Incidental Mutation 'R4615:Vmn2r15'
ID 500671
Institutional Source Beutler Lab
Gene Symbol Vmn2r15
Ensembl Gene ENSMUSG00000091375
Gene Name vomeronasal 2, receptor 15
Synonyms EG211223
MMRRC Submission 041826-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R4615 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 109434135-109445422 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 109441348 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 170 (V170A)
Ref Sequence ENSEMBL: ENSMUSP00000128333 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167133]
AlphaFold L7N2A0
Predicted Effect possibly damaging
Transcript: ENSMUST00000167133
AA Change: V170A

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000128333
Gene: ENSMUSG00000091375
AA Change: V170A

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 75 472 1e-29 PFAM
Pfam:NCD3G 514 568 5.8e-18 PFAM
Pfam:7tm_3 601 836 9.1e-55 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,369,493 (GRCm39) I363V probably benign Het
Abcc9 C G 6: 142,634,833 (GRCm39) A144P possibly damaging Het
Adgrv1 C T 13: 81,642,688 (GRCm39) probably null Het
Adprhl1 A G 8: 13,292,250 (GRCm39) probably null Het
Angptl3 A T 4: 98,919,598 (GRCm39) E119D probably benign Het
Atp8b1 T C 18: 64,686,170 (GRCm39) N671S probably null Het
C9 A G 15: 6,520,944 (GRCm39) D51G probably damaging Het
Carmil2 A G 8: 106,421,706 (GRCm39) D1019G possibly damaging Het
Cdh8 A T 8: 100,006,254 (GRCm39) I111K probably damaging Het
Cep120 T C 18: 53,847,913 (GRCm39) R649G probably damaging Het
Clptm1l A T 13: 73,755,857 (GRCm39) K158* probably null Het
Cmtm1 CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT 8: 105,036,102 (GRCm39) probably benign Het
Cnga1 A C 5: 72,762,117 (GRCm39) L466V probably damaging Het
Cpsf1 T C 15: 76,481,137 (GRCm39) T1240A possibly damaging Het
Cubn A G 2: 13,433,560 (GRCm39) S1117P probably damaging Het
Cyp2b9 T A 7: 25,900,550 (GRCm39) L396Q probably damaging Het
Cyp8b1 A T 9: 121,745,164 (GRCm39) L56* probably null Het
Dcbld2 A G 16: 58,276,457 (GRCm39) T458A probably benign Het
Dio2 G T 12: 90,696,595 (GRCm39) P131Q probably damaging Het
Dlg5 T C 14: 24,208,236 (GRCm39) Y990C probably damaging Het
Dsc3 T C 18: 20,104,545 (GRCm39) D594G possibly damaging Het
Dsp A G 13: 38,375,608 (GRCm39) E1131G probably damaging Het
Fdx1 A T 9: 51,859,945 (GRCm39) Y21* probably null Het
Gal3st4 A G 5: 138,264,525 (GRCm39) V158A probably damaging Het
Gm10269 T A 18: 20,815,820 (GRCm39) E67D probably benign Het
Gm5773 A G 3: 93,681,339 (GRCm39) H337R probably benign Het
Gng2 C T 14: 19,941,395 (GRCm39) V16I possibly damaging Het
Gpr20 T C 15: 73,567,585 (GRCm39) N268S probably benign Het
Ighv1-82 T C 12: 115,916,280 (GRCm39) T77A probably benign Het
Itprid2 A G 2: 79,492,726 (GRCm39) E1091G probably damaging Het
Lama2 C A 10: 26,857,520 (GRCm39) V3110F probably damaging Het
Mplkipl1 C T 19: 61,164,364 (GRCm39) G24R unknown Het
Mtmr4 T C 11: 87,501,761 (GRCm39) L548S probably damaging Het
Ncapg A T 5: 45,844,741 (GRCm39) M579L probably benign Het
Oog3 A T 4: 143,884,899 (GRCm39) Y346N probably benign Het
Or10ak14 T C 4: 118,611,334 (GRCm39) T134A probably benign Het
Or14c39 T C 7: 86,343,936 (GRCm39) S91P probably damaging Het
Orm2 A G 4: 63,281,536 (GRCm39) D89G probably damaging Het
Pcdhb4 T A 18: 37,441,553 (GRCm39) S288T probably benign Het
Pcsk2 G T 2: 143,637,889 (GRCm39) C375F probably damaging Het
Pdcd10 T C 3: 75,428,398 (GRCm39) I138M probably damaging Het
Pde8a T C 7: 80,970,485 (GRCm39) W536R probably damaging Het
Phkg2 C T 7: 127,176,792 (GRCm39) R61W probably damaging Het
