaging	Het
Fh1	T	A	1: 175,614,841 (GRCm38)	M148L	possibly damaging	Het
Gabra2	G	A	5: 71,007,998 (GRCm38)	P210S	probably benign	Het
Gfm1	T	G	3: 67,431,720 (GRCm38)	I52S	probably damaging	Het
Gm13089	A	T	4: 143,698,333 (GRCm38)	L180Q	probably damaging	Het
Gm281	C	T	14: 13,914,416 (GRCm38)	V9I	probably benign	Het
Gm6729	A	T	10: 86,540,619 (GRCm38)		noncoding transcript	Het
Gpr152	T	G	19: 4,142,907 (GRCm38)	L149R	probably damaging	Het
Hist3h2ba	T	A	11: 58,949,241 (GRCm38)	L101Q	probably damaging	Het
Ifnar2	A	T	16: 91,404,344 (GRCm38)	D491V	probably damaging	Het
Igkv14-126	T	C	6: 67,896,383 (GRCm38)	S32P	possibly damaging	Het
Il1rl2	A	G	1: 40,365,048 (GRCm38)	E443G	probably damaging	Het
Impg2	A	G	16: 56,268,411 (GRCm38)	D1100G	probably benign	Het
Itga2	G	A	13: 114,886,649 (GRCm38)	R56*	probably null	Het
Itga2b	A	G	11: 102,469,685 (GRCm38)	S10P	probably benign	Het
Jmjd1c	C	T	10: 67,096,681 (GRCm38)		probably benign	Het
Kdm7a	T	G	6: 39,169,096 (GRCm38)	K299T	probably damaging	Het
Large2	T	A	2: 92,365,359 (GRCm38)	D632V	probably damaging	Het
Lrp2	C	T	2: 69,467,143 (GRCm38)	C3158Y	probably damaging	Het
Malt1	T	A	18: 65,447,675 (GRCm38)	D213E	probably benign	Het
Nkapl	T	C	13: 21,467,342 (GRCm38)	Q367R	probably benign	Het
Nwd2	T	C	5: 63,807,465 (GRCm38)	L1464P	probably damaging	Het
Olfr1016	C	T	2: 85,800,018 (GRCm38)	C84Y	probably benign	Het
Olfr1037	T	A	2: 86,085,700 (GRCm38)	I26F	probably benign	Het
Olfr1385	A	C	11: 49,495,307 (GRCm38)	Y258S	probably damaging	Het
Olfr19	A	T	16: 16,673,647 (GRCm38)	D111E	possibly damaging	Het
Olfr384	C	G	11: 73,603,417 (GRCm38)	T279R	probably damaging	Het
P2ry2	A	G	7: 100,998,450 (GRCm38)	V216A	probably benign	Het
Pcdhb1	A	G	18: 37,267,146 (GRCm38)	K717E	probably damaging	Het
Pcdhgb8	G	C	18: 37,763,541 (GRCm38)	D555H	probably damaging	Het
Pcsk6	T	C	7: 66,025,308 (GRCm38)	S476P	probably damaging	Het
Phactr3	T	A	2: 178,283,152 (GRCm38)	H293Q	probably damaging	Het
Pias1	T	C	9: 62,952,004 (GRCm38)	D74G	possibly damaging	Het
Plekhg6	T	C	6: 125,373,118 (GRCm38)	T286A	probably benign	Het
Prkag2	A	C	5: 24,878,760 (GRCm38)	M75R	probably damaging	Het
Prl7c1	T	A	13: 27,776,278 (GRCm38)	M94L	probably benign	Het
Prodh	C	T	16: 18,073,640 (GRCm38)	V480I	probably benign	Het
Ptprn2	A	G	12: 116,901,008 (GRCm38)	I548V	probably benign	Het
Ptprr	T	C	10: 116,252,864 (GRCm38)	W307R	probably damaging	Het
Rab29	T	C	1: 131,869,962 (GRCm38)	S52P	possibly damaging	Het
Ralgapa2	A	G	2: 146,342,573 (GRCm38)	F1505L	probably damaging	Het
Scn8a	C	T	15: 100,971,603 (GRCm38)	A209V	probably damaging	Het
Senp2	G	T	16: 22,046,667 (GRCm38)	W580L	probably damaging	Het
Sept4	A	T	11: 87,583,316 (GRCm38)		probably null	Het
Slc17a5	C	A	9: 78,559,106 (GRCm38)	V269L	possibly damaging	Het
Slc2a9	T	C	5: 38,398,706 (GRCm38)	N299S	probably damaging	Het
Slc41a2	T	A	10: 83,301,221 (GRCm38)	H274L	probably damaging	Het
Suco	A	T	1: 161,863,959 (GRCm38)	D43E	probably benign	Het
Tacr2	T	A	10: 62,253,179 (GRCm38)	I121N	probably damaging	Het
Tanc2	G	A	11: 105,914,062 (GRCm38)		probably benign	Het
Tbl1xr1	T	C	3: 22,200,358 (GRCm38)	F322L	possibly damaging	Het
Tdrd1	T	A	19: 56,851,341 (GRCm38)	L611*	probably null	Het
Tgfbr2	T	C	9: 116,109,941 (GRCm38)	T298A	probably damaging	Het
Tmprss12	T	C	15: 100,289,304 (GRCm38)	V217A	probably damaging	Het
Ttbk1	A	T	17: 46,479,247 (GRCm38)	C91S	probably damaging	Het
Vit	A	G	17: 78,586,826 (GRCm38)	H219R	probably benign	Het
Vmn1r71	A	T	7: 10,748,248 (GRCm38)	I105K	possibly damaging	Het
Zfp945	C	T	17: 22,851,170 (GRCm38)		probably benign	Het

