Incidental Mutation 'R5189:Suds3'
ID 500913
Institutional Source Beutler Lab
Gene Symbol Suds3
Ensembl Gene ENSMUSG00000066900
Gene Name suppressor of defective silencing 3 homolog (S. cerevisiae)
Synonyms 2400003N08Rik, 2410008L21Rik
MMRRC Submission 042767-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5189 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 117229745-117254178 bp(-) (GRCm39)
Type of Mutation critical splice donor site
DNA Base Change (assembly) T to C at 117238664 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000130535 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086471] [ENSMUST00000166397]
AlphaFold Q8BR65
Predicted Effect probably benign
Transcript: ENSMUST00000086471
SMART Domains Protein: ENSMUSP00000083662
Gene: ENSMUSG00000066900

DomainStartEndE-ValueType
low complexity region 2 37 N/A INTRINSIC
Pfam:Sds3 52 223 3.6e-30 PFAM
low complexity region 225 238 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000166397
SMART Domains Protein: ENSMUSP00000130535
Gene: ENSMUSG00000066900

DomainStartEndE-ValueType
low complexity region 2 37 N/A INTRINSIC
low complexity region 44 56 N/A INTRINSIC
Pfam:Sds3 61 296 4.7e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200684
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201287
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202684
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202713
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele display early embryonic lethality in the peri-implantation period. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik C T 12: 71,240,123 (GRCm39) T1311I possibly damaging Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
4930505A04Rik T C 11: 30,376,169 (GRCm39) T233A probably damaging Het
Ankar T C 1: 72,697,573 (GRCm39) I859V probably benign Het
Cacnb2 G T 2: 14,990,849 (GRCm39) A644S possibly damaging Het
Gatb T C 3: 85,544,238 (GRCm39) V402A probably benign Het
Gpcpd1 T C 2: 132,395,892 (GRCm39) K153R probably damaging Het
Hip1 A G 5: 135,463,147 (GRCm39) L60S probably damaging Het
Hsf4 GCAGCACCGGGTCA G 8: 105,998,060 (GRCm39) probably null Het
Hydin A T 8: 111,139,843 (GRCm39) probably null Het
Igsf3 A T 3: 101,338,843 (GRCm39) T386S possibly damaging Het
Il12rb1 A G 8: 71,263,702 (GRCm39) T88A possibly damaging Het
Kank1 T C 19: 25,401,545 (GRCm39) S1051P probably damaging Het
Kap A G 6: 133,828,879 (GRCm39) probably null Het
Ly96 A G 1: 16,771,091 (GRCm39) E74G probably damaging Het
Map7d1 G T 4: 126,136,097 (GRCm39) probably null Het
Megf6 G T 4: 154,336,980 (GRCm39) R253L probably benign Het
Mex3b A G 7: 82,518,459 (GRCm39) D258G probably damaging Het
Mpzl3 T C 9: 44,973,408 (GRCm39) I49T possibly damaging Het
Myh15 C A 16: 48,921,870 (GRCm39) T472N probably benign Het
Nacad A G 11: 6,551,611 (GRCm39) S527P probably damaging Het
Nkx2-3 T G 19: 43,601,147 (GRCm39) S70A probably benign Het
Nkx2-6 A T 14: 69,409,342 (GRCm39) Q31L probably benign Het
Or6ae1 A G 7: 139,742,632 (GRCm39) V77A probably damaging Het
Pcdha6 A T 18: 37,101,844 (GRCm39) N346Y probably damaging Het
Pkd2 G A 5: 104,607,785 (GRCm39) D95N probably benign Het
Pkhd1l1 A G 15: 44,410,544 (GRCm39) T2684A probably damaging Het
Plin2 A G 4: 86,575,383 (GRCm39) Y389H probably damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Slc41a2 T C 10: 83,149,275 (GRCm39) probably null Het
Smg6 A G 11: 74,932,822 (GRCm39) T1038A probably damaging Het
Tbc1d8 T C 1: 39,424,213 (GRCm39) H626R probably benign Het
Tmem260 T A 14: 48,746,573 (GRCm39) H616Q probably benign Het
Trip10 A T 17: 57,568,288 (GRCm39) probably null Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ubr4 A G 4: 139,137,960 (GRCm39) T1106A probably benign Het
Vmn1r84 A T 7: 12,096,385 (GRCm39) S103T probably benign Het
Vps13a G T 19: 16,662,679 (GRCm39) P1602Q probably damaging Het
Other mutations in Suds3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02675:Suds3 APN 5 117,232,970 (GRCm39) splice site probably null
IGL02713:Suds3 APN 5 117,232,970 (GRCm39) splice site probably null
R1779:Suds3 UTSW 5 117,243,309 (GRCm39) missense probably benign 0.02
R1986:Suds3 UTSW 5 117,246,417 (GRCm39) missense probably damaging 0.98
R2519:Suds3 UTSW 5 117,233,018 (GRCm39) missense probably damaging 1.00
R6213:Suds3 UTSW 5 117,244,727 (GRCm39) missense probably damaging 0.99
R7756:Suds3 UTSW 5 117,253,802 (GRCm39) missense unknown
R7758:Suds3 UTSW 5 117,253,802 (GRCm39) missense unknown
R7818:Suds3 UTSW 5 117,253,814 (GRCm39) unclassified probably benign
R7879:Suds3 UTSW 5 117,236,335 (GRCm39) critical splice donor site probably null
R8978:Suds3 UTSW 5 117,232,973 (GRCm39) critical splice donor site probably null
R9613:Suds3 UTSW 5 117,243,234 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- TTCTGGAAACCTCTCCAACG -3'
(R):5'- TGGTCACATAGCTGCAGTG -3'

Sequencing Primer
(F):5'- CGAAAAGCAATAGTTGACTCCAGTGC -3'
(R):5'- CACATAGCTGCAGTGGGATGTC -3'
Posted On 2017-12-01