Plcl1 A T 1: 55,737,293 (GRCm39) N878I probably benign Het
Prkdc A T 16: 15,480,938 (GRCm39) D353V probably damaging Het
Psme4 C T 11: 30,784,287 (GRCm39) T954I probably benign Het
Ran A G 5: 129,099,162 (GRCm39) I115V probably benign Het
Reln A G 5: 22,177,870 (GRCm39) L1867P possibly damaging Het
S100a1 A G 3: 90,418,562 (GRCm39) V84A possibly damaging Het
Sall2 G A 14: 52,550,207 (GRCm39) P994L probably benign Het
Shtn1 A T 19: 59,010,648 (GRCm39) I273N probably benign Het
Slc17a9 T C 2: 180,373,699 (GRCm39) I40T probably benign Het
Slc29a2 T C 19: 5,079,292 (GRCm39) V305A probably damaging Het
Taar2 T A 10: 23,817,263 (GRCm39) F268I probably benign Het
Taf3 G A 2: 9,956,901 (GRCm39) T422I probably damaging Het
Tgs1 T C 4: 3,585,156 (GRCm39) F99L probably damaging Het
Tox2 T C 2: 163,162,567 (GRCm39) L479P probably damaging Het
Ttn A G 2: 76,597,219 (GRCm39) I19898T probably damaging Het
Ulk1 G T 5: 110,936,912 (GRCm39) T3N probably damaging Het
Vars1 A T 17: 35,232,857 (GRCm39) K900N probably damaging Het
Vmn2r53 A T 7: 12,316,229 (GRCm39) L530Q probably damaging Het
Zar1l G T 5: 150,441,528 (GRCm39) Q33K probably benign Het
Zdhhc16 T C 19: 41,932,122 (GRCm39) V358A possibly damaging Het
Other mutations in Vmn2r15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01335:Vmn2r15 APN 5 109,434,602 (GRCm39) missense possibly damaging 0.70
IGL01367:Vmn2r15 APN 5 109,441,075 (GRCm39) missense probably damaging 0.99
IGL01844:Vmn2r15 APN 5 109,434,135 (GRCm39) makesense probably null
IGL02190:Vmn2r15 APN 5 109,441,240 (GRCm39) missense probably damaging 1.00
IGL02754:Vmn2r15 APN 5 109,441,134 (GRCm39) nonsense probably null
IGL02797:Vmn2r15 APN 5 109,445,250 (GRCm39) missense probably benign 0.18
IGL03301:Vmn2r15 APN 5 109,445,221 (GRCm39) critical splice donor site probably null
IGL03407:Vmn2r15 APN 5 109,434,185 (GRCm39) nonsense probably null
BB001:Vmn2r15 UTSW 5 109,434,254 (GRCm39) missense probably damaging 1.00
BB011:Vmn2r15 UTSW 5 109,434,254 (GRCm39) missense probably damaging 1.00
PIT4445001:Vmn2r15 UTSW 5 109,435,008 (GRCm39) missense probably damaging 0.99
PIT4520001:Vmn2r15 UTSW 5 109,434,871 (GRCm39) missense probably damaging 1.00
R0038:Vmn2r15 UTSW 5 109,441,010 (GRCm39) missense possibly damaging 0.46
R0111:Vmn2r15 UTSW 5 109,435,022 (GRCm39) missense possibly damaging 0.56
R0379:Vmn2r15 UTSW 5 109,434,344 (GRCm39) missense probably damaging 1.00
R0427:Vmn2r15 UTSW 5 109,434,953 (GRCm39) missense probably damaging 1.00
R0639:Vmn2r15 UTSW 5 109,440,881 (GRCm39) missense probably benign 0.22
R0964:Vmn2r15 UTSW 5 109,445,401 (GRCm39) missense probably benign 0.34
R1147:Vmn2r15 UTSW 5 109,441,072 (GRCm39) missense probably damaging 1.00
R1147:Vmn2r15 UTSW 5 109,441,072 (GRCm39) missense probably damaging 1.00
R1232:Vmn2r15 UTSW 5 109,441,168 (GRCm39) missense probably benign 0.39
R1241:Vmn2r15 UTSW 5 109,440,770 (GRCm39) missense probably damaging 1.00
R1244:Vmn2r15 UTSW 5 109,441,092 (GRCm39) nonsense probably null
R1394:Vmn2r15 UTSW 5 109,442,014 (GRCm39) missense probably benign 0.44
R1395:Vmn2r15 UTSW 5 109,442,014 (GRCm39) missense probably benign 0.44
R1423:Vmn2r15 UTSW 5 109,441,093 (GRCm39) missense probably damaging 1.00
R1439:Vmn2r15 UTSW 5 109,441,953 (GRCm39) missense probably damaging 1.00
R1513:Vmn2r15 UTSW 5 109,441,195 (GRCm39) missense probably damaging 1.00
R1777:Vmn2r15 UTSW 5 109,442,136 (GRCm39) missense possibly damaging 0.79
R1844:Vmn2r15 UTSW 5 109,434,860 (GRCm39) nonsense probably null
R2072:Vmn2r15 UTSW 5 109,434,619 (GRCm39) missense possibly damaging 0.65
R2074:Vmn2r15 UTSW 5 109,434,619 (GRCm39) missense possibly damaging 0.65