Other mutations in Vmn2r57

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Vmn2r57	APN	7	41,428,785 (GRCm38)	missense	probably benign
IGL01108:Vmn2r57	APN	7	41,427,584 (GRCm38)	missense	probably benign	0.01
IGL01112:Vmn2r57	APN	7	41,425,043 (GRCm38)	missense	probably damaging	1.00
IGL01516:Vmn2r57	APN	7	41,399,946 (GRCm38)	missense	probably damaging	1.00
IGL01880:Vmn2r57	APN	7	41,400,195 (GRCm38)	missense	possibly damaging	0.73
IGL02117:Vmn2r57	APN	7	41,400,450 (GRCm38)	missense	probably benign	0.00
IGL02500:Vmn2r57	APN	7	41,428,226 (GRCm38)	missense	probably benign
IGL02801:Vmn2r57	APN	7	41,448,632 (GRCm38)	missense	probably benign	0.13
IGL02993:Vmn2r57	APN	7	41,428,074 (GRCm38)	missense	probably benign	0.04
IGL02996:Vmn2r57	APN	7	41,399,741 (GRCm38)	missense	probably benign	0.02
R0008:Vmn2r57	UTSW	7	41,400,652 (GRCm38)	missense	probably damaging	1.00
R0032:Vmn2r57	UTSW	7	41,399,733 (GRCm38)	splice site	probably null
R0305:Vmn2r57	UTSW	7	41,427,543 (GRCm38)	missense	probably benign	0.00
R0469:Vmn2r57	UTSW	7	41,427,792 (GRCm38)	missense	possibly damaging	0.58
R0510:Vmn2r57	UTSW	7	41,427,792 (GRCm38)	missense	possibly damaging	0.58
R0847:Vmn2r57	UTSW	7	41,428,801 (GRCm38)	missense	probably benign	0.00
R1025:Vmn2r57	UTSW	7	41,427,804 (GRCm38)	missense	probably benign	0.24
R1081:Vmn2r57	UTSW	7	41,428,211 (GRCm38)	missense	possibly damaging	0.47
R1479:Vmn2r57	UTSW	7	41,427,830 (GRCm38)	missense	possibly damaging	0.45
R1579:Vmn2r57	UTSW	7	41,400,124 (GRCm38)	missense	probably benign	0.38
R1764:Vmn2r57	UTSW	7	41,400,643 (GRCm38)	missense	probably damaging	1.00
R1848:Vmn2r57	UTSW	7	41,428,107 (GRCm38)	missense	probably damaging	1.00
R2006:Vmn2r57	UTSW	7	41,448,577 (GRCm38)	missense	probably benign	0.00
R2197:Vmn2r57	UTSW	7	41,428,825 (GRCm38)	critical splice acceptor site	probably null
R2242:Vmn2r57	UTSW	7	41,428,074 (GRCm38)	missense	probably benign	0.00
R2394:Vmn2r57	UTSW	7	41,400,195 (GRCm38)	missense	possibly damaging	0.73
R3937:Vmn2r57	UTSW	7	41,428,130 (GRCm38)	missense	probably damaging	0.97
R4423:Vmn2r57	UTSW	7	41,426,640 (GRCm38)	missense	probably damaging	1.00
R4865:Vmn2r57	UTSW	7	41,400,468 (GRCm38)	missense	probably damaging	1.00
R4947:Vmn2r57	UTSW	7	41,400,495 (GRCm38)	missense	probably damaging	1.00
R5042:Vmn2r57	UTSW	7	41,428,662 (GRCm38)	missense	probably benign	0.06
R5084:Vmn2r57	UTSW	7	41,426,550 (GRCm38)	critical splice donor site	probably null
R5177:Vmn2r57	UTSW	7	41,400,240 (GRCm38)	missense	probably benign	0.31
