Incidental Mutation 'R4201:Tnfrsf23'
ID 500499
Institutional Source Beutler Lab
Gene Symbol Tnfrsf23
Ensembl Gene ENSMUSG00000037613
Gene Name tumor necrosis factor receptor superfamily, member 23
Synonyms Tnfrh1, mSOB, mDcTrailr1
MMRRC Submission 041031-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R4201 (G1)
Quality Score 111
Status Not validated
Chromosome 7
Chromosomal Location 143219546-143239609 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 143223791 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 137 (C137S)
Ref Sequence ENSEMBL: ENSMUSP00000116742 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035742] [ENSMUST00000152703] [ENSMUST00000208017]
AlphaFold Q9ER63
Predicted Effect probably benign
Transcript: ENSMUST00000035742
SMART Domains Protein: ENSMUSP00000042431
Gene: ENSMUSG00000037613

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
TNFR 38 72 1.55e-1 SMART
TNFR 75 104 3.12e1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000152703
AA Change: C137S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000116742
Gene: ENSMUSG00000037613
AA Change: C137S

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
TNFR 38 72 1.55e-1 SMART
TNFR 75 114 1.29e-7 SMART
TNFR 116 155 2.14e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207189
Predicted Effect silent
Transcript: ENSMUST00000208017
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 96.0%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the tumor necrosis factor superfamily of proteins. The encoded receptor has been shown to bind to the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), but to have no signaling capacity. This gene shows elevated expression in mice with diet-induced fatty liver disease. This gene and other family members are present in a gene cluster on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik A G 18: 6,623,952 (GRCm39) probably null Het
Als2 A T 1: 59,219,313 (GRCm39) D1212E possibly damaging Het
Arfgef3 A G 10: 18,495,530 (GRCm39) S1167P probably benign Het
Arl6ip1 AAAATAAATAAATAAATAAATAAATA AAAATAAATAAATAAATAAATAAATAAATA 7: 117,721,122 (GRCm39) probably benign Het
Atp1b2 A G 11: 69,494,295 (GRCm39) V66A possibly damaging Het
Bag3 C A 7: 128,147,881 (GRCm39) L499I probably damaging Het
Boc T C 16: 44,310,981 (GRCm39) D751G probably damaging Het
Camk1d T C 2: 5,359,587 (GRCm39) Y145C probably benign Het
Ccdc172 G A 19: 58,525,017 (GRCm39) R158H probably benign Het
Cd101 A C 3: 100,926,001 (GRCm39) D239E probably damaging Het
Cd9 T C 6: 125,439,357 (GRCm39) D125G possibly damaging Het
Cep295 T C 9: 15,243,834 (GRCm39) I1493V probably benign Het
Chrna5 A G 9: 54,905,359 (GRCm39) D57G probably benign Het
Cul7 C T 17: 46,972,238 (GRCm39) R1201W probably damaging Het
Dnah1 A G 14: 30,984,227 (GRCm39) V3976A probably benign Het
Dnah11 T C 12: 117,930,394 (GRCm39) D3317G possibly damaging Het
Dnmt3b G T 2: 153,512,337 (GRCm39) E353* probably null Het
Gch1 T C 14: 47,393,260 (GRCm39) S241G probably benign Het
Gpr22 A T 12: 31,758,912 (GRCm39) Y366* probably null Het
Gse1 A T 8: 121,294,503 (GRCm39) M277L probably benign Het
Kcnt2 G A 1: 140,353,070 (GRCm39) V260I probably damaging Het
Nbas G T 12: 13,424,827 (GRCm39) C1022F probably benign Het
Nfix CAAAAA CAAAA 8: 85,442,876 (GRCm39) probably null Het
Or6c206 T C 10: 129,097,646 (GRCm39) V272A probably benign Het
Or6c214 A T 10: 129,590,497 (GRCm39) L274H probably damaging Het
Parp4 C A 14: 56,829,848 (GRCm39) T274K possibly damaging Het
Pgs1 A G 11: 117,893,362 (GRCm39) S230G probably damaging Het
Plin4 T G 17: 56,411,338 (GRCm39) T898P probably damaging Het
Ptprj A C 2: 90,293,439 (GRCm39) V548G probably damaging Het
Sec23a T C 12: 59,048,791 (GRCm39) I139M probably benign Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Stx17 T A 4: 48,158,870 (GRCm39) D83E probably damaging Het
Syne1 A T 10: 5,297,870 (GRCm39) D1142E probably benign Het
Tbccd1 A G 16: 22,644,698 (GRCm39) V226A probably damaging Het
Tex11 C A X: 99,977,021 (GRCm39) A487S possibly damaging Het
Tmed7 A G 18: 46,726,314 (GRCm39) probably null Het
Vmn2r87 T C 10: 130,308,448 (GRCm39) I597V probably benign Het
Other mutations in Tnfrsf23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01636:Tnfrsf23 APN 7 143,233,736 (GRCm39) missense probably damaging 0.99
IGL02409:Tnfrsf23 APN 7 143,222,308 (GRCm39) missense probably damaging 0.98
R1936:Tnfrsf23 UTSW 7 143,222,291 (GRCm39) missense probably benign 0.04
R3840:Tnfrsf23 UTSW 7 143,235,266 (GRCm39) missense probably benign 0.09
R4786:Tnfrsf23 UTSW 7 143,233,801 (GRCm39) missense probably damaging 1.00
R4858:Tnfrsf23 UTSW 7 143,235,217 (GRCm39) missense probably damaging 1.00
R5226:Tnfrsf23 UTSW 7 143,239,522 (GRCm39) missense possibly damaging 0.68
R7687:Tnfrsf23 UTSW 7 143,235,199 (GRCm39) missense probably benign 0.29
R7759:Tnfrsf23 UTSW 7 143,224,572 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GATAGAGGAGCTGGTATTCAGTTTC -3'
(R):5'- ACTGTCTGAGATGCCAGTGG -3'

Sequencing Primer
(F):5'- CTGAGGGTGTTCAATGCCACAG -3'
(R):5'- CTGAGATGCCAGTGGGTCTG -3'
Posted On 2017-12-01