R2122:Vmn2r15 UTSW 5 109,434,322 (GRCm39) missense probably damaging 1.00
R2208:Vmn2r15 UTSW 5 109,445,309 (GRCm39) missense possibly damaging 0.64
R2268:Vmn2r15 UTSW 5 109,441,073 (GRCm39) missense probably benign 0.31
R2831:Vmn2r15 UTSW 5 109,434,458 (GRCm39) missense probably damaging 1.00
R3848:Vmn2r15 UTSW 5 109,445,312 (GRCm39) missense probably benign 0.00
R4058:Vmn2r15 UTSW 5 109,441,312 (GRCm39) missense probably damaging 0.99
R4663:Vmn2r15 UTSW 5 109,441,940 (GRCm39) missense probably benign
R4681:Vmn2r15 UTSW 5 109,434,488 (GRCm39) missense probably damaging 0.97
R4751:Vmn2r15 UTSW 5 109,434,620 (GRCm39) missense probably benign 0.01
R5095:Vmn2r15 UTSW 5 109,436,317 (GRCm39) critical splice acceptor site probably null
R5300:Vmn2r15 UTSW 5 109,441,974 (GRCm39) missense probably damaging 0.99
R5309:Vmn2r15 UTSW 5 109,440,956 (GRCm39) missense probably damaging 0.99
R5335:Vmn2r15 UTSW 5 109,434,673 (GRCm39) missense probably damaging 0.99
R5421:Vmn2r15 UTSW 5 109,434,401 (GRCm39) missense probably damaging 1.00
R5805:Vmn2r15 UTSW 5 109,434,806 (GRCm39) missense possibly damaging 0.88
R6280:Vmn2r15 UTSW 5 109,441,291 (GRCm39) missense possibly damaging 0.65
R6324:Vmn2r15 UTSW 5 109,434,137 (GRCm39) makesense probably null
R6383:Vmn2r15 UTSW 5 109,441,092 (GRCm39) nonsense probably null
R6772:Vmn2r15 UTSW 5 109,434,238 (GRCm39) missense probably damaging 0.99
R6991:Vmn2r15 UTSW 5 109,441,180 (GRCm39) missense probably damaging 1.00
R7194:Vmn2r15 UTSW 5 109,440,649 (GRCm39) missense probably damaging 1.00
R7365:Vmn2r15 UTSW 5 109,445,388 (GRCm39) missense probably benign 0.15
R7365:Vmn2r15 UTSW 5 109,441,105 (GRCm39) missense probably benign 0.19
R7423:Vmn2r15 UTSW 5 109,445,394 (GRCm39) missense probably benign 0.00
R7552:Vmn2r15 UTSW 5 109,440,774 (GRCm39) nonsense probably null
R7619:Vmn2r15 UTSW 5 109,436,190 (GRCm39) critical splice donor site probably null
R7892:Vmn2r15 UTSW 5 109,434,217 (GRCm39) missense probably damaging 1.00
R7924:Vmn2r15 UTSW 5 109,434,254 (GRCm39) missense probably damaging 1.00
R8058:Vmn2r15 UTSW 5 109,440,956 (GRCm39) missense probably damaging 0.99
R8099:Vmn2r15 UTSW 5 109,441,185 (GRCm39) missense possibly damaging 0.58
R8189:Vmn2r15 UTSW 5 109,434,713 (GRCm39) missense probably benign 0.02
R8275:Vmn2r15 UTSW 5 109,434,150 (GRCm39) missense probably benign 0.08
R8277:Vmn2r15 UTSW 5 109,441,310 (GRCm39) missense probably damaging 1.00
R8277:Vmn2r15 UTSW 5 109,440,970 (GRCm39) missense probably benign 0.00
R8465:Vmn2r15 UTSW 5 109,445,302 (GRCm39) missense probably damaging 1.00
R8679:Vmn2r15 UTSW 5 109,434,779 (GRCm39) missense probably benign 0.31
R8682:Vmn2r15 UTSW 5 109,441,938 (GRCm39) missense probably damaging 0.98
R8809:Vmn2r15 UTSW 5 109,434,874 (GRCm39) missense probably benign 0.22
R9016:Vmn2r15 UTSW 5 109,442,109 (GRCm39) missense probably benign 0.01
R9372:Vmn2r15 UTSW 5 109,441,953 (GRCm39) missense possibly damaging 0.60
R9596:Vmn2r15 UTSW 5 109,440,791 (GRCm39) missense probably benign 0.01
R9619:Vmn2r15 UTSW 5 109,440,622 (GRCm39) missense possibly damaging 0.58
R9685:Vmn2r15 UTSW 5 109,440,598 (GRCm39) missense probably benign 0.05
R9716:Vmn2r15 UTSW 5 109,445,224 (GRCm39) missense possibly damaging 0.88
R9772:Vmn2r15 UTSW 5 109,434,923 (GRCm39) missense probably damaging 1.00
X0065:Vmn2r15 UTSW 5 109,441,174 (GRCm39) missense probably damaging 1.00
Z1187:Vmn2r15 UTSW 5 109,434,529 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCTAAACAGATTCCATGTCTTTGC -3'
(R):5'- CAGGCAAAACTGTTTTCTAGGAC -3'

Sequencing Primer
(F):5'- TCTTCTCTCAAGTCTGATAGAAACTG -3'
(R):5'- TTCTAGGACATTCAAATTTGTCAGG -3'
Posted On 2017-12-01