R5192:Vmn2r57	UTSW	7	41,427,939 (GRCm38)	missense	probably damaging	0.96
R5289:Vmn2r57	UTSW	7	41,399,974 (GRCm38)	missense	probably damaging	0.99
R5745:Vmn2r57	UTSW	7	41,448,471 (GRCm38)	missense	possibly damaging	0.51
R6051:Vmn2r57	UTSW	7	41,448,472 (GRCm38)	missense	probably benign	0.00
R6155:Vmn2r57	UTSW	7	41,428,690 (GRCm38)	missense	probably benign	0.14
R6248:Vmn2r57	UTSW	7	41,399,860 (GRCm38)	missense	probably benign
R6381:Vmn2r57	UTSW	7	41,428,818 (GRCm38)	missense	probably benign	0.08
R7019:Vmn2r57	UTSW	7	41,428,665 (GRCm38)	missense	probably damaging	1.00
R7126:Vmn2r57	UTSW	7	41,399,794 (GRCm38)	missense	possibly damaging	0.93
R7146:Vmn2r57	UTSW	7	41,448,471 (GRCm38)	missense	possibly damaging	0.51
R7215:Vmn2r57	UTSW	7	41,400,286 (GRCm38)	missense	probably benign	0.00
R7432:Vmn2r57	UTSW	7	41,426,724 (GRCm38)	missense	probably benign	0.01
R7633:Vmn2r57	UTSW	7	41,425,089 (GRCm38)	missense	possibly damaging	0.76
R7811:Vmn2r57	UTSW	7	41,425,015 (GRCm38)	nonsense	probably null
R8025:Vmn2r57	UTSW	7	41,426,759 (GRCm38)	missense	probably benign	0.00
R8332:Vmn2r57	UTSW	7	41,400,253 (GRCm38)	missense	probably benign	0.01
R8345:Vmn2r57	UTSW	7	41,427,544 (GRCm38)	missense	possibly damaging	0.81
R8360:Vmn2r57	UTSW	7	41,400,216 (GRCm38)	missense	probably damaging	1.00
R8738:Vmn2r57	UTSW	7	41,427,596 (GRCm38)	missense	probably benign	0.00
R8758:Vmn2r57	UTSW	7	41,428,739 (GRCm38)	missense	probably damaging	1.00
R8955:Vmn2r57	UTSW	7	41,400,147 (GRCm38)	missense	possibly damaging	0.64
R8985:Vmn2r57	UTSW	7	41,399,835 (GRCm38)	missense	probably benign
R9108:Vmn2r57	UTSW	7	41,428,768 (GRCm38)	missense	possibly damaging	0.87
R9160:Vmn2r57	UTSW	7	41,426,735 (GRCm38)	missense	possibly damaging	0.48
R9354:Vmn2r57	UTSW	7	41,400,239 (GRCm38)	missense	probably benign	0.01
R9566:Vmn2r57	UTSW	7	41,427,665 (GRCm38)	missense	probably benign	0.32
R9633:Vmn2r57	UTSW	7	41,426,582 (GRCm38)	missense	probably benign	0.00
X0026:Vmn2r57	UTSW	7	41,428,561 (GRCm38)	missense	possibly damaging	0.91
X0026:Vmn2r57	UTSW	7	41,428,125 (GRCm38)	missense	probably benign	0.03
X0065:Vmn2r57	UTSW	7	41,427,971 (GRCm38)	missense	probably benign	0.09
Z1176:Vmn2r57	UTSW	7	41,400,498 (GRCm38)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- ACAGAATCTGAGTCCCTCTGG -3'
(R):5'- TACCACAGGTGAGCAGTAGG -3'

Sequencing Primer
(F):5'- CCTCTGGGGTCATTTGGGAC -3'
(R):5'- ATGTGGGAACTGGTGTCATATATC -3'

Posted On

2017-12-01